Cognitive Remediation in Schizophrenia
Cognitive Remediation in Schizophrenia: Effects on Brain Structure, Brain Function and Social Outcome.
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses.
Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.
調査の概要
詳細な説明
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on
- Neuropsychological performance
- Brain Structure using voxel-based morphometry (VBM)
- Brain function using functional MRI (fMRI)
- Social and occupational functioning
The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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Dublin、アイルランド、8
- 募集
- Department of Psychiatry, Trinity Centre for Health Sciences, St James Hospital, James St.
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コンタクト：
- April H Hargreaves, PhD
- 電話番号：35318962624
- メール：hargrea@tcd.ie
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コンタクト：
- Rachael Dillon, BSc
- 電話番号：35318962315
- メール：radillon@tcd.ie
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主任研究者：
- Gary J Donohue, DClin Psych PhD
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Schizophrenia
- History of Psychosis
- Subjective difficulties with memory or concentration
- Aged 18-60 Years
Exclusion Criteria:
- History of head injury resulting in loss of consciousness
- Substance misuse in the last 3 months
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：トリプル
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：Cognitive Remediation Therapy
Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week.
They will meet a therapist once per week to discuss any difficulties, help motivation.
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Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
他の名前：
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プラセボコンパレーター：Placebo Comparator
Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training.
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Participant meets the therapist once per week but does not carry out the CRT intervention.
(Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).
他の名前：
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change from baseline neuropsychological performance
時間枠：Directly following study treatment period
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A battery of neuropsychological tests will be used at baseline and the same tests used directly after the intervention to measure changes in attention and memory.
Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
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Directly following study treatment period
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change from baseline neuropsychological performance at 3 to 6 months post intervention
時間枠：3 to 6 months post study treatment period
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A battery of neuropsychological tests will be used at baseline and the same tests used at 3 months post intervention to measure changes in attention and memory.
Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
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3 to 6 months post study treatment period
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Changes from baseline in brain activation during working memory testing
時間枠：Directly post study treatment period
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Changes from baseline in brain activation during working memory testing will be measured using fMRI
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Directly post study treatment period
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Change from baseline in grey matter volume
時間枠：Directly following study treatment period
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Changes in grey matter volume from baseline will be measured at 3 months post intervention using voxel based morphometry.
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Directly following study treatment period
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その他の成果指標
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Changes in social and occupational functioning
時間枠：Directly following study treatment period
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Social and occupational function will be measured at baseline and the same tests used directly following intervention.
Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
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Directly following study treatment period
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Change from baseline in social and occupational functioning 3 to 6 months post intervention
時間枠：3 to 6 months post study treatment period
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Social and occupational function will be measured at baseline and the same tests used directly following intervention.
Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
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3 to 6 months post study treatment period
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協力者と研究者
捜査官
- 主任研究者：Gary J Donoghoe, DClin Psych PhD、Trinity College Dublin, Ireland
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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