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DNA Variations in the Gene in Young Patients With Wilms' Tumor

17 mei 2016 bijgewerkt door: Children's Oncology Group

The Incidence, Inheritance, and Prognostic Significance of Polymorphisms in the RASSF1A Gene in Children With Wilms Tumors

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms' tumor.

Studie Overzicht

Toestand

Voltooid

Conditie

Nierkanker

Interventie / Behandeling

Gedetailleerde beschrijving

OBJECTIVES:

Primary

Determine the presence of the A133S polymorphism in the RASSF1A tumor suppressor gene by screening germline DNAs of children with Wilms' tumor.
Determine the inheritance pattern of the A133S polymorphism by evaluating the parents of children who carry this polymorphism.

Secondary

Determine the differences in age at diagnosis, stage, histology, site of primary tumor, and outcome, between patients with vs without the A133S polymorphism.
Determine whether the S131F RASSF1A variant is a true polymorphism in these patients.
Determine the polymorphic differences in this gene between these patients based on ethnicity and sex.

OUTLINE: This is a multicenter study. Patients are stratified according to age at diagnosis, stage, histology, site of primary tumor, and outcome.

Genomic DNA samples are purified from peripheral blood of patients and controls and analyzed by polymerase chain reaction for the RASSF1A gene. DNA is also analyzed from parents of patients with the A133S polymorphism.

PROJECTED ACCRUAL: A total of 471 participants (229 Wilms' tumor patients and 200 control participants plus 42 parents) will be accrued for this study.

Studietype

Observationeel

Inschrijving (Verwacht)

