Chemotherapy and Radiation in Treating Participants With Stage 3 Non-Small Cell Lung Cancer (PROCLAIM)
2016年5月20日 更新者：Eli Lilly and Company
Phase 3 Study of Pemetrexed, Cisplatin, and Radiotherapy Followed by Consolidation Pemetrexed Versus Etoposide, Cisplatin, and Radiotherapy Followed by Consolidation Cytotoxic Chemotherapy of Choice in Patients With Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer Other Than Predominantly Squamous Cell Histology
This study will compare the overall survival of participants with locally-advanced, Stage III Non-Small Cell Lung Cancer (NSCLC) with nonsquamous cell histology.
調査の概要
状態
完了
条件
研究の種類
介入
入学 (実際)
598
段階
- フェーズ 3
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Dublin、アイルランド
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Alabama
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Birmingham、Alabama、アメリカ、35249
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Arizona
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Scottsdale、Arizona、アメリカ、85259
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Tucson、Arizona、アメリカ、85704
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Arkansas
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Fayetteville、Arkansas、アメリカ、72703
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California
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Duarte、California、アメリカ、91010
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Fountain Valley、California、アメリカ、92708
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La Jolla、California、アメリカ、92093
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Connecticut
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New Haven、Connecticut、アメリカ、06520
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Florida
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Hollywood、Florida、アメリカ、33021
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Tampa、Florida、アメリカ、33612
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West Palm Beach、Florida、アメリカ、33401
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Georgia
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Athens、Georgia、アメリカ、30607
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Marietta、Georgia、アメリカ、30060
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Thomasville、Georgia、アメリカ、31792
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Illinois
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Chicago、Illinois、アメリカ、60637
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Quincy、Illinois、アメリカ、62301
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Indiana
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Evansville、Indiana、アメリカ、47713
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Indianapolis、Indiana、アメリカ、46237
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New Albany、Indiana、アメリカ、47150
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Kansas
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Westwood、Kansas、アメリカ、66205
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Wichita、Kansas、アメリカ、67214
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Kentucky
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Louisville、Kentucky、アメリカ、40402
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Maryland
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Columbia、Maryland、アメリカ、21044
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Massachusetts
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Fairhaven、Massachusetts、アメリカ、02719
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Michigan
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Ann Arbor、Michigan、アメリカ、48106
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Minnesota
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Minneapolis、Minnesota、アメリカ、55455
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Missouri
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Kansas City、Missouri、アメリカ、64132
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St Louis、Missouri、アメリカ、63110
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New York
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Bronx、New York、アメリカ、10467
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New York、New York、アメリカ、10065
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North Dakota
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Fargo、North Dakota、アメリカ、58122
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Ohio
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Cincinnati、Ohio、アメリカ、45242
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South Carolina
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Charleston、South Carolina、アメリカ、29425
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Tennessee
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Chattanooga、Tennessee、アメリカ、37404
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Memphis、Tennessee、アメリカ、38119
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Nashville、Tennessee、アメリカ、37203
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Texas
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Bedford、Texas、アメリカ、76022
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Dallas、Texas、アメリカ、75246
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Longview、Texas、アメリカ、75601
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Odessa、Texas、アメリカ、79761
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San Marcos、Texas、アメリカ、78666
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Sherman、Texas、アメリカ、75090
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Sugar Land、Texas、アメリカ、77479
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The Woodlands、Texas、アメリカ、77380
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Wichita Falls、Texas、アメリカ、76310
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Vermont
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Burlington、Vermont、アメリカ、05405
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Washington
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Spokane、Washington、アメリカ、99220
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Vancouver、Washington、アメリカ、98684
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West Virginia
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Morgantown、West Virginia、アメリカ、26506
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Wisconsin
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Madison、Wisconsin、アメリカ、53792
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Buenos Aires、アルゼンチン、C1188AAF
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Manchester、イギリス、M20 4BX
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Birmingham
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Edgbaston、Birmingham、イギリス、B15 2TH
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Greater London
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London、Greater London、イギリス、W6 8RF
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Scotland
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Edinburgh、Scotland、イギリス、EH4 2XU
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Bangalore、インド、560 027
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Hyderabaad、インド、500024
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Jaipur、インド、302016
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Kolkata、インド、700029
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Madurai、インド、625020
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Mumbai、インド、400053
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Trivandrum、インド、695011
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Amsterdam、オランダ、1081 HV
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Breda、オランダ、4818 CK
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S-Hertogenbosch、オランダ、5223 GZ
