ドセタキセル、カルボプラチン、トラスツズマブ、およびペルツズマブによる、ホルモン受容体陽性、HER2 陽性の手術可能または局所進行乳癌患者の治療におけるエストロゲン欠乏の有無
ドセタキセル、カルボプラチン、トラスツズマブ、およびペルツズマブ (TCHP) のネオアジュバント療法で治療されたホルモン受容体陽性、HER2 陽性、大規模な手術可能な局所進行乳癌患者における病理学的完全奏効率を評価する無作為化第 III 相試験 エストロゲン除去の有無にかかわらず
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
調査の概要
状態
条件
詳細な説明
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
研究の種類
入学 (実際)
段階
- フェーズ 3
連絡先と場所
研究場所
-
-
Alaska
-
Fairbanks、Alaska、アメリカ、99701
- Fairbanks Memorial Hospital
-
-
Arkansas
-
Hot Springs、Arkansas、アメリカ、71913
- CHI Saint Vincent Cancer Center Hot Springs
-
-
California
-
Anaheim、California、アメリカ、92806
- Kaiser Permanente-Anaheim
-
Antioch、California、アメリカ、94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande、California、アメリカ、93420
- PCR Oncology
-
Auburn、California、アメリカ、95602
- Sutter Auburn Faith Hospital
-
Auburn、California、アメリカ、95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
-
Baldwin Park、California、アメリカ、91706
- Kaiser Permanente-Baldwin Park
-
Bellflower、California、アメリカ、90706
- Kaiser Permanente-Bellflower
-
Berkeley、California、アメリカ、94704
- Alta Bates Summit Medical Center-Herrick Campus
-
Burlingame、California、アメリカ、94010
- Mills-Peninsula Medical Center
-
Cameron Park、California、アメリカ、95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
-
Castro Valley、California、アメリカ、94546
- Eden Hospital Medical Center
-
Castro Valley、California、アメリカ、94546
- East Bay Radiation Oncology Center
-
Davis、California、アメリカ、95616
- Sutter Davis Hospital
-
Dublin、California、アメリカ、94568
- Epic Care-Dublin
-
Emeryville、California、アメリカ、94608
- Bay Area Breast Surgeons Inc
-
Emeryville、California、アメリカ、94608
- Epic Care Partners in Cancer Care
-
Fontana、California、アメリカ、92335
- Kaiser Permanente-Fontana
-
Fremont、California、アメリカ、94538
- Kaiser Permanente-Fremont
-
Fresno、California、アメリカ、93720
- Kaiser Permanente-Fresno
-
Harbor City、California、アメリカ、90710
- Kaiser Permanente South Bay
-
Irvine、California、アメリカ、92618
- Kaiser Permanente-Irvine
-
Loma Linda、California、アメリカ、92354
- Loma Linda University Medical Center
-
Los Angeles、California、アメリカ、90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles、California、アメリカ、90048
- Cedars Sinai Medical Center
-
Los Angeles、California、アメリカ、90034
- Kaiser Permanente West Los Angeles
-
Martinez、California、アメリカ、94553-3156
- Contra Costa Regional Medical Center
-
Modesto、California、アメリカ、95355
- Memorial Medical Center
-
Modesto、California、アメリカ、95356
- Kaiser Permanente-Modesto
-
Mountain View、California、アメリカ、94040
- El Camino Hospital
-
Mountain View、California、アメリカ、94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View、California、アメリカ、94040
- Palo Alto Medical Foundation-Gynecologic Oncology
-
Novato、California、アメリカ、94945
- Sutter Cancer Research Consortium
-
Oakland、California、アメリカ、94611
- Kaiser Permanente-Oakland
-
Oakland、California、アメリカ、94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland、California、アメリカ、94609
- Hematology and Oncology Associates-Oakland
-
Oakland、California、アメリカ、94609
- Bay Area Tumor Institute
-
Oakland、California、アメリカ、94602
- Wilma Chan Highland Hospital
-
Orange、California、アメリカ、92868
- Saint Joseph Hospital - Orange
-
Palo Alto、California、アメリカ、94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto、California、アメリカ、94301
- Palo Alto Medical Foundation Health Care
-
Panorama City、California、アメリカ、91402
- Kaiser Permanente - Panorama City
-
Pleasanton、California、アメリカ、94588
- Valley Medical Oncology Consultants
-
Redwood City、California、アメリカ、94063
- Kaiser Permanente-Redwood City
-
Richmond、California、アメリカ、94801
- Kaiser Permanente-Richmond
-
Riverside、California、アメリカ、92505
- Kaiser Permanente-Riverside
-
Roseville、California、アメリカ、95661
- Kaiser Permanente-Roseville
-
Roseville、California、アメリカ、95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Roseville、California、アメリカ、95661
- Sutter Roseville Medical Center
-
Sacramento、California、アメリカ、95816
- Sutter Medical Center Sacramento
-
Sacramento、California、アメリカ、95823
- Kaiser Permanente-South Sacramento
-
Sacramento、California、アメリカ、95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego、California、アメリカ、92120
- Kaiser Permanente-San Diego Zion
-
San Diego、California、アメリカ、92108
- Kaiser Permanente-San Diego Mission
-
San Francisco、California、アメリカ、94115
- Kaiser Permanente-San Francisco
-
San Francisco、California、アメリカ、94115
- California Pacific Medical Center-Pacific Campus
-
San Jose、California、アメリカ、95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro、California、アメリカ、94577
- Kaiser Permanente San Leandro
-
San Marcos、California、アメリカ、92078
- Kaiser Permanente-San Marcos
-
San Pablo、California、アメリカ、94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
-
San Rafael、California、アメリカ、94903
- Kaiser Permanente-San Rafael
-
Santa Clara、California、アメリカ、95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Cruz、California、アメリカ、95065
- Palo Alto Medical Foundation-Santa Cruz
-
Santa Rosa、California、アメリカ、95403
- Kaiser Permanente-Santa Rosa
-
Santa Rosa、California、アメリカ、95403
- Sutter Pacific Medical Foundation
-
South San Francisco、California、アメリカ、94080
- Kaiser Permanente-South San Francisco
-
Stockton、California、アメリカ、95210
- Kaiser Permanente-Stockton
-
Sunnyvale、California、アメリカ、94086
- Palo Alto Medical Foundation-Sunnyvale
-
Vacaville、California、アメリカ、95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo、California、アメリカ、94589
- Kaiser Permanente-Vallejo
-
Vallejo、California、アメリカ、94589
- Sutter Solano Medical Center/Cancer Center
-
Walnut Creek、California、アメリカ、94596
- Kaiser Permanente-Walnut Creek
-
Woodland Hills、California、アメリカ、91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora、Colorado、アメリカ、80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora、Colorado、アメリカ、80012
- The Medical Center of Aurora
-
Aurora、Colorado、アメリカ、80045
- UCHealth University of Colorado Hospital
-
Boulder、Colorado、アメリカ、80303
- Boulder Community Foothills Hospital
-
Boulder、Colorado、アメリカ、80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs、Colorado、アメリカ、80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs、Colorado、アメリカ、80909
- UCHealth Memorial Hospital Central
-
Colorado Springs、Colorado、アメリカ、80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver、Colorado、アメリカ、80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver、Colorado、アメリカ、80220
- Rose Medical Center
-
Denver、Colorado、アメリカ、80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver、Colorado、アメリカ、80220
- Rocky Mountain Cancer Centers-Rose
-
Denver、Colorado、アメリカ、80218
- Colorado Blood Cancer Institute
-
