Docétaxel, carboplatine, trastuzumab et pertuzumab avec ou sans privation d'œstrogènes dans le traitement des patientes atteintes d'un cancer du sein à récepteurs hormonaux positifs, opérable HER2 positif ou localement avancé
Un essai randomisé de phase III évaluant les taux de réponse pathologique complète chez des patientes atteintes d'un cancer du sein à récepteurs hormonaux positifs, HER2-positif, de grande taille et localement avancé traité par un traitement néoadjuvant par docétaxel, carboplatine, trastuzumab et pertuzumab (TCHP) avec ou sans privation d'œstrogène
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
Aperçu de l'étude
Statut
Les conditions
- Cancer du sein de stade IB AJCC v7
- Cancer du sein de stade IIA AJCC v6 et v7
- Cancer du sein de stade IIB AJCC v6 et v7
- Cancer du sein de stade IIIA AJCC v7
- Cancer du sein de stade IIIB AJCC v7
- Cancer du sein de stade IIIC AJCC v7
- Carcinome du sein HER2-positif
- Carcinome du sein à récepteurs hormonaux positifs
Intervention / Traitement
- Médicament: Carboplatin
- Biologique: Trastuzumab
- Autre: Laboratory Biomarker Analysis
- Autre: Quality-of-Life Assessment
- Médicament: Docetaxel
- Autre: Cytology Specimen Collection Procedure
- Biologique: Pertuzumab
- Procédure: Therapeutic Conventional Surgery
- Radiation: Whole Breast Irradiation
- Médicament: Aromatase Inhibition Therapy
- Médicament: Goserelin Acetate
Description détaillée
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
Type d'étude
Inscription (Réel)
Phase
- Phase 3
Contacts et emplacements
Lieux d'étude
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San Juan, Porto Rico, 00936
- San Juan City Hospital
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Alaska
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Fairbanks, Alaska, États-Unis, 99701
- Fairbanks Memorial Hospital
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Arkansas
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Hot Springs, Arkansas, États-Unis, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, États-Unis, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, États-Unis, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, États-Unis, 93420
- PCR Oncology
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Auburn, California, États-Unis, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, États-Unis, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, États-Unis, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, États-Unis, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, États-Unis, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, États-Unis, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, États-Unis, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, États-Unis, 94546
- Eden Hospital Medical Center
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Castro Valley, California, États-Unis, 94546
- East Bay Radiation Oncology Center
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Davis, California, États-Unis, 95616
- Sutter Davis Hospital
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Dublin, California, États-Unis, 94568
- Epic Care-Dublin
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Emeryville, California, États-Unis, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, États-Unis, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, États-Unis, 92335
- Kaiser Permanente-Fontana
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Fremont, California, États-Unis, 94538
- Kaiser Permanente-Fremont
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Fresno, California, États-Unis, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, États-Unis, 90710
- Kaiser Permanente South Bay
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Irvine, California, États-Unis, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, États-Unis, 92354
- Loma Linda University Medical Center
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Los Angeles, California, États-Unis, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, États-Unis, 90048
- Cedars Sinai Medical Center
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Los Angeles, California, États-Unis, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, États-Unis, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, États-Unis, 95355
- Memorial Medical Center
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Modesto, California, États-Unis, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, États-Unis, 94040
- El Camino Hospital
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, États-Unis, 94945
- Sutter Cancer Research Consortium
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Oakland, California, États-Unis, 94611
- Kaiser Permanente-Oakland
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Oakland, California, États-Unis, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, États-Unis, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, États-Unis, 94609
- Bay Area Tumor Institute
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Oakland, California, États-Unis, 94602
- Wilma Chan Highland Hospital
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Orange, California, États-Unis, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, États-Unis, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, États-Unis, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, États-Unis, 91402
- Kaiser Permanente - Panorama City
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Pleasanton, California, États-Unis, 94588
- Valley Medical Oncology Consultants
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Redwood City, California, États-Unis, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, États-Unis, 94801
- Kaiser Permanente-Richmond
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Riverside, California, États-Unis, 92505
- Kaiser Permanente-Riverside
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Roseville, California, États-Unis, 95661
- Kaiser Permanente-Roseville
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Roseville, California, États-Unis, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, États-Unis, 95661
- Sutter Roseville Medical Center
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Sacramento, California, États-Unis, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, États-Unis, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, États-Unis, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, États-Unis, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, États-Unis, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, États-Unis, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, États-Unis, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, États-Unis, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, États-Unis, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, États-Unis, 92078
- Kaiser Permanente-San Marcos
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San Pablo, California, États-Unis, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, États-Unis, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, États-Unis, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, États-Unis, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, États-Unis, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, États-Unis, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, États-Unis, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, États-Unis, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, États-Unis, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, États-Unis, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, États-Unis, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, États-Unis, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, États-Unis, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, États-Unis, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, États-Unis, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, États-Unis, 80012
