Measuring Smoking Behaviors While Using Varenicline
15 dicembre 2014 aggiornato da: Andrew Strasser, University of Pennsylvania
Assessment of Smoking Topography and Behaviors During Response to Varenicline
This study will demonstrate the behavioral responses to varenicline, helping to better understand its mechanisms.
Hypotheses for the study are to observe decreases in smoking topography and nicotine cigarette choice on varenicline, relative to placebo; and decreases on day 21 relative to day 7 during varenicline treatment.
We also propose to examine if extended duration of treatment has clinical significance in decreasing smoking behaviors, thus increasing the efficacy of varenicline.
Panoramica dello studio
Descrizione dettagliata
This study is designed to examine the behavioral responses a cigarette smoker may have to using varenicline.
Behavioral responses may help to better understand its mechanisms which in turn could improve treatment outcomes.
The primary hypothesis for the study is to observe decreases in smoking topography, an objective measure of smoking behavior or puffing, on varenicline, relative to placebo; and decreases on day 21 relative to day 7 during varenicline treatment.
We will also examine puffing and nicotine cigarette choices during lab visits at baseline, and Days 7 and 21.
We also propose to examine if extended duration of treatment has clinical significance in decreasing smoking behaviors, thus potentially increasing the efficacy of varenicline.
Tipo di studio
Interventistico
Iscrizione (Effettivo)
48
Fase
- Fase 4
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, Stati Uniti, 19104
- Tobacco Use Research Center
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
Da 21 anni a 65 anni (Adulto, Adulto più anziano)
Accetta volontari sani
Sì
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
- self report minimum 10 daily cigarettes
- self report smoking every day past 5 years
- between the ages 21-65
- self report intention to try to quit smoking in the next 6 months
Exclusion Criteria:
- self reported use of any nicotine-containing products other than non-menthol cigarettes
- self reported history or current treatment of substance abuse (other than nicotine dependence)
- self reported alcohol use greater than 25 standard drinks per week;
- currently pregnant, planned pregnancy or lactating (females: negative urine pregnancy screen)
- self reported history or current diagnosis of any Axis 1 disorders except past depression
- self reported serious or unstable disease within past year
- self reported history of epilepsy or seizure disorder;
- self reported history or current diagnosis of COPD (chronic obstructive pulmonary disease), cardiovascular disease, heart attack, or uncontrolled hypertension
- self reported kidney function impairment
- any current or recent (30 day) use of: smoking cessation medications, anti-psychotics, anti-depressants, anti-anxiety, panic medications, stimulants or opiate-containing medications
- less than 5 years of daily smoking
- any medical condition or concomitant medication that could compromise participant safety or treatment
- provide a baseline carbon monoxide (CO) reading < 10 ppm
- self reported use of non filtered cigarettes
- inability to provide informed consent or complete any of the study tasks as determined by the Principal Investigator and/or Study Physician
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione incrociata
- Mascheramento: Doppio
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Varenicline before placebo
Drug (Varenicline (Chantix)): Placebo Intervention to be administered is: participants will receive standard dosing regimen of Varenicline for 21 days total, followed by 14-day washout and 21 days of placebo. Standard dosing: 0.5 mg days 1-3; 0.5 mg bid days 4-7; 1.0 mg bid days 8-21. |
Intervention Drug (Varenicline (Chantix) will be administered in standard dosing in pill format: 0.5 mg days 1-3; 0.5 mg bid daily days 4-7; 1.0 mg bid daily days 8-21.
Altri nomi:
|
|
Sperimentale: Placebo then Varenicline
Placebo: Drug Varenicline (Chantix) Intervention to be administered is: participants will receive 21 days of placebo, followed by 14-day washout and standard dosing regimen of Varenicline for 21 days total. Standard dosing: 0.5 mg days 1-3; 0.5 mg bid days 4-7; 1.0 mg bid days 8-21. Intervention 'Drug (Varenicline (Chantix)): Placebo' |
Intervention Drug (Varenicline (Chantix) will be administered in standard dosing in pill format: 0.5 mg days 1-3; 0.5 mg bid daily days 4-7; 1.0 mg bid daily days 8-21.
