Docetaxel, Carboplatine, Trastuzumab en Pertuzumab met of zonder oestrogeendeprivatie bij de behandeling van patiënten met hormoonreceptorpositieve, HER2-positieve operabele of lokaal gevorderde borstkanker
15 september 2026 bijgewerkt door: National Cancer Institute (NCI)
Een gerandomiseerde fase III-studie ter evaluatie van pathologische complete responspercentages bij patiënten met hormoonreceptor-positieve, HER2-positieve, grote operabele en lokaal gevorderde borstkanker behandeld met neoadjuvante therapie van docetaxel, carboplatine, trastuzumab en pertuzumab (TCHP) met of zonder oestrogeendeprivatie
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
Studie Overzicht
Toestand
Voltooid
Conditie
Interventie / Behandeling
- Geneesmiddel: Carboplatin
- Biologisch: Trastuzumab
- Ander: Laboratory Biomarker Analysis
- Ander: Quality-of-Life Assessment
- Geneesmiddel: Docetaxel
- Ander: Cytology Specimen Collection Procedure
- Biologisch: Pertuzumab
- Procedure: Therapeutic Conventional Surgery
- Straling: Whole Breast Irradiation
- Geneesmiddel: Aromatase Inhibition Therapy
- Geneesmiddel: Goserelin Acetate
Gedetailleerde beschrijving
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
Studietype
Ingrijpend
Inschrijving (Werkelijk)
315
Fase
- Fase 3
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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San Juan, Puerto Rico, 00936
- San Juan City Hospital
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Alaska
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Fairbanks, Alaska, Verenigde Staten, 99701
- Fairbanks Memorial Hospital
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Arkansas
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Hot Springs, Arkansas, Verenigde Staten, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Verenigde Staten, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Verenigde Staten, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Verenigde Staten, 93420
- PCR Oncology
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Auburn, California, Verenigde Staten, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Verenigde Staten, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Verenigde Staten, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Verenigde Staten, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Verenigde Staten, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Verenigde Staten, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Verenigde Staten, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Verenigde Staten, 94546
- Eden Hospital Medical Center
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Castro Valley, California, Verenigde Staten, 94546
- East Bay Radiation Oncology Center
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Davis, California, Verenigde Staten, 95616
- Sutter Davis Hospital
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Dublin, California, Verenigde Staten, 94568
- Epic Care-Dublin
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Emeryville, California, Verenigde Staten, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Verenigde Staten, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, Verenigde Staten, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Verenigde Staten, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Verenigde Staten, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Verenigde Staten, 90710
- Kaiser Permanente South Bay
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Irvine, California, Verenigde Staten, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, Verenigde Staten, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Verenigde Staten, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Verenigde Staten, 90048
- Cedars Sinai Medical Center
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Los Angeles, California, Verenigde Staten, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, Verenigde Staten, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Verenigde Staten, 95355
- Memorial Medical Center
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Modesto, California, Verenigde Staten, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Verenigde Staten, 94040
- El Camino Hospital
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Mountain View, California, Verenigde Staten, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Verenigde Staten, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Verenigde Staten, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Verenigde Staten, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Verenigde Staten, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Verenigde Staten, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Verenigde Staten, 94609
- Bay Area Tumor Institute
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Oakland, California, Verenigde Staten, 94602
- Wilma Chan Highland Hospital
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Orange, California, Verenigde Staten, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Verenigde Staten, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Verenigde Staten, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Verenigde Staten, 91402
- Kaiser Permanente - Panorama City
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Pleasanton, California, Verenigde Staten, 94588
- Valley Medical Oncology Consultants
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Redwood City, California, Verenigde Staten, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Verenigde Staten, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Verenigde Staten, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Verenigde Staten, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Verenigde Staten, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Verenigde Staten, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Verenigde Staten, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Verenigde Staten, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Verenigde Staten, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Verenigde Staten, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Verenigde Staten, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, Verenigde Staten, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Verenigde Staten, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Verenigde Staten, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Verenigde Staten, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Verenigde Staten, 92078
- Kaiser Permanente-San Marcos
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San Pablo, California, Verenigde Staten, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Verenigde Staten, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Verenigde Staten, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Verenigde Staten, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, Verenigde Staten, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Verenigde Staten, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Verenigde Staten, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Verenigde Staten, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Verenigde Staten, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Verenigde Staten, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Verenigde Staten, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Verenigde Staten, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Verenigde Staten, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Verenigde Staten, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Verenigde Staten, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Verenigde Staten, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Verenigde Staten, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Verenigde Staten, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Verenigde Staten, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Verenigde Staten, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Verenigde Staten, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Verenigde Staten, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Verenigde Staten, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Verenigde Staten, 80220