- The Medical Center of Aurora
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Aurora, Colorado, États-Unis, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, États-Unis, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, États-Unis, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, États-Unis, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, États-Unis, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, États-Unis, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, États-Unis, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, États-Unis, 80220
- Rose Medical Center
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Denver, Colorado, États-Unis, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, États-Unis, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, États-Unis, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, États-Unis, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, États-Unis, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, États-Unis, 80210
- AdventHealth Porter
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Durango, Colorado, États-Unis, 81301
- Mercy Medical Center
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Durango, Colorado, États-Unis, 81301
- Southwest Oncology PC
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Englewood, Colorado, États-Unis, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, États-Unis, 80113
- Swedish Medical Center
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Fort Collins, Colorado, États-Unis, 80524
- Poudre Valley Hospital
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Golden, Colorado, États-Unis, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, États-Unis, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, États-Unis, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, États-Unis, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, États-Unis, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, États-Unis, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, États-Unis, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, États-Unis, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, États-Unis, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, États-Unis, 80501
- Longmont United Hospital
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Longmont, Colorado, États-Unis, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, États-Unis, 80539
- Banner McKee Medical Center
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Parker, Colorado, États-Unis, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, États-Unis, 80138
- AdventHealth Parker
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Pueblo, Colorado, États-Unis, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, États-Unis, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, États-Unis, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, États-Unis, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, États-Unis, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, États-Unis, 06102
- Hartford Hospital
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Delaware
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Lewes, Delaware, États-Unis, 19958
- Beebe Medical Center
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Newark, Delaware, États-Unis, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, États-Unis, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, États-Unis, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, États-Unis, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, États-Unis, 19971
- Beebe Health Campus
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Seaford, Delaware, États-Unis, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, États-Unis, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, États-Unis, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, États-Unis, 20007
- MedStar Georgetown University Hospital
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Florida
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Deerfield Beach, Florida, États-Unis, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Gainesville, Florida, États-Unis, 32610
- University of Florida Health Science Center - Gainesville
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Miami, Florida, États-Unis, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Orlando, Florida, États-Unis, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, États-Unis, 32803
- AdventHealth Orlando
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Georgia
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Athens, Georgia, États-Unis, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, États-Unis, 30342
- Northside Hospital
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Augusta, Georgia, États-Unis, 30912
- Augusta University Medical Center
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Cumming, Georgia, États-Unis, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, États-Unis, 30033
- Emory Decatur Hospital
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Gainesville, Georgia, États-Unis, 30501
- Northeast Georgia Medical Center-Gainesville
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Savannah, Georgia, États-Unis, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, États-Unis, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, États-Unis, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, États-Unis, 31404
- Low Country Cancer Care
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Hawaii
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Honolulu, Hawaii, États-Unis, 96813
- Queen's Medical Center
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Honolulu, Hawaii, États-Unis, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, États-Unis, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, États-Unis, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, États-Unis, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, États-Unis, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, États-Unis, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, États-Unis, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, États-Unis, 96819
- Kaiser Permanente Moanalua Medical Center
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Kailua, Hawaii, États-Unis, 96734
- Castle Medical Center
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Lihue, Hawaii, États-Unis, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, États-Unis, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, États-Unis, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, États-Unis, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, États-Unis, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Coeur d'Alene, Idaho, États-Unis, 83814
- Kootenai Health - Coeur d'Alene
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Lewiston, Idaho, États-Unis, 83501
- Saint Joseph Regional Medical Center
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Post Falls, Idaho, États-Unis, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, États-Unis, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, États-Unis, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, États-Unis, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, États-Unis, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, États-Unis, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, États-Unis, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, États-Unis, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, États-Unis, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, États-Unis, 60612
- University of Illinois
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Chicago, Illinois, États-Unis, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, États-Unis, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, États-Unis, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, États-Unis, 60631
