- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03879226
Effects of Photobiomodulation Therapy in Aerobic Training and Detraining in Humans
In last years it has been demonstrated that photobiomodulation therapy (PBMT) has ergogenic effects. However some key aspects, such as the potentially beneficial effects of PBMT during the detraining period still remain unknown.
Therefore, the aim of this project is to evaluate the effects of PBMT applied before and after aerobic training sessions and during the detraining period.
Study Overview
Detailed Description
It will be carried out a randomized, triple-blind, placebo-controlled trial.
Seventy-two volunteers will be randomly allocated to four experimental groups:
- PBMT before and after the aerobic training sessions and PBMT during the detraining period;
- PBMT before and after the aerobic training sessions and placebo during the detraining period;
- Placebo before and after the aerobic training sessions and PBMT during the detraining period;
- Placebo before and after the aerobic training sessions and placebo during the detraining period .
The individuals randomly allocated to the different groups will be subjected to 12 consecutive weeks of aerobic training performed on a treadmill 3 times a week on non-consecutive days. Each training session will last 30 minutes, with an intensity ranging from 85 to 90% maximum heart rate. PBMT or placebo will be applied before and after each training session. After the 12-week training period, the volunteers will receive the application of PBMT or placebo depending on the group to which they are allocated for 4 weeks (3 times a week) without training.
The data will be collected by a blind assessor. It will be analyzed time of the exercise (time until exhaustion), maximum oxygen consumption in absolute and relative values in relation to body mass (VO2max). Moreover, it will be evaluated the body composition. The evaluations will be performed before starting the protocol (baseline) and after 4, 8, and 12 weeks of training. They will also be performed after 4 weeks without training (detraining period).
The findings will be tested for their normality using the Shapiro-Wilk test. Parametric data will be expressed as mean and standard deviation and nonparametric data as median and respective upper and lower limits. Parametric data will be analyzed by two-way repeated measures analysis of variance (ANOVA; time versus experimental group) with post-hoc Bonferroni correction. Non-parametric data will be analyzed using the Friedman test and, secondarily, the Wilcoxon signed-rank test. Data will be analyzed in terms of both their absolute values and their relationship to the percentage change based on the values established in the baseline tests. The significance level will be set at p<0.05.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Sao Paulo
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São Paulo, Sao Paulo, Brazil, 01504-001
- Laboratory of Phototherapy and Innovative Technologies in Health
-
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Healthy men;
- Aged from 18 to 35 years;
- Complete at least 80% of the study procedures will be included in the study.
Exclusion Criteria:
- History of musculoskeletal injury in the hip and knee regions in the 2 months before the study;
- Become injured during the study;
- Regularly use pharmacological agents and/ or nutritional supplements;
- Signs and symptoms of any neurological, metabolic, inflammatory, pulmonary, oncological, or cardiovascular disease that may limit the execution of high-intensity exercises.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: PBMT + training/ PBMT + detraining
PBMT applied before and after the aerobic training sessions (12 weeks, 3 times a week) and PBMT applied during the detraining period (4 weeks, 3 times a week).
|
PBMT will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
A 12-diode cluster, with 4 905-nm laser diodes (12.5W peak power for each diode), 4 875-nm LED diodes (17.5 mW mean power for each diode), and 4 640-nm LED diodes (15 mW mean power for each diode), manufactured by Multi Radiance Medical® (Solon, OH, USA), will be used to apply the PBMT.
The dose used for the applications during the training and/or detraining periods will be 30 Joules (J) per site (510 J per lower limb).
PBMT will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
|
Experimental: PBMT + training/ placebo + detraining
PBMT applied before and after the aerobic training sessions (12 weeks, 3 times a week) and placebo applied during the detraining period (4 weeks, 3 times a week).
|
PBMT will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
A 12-diode cluster, with 4 905-nm laser diodes (12.5W peak power for each diode), 4 875-nm LED diodes (17.5 mW mean power for each diode), and 4 640-nm LED diodes (15 mW mean power for each diode), manufactured by Multi Radiance Medical® (Solon, OH, USA), will be used to apply the PBMT.
The dose used for the applications during the training and/or detraining periods will be 30 Joules (J) per site (510 J per lower limb).
PBMT will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
Placebo will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
The placebo PBMT will per performed using the dose of 0 J per diode.