471

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

Australië
- New South Wales
  - Randwick, New South Wales, Australië, 2031
    - Sydney Children's Hospital
  - Westmead, New South Wales, Australië, 2145
    - Children's Hospital at Westmead
- South Australia
  - North Adelaide, South Australia, Australië, 5006
    - Women's and Children's Hospital
- Victoria
  - Parkville, Victoria, Australië, 3052
    - Royal Children's Hospital
- Western Australia
  - Perth, Western Australia, Australië, 6001
    - Princess Margaret Hospital for Children
Canada
- Alberta
  - Calgary, Alberta, Canada, T2T 5C7
    - Alberta Children's Hospital
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Vancouver, British Columbia, Canada, V6H 3V4
    - British Columbia Children's Hospital
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B 3V6
    - Janeway Children's Health and Rehabilitation Centre
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3J 3G9
    - IWK Health Centre
- Ontario
  - Hamilton, Ontario, Canada, L8S 4J9
    - McMaster Children's Hospital at Hamilton Health Sciences
  - London, Ontario, Canada, N6C 2V5
    - Children's Hospital of Western Ontario
  - Ottawa, Ontario, Canada, K1H 8L1
    - Children's Hospital of Eastern Ontario
  - Toronto, Ontario, Canada, M5G 1X8
    - Hospital for Sick Children
- Quebec
  - Montreal, Quebec, Canada, H3T 1C5
    - Hopital Sainte Justine
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal Children's Hospital at McGill University Health Center
  - Sainte Foy, Quebec, Canada, GIV 4G2
    - Centre de Recherche du Centre Hospitalier de l'Universite Laval
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Nederland
- - Groningen, Nederland, 9700 RB
    - Academisch Ziekenhuis Groningen
Nieuw-Zeeland
- - Auckland, Nieuw-Zeeland
    - Starship Children's Health
Puerto Rico
- - San Juan, Puerto Rico, 00936-5067
    - Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus
  - Santurce, Puerto Rico, 00912
    - San Jorge Childrens Hospital
Verenigde Staten
- Alabama
  - Birmingham, Alabama, Verenigde Staten, 35233
    - University of Alabama at Birmingham Comprehensive Cancer Center
  - Mobile, Alabama, Verenigde Staten, 36604
    - University of South Alabama Cancer Research Institute
- Arizona
  - Phoenix, Arizona, Verenigde Staten, 85016
    - Phoenix Children's Hospital
  - Tucson, Arizona, Verenigde Staten, 85724
    - Arizona Cancer Center at University of Arizona Health Sciences Center
- Arkansas
  - Little Rock, Arkansas, Verenigde Staten, 72205
    - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- California
  - Downey, California, Verenigde Staten, 90242
    - Southern California Permanente Medical Group
  - La Jolla, California, Verenigde Staten, 92093-0658
    - Rebecca and John Moores UCSD Cancer Center
  - Loma Linda, California, Verenigde Staten, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Long Beach, California, Verenigde Staten, 90801-1428
    - Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
  - Los Angeles, California, Verenigde Staten, 90048
    - Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
  - Los Angeles, California, Verenigde Staten, 90095-1781
    - Jonsson Comprehensive Cancer Center, UCLA
  - Los Angeles, California, Verenigde Staten, 90027-0700
    - Children's Hospital Los Angeles
  - Madera, California, Verenigde Staten, 93638-8762
    - Children's Hospital Central California
  - Oakland, California, Verenigde Staten, 94609-1809
    - Children's Hospital and Research Center at Oakland
  - Orange, California, Verenigde Staten, 92868
    - Children's Hospital of Orange County
  - Orange, California, Verenigde Staten, 92868
    - Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
  - Palo Alto, California, Verenigde Staten, 94304
    - Lucile Packard Children's Hospital at Stanford University Medical Center
  - Sacramento, California, Verenigde Staten, 95816
    - Sutter Cancer Center
  - Sacramento, California, Verenigde Staten, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - San Diego, California, Verenigde Staten, 92120
    - Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
  - San Diego, California, Verenigde Staten, 92123-4282
    - Children's Hospital and Health Center, San Diego
  - San Francisco, California, Verenigde Staten, 94143
    - UCSF Comprehensive Cancer Center
  - Santa Barbara, California, Verenigde Staten, 93102
    - Santa Barbara Cottage Hospital
  - Santa Clara, California, Verenigde Staten, 95051-5386