- Presence Resurrection Medical Center
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Danville, Illinois, États-Unis, 61832
- Carle at The Riverfront
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Decatur, Illinois, États-Unis, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, États-Unis, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, États-Unis, 62401
- Crossroads Cancer Center
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Effingham, Illinois, États-Unis, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, États-Unis, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, États-Unis, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, États-Unis, 60202
- Saint Francis Hospital
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Galesburg, Illinois, États-Unis, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, États-Unis, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, États-Unis, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, États-Unis, 60426
- Ingalls Memorial Hospital
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Kankakee, Illinois, États-Unis, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, États-Unis, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, États-Unis, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, États-Unis, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, États-Unis, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, États-Unis, 60540
- Edward Hospital/Cancer Center
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O'Fallon, Illinois, États-Unis, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, États-Unis, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, États-Unis, 61350
- Radiation Oncology of Northern Illinois
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Pekin, Illinois, États-Unis, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, États-Unis, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, États-Unis, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, États-Unis, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, États-Unis, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, États-Unis, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, États-Unis, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, États-Unis, 61354
- Valley Radiation Oncology
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Plainfield, Illinois, États-Unis, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, États-Unis, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, États-Unis, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, États-Unis, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, États-Unis, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, États-Unis, 62702
- Springfield Clinic
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Springfield, Illinois, États-Unis, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, États-Unis, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, États-Unis, 61801
- Carle Cancer Center
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Urbana, Illinois, États-Unis, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, États-Unis, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, États-Unis, 60560
- Rush-Copley Healthcare Center
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Indiana
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Crown Point, Indiana, États-Unis, 46307
- Michiana Hematology Oncology PC-Crown Point
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Elkhart, Indiana, États-Unis, 46515
- Elkhart General Hospital
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Elkhart, Indiana, États-Unis, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, États-Unis, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, États-Unis, 46237
- Franciscan Health Indianapolis
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Kokomo, Indiana, États-Unis, 46904
- Community Howard Regional Health
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La Porte, Indiana, États-Unis, 46350
- IU Health La Porte Hospital
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Michigan City, Indiana, États-Unis, 46360
- Franciscan Saint Anthony Health-Michigan City
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Michigan City, Indiana, États-Unis, 46360
- Woodland Cancer Care Center
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Mishawaka, Indiana, États-Unis, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, États-Unis, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Munster, Indiana, États-Unis, 46321
- The Community Hospital
-
Plymouth, Indiana, États-Unis, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, États-Unis, 47374
- Reid Health
-
South Bend, Indiana, États-Unis, 46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute, Indiana, États-Unis, 47804
- Union Hospital
-
Westville, Indiana, États-Unis, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, États-Unis, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, États-Unis, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, États-Unis, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, États-Unis, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, États-Unis, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, États-Unis, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, États-Unis, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, États-Unis, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, États-Unis, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, États-Unis, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, États-Unis, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, États-Unis, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, États-Unis, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, États-Unis, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, États-Unis, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, États-Unis, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, États-Unis, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, États-Unis, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, États-Unis, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, États-Unis, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, États-Unis, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, États-Unis, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, États-Unis, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, États-Unis, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, États-Unis, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, États-Unis, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, États-Unis, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, États-Unis, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, États-Unis, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, États-Unis, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, États-Unis, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, États-Unis, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, États-Unis, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, États-Unis, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, États-Unis, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, États-Unis, 67208
- Associates In Womens Health
-
Wichita, Kansas, États-Unis, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, États-Unis, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, États-Unis, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, États-Unis, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, États-Unis, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, États-Unis, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, États-Unis, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, États-Unis, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, États-Unis, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, États-Unis, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, États-Unis, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, États-Unis, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, États-Unis, 40202