- Rose Medical Center
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Denver, Colorado, Verenigde Staten, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Verenigde Staten, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Verenigde Staten, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Verenigde Staten, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, Verenigde Staten, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Verenigde Staten, 80210
- AdventHealth Porter
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Durango, Colorado, Verenigde Staten, 81301
- Mercy Medical Center
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Durango, Colorado, Verenigde Staten, 81301
- Southwest Oncology PC
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Englewood, Colorado, Verenigde Staten, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Verenigde Staten, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Verenigde Staten, 80524
- Poudre Valley Hospital
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Golden, Colorado, Verenigde Staten, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, Verenigde Staten, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, Verenigde Staten, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, Verenigde Staten, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Verenigde Staten, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Verenigde Staten, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Verenigde Staten, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Verenigde Staten, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Verenigde Staten, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Verenigde Staten, 80501
- Longmont United Hospital
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Longmont, Colorado, Verenigde Staten, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Verenigde Staten, 80539
- Banner McKee Medical Center
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Parker, Colorado, Verenigde Staten, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Verenigde Staten, 80138
- AdventHealth Parker
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Pueblo, Colorado, Verenigde Staten, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Verenigde Staten, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Verenigde Staten, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, Verenigde Staten, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, Verenigde Staten, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Verenigde Staten, 06102
- Hartford Hospital
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Delaware
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Lewes, Delaware, Verenigde Staten, 19958
- Beebe Medical Center
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Newark, Delaware, Verenigde Staten, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Verenigde Staten, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Verenigde Staten, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Verenigde Staten, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Verenigde Staten, 19971
- Beebe Health Campus
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Seaford, Delaware, Verenigde Staten, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Verenigde Staten, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Verenigde Staten, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Verenigde Staten, 20007
- MedStar Georgetown University Hospital
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Florida
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Deerfield Beach, Florida, Verenigde Staten, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Gainesville, Florida, Verenigde Staten, 32610
- University of Florida Health Science Center - Gainesville
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Miami, Florida, Verenigde Staten, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Orlando, Florida, Verenigde Staten, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, Verenigde Staten, 32803
- AdventHealth Orlando
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Georgia
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Athens, Georgia, Verenigde Staten, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Verenigde Staten, 30342
- Northside Hospital
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Augusta, Georgia, Verenigde Staten, 30912
- Augusta University Medical Center
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Cumming, Georgia, Verenigde Staten, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, Verenigde Staten, 30033
- Emory Decatur Hospital
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Gainesville, Georgia, Verenigde Staten, 30501
- Northeast Georgia Medical Center-Gainesville
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Savannah, Georgia, Verenigde Staten, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Verenigde Staten, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, Verenigde Staten, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, Verenigde Staten, 31404
- Low Country Cancer Care
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Hawaii
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Honolulu, Hawaii, Verenigde Staten, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Verenigde Staten, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Verenigde Staten, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Verenigde Staten, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Verenigde Staten, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Verenigde Staten, 96819
- Kaiser Permanente Moanalua Medical Center
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Kailua, Hawaii, Verenigde Staten, 96734
- Castle Medical Center
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Lihue, Hawaii, Verenigde Staten, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Verenigde Staten, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Verenigde Staten, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Coeur d'Alene, Idaho, Verenigde Staten, 83814
- Kootenai Health - Coeur d'Alene
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Lewiston, Idaho, Verenigde Staten, 83501
- Saint Joseph Regional Medical Center
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Post Falls, Idaho, Verenigde Staten, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Verenigde Staten, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, Verenigde Staten, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Verenigde Staten, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Verenigde Staten, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Verenigde Staten, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Verenigde Staten, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, Verenigde Staten, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Verenigde Staten, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Verenigde Staten, 60612
- University of Illinois
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Chicago, Illinois, Verenigde Staten, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Verenigde Staten, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Verenigde Staten, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Verenigde Staten, 60631
