Dyspnea in Patients With Pulmonary Fibrosis
This study has two aims:
- To determine the relationship of shortness of breath (dyspnea) to other conditions present in patients with pulmonary fibrosis.
- To define the relationship between shortness of breath and rate of functional decline in patients with pulmonary fibrosis.
調査の概要
状態
条件
詳細な説明
Idiopathic Pulmonary Fibrosis is the most common form of chronic fibrosing lung disease seen by pulmonologists, with an estimated 128,000 cases in the United States alone. It is almost surely a disorder related to aging, with a median age at the time of diagnosis of approximately 65 years; IPF is almost unheard of under the age of 50. Dyspnea is common in patients with IPF, and is often the primary symptom of the disease. It is tightly linked to quality of life in IPF, suggesting that the experience of dyspnea has wide-ranging and clinically-significant consequences. Despite its importance, surprisingly little is known about the etiology or functional impact of dyspnea in this disease.
This research proposal focuses on defining the relationship of dyspnea to comorbidity and the rate of functional decline in patients with IPF
Aim 1: To determine the relationship of dyspnea to other conditions present in patients with IPF.
Dyspnea is a complex symptom, related to both mechanical and cognitive factors. The mechanisms of dyspnea in IPF remain unknown, but there are several likely contributors that are both IPF and non-IPF related. Although IPF is a chronic disease of the elderly, no one has investigated the relationship between common geriatric conditions and dyspnea. It is well established that the perception of dyspnea depends equally on factors that influence the intensity of the experience of breathlessness (such as thoracic restriction and weakness) and the distress which that intensity produces. Gender, ethnicity, anxiety, pain, and depression all may contribute to the distress caused by dyspnea (and therefore its intensity) in IPF.
Aim 2: To define the relationship between dyspnea and rate of functional decline in IPF.
Numerous studies have looked at predictors of survival in patients with IPF, and both baseline and change in dyspnea over time have been shown to be significantly associated. The prediction of future morbidity, however, is largely unstudied. Established markers of functional decline in geriatric patients include weight loss, decline in walking speed over 4 meters, and the onset of disability as defined by the ability to perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Dyspnea likely impacts patients' activity levels and/or motivation to stay active, and may contribute to worsening functional decline.
研究の種類
入学 (実際)
連絡先と場所
研究場所
-
-
California
-
San Francisco、California、アメリカ、94143
- University of California San Francisco
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- 18 years of age and older with pulmonary fibrosis, and able to travel to University of California San Francisco for study visits
Exclusion Criteria:
- None
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 観測モデル:コホート
- 時間の展望:見込みのある
コホートと介入
グループ/コホート |
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1
Patients with Pulmonary Fibrosis
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
時間枠 |
---|---|
Dyspnea
時間枠:6 months
|
6 months
|
二次結果の測定
結果測定 |
時間枠 |
---|---|
Functional status
時間枠:6 months
|
6 months
|
協力者と研究者
協力者
捜査官
- 主任研究者:Harold R. Collard, MD、University of California, San Francisco
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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