- Jewish Hospital
-
Louisville, Kentucky, États-Unis, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, États-Unis, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, États-Unis, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, États-Unis, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, États-Unis, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, États-Unis, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, États-Unis, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, États-Unis, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, États-Unis, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, États-Unis, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, États-Unis, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, États-Unis, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, États-Unis, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, États-Unis, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River, Massachusetts, États-Unis, 02721
- Saint Anne's Hospital
-
Pittsfield, Massachusetts, États-Unis, 01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian, Michigan, États-Unis, 49221
- Bixby Medical Center
-
Adrian, Michigan, États-Unis, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, États-Unis, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, États-Unis, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor, Michigan, États-Unis, 48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn, Michigan, États-Unis, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, États-Unis, 48202
- Henry Ford Hospital
-
Detroit, Michigan, États-Unis, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, États-Unis, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, États-Unis, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, États-Unis, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
-
Flint, Michigan, États-Unis, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe, Michigan, États-Unis, 48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson, Michigan, États-Unis, 49201
- Allegiance Health
-
Kalamazoo, Michigan, États-Unis, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, États-Unis, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, États-Unis, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, États-Unis, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, États-Unis, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, États-Unis, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac, Michigan, États-Unis, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, États-Unis, 48060
- Lake Huron Medical Center
-
Roseville, Michigan, États-Unis, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, États-Unis, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, États-Unis, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, États-Unis, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, États-Unis, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, États-Unis, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, États-Unis, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, États-Unis, 48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights, Michigan, États-Unis, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, États-Unis, 48314
- Mitchell Folbe MD PC
-
Troy, Michigan, États-Unis, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, États-Unis, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, États-Unis, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, États-Unis, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, États-Unis, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, États-Unis, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, États-Unis, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, États-Unis, 55433
- Mercy Hospital
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, États-Unis, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, États-Unis, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, États-Unis, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, États-Unis, 55432
- Unity Hospital
-
Hutchinson, Minnesota, États-Unis, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, États-Unis, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, États-Unis, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, États-Unis, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, États-Unis, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, États-Unis, 55454
- Health Partners Inc
-
New Ulm, Minnesota, États-Unis, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, États-Unis, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, États-Unis, 55101
- Regions Hospital
-
Saint Paul, Minnesota, États-Unis, 55102
- United Hospital
-
Shakopee, Minnesota, États-Unis, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, États-Unis, 55082
- Lakeview Hospital
-
Waconia, Minnesota, États-Unis, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, États-Unis, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, États-Unis, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin, Missouri, États-Unis, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, États-Unis, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, États-Unis, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, États-Unis, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, États-Unis, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, États-Unis, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, États-Unis, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City, Missouri, États-Unis, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, États-Unis, 64804
- Freeman Health System
-
Joplin, Missouri, États-Unis, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, États-Unis, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, États-Unis, 65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve, Missouri, États-Unis, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, États-Unis, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, États-Unis, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, États-Unis, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, États-Unis, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, États-Unis, 63141
- Mercy Hospital Saint Louis
-
Sullivan, Missouri, États-Unis, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, États-Unis, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, États-Unis, 59711
- Community Hospital of Anaconda
-
Billings, Montana, États-Unis, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, États-Unis, 59101
- Saint Vincent Healthcare
-
Billings, Montana, États-Unis, 59102
- Montana Cancer Consortium NCORP
-
Bozeman, Montana, États-Unis, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, États-Unis, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, États-Unis, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, États-Unis, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, États-Unis, 59901
- Logan Health Medical Center
-
