- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT05147337
A Study to Assess the Safety and Tolerability of E2511 in Healthy Adult and Elderly Participants
8 septembre 2022 mis à jour par: Eisai Inc.
A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2511 in Healthy Adult and Elderly Subjects
The primary objective of this study is to evaluate the safety, tolerability, and plasma pharmacokinetic (PK) of E2511 following multiple oral doses in healthy adult participants.
Aperçu de l'étude
Statut
Complété
Les conditions
Intervention / Traitement
Type d'étude
Interventionnel
Inscription (Réel)
47
Phase
- La phase 1
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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California
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Glendale, California, États-Unis, 91206
- California Clinical Trials Medical Group
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans à 85 ans (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Oui
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- Non-smoking, male, or female, non-Japanese participants age >=18 years and <55 years old (Cohorts 1 to 4) or age >=55 years and <=85 years old (Cohort 8); or Japanese participants age >=20 years and <55 years old (Cohorts 5 to 7) at the time of informed consent
Japanese participants must also satisfy the following requirements:
- Must have been born in Japan of Japanese parents and Japanese grandparents
- Must have lived no more than 5 years outside of Japan
- Must not have changed their lifestyle or habits, including diet, while living outside of Japan
- Weight of at least 50 kilogram (kg) and body mass index (BMI) >=18 and <30 kilogram per square meter (kg/m^2) (Cohorts 1 to 7) or BMI >=18 and <32 kg/m^2 (Cohort 8) at Screening
Exclusion Criteria:
- Females who are breastfeeding or pregnant at Screening or Baseline
Females of childbearing potential who:
- Within 28 days before study entry, did not use a highly effective method of contraception
- Do not agree to use a highly effective method of contraception throughout the entire study period and for 28 days after study drug discontinuation.
- Clinically significant illness that requires medical treatment within 8 weeks or a clinically significant infection that requires medical treatment within 4 weeks of dosing
- Evidence of disease that may influence the outcome of the study within 4 weeks before dosing; example, psychiatric disorders and disorders of the gastrointestinal tract, liver, kidney, respiratory system, endocrine system, hematological system, neurological system, or cardiovascular system, or participants who have a congenital abnormality in metabolism
- Evidence of disease within 4 weeks before dosing related to chronic headaches, migraines, joint pain, or other disorders or disease resulting in chronic or intermittent pain
- Any personal or family history of seizures (including febrile seizures) or diagnosis of epilepsy or episode of unexplained loss of consciousness
- Any history of neurological or other medical conditions which in the opinion of the investigator has the potential to reduce seizure threshold
- Any history of gastrointestinal surgery that may affect PK profiles of E2511, example, hepatectomy, nephrectomy, digestive organ resection at Screening
- Any clinically abnormal symptom or organ impairment found by medical history at Screening, and physical examinations, vital signs, ECG finding, or laboratory test results that require medical treatment at Screening or Baseline
- A prolonged QT/QT interval corrected for heart rate (QTc) interval or a prolonged QT/QTc interval (QT interval corrected for heart rate using Fridericia's formula [QTcF] greater than [>] 450 milliseconds [ms]). A history of risk factors for torsade de pointes
- HR <50 or more than 100 beats per minute at Screening or Baseline (Cohorts 1 through 7); or HR <55 or more than 100 beats per minute at Screening or Baseline (Cohort 8) NOTE: At Baseline, HR must meet the above criteria on 3 assessments (each separated by 15 minutes) to ensure eligibility
- Left bundle branch block
- History of myocardial infarction or active ischemic heart disease
- History of clinically significant arrhythmia or uncontrolled arrhythmia
- Any lifetime history of suicidal ideation or any lifetime history of suicidal behavior as indicated by the C-SSRS
- Any lifetime history of psychiatric disease
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Autre
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Double
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
---|---|
Expérimental: Cohort 1: E2511 10 mg or Placebo
Non-Japanese adult (greater than or equal to [>=] 18 years and less than [<] 55 years old) participants will receive 10 milligram (mg) E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
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Comprimés E2511.