    - Kaiser Permanente Medical Center - Santa Clara
  - Travis Air Force Base, California, Verenigde Staten, 94535
    - David Grant Medical Center
- Colorado
  - Denver, Colorado, Verenigde Staten, 80218-1088
    - Children's Hospital of Denver
  - Denver, Colorado, Verenigde Staten, 80218
    - Presbyterian - St. Luke's Medical Center
- Connecticut
  - Farmington, Connecticut, Verenigde Staten, 06360-7106
    - University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
  - New Haven, Connecticut, Verenigde Staten, 06520-8028
    - Yale Comprehensive Cancer Center
- Delaware
  - Wilmington, Delaware, Verenigde Staten, 19899
    - Alfred I. DuPont Hospital for Children
- District of Columbia
  - Washington, District of Columbia, Verenigde Staten, 20007
    - Lombardi Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, Verenigde Staten, 20010-2970
    - Children's National Medical Center
- Florida
  - Fort Lauderdale, Florida, Verenigde Staten, 33316
    - Broward General Medical Center
  - Fort Myers, Florida, Verenigde Staten, 33908
    - Children's Hospital of Southwest Florida
  - Gainesville, Florida, Verenigde Staten, 32610-0296
    - Shands Cancer Center at the University of Florida Health Science Center
  - Hollywood, Florida, Verenigde Staten, 33021
    - Joe DiMaggio Children's Hospital at Memorial
  - Jacksonville, Florida, Verenigde Staten, 32207
    - Nemours Children's Clinic
  - Miami, Florida, Verenigde Staten, 33155
    - Miami Children's Hospital
  - Miami, Florida, Verenigde Staten, 33136
    - Jackson Memorial Hospital
  - Miami, Florida, Verenigde Staten, 33176-2197
    - Baptist-South Miami Regional Cancer Program
  - Orlando, Florida, Verenigde Staten, 32804
    - Florida Hospital Cancer Institute
  - Orlando, Florida, Verenigde Staten, 32806
    - Nemours Children's Clinic-Orlando
  - Pensacola, Florida, Verenigde Staten, 32504
    - Sacred Heart Children's Hospital
  - St. Petersburg, Florida, Verenigde Staten, 33701
    - All Children's Hospital
  - Tampa, Florida, Verenigde Staten, 33677-4227
    - St. Joseph's Children's Hospital
  - West Palm Beach, Florida, Verenigde Staten, 33407
    - St. Mary's Hospital
- Georgia
  - Augusta, Georgia, Verenigde Staten, 30912-4000
    - MBCCOP-Medical College of Georgia Cancer Center
  - Macon, Georgia, Verenigde Staten, 31201
    - Medical Center of Central Georgia
  - Savannah, Georgia, Verenigde Staten, 31405
    - Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Hawaii
  - Honolulu, Hawaii, Verenigde Staten, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, Verenigde Staten, 96813
    - MBCCOP - Hawaii
- Idaho
  - Boise, Idaho, Verenigde Staten, 83712
    - Mountain States Tumor Institute - Boise
- Illinois
  - Chicago, Illinois, Verenigde Staten, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Verenigde Staten, 60614
    - Children's Memorial Hospital - Chicago
  - Chicago, Illinois, Verenigde Staten, 60601
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, Verenigde Staten, 60612
    - University of Illinois Medical Center
  - Oak Lawn, Illinois, Verenigde Staten, 60453
    - Advocate Hope Children's Hospital
  - Park Ridge, Illinois, Verenigde Staten, 60068-1174
    - Lutheran General Cancer Care Center
  - Peoria, Illinois, Verenigde Staten, 61637
    - Saint Jude Midwest Affiliate
  - Springfield, Illinois, Verenigde Staten, 62794-9658
    - Southern Illinois University School of Medicine
- Indiana
  - Indianapolis, Indiana, Verenigde Staten, 46202-5225
    - Riley Children Cancer Center at Riley Hospital for Children
  - Indianapolis, Indiana, Verenigde Staten, 46260
    - St. Vincent Hospitals and Health Care Centers
- Iowa
  - Des Moines, Iowa, Verenigde Staten, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Verenigde Staten, 50308
    - Blank Children's Hospital
  - Iowa City, Iowa, Verenigde Staten, 52242-1009
    - Holden Comprehensive Cancer Center at University of Iowa
- Kansas
  - Wichita, Kansas, Verenigde Staten, 67214
    - Wesley Medical Center
- Kentucky
  - Lexington, Kentucky, Verenigde Staten, 40536-0284
    - Markey Cancer Center at University of Kentucky Chandler Medical Center
  - Louisville, Kentucky, Verenigde Staten, 40202-3830
    - Kosair Children's Hospital
- Louisiana
  - New Orleans, Louisiana, Verenigde Staten, 70121
    - Ochsner Clinic Foundation
  - New Orleans, Louisiana, Verenigde Staten, 70118
    - Children's Hospital of New Orleans
  - New Orleans, Louisiana, Verenigde Staten, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, Verenigde Staten, 70112