Missoula, Montana, États-Unis, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, États-Unis, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, États-Unis, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, États-Unis, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, États-Unis, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, États-Unis, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, États-Unis, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, États-Unis, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, États-Unis, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, États-Unis, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, États-Unis, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, États-Unis, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, États-Unis, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, États-Unis, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, États-Unis, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, États-Unis, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, États-Unis, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, États-Unis, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, États-Unis, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, États-Unis, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, États-Unis, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, États-Unis, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, États-Unis, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, États-Unis, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, États-Unis, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, États-Unis, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, États-Unis, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, États-Unis, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, États-Unis, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, États-Unis, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, États-Unis, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, États-Unis, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, États-Unis, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, États-Unis, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, États-Unis, 89120
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, États-Unis, 89502
- Renown Regional Medical Center
-
Reno, Nevada, États-Unis, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, États-Unis, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth, New Jersey, États-Unis, 07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood, New Jersey, États-Unis, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, États-Unis, 08822
- Hunterdon Medical Center
-
Mullica Hill, New Jersey, États-Unis, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, États-Unis, 07112
- Newark Beth Israel Medical Center
-
Newton, New Jersey, États-Unis, 07860
- Newton Medical Center
-
Pompton, New Jersey, États-Unis, 07444
- Chilton Medical Center
-
Summit, New Jersey, États-Unis, 07902
- Overlook Hospital
-
Vineland, New Jersey, États-Unis, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, États-Unis, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, États-Unis, 87106
- Hematology Oncology Associates
-
Las Cruces, New Mexico, États-Unis, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, États-Unis, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, États-Unis, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, États-Unis, 12801
- Glens Falls Hospital
-
Middletown, New York, États-Unis, 10940
- Garnet Health Medical Center
-
New York, New York, États-Unis, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, États-Unis, 27203
- Randolph Hospital
-
Asheville, North Carolina, États-Unis, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, États-Unis, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, États-Unis, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, États-Unis, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, États-Unis, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, États-Unis, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, États-Unis, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, États-Unis, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, États-Unis, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville, North Carolina, États-Unis, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, États-Unis, 28501
- ECU Health Oncology Kinston
-
Mebane, North Carolina, États-Unis, 27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy, North Carolina, États-Unis, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, États-Unis, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, États-Unis, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, États-Unis, 27320
- Annie Penn Memorial Hospital
-
Salisbury, North Carolina, États-Unis, 28144
- Novant Health Cancer Institute - Rowan
-
Statesville, North Carolina, États-Unis, 28677
- Iredell Memorial Hospital
-
Stateville, North Carolina, États-Unis, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, États-Unis, 27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem, North Carolina, États-Unis, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, États-Unis, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, États-Unis, 27103
- Novant Health Oncology Specialists
-
Winston-Salem, North Carolina, États-Unis, 27103
- Winston-Salem Health Care
-
Winston-Salem, North Carolina, États-Unis, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, États-Unis, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, États-Unis, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, États-Unis, 58201
- Altru Cancer Center
-
Minot, North Dakota, États-Unis, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, États-Unis, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, États-Unis, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, États-Unis, 44203
- Summa Health System - Barberton Campus
-
Belpre, Ohio, États-Unis, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, États-Unis, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, États-Unis, 44710
- Aultman Health Foundation
-
Centerville, Ohio, États-Unis, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, États-Unis, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, États-Unis, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, États-Unis, 45219
- The Christ Hospital
-
Cincinnati, Ohio, États-Unis, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, États-Unis, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, États-Unis, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, États-Unis, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, États-Unis, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, États-Unis, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, États-Unis, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, États-Unis, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, États-Unis, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, États-Unis, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, États-Unis, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, États-Unis, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, États-Unis, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, États-Unis, 43228
- Doctors Hospital
-
Columbus, Ohio, États-Unis, 43215
- Grant Medical Center
-
Columbus, Ohio, États-Unis, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, États-Unis, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, États-Unis, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, États-Unis, 45409
- Miami Valley Hospital
-
Dayton, Ohio, États-Unis, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, États-Unis, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, États-Unis, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, États-Unis, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, États-Unis, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, États-Unis, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, États-Unis, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, États-Unis, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, États-Unis, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, États-Unis, 45840
- Orion Cancer Care
-
Franklin, Ohio, États-Unis, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, États-Unis, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, États-Unis, 45331
- Wayne Hospital
-
Greenville, Ohio, États-Unis, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, États-Unis, 45429
- Kettering Medical Center
-
