Cognitive Remediation in Schizophrenia
Cognitive Remediation in Schizophrenia: Effects on Brain Structure, Brain Function and Social Outcome.
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses.
Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.
研究概览
详细说明
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on
- Neuropsychological performance
- Brain Structure using voxel-based morphometry (VBM)
- Brain function using functional MRI (fMRI)
- Social and occupational functioning
The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Dublin、爱尔兰、8
- 招聘中
- Department of Psychiatry, Trinity Centre for Health Sciences, St James Hospital, James St.
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接触：
- April H Hargreaves, PhD
- 电话号码：35318962624
- 邮箱：hargrea@tcd.ie
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接触：
- Rachael Dillon, BSc
- 电话号码：35318962315
- 邮箱：radillon@tcd.ie
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首席研究员：
- Gary J Donohue, DClin Psych PhD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Schizophrenia
- History of Psychosis
- Subjective difficulties with memory or concentration
- Aged 18-60 Years
Exclusion Criteria:
- History of head injury resulting in loss of consciousness
- Substance misuse in the last 3 months
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：三倍
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的：Cognitive Remediation Therapy
Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week.
They will meet a therapist once per week to discuss any difficulties, help motivation.
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Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
其他名称：
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安慰剂比较：Placebo Comparator
Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training.
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Participant meets the therapist once per week but does not carry out the CRT intervention.
(Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Change from baseline neuropsychological performance
大体时间：Directly following study treatment period
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A battery of neuropsychological tests will be used at baseline and the same tests used directly after the intervention to measure changes in attention and memory.
Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
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Directly following study treatment period
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change from baseline neuropsychological performance at 3 to 6 months post intervention
大体时间：3 to 6 months post study treatment period
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A battery of neuropsychological tests will be used at baseline and the same tests used at 3 months post intervention to measure changes in attention and memory.
Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
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3 to 6 months post study treatment period
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Changes from baseline in brain activation during working memory testing
大体时间：Directly post study treatment period
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Changes from baseline in brain activation during working memory testing will be measured using fMRI
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Directly post study treatment period
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Change from baseline in grey matter volume
大体时间：Directly following study treatment period
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Changes in grey matter volume from baseline will be measured at 3 months post intervention using voxel based morphometry.
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Directly following study treatment period
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其他结果措施
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Changes in social and occupational functioning
大体时间：Directly following study treatment period
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Social and occupational function will be measured at baseline and the same tests used directly following intervention.
Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
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Directly following study treatment period
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Change from baseline in social and occupational functioning 3 to 6 months post intervention
大体时间：3 to 6 months post study treatment period
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Social and occupational function will be measured at baseline and the same tests used directly following intervention.
Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
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3 to 6 months post study treatment period
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合作者和调查者
调查人员
- 首席研究员：Gary J Donoghoe, DClin Psych PhD、Trinity College Dublin, Ireland
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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