    - Tulane Cancer Center at Tulane University Hospital and Clinic
- Maine
  - Bangor, Maine, Verenigde Staten, 04401
    - Eastern Maine Medical Center
  - Scarborough, Maine, Verenigde Staten, 04074-9308
    - Maine Children's Cancer Program
- Maryland
  - Baltimore, Maryland, Verenigde Staten, 21231-2410
    - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  - Baltimore, Maryland, Verenigde Staten, 21201-1595
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Baltimore, Maryland, Verenigde Staten, 21225
    - Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
  - Silver Spring, Maryland, Verenigde Staten, 20910
    - Walter Reed Army Medical Center
- Massachusetts
  - Boston, Massachusetts, Verenigde Staten, 02115
    - Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
  - Boston, Massachusetts, Verenigde Staten, 02111
    - Floating Hospital for Children
  - Springfield, Massachusetts, Verenigde Staten, 01107
    - Baystate Regional Cancer Program at Baystate Medical Center
  - Worcester, Massachusetts, Verenigde Staten, 01655
    - UMASS Memorial Cancer Center - University Campus
- Michigan
  - Ann Arbor, Michigan, Verenigde Staten, 48109-0914
    - University of Michigan Comprehensive Cancer Center
  - Detroit, Michigan, Verenigde Staten, 48201
    - Children's Hospital of Michigan
  - Detroit, Michigan, Verenigde Staten, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Detroit, Michigan, Verenigde Staten, 48202
    - Josephine Ford Cancer Center at Henry Ford Health System
  - Flint, Michigan, Verenigde Staten, 48503
    - Hurley Medical Center
  - Grand Rapids, Michigan, Verenigde Staten, 49503
    - Spectrum Health and DeVos Children's Hospital
  - Kalamazoo, Michigan, Verenigde Staten, 49007-5364
    - Bronson Methodist Hospital
  - Lansing, Michigan, Verenigde Staten, 48910
    - Breslin Cancer Center at Ingham Regional Medical Center
  - Royal Oak, Michigan, Verenigde Staten, 48073-6769
    - CCOP - Beaumont
  - Royal Oak, Michigan, Verenigde Staten, 48073-6769
    - William Beaumont Hospital - Royal Oak
- Minnesota
  - Duluth, Minnesota, Verenigde Staten, 55805
    - St. Mary's - Duluth Clinic Cancer Center
  - Minneapolis, Minnesota, Verenigde Staten, 55404
    - Children's Hospitals and Clinics - Minneapolis
  - Rochester, Minnesota, Verenigde Staten, 55905
    - Mayo Clinic Cancer Center
  - Saint Paul, Minnesota, Verenigde Staten, 55102
    - Children's Hospitals and Clinics - Minnesota
- Mississippi
  - Jackson, Mississippi, Verenigde Staten, 39216-4505
    - University of Mississippi Medical Center
- Missouri
  - Columbia, Missouri, Verenigde Staten, 65212
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Kansas City, Missouri, Verenigde Staten, 64108
    - Children's Mercy Hospital
  - Saint Louis, Missouri, Verenigde Staten, 63110
    - St. Louis Children's Hospital
  - Saint Louis, Missouri, Verenigde Staten, 63104
    - Cardinal Glennon Children's Hospital
- Nebraska
  - Omaha, Nebraska, Verenigde Staten, 68114
    - Children's Hospital of Omaha
  - Omaha, Nebraska, Verenigde Staten, 68198-2168
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
- Nevada
  - Las Vegas, Nevada, Verenigde Staten, 89109
    - Sunrise Hospital and Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Verenigde Staten, 03756
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- New Jersey
  - Hackensack, New Jersey, Verenigde Staten, 07601
    - Cancer Center at Hackensack University Medical Center
  - New Brunswick, New Jersey, Verenigde Staten, 08903
    - Cancer Institute of New Jersey at Robert Wood Johnson University Hospital
  - Newark, New Jersey, Verenigde Staten, 07112-2094
    - Newark Beth Israel Medical Center
  - Paterson, New Jersey, Verenigde Staten, 07503
    - St. Joseph's Hospital and Medical Center
  - Summit, New Jersey, Verenigde Staten, 07901
    - Valerie Fund Children's Center at Atlantic Health
- New Mexico
  - Albuquerque, New Mexico, Verenigde Staten, 87131
    - University of New Mexico Cancer Research and Treatment Center
- New York
  - Albany, New York, Verenigde Staten, 12208
    - Cancer Center of Albany Medical Center
  - Bronx, New York, Verenigde Staten, 10461
    - Albert Einstein Clinical Cancer Center
  - Brooklyn, New York, Verenigde Staten, 11203
    - SUNY Downstate Medical Center
  - Brooklyn, New York, Verenigde Staten, 11212
    - Brookdale University Hospital and Medical Center
  - Brooklyn, New York, Verenigde Staten, 11201-5493
    - Brooklyn Hospital Center