Denver、Colorado、アメリカ、80222
- Western States Cancer Research NCORP
-
Denver、Colorado、アメリカ、80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver、Colorado、アメリカ、80210
- AdventHealth Porter
-
Durango、Colorado、アメリカ、81301
- Mercy Medical Center
-
Durango、Colorado、アメリカ、81301
- Southwest Oncology PC
-
Englewood、Colorado、アメリカ、80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood、Colorado、アメリカ、80113
- Swedish Medical Center
-
Fort Collins、Colorado、アメリカ、80524
- Poudre Valley Hospital
-
Golden、Colorado、アメリカ、80401
- Mountain Blue Cancer Care Center
-
Greeley、Colorado、アメリカ、80631
- Banner North Colorado Medical Center
-
Greenwood Village、Colorado、アメリカ、80111
- Rocky Mountain Cancer Centers-Greenwood Village
-
Lakewood、Colorado、アメリカ、80228
- Saint Anthony Hospital
-
Lakewood、Colorado、アメリカ、80228
- Rocky Mountain Cancer Centers-Lakewood
-
Littleton、Colorado、アメリカ、80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton、Colorado、アメリカ、80122
- AdventHealth Littleton
-
Lone Tree、Colorado、アメリカ、80124
- Sky Ridge Medical Center
-
Lone Tree、Colorado、アメリカ、80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont、Colorado、アメリカ、80501
- Longmont United Hospital
-
Longmont、Colorado、アメリカ、80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland、Colorado、アメリカ、80539
- Banner McKee Medical Center
-
Parker、Colorado、アメリカ、80138
- Rocky Mountain Cancer Centers-Parker
-
Parker、Colorado、アメリカ、80138
- AdventHealth Parker
-
Pueblo、Colorado、アメリカ、81004
- Saint Mary Corwin Medical Center
-
Pueblo、Colorado、アメリカ、81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton、Colorado、アメリカ、80260
- Rocky Mountain Cancer Centers-Thornton
-
Wheat Ridge、Colorado、アメリカ、80401
- Intermountain Health Lutheran Hospital
-
-
Connecticut
-
Hartford、Connecticut、アメリカ、06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
Hartford、Connecticut、アメリカ、06102
- Hartford Hospital
-
-
Delaware
-
Lewes、Delaware、アメリカ、19958
- Beebe Medical Center
-
Newark、Delaware、アメリカ、19713
- Helen F Graham Cancer Center
-
Newark、Delaware、アメリカ、19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark、Delaware、アメリカ、19713
- Medical Oncology Hematology Consultants PA
-
Newark、Delaware、アメリカ、19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach、Delaware、アメリカ、19971
- Beebe Health Campus
-
Seaford、Delaware、アメリカ、19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington、Delaware、アメリカ、19801
- Christiana Care Health System-Wilmington Hospital
-
-
District of Columbia
-
Washington D.C.、District of Columbia、アメリカ、20010
- MedStar Washington Hospital Center
-
Washington D.C.、District of Columbia、アメリカ、20007
- MedStar Georgetown University Hospital
-
-
Florida
-
Deerfield Beach、Florida、アメリカ、33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Gainesville、Florida、アメリカ、32610
- University of Florida Health Science Center - Gainesville
-
Miami、Florida、アメリカ、33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Orlando、Florida、アメリカ、32806
- Orlando Health Cancer Institute
-
Orlando、Florida、アメリカ、32803
- AdventHealth Orlando
-
-
Georgia
-
Athens、Georgia、アメリカ、30607
- University Cancer and Blood Center LLC
-
Atlanta、Georgia、アメリカ、30342
- Northside Hospital
-
Augusta、Georgia、アメリカ、30912
- Augusta University Medical Center
-
Cumming、Georgia、アメリカ、30041
- Northside Hospital-Forsyth
-
Decatur、Georgia、アメリカ、30033
- Emory Decatur Hospital
-
Gainesville、Georgia、アメリカ、30501
- Northeast Georgia Medical Center-Gainesville
-
Savannah、Georgia、アメリカ、31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah、Georgia、アメリカ、31404
- Memorial Health University Medical Center
-
Savannah、Georgia、アメリカ、31404
- Summit Cancer Care-Memorial
-
Savannah、Georgia、アメリカ、31404
- Low Country Cancer Care
-
-
Hawaii
-
Honolulu、Hawaii、アメリカ、96813
- Queen's Medical Center
-
Honolulu、Hawaii、アメリカ、96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu、Hawaii、アメリカ、96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu、Hawaii、アメリカ、96813
- Straub Clinic and Hospital
-
Honolulu、Hawaii、アメリカ、96813
- University of Hawaii Cancer Center
-
Honolulu、Hawaii、アメリカ、96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu、Hawaii、アメリカ、96817
- Kuakini Medical Center
-
Honolulu、Hawaii、アメリカ、96817
- Queen's Cancer Center - Kuakini
-
Honolulu、Hawaii、アメリカ、96819
- Kaiser Permanente Moanalua Medical Center
-
Kailua、Hawaii、アメリカ、96734
- Castle Medical Center
-
Lihue、Hawaii、アメリカ、96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea、Hawaii、アメリカ、96701
- Pali Momi Medical Center
-
‘Aiea、Hawaii、アメリカ、96701
- Queen's Cancer Center - Pearlridge
-
‘Aiea、Hawaii、アメリカ、96701
- The Cancer Center of Hawaii-Pali Momi
-
-
Idaho
-
Boise、Idaho、アメリカ、83706
- Saint Alphonsus Cancer Care Center-Boise
-
Coeur d'Alene、Idaho、アメリカ、83814
- Kootenai Health - Coeur d'Alene
-
Lewiston、Idaho、アメリカ、83501
- Saint Joseph Regional Medical Center
-
Post Falls、Idaho、アメリカ、83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint、Idaho、アメリカ、83864
- Kootenai Clinic Cancer Services - Sandpoint
-
-
Illinois
-
Aurora、Illinois、アメリカ、60504
- Rush-Copley Medical Center
-
Bloomington、Illinois、アメリカ、61704
- Illinois CancerCare-Bloomington
-
Bloomington、Illinois、アメリカ、61701
- OSF Saint Joseph Medical Center
-
Canton、Illinois、アメリカ、61520
- Illinois CancerCare-Canton
-
Carbondale、Illinois、アメリカ、62902
- Memorial Hospital of Carbondale
-
Carthage、Illinois、アメリカ、62321
- Illinois CancerCare-Carthage
-
Centralia、Illinois、アメリカ、62801
- Centralia Oncology Clinic
-
Chicago、Illinois、アメリカ、60612
- University of Illinois
-
Chicago、Illinois、アメリカ、60612
- John H Stroger Jr Hospital of Cook County
-
Chicago、Illinois、アメリカ、60608
- Mount Sinai Hospital Medical Center
-
Chicago、Illinois、アメリカ、60625
- Swedish Covenant Hospital
-
Chicago、Illinois、アメリカ、60631
- Presence Resurrection Medical Center
-
Danville、Illinois、アメリカ、61832
- Carle at The Riverfront
-
Decatur、Illinois、アメリカ、62526
- Decatur Memorial Hospital
-
Decatur、Illinois、アメリカ、62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham、Illinois、アメリカ、62401
- Crossroads Cancer Center
-
Effingham、Illinois、アメリカ、62401
- Carle Physician Group-Effingham
-
Elk Grove Village、Illinois、アメリカ、60007
- Ascension Alexian Brothers - Elk Grove Village
-
Eureka、Illinois、アメリカ、61530
- Illinois CancerCare-Eureka
-
Evanston、Illinois、アメリカ、60202
- Saint Francis Hospital
-
Galesburg、Illinois、アメリカ、61401
- Western Illinois Cancer Treatment Center
-
Galesburg、Illinois、アメリカ、61401
- Illinois CancerCare-Galesburg
-
Geneva、Illinois、アメリカ、60134
- Northwestern Medicine Cancer Center Delnor
-
Harvey、Illinois、アメリカ、60426
- Ingalls Memorial Hospital
-
Kankakee、Illinois、アメリカ、60901
- Presence Saint Mary's Hospital