Kettering, Ohio, États-Unis, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, États-Unis, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, États-Unis, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, États-Unis, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, États-Unis, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, États-Unis, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, États-Unis, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina, Ohio, États-Unis, 44256
- Summa Health Medina Medical Center
-
Middletown, Ohio, États-Unis, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, États-Unis, 43050
- Knox Community Hospital
-
Newark, Ohio, États-Unis, 43055
- Licking Memorial Hospital
-
Newark, Ohio, États-Unis, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, États-Unis, 43616
- Saint Charles Hospital
-
Oregon, Ohio, États-Unis, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, États-Unis, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, États-Unis, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, États-Unis, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, États-Unis, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, États-Unis, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, États-Unis, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, États-Unis, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, États-Unis, 43614
- University of Toledo
-
Toledo, Ohio, États-Unis, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, États-Unis, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, États-Unis, 45373
- Upper Valley Medical Center
-
Troy, Ohio, États-Unis, 45373
- Dayton Physicians LLC - Troy
-
Wauseon, Ohio, États-Unis, 43567
- Fulton County Health Center
-
West Chester, Ohio, États-Unis, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, États-Unis, 43081
- Saint Ann's Hospital
-
Wpafb, Ohio, États-Unis, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, États-Unis, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, États-Unis, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, États-Unis, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, États-Unis, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, États-Unis, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, États-Unis, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland, Oregon, États-Unis, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver, Pennsylvania, États-Unis, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, États-Unis, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, États-Unis, 17822
- Geisinger Medical Center
-
Easton, Pennsylvania, États-Unis, 18042
- Easton Hospital
-
Greensburg, Pennsylvania, États-Unis, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, États-Unis, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, États-Unis, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, États-Unis, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills, Pennsylvania, États-Unis, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, États-Unis, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, États-Unis, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, États-Unis, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, États-Unis, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville, Pennsylvania, États-Unis, 15146
- Forbes Hospital
-
Moon Township, Pennsylvania, États-Unis, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, États-Unis, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19114
- Jefferson Torresdale Hospital
-
Phoenixville, Pennsylvania, États-Unis, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, États-Unis, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, États-Unis, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, États-Unis, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, États-Unis, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, États-Unis, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, États-Unis, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, États-Unis, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, États-Unis, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, États-Unis, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, États-Unis, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, États-Unis, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, États-Unis, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, États-Unis, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, États-Unis, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, États-Unis, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence, Rhode Island, États-Unis, 02905
- Women and Infants Hospital
-
Warwick, Rhode Island, États-Unis, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, États-Unis, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, États-Unis, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, États-Unis, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, États-Unis, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, États-Unis, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, États-Unis, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, États-Unis, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, États-Unis, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, États-Unis, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, États-Unis, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, États-Unis, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, États-Unis, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, États-Unis, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, États-Unis, 29303
- Spartanburg Medical Center
-
Union, South Carolina, États-Unis, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, États-Unis, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, États-Unis, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, États-Unis, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, États-Unis, 37404
- Memorial Hospital
-
Hixson, Tennessee, États-Unis, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, États-Unis, 38301
- Jackson-Madison County General Hospital
-
Nashville, Tennessee, États-Unis, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, États-Unis, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, États-Unis, 79601
- Hendrick Medical Center
-
Houston, Texas, États-Unis, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, États-Unis, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, États-Unis, 77030
- Ben Taub General Hospital
-
Laredo, Texas, États-Unis, 78041
- Doctor's Hospital of Laredo
-
San Antonio, Texas, États-Unis, 78229
- University Hospital
-
San Antonio, Texas, États-Unis, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, États-Unis, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, États-Unis, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners, Vermont, États-Unis, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, États-Unis, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, États-Unis, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg, Virginia, États-Unis, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, États-Unis, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville, Virginia, États-Unis, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, États-Unis, 23114
- Bon Secours Saint Francis Medical Center
-
Richmond, Virginia, États-Unis, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, États-Unis, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, États-Unis, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, États-Unis, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn, Washington, États-Unis, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, États-Unis, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, États-Unis, 98004
- Overlake Medical Center
-
Burien, Washington, États-Unis, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, États-Unis, 98531
- Providence Regional Cancer System-Centralia
-