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New South Wales
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Wollongong、New South Wales、オーストラリア、2500
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Tasmania
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Launceston、Tasmania、オーストラリア、7250
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Victoria
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Frankston、Victoria、オーストラリア、3199
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Alberta
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Edmonton、Alberta、カナダ、T6G 1Z2
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Ontario
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London、Ontario、カナダ、N6A 4L6
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Newmarket、Ontario、カナダ、L3Y2P9
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Toronto、Ontario、カナダ、M5G 2M9
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Quebec
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Montreal、Quebec、カナダ、H3G 1A4
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Athens、ギリシャ、18537
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Patras、ギリシャ、26500
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Alicante、スペイン、03010
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Badalona、スペイン、08915
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Elche、スペイン、03202
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Hospitalet De Llobregat、スペイン、08908
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Madrid、スペイン、28050
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Majadahonda、スペイン、28222
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Pamplona、スペイン、31008
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Terrassa、スペイン、08227
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Erlangen、ドイツ、91054
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Frankfurt、ドイツ、60596
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Hannover、ドイツ、30625
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Hemer、ドイツ、58675
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Immenhausen、ドイツ、34376
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Köln、ドイツ、51109
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Mainz、ドイツ、55131
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Mannheim、ドイツ、68167
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Oldenburg、ドイツ、26121
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Rheine、ドイツ、48431
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Ulm、ドイツ、89081
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Bayonne、フランス、64100
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Lille、フランス、59020
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Paris、フランス、75475
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Pierre Benite、フランス、69495
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Barretos、ブラジル、14784700
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Curitiba、ブラジル、81520-060
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Porto Alegre、ブラジル、90610-970
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Rio De Janeiro、ブラジル、20231-050
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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São Paulo、ブラジル、01246000
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Antwerp、ベルギー、2020
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Edegem、ベルギー、2650
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Gent、ベルギー、9000
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Gilly、ベルギー、6060
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Haine-St.- Paul、ベルギー、7100
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Leuven、ベルギー、3000
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Namur、ベルギー、5000
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Turnhout、ベルギー、2300
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Lisbon、ポルトガル、1649-035
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Santa Maria Da Feira、ポルトガル、4520-211
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Vila Franca De Xira、ポルトガル、4434-502
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Fatih、七面鳥、34098
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Gaziantep、七面鳥、27310
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Izmir、七面鳥、35100
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Melikgazi、七面鳥、38039
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Umuttepe、七面鳥、41380
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Beijing、中国、100021
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Guang Zhou、中国、510060
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Jinan、中国
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Shanghai、中国、200030
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Sichuan、中国、610041
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Wu Han、中国、430030
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Kaohsiung、台湾、813
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Kuei Shan Hsiang、台湾、33305
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Taichung、台湾、40705
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Taipei、台湾、100
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Incheon、大韓民国、405-760
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Seoul、大韓民国、139-706
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Suwon-City、大韓民国、442-723
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年歳以上 (大人、高齢者)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
説明
Inclusion Criteria:
- Participants must have Stage IIIA or IIIIB NSCLC of the non-squamous type
- Participants must have measureable tumor lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines or disease that can be evaluated on computerized tomography (CT) scan
- Participants must be physically mobile, take care of themselves and must be up and about and able to perform light activities, such as light housework or office work
- Participants must be 18 years of age or older
- Participants must have lost no more than 10% of their body weight in the previous 3 months
- Women must be sterile, postmenopausal, or on contraception, and men must be sterile or on contraception
- Participants' test results assessing the function of their blood forming tissue, kidneys, liver, and lungs must be satisfactory
- Participants with Stage IIIB NSCLC who have supraclavicular nodal involvement may be entered into this study. However, participants with cervical nodes are not permitted. The upper border of supraclavicular nodes must not extend above the upper border of the lateral end of the clavicle, extended medially.
Exclusion Criteria:
- Participants cannot have other on-going (uncontrolled) illnesses, including active infections, recent heart problems, or psychiatric illnesses
- Participants who are unable to take vitamins (including injections of vitamin B12) or oral cortisone medication
- Participants who have had a heart attack (myocardial infarction) or other cardiac issues within 6 months of the trial
- Participants who have received other investigational drugs within the last 30 days
- Participants who are unable to stop taking more than 1.3 grams of aspirin on a daily basis or non-steroidal anti-inflammatory agents
- Participants who have diseases considered for surgical treatment as part of their care plan, such as Pancoast or superior sulcus tumors
- Participants who had prior thoracic radiation. However, other prior radiotherapy is allowed. Participants must have recovered from the toxic effects of the treatment prior to study enrollment. Participants may not have received whole pelvis radiation or radiation to more than 25% of their bone marrow. Prior radiotherapy must have been completed at least 30 days prior to study treatment.