-
Kewanee、Illinois、アメリカ、61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb、Illinois、アメリカ、61455
- Illinois CancerCare-Macomb
-
Mattoon、Illinois、アメリカ、61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon、Illinois、アメリカ、62864
- SSM Health Good Samaritan
-
Naperville、Illinois、アメリカ、60540
- Edward Hospital/Cancer Center
-
O'Fallon、Illinois、アメリカ、62269
- Cancer Care Center of O'Fallon
-
Ottawa、Illinois、アメリカ、61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa、Illinois、アメリカ、61350
- Radiation Oncology of Northern Illinois
-
Pekin、Illinois、アメリカ、61554
- Illinois CancerCare-Pekin
-
Pekin、Illinois、アメリカ、61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria、Illinois、アメリカ、61636
- Methodist Medical Center of Illinois
-
Peoria、Illinois、アメリカ、61637
- OSF Saint Francis Medical Center
-
Peoria、Illinois、アメリカ、61615
- Illinois CancerCare-Peoria
-
Peoria、Illinois、アメリカ、61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru、Illinois、アメリカ、61354
- Illinois CancerCare-Peru
-
Peru、Illinois、アメリカ、61354
- Valley Radiation Oncology
-
Plainfield、Illinois、アメリカ、60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton、Illinois、アメリカ、61356
- Illinois CancerCare-Princeton
-
Rockford、Illinois、アメリカ、61108
- OSF Saint Anthony Medical Center
-
Rockford、Illinois、アメリカ、61114
- UW Health Carbone Cancer Center Rockford
-
Springfield、Illinois、アメリカ、62702
- Southern Illinois University School of Medicine
-
Springfield、Illinois、アメリカ、62702
- Springfield Clinic
-
Springfield、Illinois、アメリカ、62702
- Central Illinois Hematology Oncology Center
-
Springfield、Illinois、アメリカ、62781
- Springfield Memorial Hospital
-
Urbana、Illinois、アメリカ、61801
- Carle Cancer Center
-
Urbana、Illinois、アメリカ、61801
- The Carle Foundation Hospital
-
Warrenville、Illinois、アメリカ、60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville、Illinois、アメリカ、60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Crown Point、Indiana、アメリカ、46307
- Michiana Hematology Oncology PC-Crown Point
-
Elkhart、Indiana、アメリカ、46515
- Elkhart General Hospital
-
Elkhart、Indiana、アメリカ、46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart、Indiana、アメリカ、46514-2098
- Elkhart Clinic
-
Indianapolis、Indiana、アメリカ、46237
- Franciscan Health Indianapolis
-
Kokomo、Indiana、アメリカ、46904
- Community Howard Regional Health
-
La Porte、Indiana、アメリカ、46350
- IU Health La Porte Hospital
-
Michigan City、Indiana、アメリカ、46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City、Indiana、アメリカ、46360
- Woodland Cancer Care Center
-
Mishawaka、Indiana、アメリカ、46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka、Indiana、アメリカ、46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Munster、Indiana、アメリカ、46321
- The Community Hospital
-
Plymouth、Indiana、アメリカ、46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond、Indiana、アメリカ、47374
- Reid Health
-
South Bend、Indiana、アメリカ、46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute、Indiana、アメリカ、47804
- Union Hospital
-
Westville、Indiana、アメリカ、46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames、Iowa、アメリカ、50010
- Mary Greeley Medical Center
-
Ames、Iowa、アメリカ、50010
- McFarland Clinic - Ames
-
Boone、Iowa、アメリカ、50036
- McFarland Clinic - Boone
-
Cedar Rapids、Iowa、アメリカ、52403
- Mercy Hospital
-
Cedar Rapids、Iowa、アメリカ、52403
- Oncology Associates at Mercy Medical Center
-
Clive、Iowa、アメリカ、50325
- Mercy Cancer Center-West Lakes
-
Clive、Iowa、アメリカ、50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs、Iowa、アメリカ、51503
- Alegent Health Mercy Hospital
-
Creston、Iowa、アメリカ、50801
- Greater Regional Medical Center
-
Des Moines、Iowa、アメリカ、50314
- Mercy Medical Center - Des Moines
-
Des Moines、Iowa、アメリカ、50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge、Iowa、アメリカ、50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City、Iowa、アメリカ、52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson、Iowa、アメリカ、50129
- McFarland Clinic - Jefferson
-
Marshalltown、Iowa、アメリカ、50158
- McFarland Clinic - Marshalltown
-
West Des Moines、Iowa、アメリカ、50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute、Kansas、アメリカ、66720
- Cancer Center of Kansas - Chanute
-
Dodge City、Kansas、アメリカ、67801
- Cancer Center of Kansas - Dodge City
-
El Dorado、Kansas、アメリカ、67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott、Kansas、アメリカ、66701
- Cancer Center of Kansas - Fort Scott
-
Independence、Kansas、アメリカ、67301
- Cancer Center of Kansas-Independence
-
Kingman、Kansas、アメリカ、67068
- Cancer Center of Kansas-Kingman
-
Lawrence、Kansas、アメリカ、66044
- Lawrence Memorial Hospital
-
Liberal、Kansas、アメリカ、67905
- Cancer Center of Kansas-Liberal
-
Manhattan、Kansas、アメリカ、66502
- Cancer Center of Kansas-Manhattan
-
McPherson、Kansas、アメリカ、67460
- Cancer Center of Kansas - McPherson
-
Newton、Kansas、アメリカ、67114
- Cancer Center of Kansas - Newton
-
Parsons、Kansas、アメリカ、67357
- Cancer Center of Kansas - Parsons
-
Pratt、Kansas、アメリカ、67124
- Cancer Center of Kansas - Pratt
-
Salina、Kansas、アメリカ、67401
- Cancer Center of Kansas - Salina
-
Topeka、Kansas、アメリカ、66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington、Kansas、アメリカ、67152
- Cancer Center of Kansas - Wellington
-
Wichita、Kansas、アメリカ、67214
- Ascension Via Christi Hospitals Wichita
-
Wichita、Kansas、アメリカ、67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita、Kansas、アメリカ、67214
- Cancer Center of Kansas - Wichita
-
Wichita、Kansas、アメリカ、67208
- Associates In Womens Health
-
Wichita、Kansas、アメリカ、67214
- Wichita NCI Community Oncology Research Program
-
Winfield、Kansas、アメリカ、67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown、Kentucky、アメリカ、40004
- Flaget Memorial Hospital
-
Corbin、Kentucky、アメリカ、40701
- Baptist Health Corbin
-
Corbin、Kentucky、アメリカ、40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills、Kentucky、アメリカ、41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown、Kentucky、アメリカ、42701
- Baptist Health Hardin
-
Lexington、Kentucky、アメリカ、40536
- University of Kentucky/Markey Cancer Center
-
Lexington、Kentucky、アメリカ、40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington、Kentucky、アメリカ、40509
- Saint Joseph Hospital East
-
Lexington、Kentucky、アメリカ、40503
- Baptist Health Lexington
-
Louisville、Kentucky、アメリカ、40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville、Kentucky、アメリカ、40202
- Jewish Hospital
-
Louisville、Kentucky、アメリカ、40245
- UofL Health Medical Center Northeast
-
Louisville、Kentucky、アメリカ、40207
- Baptist Health Louisville
-
Louisville、Kentucky、アメリカ、40215
- Saints Mary and Elizabeth Hospital
-
Madisonville、Kentucky、アメリカ、42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah、Kentucky、アメリカ、42003
- Baptist Health Paducah
-