  - Brooklyn, New York, Verenigde Staten, 11219
    - Comprehensive Cancer Center at Maimonides Medical Center
  - Buffalo, New York, Verenigde Staten, 14263-0001
    - Roswell Park Cancer Institute
  - New Hyde Park, New York, Verenigde Staten, 11042
    - Schneider Children's Hospital
  - New York, New York, Verenigde Staten, 10021
    - Memorial Sloan-Kettering Cancer Center
  - New York, New York, Verenigde Staten, 10029
    - Mount Sinai School of Medicine
  - New York, New York, Verenigde Staten, 10021
    - New York Weill Cornell Cancer Center at Cornell University
  - New York, New York, Verenigde Staten, 10032
    - Herbert Irving Comprehensive Cancer Center at Columbia University
  - Rochester, New York, Verenigde Staten, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Stony Brook, New York, Verenigde Staten, 11794
    - Long Island Cancer Center at Stony Brook University Hospital
  - Syracuse, New York, Verenigde Staten, 13210
    - SUNY Upstate Medical University Hospital
  - Valhalla, New York, Verenigde Staten, 10595
    - New York Medical College
- North Carolina
  - Asheville, North Carolina, Verenigde Staten, 28801
    - Mission Hospitals
  - Chapel Hill, North Carolina, Verenigde Staten, 27599-7295
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, Verenigde Staten, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Charlotte, North Carolina, Verenigde Staten, 28233
    - Presbyterian Healthcare
  - Durham, North Carolina, Verenigde Staten, 27710
    - Duke Comprehensive Cancer Center
  - Greenville, North Carolina, Verenigde Staten, 27858-4354
    - Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
  - Winston-Salem, North Carolina, Verenigde Staten, 27157-1081
    - Comprehensive Cancer Center at Wake Forest University
- North Dakota
  - Fargo, North Dakota, Verenigde Staten, 58103-4940
    - Dakota Cancer Institute at Innovis Health - Dakota Clinic
- Ohio
  - Akron, Ohio, Verenigde Staten, 44308-1062
    - Children's Hospital Medical Center of Akron
  - Cincinnati, Ohio, Verenigde Staten, 45229-3039
    - Cincinnati Children's Hospital Medical Center
  - Cleveland, Ohio, Verenigde Staten, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, Verenigde Staten, 44106-5065
    - Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
  - Columbus, Ohio, Verenigde Staten, 43205-2696
    - Columbus Children's Hospital
  - Dayton, Ohio, Verenigde Staten, 45404
    - Children's Medical Center - Dayton
  - Toledo, Ohio, Verenigde Staten, 43601
    - Toledo Children's Hospital
  - Toledo, Ohio, Verenigde Staten, 43608
    - St. Vincent Mercy Medical Center
  - Youngstown, Ohio, Verenigde Staten, 44501
    - Forum Health-Tod Childrens Hospital
- Oklahoma
  - Oklahoma City, Oklahoma, Verenigde Staten, 73104
    - Children's Hospital at Oklahoma University Medical Center
  - Tulsa, Oklahoma, Verenigde Staten, 74136
    - Natalie Warren Bryant Cancer Center
  - Tulsa, Oklahoma, Verenigde Staten, 74136
    - CCOP - Oklahoma
- Oregon
  - Portland, Oregon, Verenigde Staten, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Verenigde Staten, 97227
    - Legacy Emanuel Hospital and Health Center & Children's Hospital
  - Portland, Oregon, Verenigde Staten, 97239-3098
    - Doernbecher Children's Hospital at Oregon Health & Science University
- Pennsylvania
  - Danville, Pennsylvania, Verenigde Staten, 17822-1320
    - Geisinger Medical Center
  - Hershey, Pennsylvania, Verenigde Staten, 17033
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Philadelphia, Pennsylvania, Verenigde Staten, 19104
    - Children's Hospital of Philadelphia
  - Philadelphia, Pennsylvania, Verenigde Staten, 19134-1095
    - St. Christopher's Hospital for Children
  - Pittsburgh, Pennsylvania, Verenigde Staten, 15213-2583
    - Children's Hospital of Pittsburgh
- Rhode Island
  - Providence, Rhode Island, Verenigde Staten, 02903
    - Rhode Island Hospital
- South Carolina
  - Charleston, South Carolina, Verenigde Staten, 29425-0721
    - Hollings Cancer Center at Medical University of South Carolina
  - Columbia, South Carolina, Verenigde Staten, 29203
    - Palmetto Health South Carolina Cancer Center
  - Greenville, South Carolina, Verenigde Staten, 29605
    - Children's Hospital of Greenville Hospital System
- South Dakota
  - Sioux Falls, South Dakota, Verenigde Staten, 57105-1080
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Verenigde Staten, 57117-5039
    - Sioux Valley Hospital at University of South Dakota Medical Center
- Tennessee
  - Johnson City, Tennessee, Verenigde Staten, 37614-0622
    - East Tennessee State University Cancer Center at Johnson City Medical Center
  - Knoxville, Tennessee, Verenigde Staten, 37901
    - East Tennessee Children's Hospital
  - Memphis, Tennessee, Verenigde Staten, 38105-2794
    - St. Jude Children's Research Hospital
  - Nashville, Tennessee, Verenigde Staten, 37232-6310
    - Vanderbilt Children's Hospital
- Texas
  - Amarillo, Texas, Verenigde Staten, 79106
    - Texas Tech University Health Sciences Center School of Medicine
  - Austin, Texas, Verenigde Staten, 78701
    - Children's Hospital of Austin
  - Dallas, Texas, Verenigde Staten, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Verenigde Staten, 75390-9063
    - Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
  - Fort Worth, Texas, Verenigde Staten, 76104
    - Cook Children's Medical Center - Fort Worth
  - Galveston, Texas, Verenigde Staten, 77555-0361
    - University of Texas Medical Branch
  - Houston, Texas, Verenigde Staten, 77030
    - Baylor College of Medicine
  - Houston, Texas, Verenigde Staten, 77030-4009
    - University of Texas - MD Anderson Cancer Center
  - Lackland Air Force Base, Texas, Verenigde Staten, 78236
    - San Antonio Military Pediatric Cancer and Blood Disorders Center
  - Lubbock, Texas, Verenigde Staten, 79410
    - Covenant Children's Hospital
  - San Antonio, Texas, Verenigde Staten, 78207
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Verenigde Staten, 78229-3900
    - MBCCOP - South Texas Pediatrics
  - San Antonio, Texas, Verenigde Staten, 78229-3902
    - Methodist Cancer Center at Methodist Specialty and Transplant Hospital
  - Temple, Texas, Verenigde Staten, 76508
    - CCOP - Scott and White Hospital
  - Temple, Texas, Verenigde Staten, 76508
    - Center for Cancer Prevention and Care at Scott and White Clinic
- Utah
  - Salt Lake City, Utah, Verenigde Staten, 84112
    - Huntsman Cancer Institute
- Vermont
  - Burlington, Vermont, Verenigde Staten, 05401-3498
    - Vermont Cancer Center at University of Vermont
- Virginia
  - Charlottesville, Virginia, Verenigde Staten, 22908
    - Cancer Center at the University of Virginia
  - Falls Church, Virginia, Verenigde Staten, 22042-3300
    - Inova Fairfax Hospital
  - Norfolk, Virginia, Verenigde Staten, 23507
    - Children's Hospital of The King's Daughters
  - Portsmouth, Virginia, Verenigde Staten, 23708-5100
    - Naval Medical Center, Portsmouth
  - Richmond, Virginia, Verenigde Staten, 23298-0121
    - Massey Cancer Center at Virginia Commonwealth University
  - Roanoke, Virginia, Verenigde Staten, 24029
    - Carilion Medical Center for Children
- Washington
  - Seattle, Washington, Verenigde Staten, 98105
    - Children's Hospital and Regional Medical Center - Seattle
  - Seattle, Washington, Verenigde Staten, 98109-1024
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Verenigde Staten, 98112
    - Group Health Central Hospital
  - Spokane, Washington, Verenigde Staten, 99210-0248
    - Deaconess Medical Center
  - Tacoma, Washington, Verenigde Staten, 98431-5000
    - Madigan Army Medical Center
  - Tacoma, Washington, Verenigde Staten, 98415-0299
    - Mary Bridge Children's Hospital and Health Center
- West Virginia
  - Charleston, West Virginia, Verenigde Staten, 25302
    - West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
  - Huntington, West Virginia, Verenigde Staten, 25701
    - Cabell Huntington Hospital
  - Morgantown, West Virginia, Verenigde Staten, 26506-9300
    - West Virginia University Hospitals
- Wisconsin
  - Green Bay, Wisconsin, Verenigde Staten, 54301
    - CCOP - St. Vincent Hospital Cancer Center, Green Bay
  - Green Bay, Wisconsin, Verenigde Staten, 54301
    - Bellin Memorial Hospital
  - Green Bay, Wisconsin, Verenigde Staten, 54307-9070
    - St. Vincent Hospital
  - La Crosse, Wisconsin, Verenigde Staten, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Verenigde Staten, 53792-6164
    - University of Wisconsin Comprehensive Cancer Center
  - Marshfield, Wisconsin, Verenigde Staten, 54449-5772
    - Marshfield Clinic
  - Marshfield, Wisconsin, Verenigde Staten, 54449
    - CCOP - Marshfield Clinic Research Foundation
  - Milwaukee, Wisconsin, Verenigde Staten, 53226
    - Midwest Children's Cancer Center
Zwitserland
- - Bern, Zwitserland, CH 3010
    - Swiss Pediatric Oncology Group Bern
  - Geneva, Zwitserland, CH 1211
    - Swiss Pediatric Oncology Group Geneva
  - Lausanne, Zwitserland, CH 1011
    - Swiss Pediatric Oncology Group Lausanne

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

Niet ouder dan 18 jaar (Kind, Volwassen)

Accepteert gezonde vrijwilligers

Geslachten die in aanmerking komen voor studie

Allemaal

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

Diagnosis of Wilms' tumor or control participants matched for race, sex, and age.

Beschrijving

DISEASE CHARACTERISTICS:

Diagnosis of Wilms' tumor OR
Control participants matched for race, sex, and age
- No prior or concurrent history of cancer OR
Parents of children involved in the study

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Presence of the A133S polymorphism of the RASSF1A tumor suppressor gene in germline DNAs of children with Wilms' tumor
Inheritance pattern of the A133S polymorphism in the parents of children who carry this polymorphism

Secundaire uitkomstmaten

Uitkomstmaat
Differences in age at diagnosis, stage, histology, site of primary tumor, and outcome between patients with vs without the A133S polymorphism
Whether the S131F RASSF1A variant is a true polymorphism
Polymorphic differences in this gene based on ethnicity and sex

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Children's Oncology Group

Medewerkers

National Cancer Institute (NCI)

Onderzoekers

Studie stoel: Gail E. Tomlinson, MD, PhD, Simmons Cancer Center

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start

1 augustus 2004

Primaire voltooiing (Werkelijk)

1 mei 2016

Studieregistratiedata

Eerst ingediend

4 augustus 2004

Eerst ingediend dat voldeed aan de QC-criteria

4 augustus 2004

Eerst geplaatst (Schatting)

5 augustus 2004

Updates van studierecords

Laatste update geplaatst (Schatting)

19 mei 2016

Laatste update ingediend die voldeed aan QC-criteria

17 mei 2016

Laatst geverifieerd