- Participants who have a radiation treatment plan that would expose more than 35% of the volume of their lung to 20 gray (Gy) or more of radiation
- Participants who have concurrent cancer from another primary site requiring treatment of any kind within the past 5 years. Exemptions to this will be permitted on a case-by-case basis after prior approval by the Sponsor physician or designate if the investigator believes the participant's risk of recurrence and death is very low. Curatively treated nonmelanoma skin cancer or in situ carcinoma of any origin is allowed. Participants with recurrence of a previously resected lung cancer or who have a second primary lung cancer are ineligible.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Arm A: Pemetrexed + Cisplatin and TRT
Participants were treated with Pemetrexed plus Cisplatin and concurrent thoracic radiation therapy (TRT) ("Concurrent Phase") for three 21-day cycles, followed by a 3-5 week "Recovery Period," then treated with consolidation chemotherapy with pemetrexed ("Consolidation Phase") for up to four 21-day cycles Concurrent Phase: Pemetrexed: 500 milligrams per meter squared (mg/m^2), intravenous (IV) on Day 1 of each 21-day cycle for 3 cycles. Cisplatin: 75 mg/m^2, IV on Day 1 of each 21-day cycle x 3 cycles. TRT: Beginning on Day 1 of chemotherapy, once daily fractions (2 Gray [Gy] per day), 5 days a week for 6 weeks and 3 days to target 66 Gy in 33 fractions. Consolidation Phase: Pemetrexed: 500 mg/m^2, IV on Day 1 of each 21-day cycle up to 4 cycles |
infusion over 10 minutes
他の名前：
infusion over 60 minutes with adequate anti-emetic treatment and appropriate hydration per local practice guidelines
|
|
アクティブコンパレータ：Arm B: Etoposide + Cisplatin and TRT
Participants were treated with Etoposide plus Cisplatin and concurrent TRT ("Concurrent Phase") for two 28-day cycles, followed by a 3-5 week "Recovery Period," then received consolidation treatment with cytotoxic chemotherapy of choice ("Consolidation Phase") for up to 2 cycles Concurrent Phase: Etoposide/Cisplatin (28-day cycle); Etoposide: 50 mg/m^2, IV on Days 1 to 5 and Days 29 to 33 and Cisplatin: 50 mg/m^2, IV on Days1, 8, 29, and 36 Consolidation Phase options: Option 1: Continue the same treatment plan as Concurrent Phase Option 2: Vinorelbine/Cisplatin (21-day cycle); Vinorelbine: 30 mg/m^2, IV on Days 1, 8, 22, and 29; Cisplatin: 75 mg/m^2, IV on Days 1 and 22 Option 3: Paclitaxel/Carboplatin (21-day cycle); Paclitaxel: 200 mg/m^2, IV, on Days 1 and 22; Carboplatin: area under the concentration-time curve (AUC) = 6 (Carboplatin dosing based on calculated creatinine clearance), IV on Days 1 and 22 |
infusion over 60 minutes with adequate anti-emetic treatment and appropriate hydration per local practice guidelines
administered per local practice guidelines over a minimum of 30 minutes
administered over 6-10 minutes infusion per local practice guidelines
administered as a 3-hour infusion
administered per local practice guidelines over 30 minutes
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Overall Survival
時間枠：Baseline to Date of Death from Any Cause (Up to 71.4 Months)
|
Overall survival (OS) time is from baseline to the date of death from any cause.
For participants not known to have died as of the data cut-off date, OS time was censored at the last contact date the participant was known to be alive prior to the data cut-off date.
OS was summarized using Kaplan-Meier estimates.
|
Baseline to Date of Death from Any Cause (Up to 71.4 Months)
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Progression-free Survival (PFS)
時間枠：Baseline to Measured Progressive Disease or Death from Any Cause (Up to 66.6 Months)
|
Progression-free survival (PFS) time is from baseline to the first date of documented objective progressive disease (PD) or death from any cause.
For participants who were not known to have died or to have had objective PD as of the data inclusion cut-off date for a particular analysis, PFS was censored at the date of the last objective progression-free disease assessments.
For participants who took any subsequent systemic anticancer therapy prior to progression or death, PFS was censored at the date of the last objective progression-free disease assessment prior to the start date of any subsequent systemic anticancer therapy.
PFS time was summarized using Kaplan-Meier estimates.
|
Baseline to Measured Progressive Disease or Death from Any Cause (Up to 66.6 Months)
|
|
Objective Response Rate (Complete Response [CR] + Partial Response [PR])
時間枠：Baseline to Measured Progressive Disease (Up to 7 Months)
|
Overall response rate (ORR) is the best response of CR or PR as classified by the investigators according to the Response Evaluation Criteria in Solid Tumors (RECIST, v1.1) guidelines.