Shepherdsville、Kentucky、アメリカ、40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge、Louisiana、アメリカ、70809
- Ochsner Health Center-Summa
-
Kenner、Louisiana、アメリカ、70065
- Ochsner Medical Center Kenner
-
New Orleans、Louisiana、アメリカ、70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor、Maine、アメリカ、04401
- Eastern Maine Medical Center
-
Brewer、Maine、アメリカ、04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore、Maryland、アメリカ、21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore、Maryland、アメリカ、21204
- Greater Baltimore Medical Center
-
Elkton、Maryland、アメリカ、21921
- Christiana Care - Union Hospital
-
Frederick、Maryland、アメリカ、21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River、Massachusetts、アメリカ、02721
- Saint Anne's Hospital
-
Pittsfield、Massachusetts、アメリカ、01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian、Michigan、アメリカ、49221
- Bixby Medical Center
-
Adrian、Michigan、アメリカ、49221
- Hickman Cancer Center
-
Ann Arbor、Michigan、アメリカ、48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor、Michigan、アメリカ、48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor、Michigan、アメリカ、48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn、Michigan、アメリカ、48124
- Corewell Health Dearborn Hospital
-
Detroit、Michigan、アメリカ、48202
- Henry Ford Hospital
-
Detroit、Michigan、アメリカ、48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit、Michigan、アメリカ、48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills、Michigan、アメリカ、48334
- Weisberg Cancer Treatment Center
-
Farmington Hills、Michigan、アメリカ、48336
- Corewell Health Farmington Hills Hospital
-
Flint、Michigan、アメリカ、48503
- Hurley Medical Center
-
Flint、Michigan、アメリカ、48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe、Michigan、アメリカ、48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson、Michigan、アメリカ、49201
- Allegiance Health
-
Kalamazoo、Michigan、アメリカ、49007
- West Michigan Cancer Center
-
Lansing、Michigan、アメリカ、48912
- University of Michigan Health - Sparrow Lansing
-
Livonia、Michigan、アメリカ、48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland、Michigan、アメリカ、48670
- MyMichigan Medical Center Midland
-
Monroe、Michigan、アメリカ、48162
- Mercy Memorial Hospital
-
Monroe、Michigan、アメリカ、48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac、Michigan、アメリカ、48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron、Michigan、アメリカ、48060
- Lake Huron Medical Center
-
Roseville、Michigan、アメリカ、48066
- Michigan Cancer Specialists
-
Royal Oak、Michigan、アメリカ、48073
- Cancer Care Associates PC
-
Royal Oak、Michigan、アメリカ、48073
- Comprehensive Medical Center PLLC
-
Royal Oak、Michigan、アメリカ、48073
- Oakland Medical Group
-
Royal Oak、Michigan、アメリカ、48067
- Oakland Colon Rectal Associates
-
Royal Oak、Michigan、アメリカ、48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak、Michigan、アメリカ、48073
- Corewell Health William Beaumont University Hospital
-
Saginaw、Michigan、アメリカ、48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights、Michigan、アメリカ、48312
- Premier Hematology Oncology Care
-
Sterling Heights、Michigan、アメリカ、48314
- Mitchell Folbe MD PC
-
Troy、Michigan、アメリカ、48084
- Michigan Institute of Urology-Town Center
-
Troy、Michigan、アメリカ、48085
- Claudia BR Herke MD PC
-
Troy、Michigan、アメリカ、48098
- Hematology Oncology Consultants PC-Troy
-
Troy、Michigan、アメリカ、48085
- Corewell Health Beaumont Troy Hospital
-
Warren、Michigan、アメリカ、48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji、Minnesota、アメリカ、56601
- Sanford Joe Lueken Cancer Center
-
Brainerd、Minnesota、アメリカ、56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville、Minnesota、アメリカ、55337
- Fairview Ridges Hospital
-
Coon Rapids、Minnesota、アメリカ、55433
- Mercy Hospital
-
Duluth、Minnesota、アメリカ、55805
- Essentia Health Cancer Center
-
Duluth、Minnesota、アメリカ、55805
- Essentia Health Saint Mary's Medical Center
-
Duluth、Minnesota、アメリカ、55805
- Miller-Dwan Hospital
-
Edina、Minnesota、アメリカ、55435
- Fairview Southdale Hospital
-
Fergus Falls、Minnesota、アメリカ、56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley、Minnesota、アメリカ、55432
- Unity Hospital
-
Hutchinson、Minnesota、アメリカ、55350
- Hutchinson Area Health Care
-
Maplewood、Minnesota、アメリカ、55109
- Saint John's Hospital - Healtheast
-
Maplewood、Minnesota、アメリカ、55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis、Minnesota、アメリカ、55415
- Hennepin County Medical Center
-
Minneapolis、Minnesota、アメリカ、55407
- Abbott-Northwestern Hospital
-
Minneapolis、Minnesota、アメリカ、55454
- Health Partners Inc
-
New Ulm、Minnesota、アメリカ、56073
- New Ulm Medical Center
-
Robbinsdale、Minnesota、アメリカ、55422
- North Memorial Medical Health Center
-
Saint Louis Park、Minnesota、アメリカ、55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park、Minnesota、アメリカ、55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul、Minnesota、アメリカ、55101
- Regions Hospital
-
Saint Paul、Minnesota、アメリカ、55102
- United Hospital
-
Shakopee、Minnesota、アメリカ、55379
- Saint Francis Regional Medical Center
-
Stillwater、Minnesota、アメリカ、55082
- Lakeview Hospital
-
Waconia、Minnesota、アメリカ、55387
- Ridgeview Medical Center
-
Willmar、Minnesota、アメリカ、56201
- Rice Memorial Hospital
-
Woodbury、Minnesota、アメリカ、55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin、Missouri、アメリカ、63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar、Missouri、アメリカ、65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre、Missouri、アメリカ、63628
- Parkland Health Center-Bonne Terre
-
Branson、Missouri、アメリカ、65616
- Cox Cancer Center Branson
-
Cape Girardeau、Missouri、アメリカ、63703
- Saint Francis Medical Center
-
Cape Girardeau、Missouri、アメリカ、63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia、Missouri、アメリカ、65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City、Missouri、アメリカ、65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin、Missouri、アメリカ、64804
- Freeman Health System
-
Joplin、Missouri、アメリカ、64804
- Mercy Hospital Joplin
-
Rolla、Missouri、アメリカ、65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla、Missouri、アメリカ、65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve、Missouri、アメリカ、63670
- Sainte Genevieve County Memorial Hospital
-
Springfield、Missouri、アメリカ、65807
- CoxHealth South Hospital
-
Springfield、Missouri、アメリカ、65804
- Mercy Hospital Springfield
-
St Louis、Missouri、アメリカ、63131
- Missouri Baptist Medical Center
-
St Louis、Missouri、アメリカ、63109
- Mercy Infusion Center - Chippewa
-
St Louis、Missouri、アメリカ、63141
- Mercy Hospital Saint Louis
-
Sullivan、Missouri、アメリカ、63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills、Missouri、アメリカ、63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda、Montana、アメリカ、59711
- Community Hospital of Anaconda
-
Billings、Montana、アメリカ、59101