Altri nomi:
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Smoking Topography: Total Puff Volume
Lasso di tempo: Days 1-21 of each of 2 study periods
|
Total puff volume was created by summing all of the puffs from the cigarette smoked in the lab at each time point (each lab visit).
This value represents the total volume of smoke extracted from a single cigarette and it a standard measure of smoking behavior.
A total puff volume represents the total smoking volume from a cigarette.
Values are reported in milliliters.
Value of interest is the average puff volume across all sessions for all participants in a group and is reported as a key measure of smoking behavior.
Analyses were repeated measures analysis of variance where individual, time and drug were within factors.
|
Days 1-21 of each of 2 study periods
|
|
The Number of Choices of a Nicotine Containing Cigarette Compared to a Non-nicotine Cigarette.
Lasso di tempo: Days 1, 7, 21 of each of two 21 day study periods
|
Participants were given 4 puff choices (between a nicotine containing and de-nicotinized cigarette) on 6 study visits, for a total of 24 choices.
Number of puffs reported is average across both study periods.
|
Days 1, 7, 21 of each of two 21 day study periods
|
|
Daily Cigarette Consumption
Lasso di tempo: Two 21 day study periods
|
Average of the number of cigarettes smoked per day
|
Two 21 day study periods
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Total Nicotine Metabolites From Urine Samples
Lasso di tempo: Samples from Day 1 and Day 21 of two 21 day Periods
|
Total urinary metabolites from urine samples collected at Day 1 and Day 21
|
Samples from Day 1 and Day 21 of two 21 day Periods
|
|
Nicotine Levels From Urine Samples
Lasso di tempo: Samples from Day 1 and Day 21 of two 21 day Periods
|
Nicotine levels from urine samples collected at Day 1 and Day 21.
|
Samples from Day 1 and Day 21 of two 21 day Periods
|
|
Cotinine Levels From Urine Samples
Lasso di tempo: Samples from Day 1 and Day 21 of two 21 day Periods
|
Cotinine levels from urine samples collected at Day 1 and Day 21.
|
Samples from Day 1 and Day 21 of two 21 day Periods
|
|
Carbon Monoxide Levels
Lasso di tempo: Samples from Day 1 and Day 21 of two 21 day Periods
|
Exhaled breath carbon monoxide levels collected at Day 1 and Day 21 sessions.
Alveolar carbon monoxide is a validated assessment of smoke exposure.
|
Samples from Day 1 and Day 21 of two 21 day Periods
|
|
Subjective Measures to Assess Smoking Urges
Lasso di tempo: Days 21 of each of the two 21-day study periods, range 1(low)-7(high)
|
Craving for cigarettes was assessed with the 32-item Questionnaire of Smoking Urges (QSU) during each study visit.
In order to calculate the QSU measure, each item is rated on a Likert-type scale from 1 (strongly disagree) to 7 (strongly agree).
The values are then summed to create a single total score.
Well validated 2 factor subscale scores were also created by summing the item scores for the 2 factors: Factor 1 reflects the desire to smoke for pleasure and Factor 2 reflects urges to smoke to relieve withdrawal-related negative affect.
Internal consistency for each scale across all time points was high (Cronbach's α > 0.95, 0.85, and 0.95 for Factor 1, Factor 2, and QSU total, respectively).
Scale range is 1-7 where 1 is low urge to smoke and 7 represents high urge to smoke.
Data was collected at each time point but outcome measure of interest is end of period.
|
Days 21 of each of the two 21-day study periods, range 1(low)-7(high)
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Collaboratori
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio
1 gennaio 2009
Completamento primario (Effettivo)
1 novembre 2010
Completamento dello studio (Effettivo)
1 novembre 2010
Date di iscrizione allo studio
Primo inviato
28 luglio 2009
Primo inviato che soddisfa i criteri di controllo qualità
28 luglio 2009
Primo Inserito (Stima)
29 luglio 2009
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Stima)
16 dicembre 2014
Ultimo aggiornamento inviato che soddisfa i criteri QC
15 dicembre 2014
Ultimo verificato
1 dicembre 2014
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- 808930
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .