Effects of photobiomodulation therapy in aerobic endurance training and detraining in humans: Protocol for a randomized placebo-controlled trial

Paulo Roberto Vicente de Paiva, Heliodora Leão Casalechi, Shaiane Silva Tomazoni, Caroline Dos Santos Monteiro Machado, Eduardo Foschini Miranda, Neide Firmo Ribeiro, Amanda Lima Pereira, Amanda Sampaio da Costa, Luana Barbosa Dias, Bianca Cristina Gomes Souza, Matheus Marinho Aguiar Lino, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior, Paulo Roberto Vicente de Paiva, Heliodora Leão Casalechi, Shaiane Silva Tomazoni, Caroline Dos Santos Monteiro Machado, Eduardo Foschini Miranda, Neide Firmo Ribeiro, Amanda Lima Pereira, Amanda Sampaio da Costa, Luana Barbosa Dias, Bianca Cristina Gomes Souza, Matheus Marinho Aguiar Lino, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior

Abstract

Introduction: Over the last 10 years, it has been demonstrated that photobiomodulation therapy (PBMT), also known as phototherapy, using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has ergogenic effects, improving athletic performance and also accelerating post-exercise recovery. However, many aspects related to these effects and its clinical applicability remain unknown. Therefore, the aim of this project is to evaluate the ergogenic effects of PBMT in detraining after an aerobic endurance training protocol.

Methods and analyzes: A randomized, triple-blind, placebo-controlled clinical trial will be carried out. Healthy male volunteers will be randomly distributed into 4 experimental groups: PBMT before and after training sessions + PBMT during detraining, PBMT before and after training sessions + placebo during detraining, placebo before and after training sessions + PBMT during detraining, and placebo before and after training sessions + placebo during detraining. The aerobic endurance training sessions will be carried out using motorized treadmills during 12 weeks, and the detraining period will consist in the next 4 weeks after that. It will be analyzed the time until exhaustion, maximal oxygen uptake (VO2max), and fat percentage of volunteers.

Discussion: Despite the increasing body of evidence for the use of PBMT as an ergogenic agent, several aspects remain unknown. The findings of this study will contribute to the advance of knowledge in this field regarding clinical applications.

Ethics and dissemination: This study was approved by the Research Ethics Committee of Nove de Julho University. The results from this study will be further disseminated through scientific publications in international peer-reviewed journals and presentations at national and international scientific meetings.

Trial registration number: NCT03879226.

Conflict of interest statement

Professor Ernesto Cesar Pinto Leal-Junior receives research support from Multi Radiance Medical (Solon - OH, USA), a laser device manufacturer. The remaining authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
CONSORT flowchart.
Figure 2
Figure 2
(A) Irradiation sites for PBMT in anterior thigh muscles. (B) Irradiation sites for PBMT in posterior thigh muscles and plantar flexor muscles.

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Source: PubMed

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