- Billings Clinic Cancer Center
-
Billings、Montana、アメリカ、59101
- Saint Vincent Healthcare
-
Billings、Montana、アメリカ、59102
- Montana Cancer Consortium NCORP
-
Bozeman、Montana、アメリカ、59715
- Bozeman Health Deaconess Hospital
-
Butte、Montana、アメリカ、59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls、Montana、アメリカ、59405
- Benefis Sletten Cancer Institute
-
Helena、Montana、アメリカ、59601
- Saint Peter's Community Hospital
-
Kalispell、Montana、アメリカ、59901
- Logan Health Medical Center
-
Missoula、Montana、アメリカ、59802
- Saint Patrick Hospital - Community Hospital
-
Missoula、Montana、アメリカ、59804
- Community Medical Center
-
-
Nebraska
-
Grand Island、Nebraska、アメリカ、68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney、Nebraska、アメリカ、68847
- CHI Health Good Samaritan
-
Kearney、Nebraska、アメリカ、68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln、Nebraska、アメリカ、68510
- Saint Elizabeth Regional Medical Center
-
Omaha、Nebraska、アメリカ、68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha、Nebraska、アメリカ、68122
- Alegent Health Immanuel Medical Center
-
Omaha、Nebraska、アメリカ、68130
- Alegent Health Lakeside Hospital
-
Omaha、Nebraska、アメリカ、68131
- Creighton University Medical Center
-
Omaha、Nebraska、アメリカ、68122
- Hematology and Oncology Consultants PC
-
Papillion、Nebraska、アメリカ、68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson、Nevada、アメリカ、89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson、Nevada、アメリカ、89052
- Cancer and Blood Specialists-Henderson
-
Henderson、Nevada、アメリカ、89052
- Las Vegas Cancer Center-Henderson
-
Henderson、Nevada、アメリカ、89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson、Nevada、アメリカ、89074
- GenesisCare USA - Henderson
-
Las Vegas、Nevada、アメリカ、89144
- Summerlin Hospital Medical Center
-
Las Vegas、Nevada、アメリカ、89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas、Nevada、アメリカ、89109
- GenesisCare USA - Las Vegas
-
Las Vegas、Nevada、アメリカ、89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas、Nevada、アメリカ、89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas、Nevada、アメリカ、89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas、Nevada、アメリカ、89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas、Nevada、アメリカ、89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas、Nevada、アメリカ、89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas、Nevada、アメリカ、89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas、Nevada、アメリカ、89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas、Nevada、アメリカ、89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas、Nevada、アメリカ、89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas、Nevada、アメリカ、89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas、Nevada、アメリカ、89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas、Nevada、アメリカ、89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas、Nevada、アメリカ、89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas、Nevada、アメリカ、89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas、Nevada、アメリカ、89148
- GenesisCare USA - Fort Apache
-
Las Vegas、Nevada、アメリカ、89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas、Nevada、アメリカ、89120
- Nevada Cancer Research Foundation NCORP
-
Reno、Nevada、アメリカ、89502
- Renown Regional Medical Center
-
Reno、Nevada、アメリカ、89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon、New Hampshire、アメリカ、03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth、New Jersey、アメリカ、07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood、New Jersey、アメリカ、07631
- Englewood Hospital and Medical Center
-
Flemington、New Jersey、アメリカ、08822
- Hunterdon Medical Center
-
Mullica Hill、New Jersey、アメリカ、08062
- Inspira Medical Center Mullica Hill
-
Newark、New Jersey、アメリカ、07112
- Newark Beth Israel Medical Center
-
Newton、New Jersey、アメリカ、07860
- Newton Medical Center
-
Pompton、New Jersey、アメリカ、07444
- Chilton Medical Center
-
Summit、New Jersey、アメリカ、07902
- Overlook Hospital
-
Vineland、New Jersey、アメリカ、08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque、New Mexico、アメリカ、87106
- University of New Mexico Cancer Center
-
Albuquerque、New Mexico、アメリカ、87106
- Hematology Oncology Associates
-
Las Cruces、New Mexico、アメリカ、88011
- Memorial Medical Center-Las Cruces
-
Santa Fe、New Mexico、アメリカ、87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo、New York、アメリカ、14263
- Roswell Park Cancer Institute
-
Glens Falls、New York、アメリカ、12801
- Glens Falls Hospital
-
Middletown、New York、アメリカ、10940
- Garnet Health Medical Center
-
New York、New York、アメリカ、10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro、North Carolina、アメリカ、27203
- Randolph Hospital
-
Asheville、North Carolina、アメリカ、28803
- AdventHealth Infusion Center Asheville
-
Burlington、North Carolina、アメリカ、27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill、North Carolina、アメリカ、27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton、North Carolina、アメリカ、28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro、North Carolina、アメリカ、27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro、North Carolina、アメリカ、27534
- Wayne Memorial Hospital
-
Greensboro、North Carolina、アメリカ、27403
- Cone Health Cancer Center
-
Hendersonville、North Carolina、アメリカ、28792
- AdventHealth Hendersonville
-
Jacksonville、North Carolina、アメリカ、28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville、North Carolina、アメリカ、27284
- Novant Health Cancer Institute - Kernersville
-
Kinston、North Carolina、アメリカ、28501
- ECU Health Oncology Kinston
-
Mebane、North Carolina、アメリカ、27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy、North Carolina、アメリカ、27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro、North Carolina、アメリカ、28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst、North Carolina、アメリカ、28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville、North Carolina、アメリカ、27320
- Annie Penn Memorial Hospital
-
Salisbury、North Carolina、アメリカ、28144
- Novant Health Cancer Institute - Rowan
-
Statesville、North Carolina、アメリカ、28677
- Iredell Memorial Hospital
-
Stateville、North Carolina、アメリカ、28625
- Novant Health Cancer Institute - Statesville
-
Thomasville、North Carolina、アメリカ、27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem、North Carolina、アメリカ、27157
- Wake Forest University Health Sciences
-
Winston-Salem、North Carolina、アメリカ、27103
- Novant Health Forsyth Medical Center
-
Winston-Salem、North Carolina、アメリカ、27103
- Novant Health Oncology Specialists
-
Winston-Salem、North Carolina、アメリカ、27103
- Winston-Salem Health Care
-
Winston-Salem、North Carolina、アメリカ、27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck、North Dakota、アメリカ、58501
- Sanford Bismarck Medical Center
-
