Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors

Inclusion Criteria:

• Breast cancer survivors (Stage I-III) 2-6 years post all cancer treatments, but currently receiving hormone therapy.
• History of treatment with chemotherapy and/or hormonal therapy, or hormone therapy only.
• No evidence of active/recurrent disease.
• Less than 70 years old at time of recruitment.
• Post-menopausal prior to initial treatment.
• In the judgment of the consenting professional, is able to provide informed consent.
• Patient is able to understand English, through verbal and written communication.

Exclusion Criteria:

• Recurrence of breast cancer or diagnosis of another cancer except basal cell carcinoma.
• Exposure to chemotherapy or radiation therapy for any medical condition unrelated to breast cancer.
• Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness > 60 min or evidence of structural brain changes on imaging).
• Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.
• Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome.
• Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
• Disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
• Male.

Healthy Control Inclusion Criteria:

• Have had no diagnosis of cancer except basal cell carcinoma.
• Less than 70 years old at time of recruitment.
• Post-menopausal.
• In the judgment of the consenting professional, is able to provide informed consent.
• Patient is able to understand English, through verbal and written communication

Healthy Control Exclusion Criteria:

• Exposure to chemotherapy or radiation therapy for any medical condition.
• Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness > 60 min or evidence of structural brain changes on imaging).
• Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis etc.
• Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome.
• Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
• Male.