E2511 matched placebo tablets.
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Expérimental: Cohort 2: E2511 20 mg or Placebo
Non-Japanese adult participants will receive 20 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
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Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 3: E2511 40 mg or Placebo
Non-Japanese adult participants will receive 40 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 4: E2511 80 mg or Placebo
Non-Japanese adult participants will receive 80 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 5: E2511 20 mg or Placebo
Japanese adult (>=20 years and <55 years old) participants will receive 20 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 6: E2511 40 mg or Placebo
Japanese adult participants will receive 40 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 7: E2511 80 mg or Placebo
Japanese adult participants will receive 80 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Expérimental: Cohort 8: E2511 40 mg or Placebo
Non-Japanese older (>=55 years and less than or equal to [<=] 85 years old) participants will receive 40 mg E2511 or E2511 matched placebo, tablets, orally, once daily from Day 1 to Day 14.
|
Comprimés E2511.
E2511 matched placebo tablets.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Number of Participants With Treatment-emergent Adverse Events (TEAEs)
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
|
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Number of Participants With Serious Adverse Events (SAEs)
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
|
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Number of Participants With Clinically Significant Abnormal Laboratory Values
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
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Number of Participants With Clinically Significant Abnormal Vital Signs Values
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
|
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Number of Participants With Clinically Significant Abnormal Electrocardiograms (ECGs) Findings
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
|
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Number of Participants With Clinically Significant Abnormal Ambulatory Blood Pressure
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
|
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Number of Participants With Suicidal Ideation or Suicidal Behavior as Measured Using Columbia-suicide Severity Rating Scale (C-SSRS)
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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The C-SSRS (mapped to Columbia Classification Algorithm of Suicide Assessment [C-CASA]) is an interview-based rating scale to systematically assess any suicidality, suicidal behavior, or suicidal ideation.
Any suicidality is emergence of any suicidal ideation or suicidal behavior.
Any suicidal behavior is indicated when response is "yes" for any these questions- actual attempt to suicide, engaged in non-suicidal self-injurious behavior, interrupted attempt, aborted attempt, preparatory acts.
Any suicidal ideation is indicated when response is "yes" for any of these questions- wish to be dead, non-specific active suicidal thoughts, active suicidal ideation with methods without intent to act or some intent to act, without specific plan or with specific plan and intent to suicide.
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
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Number of Participants With Clinically Significant Abnormal Physical Examination Findings
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
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Number of Participants With Clinically Significant Abnormal Neurological Examination Findings
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
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Number of Participants With Clinically Significant Abnormal Electroencephalogram (EEG) Findings
Délai: From Screening up to 14 days after the last dose of study drug (up to 56 days)
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From Screening up to 14 days after the last dose of study drug (up to 56 days)
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Cmax: Maximum Observed Plasma Concentration for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose
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Css,max: Maximum Observed Plasma Concentration at Steady State for E2511
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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tmax: Time to Reach Maximum Observed Plasma Concentration (Cmax) for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose
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tss,max: Time to Reach Maximum Observed Plasma Concentration (Cmax) at Steady State for E2511
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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Css,av: Average Steady State Plasma Concentration for E2511
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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AUC(0-t): Area Under the Plasma Concentration-time Curve From Time Zero to Time of Last Quantifiable Concentration for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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AUC(0-inf): Area Under the Plasma Concentration-time Curve From Time Zero to Infinite for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose
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AUC(0-24h): Area Under the Plasma Concentration-time Curve From Time Zero to 24 hours Post-dose for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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t1/2: Terminal Elimination Phase Half-life for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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PTF: Peak-trough Fluctuation for E2511
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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CL/F: Apparent Total Clearance for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose
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CLss/F: Apparent Total Clearance at Steady State for E2511
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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Vz/F: Apparent Volume of Distribution at Terminal Phase for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Rac: Accumulation Ratio for E2511 Based on Cmax and AUC
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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Rss: Accumulation Ratio for E2511 Based on Time and Concentration
Délai: Day 14: pre-dose up to 24 hours post-dose
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Day 14: pre-dose up to 24 hours post-dose
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Change From Baseline in the Concentration of Acetylcholine (ACh) in Cerebrospinal Fluid (CSF)
Délai: Baseline, Day 13
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Baseline, Day 13
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Change From Baseline in Heart Rate (HR)
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Change From Baseline in PR Interval of the ECG (PR), QRS Interval of the ECG (QRS), and QT Interval Corrected for Heart Rate (QTc) of the ECG
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Placebo Corrected Change From Baseline in HR
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Placebo Corrected Change From Baseline in PR, QRS, and QTc Interval
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Number of Participants With Categorical Outliers for HR, PR, QRS and QTc Interval
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Number of Participants With Treatment-emergent T-wave and U-wave abnormalities
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Mean Change From Baseline in 24-hours Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) up to Day 15
Délai: Up to Day 15
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The blood pressure (BP) will be evaluated by Ambulatory Blood Pressure Monitoring (ABPM) for all participants based on the measurement of BP recordings after every 24 hours.