Fargo、North Dakota、アメリカ、58122
- Sanford Roger Maris Cancer Center
-
Fargo、North Dakota、アメリカ、58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo、North Dakota、アメリカ、58122
- Sanford Broadway Medical Center
-
Grand Forks、North Dakota、アメリカ、58201
- Altru Cancer Center
-
Minot、North Dakota、アメリカ、58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron、Ohio、アメリカ、44307
- Cleveland Clinic Akron General
-
Akron、Ohio、アメリカ、44304
- Summa Health System - Akron Campus
-
Barberton、Ohio、アメリカ、44203
- Summa Health System - Barberton Campus
-
Belpre、Ohio、アメリカ、45714
- Strecker Cancer Center-Belpre
-
Bowling Green、Ohio、アメリカ、43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton、Ohio、アメリカ、44710
- Aultman Health Foundation
-
Centerville、Ohio、アメリカ、45459
- Miami Valley Hospital South
-
Centerville、Ohio、アメリカ、45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe、Ohio、アメリカ、45601
- Adena Regional Medical Center
-
Cincinnati、Ohio、アメリカ、45219
- The Christ Hospital
-
Cincinnati、Ohio、アメリカ、45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati、Ohio、アメリカ、45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati、Ohio、アメリカ、45242
- Bethesda North Hospital
-
Cincinnati、Ohio、アメリカ、45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati、Ohio、アメリカ、45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati、Ohio、アメリカ、45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati、Ohio、アメリカ、45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati、Ohio、アメリカ、45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati、Ohio、アメリカ、45247
- TriHealth Cancer Institute-Westside
-
Cincinnati、Ohio、アメリカ、45255
- TriHealth Cancer Institute-Anderson
-
Columbus、Ohio、アメリカ、43214
- Riverside Methodist Hospital
-
Columbus、Ohio、アメリカ、43219
- The Mark H Zangmeister Center
-
Columbus、Ohio、アメリカ、43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus、Ohio、アメリカ、43228
- Doctors Hospital
-
Columbus、Ohio、アメリカ、43215
- Grant Medical Center
-
Columbus、Ohio、アメリカ、43222
- Mount Carmel Health Center West
-
Columbus、Ohio、アメリカ、43215
- Columbus NCI Community Oncology Research Program
-
Dayton、Ohio、アメリカ、45406
- Good Samaritan Hospital - Dayton
-
Dayton、Ohio、アメリカ、45409
- Miami Valley Hospital
-
Dayton、Ohio、アメリカ、45415
- Miami Valley Hospital North
-
Dayton、Ohio、アメリカ、45459
- Dayton NCI Community Oncology Research Program
-
Dayton、Ohio、アメリカ、45415
- Dayton Physician LLC - Englewood
-
Delaware、Ohio、アメリカ、43015
- Delaware Health Center-Grady Cancer Center
-
Delaware、Ohio、アメリカ、43015
- Delaware Radiation Oncology
-
Delaware、Ohio、アメリカ、43015
- Grady Memorial Hospital
-
Fairfield、Ohio、アメリカ、45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay、Ohio、アメリカ、45840
- Blanchard Valley Hospital
-
Findlay、Ohio、アメリカ、45840
- Armes Family Cancer Center
-
Findlay、Ohio、アメリカ、45840
- Orion Cancer Care
-
Franklin、Ohio、アメリカ、45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin、Ohio、アメリカ、45005
- Dayton Physicians LLC-Atrium
-
Greenville、Ohio、アメリカ、45331
- Wayne Hospital
-
Greenville、Ohio、アメリカ、45331
- Dayton Physicians LLC-Wayne
-
Kettering、Ohio、アメリカ、45429
- Kettering Medical Center
-
Kettering、Ohio、アメリカ、45409
- Greater Dayton Cancer Center
-
Lancaster、Ohio、アメリカ、43130
- Fairfield Medical Center
-
Lancaster、Ohio、アメリカ、43130
- Lancaster Radiation Oncology
-
Lima、Ohio、アメリカ、45804
- Lima Memorial Hospital
-
Marietta、Ohio、アメリカ、45750
- Marietta Memorial Hospital
-
Maumee、Ohio、アメリカ、43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee、Ohio、アメリカ、43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina、Ohio、アメリカ、44256
- Summa Health Medina Medical Center
-
Middletown、Ohio、アメリカ、45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon、Ohio、アメリカ、43050
- Knox Community Hospital
-
Newark、Ohio、アメリカ、43055
- Licking Memorial Hospital
-
Newark、Ohio、アメリカ、43055
- Newark Radiation Oncology
-
Oregon、Ohio、アメリカ、43616
- Saint Charles Hospital
-
Oregon、Ohio、アメリカ、43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth、Ohio、アメリカ、45662
- Southern Ohio Medical Center
-
Sidney、Ohio、アメリカ、45365
- Dayton Physicians LLC-Wilson
-
Springfield、Ohio、アメリカ、45504
- Springfield Regional Cancer Center
-
Springfield、Ohio、アメリカ、45504
- Springfield Regional Medical Center
-
Sylvania、Ohio、アメリカ、43560
- ProMedica Flower Hospital
-
Tiffin、Ohio、アメリカ、44883
- Mercy Hospital of Tiffin
-
Toledo、Ohio、アメリカ、43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo、Ohio、アメリカ、43623
- Mercy Health - Saint Anne Hospital
-
Toledo、Ohio、アメリカ、43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo、Ohio、アメリカ、43614
- University of Toledo
-
Toledo、Ohio、アメリカ、43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo、Ohio、アメリカ、43608
- Mercy Health - Saint Vincent Hospital
-
Troy、Ohio、アメリカ、45373
- Upper Valley Medical Center
-
Troy、Ohio、アメリカ、45373
- Dayton Physicians LLC - Troy
-
Wauseon、Ohio、アメリカ、43567
- Fulton County Health Center
-
West Chester、Ohio、アメリカ、45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville、Ohio、アメリカ、43081
- Saint Ann's Hospital
-
Wpafb、Ohio、アメリカ、45433
- Wright-Patterson Medical Center
-
Zanesville、Ohio、アメリカ、43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton、Oklahoma、アメリカ、73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City、Oklahoma、アメリカ、73104
- University of Oklahoma Health Sciences Center
-
Tulsa、Oklahoma、アメリカ、74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa、Oklahoma、アメリカ、74136
- Surgical Associates Inc
-
Tulsa、Oklahoma、アメリカ、74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland、Oregon、アメリカ、97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver、Pennsylvania、アメリカ、15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford、Pennsylvania、アメリカ、19317
- Christiana Care Health System-Concord Health Center
-
Danville、Pennsylvania、アメリカ、17822
- Geisinger Medical Center
-
Easton、Pennsylvania、アメリカ、18042
- Easton Hospital
-
Greensburg、Pennsylvania、アメリカ、15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg、Pennsylvania、アメリカ、17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton、Pennsylvania、アメリカ、18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey、Pennsylvania、アメリカ、17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills、Pennsylvania、アメリカ、15025
- Jefferson Hospital
-
Johnstown、Pennsylvania、アメリカ、15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg、Pennsylvania、アメリカ、17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown、Pennsylvania、アメリカ、17044
- Lewistown Hospital
-
McKeesport、Pennsylvania、アメリカ、15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville、Pennsylvania、アメリカ、15146
- Forbes Hospital
-
Moon Township、Pennsylvania、アメリカ、15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia、Pennsylvania、アメリカ、19107