Enumclaw, Washington, États-Unis, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, États-Unis, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, États-Unis, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, États-Unis, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, États-Unis, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, États-Unis, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, États-Unis, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, États-Unis, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, États-Unis, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, États-Unis, 98036
- Virginia Mason Lynnwood Medical Center
-
Olympia, Washington, États-Unis, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, États-Unis, 98507
- Capital Medical Center
-
Port Townsend, Washington, États-Unis, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, États-Unis, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, États-Unis, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, États-Unis, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, États-Unis, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, États-Unis, 98101
- Virginia Mason Medical Center
-
Silverdale, Washington, États-Unis, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, États-Unis, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, États-Unis, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, États-Unis, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, États-Unis, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, États-Unis, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, États-Unis, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, États-Unis, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, États-Unis, 98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport, West Virginia, États-Unis, 26330
- United Hospital Center
-
Charleston, West Virginia, États-Unis, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, États-Unis, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, États-Unis, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, États-Unis, 26506
- West Virginia University Healthcare
-
Morgantown, West Virginia, États-Unis, 26505
- Monongalia Hospital
-
Parkersburg, West Virginia, États-Unis, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington, Wisconsin, États-Unis, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, États-Unis, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, États-Unis, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, États-Unis, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, États-Unis, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, États-Unis, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, États-Unis, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, États-Unis, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, États-Unis, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, États-Unis, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha, Wisconsin, États-Unis, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, États-Unis, 54848
- Marshfield Medical Center - Ladysmith
-
Marinette, Wisconsin, États-Unis, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, États-Unis, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, États-Unis, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, États-Unis, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, États-Unis, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, États-Unis, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, États-Unis, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, États-Unis, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, États-Unis, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, États-Unis, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, États-Unis, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, États-Unis, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, États-Unis, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, États-Unis, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, États-Unis, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, États-Unis, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, États-Unis, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, États-Unis, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, États-Unis, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, États-Unis, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, États-Unis, 54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, États-Unis, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, États-Unis, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, États-Unis, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, États-Unis, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, États-Unis, 82801
- Welch Cancer Center
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Comparateur actif: Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Autres noms:
Given IV
Autres noms:
Correlative studies Ancillary studies
Autres noms:
Given IV
Autres noms:
Undergo 2 core biopsies
Autres noms:
Given IV
Autres noms:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
Expérimental: Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Autres noms:
Given IV
Autres noms:
Correlative studies Ancillary studies
Autres noms:
Given IV
Autres noms:
Undergo 2 core biopsies
Autres noms:
Given IV
Autres noms:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
Autres noms:
Given SC
Autres noms:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Délai: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Délai: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
Délai: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
Délai: Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
Délai: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Délai: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Délai: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
Délai: Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Délai: Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Délai: 2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Délai: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
Collaborateurs et enquêteurs
Parrainer
Collaborateurs
Les enquêteurs
- Chercheur principal: Mothaffar F Rimawi, NRG Oncology
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimé)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
- Tumeurs par site
- Tumeurs
- Maladies de la peau
- Maladies du sein
- Maladies de la peau et du tissu conjonctif
- Tumeurs mammaires
- Effets physiologiques des drogues
- Mécanismes moléculaires d'action pharmacologique
- Hormones
- Hormones, substituts hormonaux et antagonistes hormonaux
- Inhibiteurs d'enzymes
- Inhibiteurs de la synthèse des stéroïdes
- Antagonistes hormonaux
- Antagonistes des œstrogènes
- Hormones de libération d'hormones hypophysaires
- Hormones hypothalamiques
- Hormones peptidiques
- Neuropeptides
- Peptides
- Acides aminés, peptides et protéines
- Oligopeptides
- Protéines de tissu nerveux
- Protéines
- Produits chimiques organiques
- Actions pharmacologiques
- Actions et utilisations chimiques
- Hydrocarbures
- Cycloparaffines
- Hydrocarbures, alicyclique
- Hydrocarbures, cyclique
- Terpènes
- Anticorps, monoclonal, humanisé
- Anticorps, monoclonal
- Anticorps
- Immunoglobulines
- Immunoprotéines
- Protéines sanguines
- Globulines sériques
- Globulines
- Complexes de coordination
- Taxes
- Cyclodécanes
- Diterpènes
- Hormone de libération de la gonadotrophine
- Docétaxel
- Trastuzumab
- Carboplatine
- Goséréline
- Inhibiteurs de l'aromatase
- pertuzumab
- Anticorps 2c4
- CT-P6
- PF-05280014
- trastuzumab biosimilaire hlx02
- Ogivri
- Ontruzant
Autres numéros d'identification d'étude
- NCI-2013-02228
- U10CA180868 (Subvention/contrat des NIH des États-Unis)
- U10CA012027 (Subvention/contrat des NIH des États-Unis)
- NCI-2013-02228 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (Autre identifiant: CTEP)
- NSABP-B-52 (Autre identifiant: NRG Oncology)
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