CR is defined as the disappearance of all target and non-target lesions, normalization of tumor marker level of non-target lesions, and any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 millimeter (mm).
PR is an at least 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameter) without progression of non-target lesions or appearance of new lesions.
Overall response rate is calculated as a total number of participants with CR or PR divided by the total number of participants with at least 1 measurable lesion, multiplied by 100.
|
Baseline to Measured Progressive Disease (Up to 7 Months)
|
|
Survival Rates at 1, 2, and 3 Years
時間枠：Baseline to Date of Death from Any Cause (Up to 71.4 Months)
|
The probability that survival time is at least 1, 2, or 3 years was summarized using Kaplan-Meier estimates.
|
Baseline to Date of Death from Any Cause (Up to 71.4 Months)
|
|
First Site of Disease Failure in Terms of Relapse
時間枠：Baseline to Relapse (Up to 66.6 Months)
|
The percentage of participants with first sites of disease failure in terms of relapse within the radiation treatment field, inside the thorax, (outside of the radiation field), or distant disease are presented.
Results were summarized using Kaplan-Meier estimates.
Some participants relapsed in more than 1 location/site and appear in more than a single category.
|
Baseline to Relapse (Up to 66.6 Months)
|
|
Percentage of Participants With a Post Baseline Swallowing Diary Score >=4
時間枠：Baseline through 30 Days Post Study
|
Participants were provided with a swallowing diary to record issues with swallowing using a 5-point categorical scale: (1) no problems; (2) mild soreness; (3) swallowing solids with some difficulty; (4) inability to swallow solids; and (5) inability to swallow liquids.
Participants rated swallowing over the previous 24 hours.
The percentage of participants was calculated by dividing the number of with a post baseline swallowing diary score >=4 by total number of participants analyzed, multiplied by 100.
No adjustments were made for the number of available assessments nor were any interpolation of missing assessments made.
|
Baseline through 30 Days Post Study
|
その他の成果指標
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Adverse Events: The Number of Deaths Per Treatment Group
時間枠：Baseline through 30 Days Post Study
|
The number of deaths that occurred while on study drug, the number of deaths due to adverse events (AEs) while on study drug, and the number of deaths due to the study disease (that is, disease progression) while on study drug are presented.
In addition, the number of deaths within 30 days of treatment discontinuation, the number of deaths due to AEs within 30 days of treatment discontinuation, and the number of deaths due to study disease within 30 days of treatment discontinuation are presented.
For both the deaths due to AEs that occurred on study and for deaths due to AEs that occurred within 30 days of treatment discontinuation, the causality (events assess as possibly related [poss related] to study drug per investigator judgement) is also presented.
A summary of serious and other non-serious adverse events regardless of causality is located in the Reported Adverse Events module.
|
Baseline through 30 Days Post Study
|
協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
スポンサー
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
- Govindan R, Senan S, Dickgreber N, Provencio M, Wu YL, Syrigos K, Parente B, Wilson M, Ziemiecki R, Chouaki N, Hossain A, San Antonio B, Winfree K, Vokes EE. Healthcare resource utilization and associated cost analysis of the PROCLAIM study in patients with stage III non-small-cell lung cancer. Curr Med Res Opin. 2019 Oct;35(10):1761-1767. doi: 10.1080/03007995.2019.1623185. Epub 2019 Jul 5.
- Brade AM, Wenz F, Koppe F, Lievens Y, San Antonio B, Iscoe NA, Hossain A, Chouaki N, Senan S. Radiation Therapy Quality Assurance (RTQA) of Concurrent Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer in the PROCLAIM Phase 3 Trial. Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):927-934. doi: 10.1016/j.ijrobp.2018.04.015. Epub 2018 Apr 12.
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始
2008年9月1日
一次修了 (実際)
2014年10月1日
研究の完了 (実際)
2014年11月1日
試験登録日
最初に提出
2008年5月28日
QC基準を満たした最初の提出物
2008年5月28日
最初の投稿 (見積もり)
2008年5月30日
学習記録の更新
投稿された最後の更新 (見積もり)
2016年6月28日
QC基準を満たした最後の更新が送信されました
2016年5月20日
最終確認日
2016年5月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
非小細胞肺がんの臨床試験
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Adelphi Values LLCBlueprint Medicines Corporation完了肥満細胞性白血病 (MCL) | 攻撃的な全身性肥満細胞症 (ASM) | SM w Assoc Clonal Hema Non-mast Cell Lineage Disease (SM-AHNMD) | くすぶり全身性肥満細胞症 (SSM) | 無痛性全身性肥満細胞症 (ISM) ISM サブグループが完全に募集されましたアメリカ
Pemetrexedの臨床試験
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Instituto Nacional de Cancer, BrazilEli Lilly and Company完了