- Thomas Jefferson University Hospital
-
Philadelphia、Pennsylvania、アメリカ、19114
- Jefferson Torresdale Hospital
-
Phoenixville、Pennsylvania、アメリカ、19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh、Pennsylvania、アメリカ、15212
- Allegheny General Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15224
- West Penn Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15213
- UPMC-Magee Womens Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh、Pennsylvania、アメリカ、15232
- UPMC-Shadyside Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15213
- UPMC-Presbyterian Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15215
- UPMC-Saint Margaret
-
Pittsburgh、Pennsylvania、アメリカ、15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh、Pennsylvania、アメリカ、15237
- UPMC-Passavant Hospital
-
Pittsburgh、Pennsylvania、アメリカ、15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville、Pennsylvania、アメリカ、17901
- Geisinger Cancer Services-Pottsville
-
Scranton、Pennsylvania、アメリカ、18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca、Pennsylvania、アメリカ、16346
- UPMC Cancer Center at UPMC Northwest
-
State College、Pennsylvania、アメリカ、16801
- Geisinger Medical Group
-
Uniontown、Pennsylvania、アメリカ、15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington、Pennsylvania、アメリカ、15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester、Pennsylvania、アメリカ、19380
- Chester County Hospital
-
West Grove、Pennsylvania、アメリカ、19390
- Jennersville Regional Hospital
-
West Reading、Pennsylvania、アメリカ、19611
- Reading Hospital
-
Wilkes-Barre、Pennsylvania、アメリカ、18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport、Pennsylvania、アメリカ、17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence、Rhode Island、アメリカ、02905
- Women and Infants Hospital
-
Warwick、Rhode Island、アメリカ、02886
- Kent Hospital
-
-
South Carolina
-
Anderson、South Carolina、アメリカ、29621
- AnMed Health Cancer Center
-
Boiling Springs、South Carolina、アメリカ、29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley、South Carolina、アメリカ、29640
- Prisma Health Cancer Institute - Easley
-
Georgetown、South Carolina、アメリカ、29440
- Tidelands Georgetown Memorial Hospital
-
Greenville、South Carolina、アメリカ、29605
- Prisma Health Cancer Institute - Faris
-
Greenville、South Carolina、アメリカ、29607
- Saint Francis Cancer Center
-
Greenville、South Carolina、アメリカ、29615
- Prisma Health Cancer Institute - Eastside
-
Greenville、South Carolina、アメリカ、29605
- Prisma Health Cancer Institute - Butternut
-
Greenville、South Carolina、アメリカ、29601
- Saint Francis Hospital
-
Greenville、South Carolina、アメリカ、29605
- Prisma Health Greenville Memorial Hospital
-
Greenville、South Carolina、アメリカ、29601
- Greenville Health System Cancer Institute-Andrews
-
Greer、South Carolina、アメリカ、29650
- Prisma Health Cancer Institute - Greer
-
Greer、South Carolina、アメリカ、29651
- Gibbs Cancer Center-Pelham
-
Lancaster、South Carolina、アメリカ、29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill、South Carolina、アメリカ、29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca、South Carolina、アメリカ、29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg、South Carolina、アメリカ、29303
- Spartanburg Medical Center
-
Union、South Carolina、アメリカ、29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls、South Dakota、アメリカ、57105
- Avera Cancer Institute
-
Sioux Falls、South Dakota、アメリカ、57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls、South Dakota、アメリカ、57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga、Tennessee、アメリカ、37404
- Memorial Hospital
-
Hixson、Tennessee、アメリカ、37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson、Tennessee、アメリカ、38301
- Jackson-Madison County General Hospital
-
Nashville、Tennessee、アメリカ、37208
- Meharry Medical College
-
Ooltewah、Tennessee、アメリカ、37363
- Memorial GYN Plus
-
-
Texas
-
Abilene、Texas、アメリカ、79601
- Hendrick Medical Center
-
Houston、Texas、アメリカ、77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston、Texas、アメリカ、77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston、Texas、アメリカ、77030
- Ben Taub General Hospital
-
Laredo、Texas、アメリカ、78041
- Doctor's Hospital of Laredo
-
San Antonio、Texas、アメリカ、78229
- University Hospital
-
San Antonio、Texas、アメリカ、78229
- University of Texas Health Science Center at San Antonio
-
San Antonio、Texas、アメリカ、78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City、Utah、アメリカ、84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners、Vermont、アメリカ、05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington、Vermont、アメリカ、05401
- University of Vermont Medical Center
-
Burlington、Vermont、アメリカ、05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg、Virginia、アメリカ、22401
- Fredericksburg Oncology Inc
-
Fredericksburg、Virginia、アメリカ、22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville、Virginia、アメリカ、23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian、Virginia、アメリカ、23114
- Bon Secours Saint Francis Medical Center
-
Richmond、Virginia、アメリカ、23226
- Bon Secours Saint Mary's Hospital
-
Richmond、Virginia、アメリカ、23298
- VCU Massey Comprehensive Cancer Center
-
South Hill、Virginia、アメリカ、23970
- VCU Community Memorial Health Center
-
Winchester、Virginia、アメリカ、22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn、Washington、アメリカ、98001
- MultiCare Auburn Medical Center
-
Bainbridge Island、Washington、アメリカ、98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue、Washington、アメリカ、98004
- Overlake Medical Center
-
Burien、Washington、アメリカ、98166
- Highline Medical Center-Main Campus
-
Centralia、Washington、アメリカ、98531
- Providence Regional Cancer System-Centralia
-
Enumclaw、Washington、アメリカ、98022
- Saint Elizabeth Hospital
-
Everett、Washington、アメリカ、98201
- Providence Regional Cancer Partnership
-
Federal Way、Washington、アメリカ、98002
- Virginia Mason Federal Way Medical Center
-
Federal Way、Washington、アメリカ、98003
- Saint Francis Hospital
-
Gig Harbor、Washington、アメリカ、98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor、Washington、アメリカ、98335
- MultiCare Gig Harbor Medical Park
-
Kennewick、Washington、アメリカ、99336
- Northwest Cancer Clinic
-
Lacey、Washington、アメリカ、98503
- Providence Regional Cancer System-Lacey
-
Lakewood、Washington、アメリカ、98499
- Saint Clare Hospital
-
Lynnwood、Washington、アメリカ、98036
- Virginia Mason Lynnwood Medical Center
-
Olympia、Washington、アメリカ、98506-5166
- Providence - Saint Peter Hospital
-
Olympia、Washington、アメリカ、98507
- Capital Medical Center
-
Port Townsend、Washington、アメリカ、98368
- Jefferson Healthcare
-
Poulsbo、Washington、アメリカ、98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo、Washington、アメリカ、98370
- Peninsula Cancer Center
-