The sounds and signals emitted from the device as well as the information displayed on the screen will be identical, regardless of the type of treatment (active or placebo).
Placebo will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
|
Experimental: Placebo + training/ PBMT + detraining
Placebo applied before and after the aerobic training sessions (12 weeks, 3 times a week) and PBMT applied during the detraining period (4 weeks, 3 times a week).
|
PBMT will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
A 12-diode cluster, with 4 905-nm laser diodes (12.5W peak power for each diode), 4 875-nm LED diodes (17.5 mW mean power for each diode), and 4 640-nm LED diodes (15 mW mean power for each diode), manufactured by Multi Radiance Medical® (Solon, OH, USA), will be used to apply the PBMT.
The dose used for the applications during the training and/or detraining periods will be 30 Joules (J) per site (510 J per lower limb).
PBMT will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
Placebo will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
The placebo PBMT will per performed using the dose of 0 J per diode.
The sounds and signals emitted from the device as well as the information displayed on the screen will be identical, regardless of the type of treatment (active or placebo).
Placebo will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
|
Placebo Comparator: Placebo + training/ placebo + detraining
Placebo applied before and after the aerobic training sessions (12 weeks, 3 times a week) and placebo applied during the detraining period (4 weeks, 3 times a week).
|
Placebo will be applied bilaterally using the direct contact method with light pressure on the skin at different sites, namely 9 sites on the knee extensor muscles, 6 sites on the knee flexor muscles, and 2 sites on the plantar flexor muscles.
The placebo PBMT will per performed using the dose of 0 J per diode.
The sounds and signals emitted from the device as well as the information displayed on the screen will be identical, regardless of the type of treatment (active or placebo).
Placebo will be applied before and after each training session and during the detraining period, depending on the group to which the volunteers are allocated.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Time until exhaustion.
Time Frame: 16 weeks - 4 weeks after completing the training (detraining period).
|
The time until exhaustion will be measured by the software of ergospirometry system.
|
16 weeks - 4 weeks after completing the training (detraining period).
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Time until exhaustion.
Time Frame: 4, 8, and 12 weeks after starting the training period.
|
The time until exhaustion will be measured by the software of ergospirometry system.
|
4, 8, and 12 weeks after starting the training period.
|
Maximum oxygen consumption (VO2).
Time Frame: 4, 8, and 12 weeks after starting the training period, and at 4 weeks after completing the training (detraining period).
|
The rates of maximum oxygen consumption will be measured by an ergospirometry test.
|
4, 8, and 12 weeks after starting the training period, and at 4 weeks after completing the training (detraining period).
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Fat percentage.
Time Frame: 4, 8, and 12 weeks after starting the training period, and at 4 weeks after completing the training (detraining period).
|
Fat percentage will be measured by diameters, perimeters, and skinfolds.
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4, 8, and 12 weeks after starting the training period, and at 4 weeks after completing the training (detraining period).
|
Collaborators and Investigators
Sponsor
Collaborators
Publications and helpful links
General Publications
- de Paiva PRV, Casalechi HL, Tomazoni SS, Machado CDSM, Ribeiro NF, Pereira AL, de Oliveira MFD, Alves MNDS, Dos Santos MC, Takara IET, Miranda EF, de Carvalho PTC, Leal-Junior ECP. Does the combination of photobiomodulation therapy (PBMT) and static magnetic fields (sMF) potentiate the effects of aerobic endurance training and decrease the loss of performance during detraining? A randomised, triple-blinded, placebo-controlled trial. BMC Sports Sci Med Rehabil. 2020 Apr 10;12:23. doi: 10.1186/s13102-020-00171-2. eCollection 2020.
- de Paiva PRV, Casalechi HL, Tomazoni SS, Machado CDSM, Miranda EF, Ribeiro NF, Pereira AL, da Costa AS, Dias LB, Souza BCG, Aguiar Lino MM, de Carvalho PTC, Leal-Junior ECP. Effects of photobiomodulation therapy in aerobic endurance training and detraining in humans: Protocol for a randomized placebo-controlled trial. Medicine (Baltimore). 2019 May;98(18):e15317. doi: 10.1097/MD.0000000000015317.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 1781602-2
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Supporting Information Type
- Study Protocol
- Statistical Analysis Plan (SAP)
- Clinical Study Report (CSR)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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