Assessment of Lung Structure and Function of Infants Born Prematurely
調査の概要
詳細な説明
SPECIFIC AIM #1:
Determine the relationship between parenchymal tissue and alveolar volume with normal lung growth early in life.
We hypothesize that during the first two years of life that parenchymal surface area and alveolar volume increase with somatic growth; however, the ratio of surface area to volume remains constant, while ventilation within the lung becomes more homogenous.
SPECIFIC AIM #2:
Determine the pulmonary sequelae of premature birth and assess the effectiveness of early treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma and the airways. In addition, initiating continuous positive airway pressure (CPAP) and a permissive ventilatory strategy in very premature infants at birth will improve lung growth and lung function compared to treatment with early surfactant and conventional ventilation.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Indiana
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Indianapolis、Indiana、アメリカ、46202
- Riley Hospital for Children
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
Group 1:
- 37 weeks or greater gestational age
- Age 2 to 36 months
Group 2:
- 37 weeks or greater gestational age having a CT scan for non-respiratory issues.
- Age 2-36 months
Group 3:
- 23-35 weeks gestational age
Exclusion Criteria:
Group 1 and Group 2:
- Congenital cardio-respiratory disease
- Hospitalization for respiratory illness
- Treatment with asthma medications
- Small for gestational age at birth
Group 3:
- Congenital cardio-respiratory disease
- Severe developmental delay
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：ケースコントロール
- 時間の展望：断面図
コホートと介入
グループ/コホート |
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1-Healthy Infants
Group 1: The investigators will recruit 80 healthy infants born at > 37 weeks gestation, and between 2 and 36 months of age. Infants will be excluded for any of the following reasons:
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2-Healthy Infants computerized Tomography
Group 2: The investigators recruited 4 infants born at > 37 weeks gestation and they were evaluated between 2 and 36 months of age when scheduled for high resolution computed tomography (HRCT) imaging for non-respiratory medical problems. Subjects were enrolled and HRCT of the chest were obtained. Infants were excluded for the following reasons:
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3-Premature Infants
Group 3: The investigators have recruited 45 infants born prematurely at 23-35 weeks gestation. Subjects were evaluated at corrected age at between 2 and 24 months. The subjects had no oxygen requirements, and were clinically stable outpatients when evaluated. Infants were excluded for any of the following reasons:
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Pulmonary Function Testing
時間枠：day of testing
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Forced expiratory Flows, Single-breath diffusion capacity and alveolar volume
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day of testing
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協力者と研究者
捜査官
- 主任研究者：Robert S. Tepper, MD, PhD、Indiana University
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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