Puyallup、Washington、アメリカ、98372
- MultiCare Good Samaritan Hospital
-
Puyallup、Washington、アメリカ、98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle、Washington、アメリカ、98101
- Virginia Mason Medical Center
-
Silverdale、Washington、アメリカ、98383
- Saint Michael Cancer Center
-
Tacoma、Washington、アメリカ、98405
- Northwest Medical Specialties PLLC
-
Tacoma、Washington、アメリカ、98405
- MultiCare Tacoma General Hospital
-
Tacoma、Washington、アメリカ、98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma、Washington、アメリカ、97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma、Washington、アメリカ、98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma、Washington、アメリカ、98405
- MultiCare Allenmore Hospital
-
Tacoma、Washington、アメリカ、98405
- Northwest NCI Community Oncology Research Program
-
Tacoma、Washington、アメリカ、98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport、West Virginia、アメリカ、26330
- United Hospital Center
-
Charleston、West Virginia、アメリカ、25304
- West Virginia University Charleston Division
-
Huntington、West Virginia、アメリカ、25701
- Edwards Comprehensive Cancer Center
-
Martinsburg、West Virginia、アメリカ、25401
- WVUH-Berkely Medical Center
-
Morgantown、West Virginia、アメリカ、26506
- West Virginia University Healthcare
-
Morgantown、West Virginia、アメリカ、26505
- Monongalia Hospital
-
Parkersburg、West Virginia、アメリカ、26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington、Wisconsin、アメリカ、53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls、Wisconsin、アメリカ、54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire、Wisconsin、アメリカ、54701
- HSHS Sacred Heart Hospital
-
Eau Claire、Wisconsin、アメリカ、54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac、Wisconsin、アメリカ、54937
- Aurora Health Center-Fond du Lac
-
Germantown、Wisconsin、アメリカ、53022
- Aurora Health Care Germantown Health Center
-
Grafton、Wisconsin、アメリカ、53024
- Aurora Cancer Care-Grafton
-
Green Bay、Wisconsin、アメリカ、54311
- Aurora BayCare Medical Center
-
Green Bay、Wisconsin、アメリカ、54301
- Bellin Memorial Hospital
-
Janesville、Wisconsin、アメリカ、53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha、Wisconsin、アメリカ、53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith、Wisconsin、アメリカ、54848
- Marshfield Medical Center - Ladysmith
-
Marinette、Wisconsin、アメリカ、54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield、Wisconsin、アメリカ、54449
- Marshfield Medical Center-Marshfield
-
Marshfield、Wisconsin、アメリカ、54449
- Marshfield Medical Center
-
Milwaukee、Wisconsin、アメリカ、53226
- Medical College of Wisconsin
-
Milwaukee、Wisconsin、アメリカ、53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee、Wisconsin、アメリカ、53215
- Aurora Saint Luke's Medical Center
-
Milwaukee、Wisconsin、アメリカ、53233
- Aurora Sinai Medical Center
-
Minocqua、Wisconsin、アメリカ、54548
- Marshfield Medical Center - Minocqua
-
New Richmond、Wisconsin、アメリカ、54017
- Cancer Center of Western Wisconsin
-
Oshkosh、Wisconsin、アメリカ、54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine、Wisconsin、アメリカ、53406
- Aurora Cancer Care-Racine
-
Rhinelander、Wisconsin、アメリカ、54501
- Saint Mary's Hospital
-
Rhinelander、Wisconsin、アメリカ、54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake、Wisconsin、アメリカ、54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan、Wisconsin、アメリカ、53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point、Wisconsin、アメリカ、54481
- Aspirus Cancer Care - Stevens Point
-
Summit、Wisconsin、アメリカ、53066
- Aurora Medical Center in Summit
-
Two Rivers、Wisconsin、アメリカ、54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha、Wisconsin、アメリカ、53188
- Aurora Cancer Care-Waukesha
-
Wausau、Wisconsin、アメリカ、54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa、Wisconsin、アメリカ、53226
- Aurora Cancer Care-Milwaukee West
-
West Allis、Wisconsin、アメリカ、53227
- Aurora West Allis Medical Center
-
Weston、Wisconsin、アメリカ、54476
- Marshfield Medical Center - Weston
-
Weston、Wisconsin、アメリカ、54476
- Diagnostic and Treatment Center
-
Weston、Wisconsin、アメリカ、54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids、Wisconsin、アメリカ、54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper、Wyoming、アメリカ、82609
- Rocky Mountain Oncology
-
Cheyenne、Wyoming、アメリカ、82001
- Cheyenne Regional Medical Center-West
-
Cody、Wyoming、アメリカ、82414
- Big Horn Basin Cancer Center
-
Cody、Wyoming、アメリカ、82414
- Billings Clinic-Cody
-
Sheridan、Wyoming、アメリカ、82801
- Welch Cancer Center
-
-
-
-
-
San Juan、プエルトリコ、00936
- San Juan City Hospital
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
アクティブコンパレータ：Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
他の名前：
Given IV
他の名前：
Correlative studies Ancillary studies
他の名前：
Given IV
他の名前：
Undergo 2 core biopsies
他の名前：
Given IV
他の名前：
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
実験的：Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
他の名前：
Given IV
他の名前：
Correlative studies Ancillary studies
他の名前：
Given IV
他の名前：
Undergo 2 core biopsies
他の名前：
Given IV
他の名前：
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
他の名前：
Given SC
他の名前：
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
時間枠：Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
時間枠：Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
時間枠：Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
時間枠：Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
時間枠：Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
時間枠：Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
時間枠：Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
時間枠：Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
時間枠：Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
時間枠：2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
時間枠：The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (推定)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
- 部位別新生物
- 新生物
- 皮膚疾患
- 乳房の病気
- 皮膚および結合組織疾患
- 乳房腫瘍
- 薬物の生理学的影響
- 薬理作用の分子機構
- ホルモン
- ホルモン、ホルモン代替品、ホルモン拮抗薬
- 酵素阻害剤
- ステロイド合成阻害剤
- ホルモン拮抗薬
- エストロゲン拮抗薬
- 下垂体ホルモン放出ホルモン
- 視床下部ホルモン
- ペプチドホルモン
- 神経ペプチド
- ペプチド
- アミノ酸、ペプチド、およびタンパク質
- オリゴペプチド
- 神経組織タンパク質
- タンパク質
- 有機化学物質
- 薬理学的行動
- 化学作用と用途
- 炭化水素
- シクロパラフィン
- 炭化水素、環状
- 炭化水素、周期的
- テルペン
- 抗体、モノクローナル、ヒト化
- 抗体、モノクローナル
- 抗体
- 免疫グロブリン
- 免疫タンパク質
- 血液タンパク質
- 血清グロブリン
- グロブリン
- 調整錯体
- タキソイド
- シクロデカン
- Diterpenes
- ゴナドトロピン放出ホルモン
- ドセタキセル
- トラスツズマブ
- カルボプラチン
- ゴセレリン
- アロマターゼ阻害剤
- ペルズマブ
- 2C4抗体
- CT-P6
- PF-05280014
- トラスツズマブバイオシミラーHLX02
- オギブリ
- Ontruzant
その他の研究ID番号
- NCI-2013-02228
- U10CA180868 (米国 NIH グラント/契約)
- U10CA012027 (米国 NIH グラント/契約)
- NCI-2013-02228 (レジストリ識別子：CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (その他の識別子：CTEP)
- NSABP-B-52 (その他の識別子：NRG Oncology)
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。