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Up to Day 15
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Mean Change From Baseline in Day-time, Night-time, and Hourly SBP and DBP
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Mean Change From Baseline in Day-time, Night-time, and Hourly HR
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Mean Change From Baseline in Day-time, Night-time, and Hourly Mean Arterial Pressure (MAP) and Pulse Pressure (PP)
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Placebo Corrected Mean Change From Baseline in 24-hours SBP and DBP up to Day 15
Délai: Up to Day 15
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The BP will be evaluated by ABPM for all participants based on the measurement of BP recordings after every 24 hours.
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Up to Day 15
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Placebo Corrected Mean Change From Baseline in Day-time, Night-time, and Hourly SBP and DBP
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Placebo Corrected Mean Change From Baseline in Day-time, Night-time, and Hourly HR
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Placebo Corrected Mean Change From Baseline in Day-time, Night-time, and Hourly MAP and PP
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Number of Participants With Categorical Outliers for SBP and DBP
Délai: Baseline up to Day 15
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Baseline up to Day 15
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Geometric Mean Ratio of Cmax Between the Healthy Japanese and Non-japanese Participants for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Geometric Mean Ratio of AUC Between the Healthy Japanese and Non-japanese Participants for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Geometric Mean Ratio of Cmax Between the Younger Non-japanese (>=18 and <55 years) and older Non-japanese (>=55 to <=85 years) Participants for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Geometric Mean Ratio of AUC Between the Younger Non-japanese (>=18 and <55 years) and older Non-japanese (>=55 to <=85 years) Participants for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
|
Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Geometric Mean Ratio Between the Non-japanese (>=18 and <55 years) and Elderly Non-japanese (>=65 to <=85 years) Participants for E2511
Délai: Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Day 1: pre-dose up to 24 hours post-dose; Day 14: pre-dose up to 24 hours post-dose
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
1 décembre 2021
Achèvement primaire (Réel)
18 août 2022
Achèvement de l'étude (Réel)
18 août 2022
Dates d'inscription aux études
Première soumission
24 novembre 2021
Première soumission répondant aux critères de contrôle qualité
24 novembre 2021
Première publication (Réel)
7 décembre 2021
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
9 septembre 2022
Dernière mise à jour soumise répondant aux critères de contrôle qualité
8 septembre 2022
Dernière vérification
1 mars 2022
Plus d'information
Termes liés à cette étude
Autres numéros d'identification d'étude
- E2511-A001-005
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
OUI
Description du régime IPD
Eisai's data sharing commitment and further information on how to request data can be found on our website http://eisaiclinicaltrials.com/.
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Oui
Étudie un produit d'appareil réglementé par la FDA américaine
Non
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
Essais cliniques sur Volontaires en bonne santé
-
AstraZenecaParexelComplété
Essais cliniques sur E2511
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Eisai Inc.ComplétéVolontaires en bonne santéÉtats-Unis