- Presence Resurrection Medical Center
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Danville, Illinois, Verenigde Staten, 61832
- Carle at The Riverfront
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Decatur, Illinois, Verenigde Staten, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Verenigde Staten, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, Verenigde Staten, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Verenigde Staten, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, Verenigde Staten, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, Verenigde Staten, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Verenigde Staten, 60202
- Saint Francis Hospital
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Galesburg, Illinois, Verenigde Staten, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Verenigde Staten, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Verenigde Staten, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, Verenigde Staten, 60426
- Ingalls Memorial Hospital
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Kankakee, Illinois, Verenigde Staten, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Verenigde Staten, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Verenigde Staten, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Verenigde Staten, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, Verenigde Staten, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, Verenigde Staten, 60540
- Edward Hospital/Cancer Center
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O'Fallon, Illinois, Verenigde Staten, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Verenigde Staten, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Verenigde Staten, 61350
- Radiation Oncology of Northern Illinois
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Pekin, Illinois, Verenigde Staten, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Verenigde Staten, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Verenigde Staten, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Verenigde Staten, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Verenigde Staten, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Verenigde Staten, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Verenigde Staten, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Verenigde Staten, 61354
- Valley Radiation Oncology
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Plainfield, Illinois, Verenigde Staten, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Verenigde Staten, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, Verenigde Staten, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, Verenigde Staten, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, Verenigde Staten, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Verenigde Staten, 62702
- Springfield Clinic
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Springfield, Illinois, Verenigde Staten, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, Verenigde Staten, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Verenigde Staten, 61801
- Carle Cancer Center
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Urbana, Illinois, Verenigde Staten, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Verenigde Staten, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Verenigde Staten, 60560
- Rush-Copley Healthcare Center
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Indiana
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Crown Point, Indiana, Verenigde Staten, 46307
- Michiana Hematology Oncology PC-Crown Point
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Elkhart, Indiana, Verenigde Staten, 46515
- Elkhart General Hospital
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Elkhart, Indiana, Verenigde Staten, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, Verenigde Staten, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, Verenigde Staten, 46237
- Franciscan Health Indianapolis
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Kokomo, Indiana, Verenigde Staten, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Verenigde Staten, 46350
- IU Health La Porte Hospital
-
Michigan City, Indiana, Verenigde Staten, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Verenigde Staten, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Verenigde Staten, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Verenigde Staten, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Munster, Indiana, Verenigde Staten, 46321
- The Community Hospital
-
Plymouth, Indiana, Verenigde Staten, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Verenigde Staten, 47374
- Reid Health
-
South Bend, Indiana, Verenigde Staten, 46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute, Indiana, Verenigde Staten, 47804
- Union Hospital
-
Westville, Indiana, Verenigde Staten, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Verenigde Staten, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Verenigde Staten, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, Verenigde Staten, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Verenigde Staten, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Verenigde Staten, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Verenigde Staten, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Verenigde Staten, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Verenigde Staten, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Verenigde Staten, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Verenigde Staten, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Verenigde Staten, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Verenigde Staten, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Verenigde Staten, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Verenigde Staten, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Verenigde Staten, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Verenigde Staten, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Verenigde Staten, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Verenigde Staten, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Verenigde Staten, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Verenigde Staten, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Verenigde Staten, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Verenigde Staten, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Verenigde Staten, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Verenigde Staten, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Verenigde Staten, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Verenigde Staten, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Verenigde Staten, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, Verenigde Staten, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, Verenigde Staten, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Verenigde Staten, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Verenigde Staten, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Verenigde Staten, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Verenigde Staten, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Verenigde Staten, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Verenigde Staten, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Verenigde Staten, 67208
- Associates In Womens Health
-
Wichita, Kansas, Verenigde Staten, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, Verenigde Staten, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Verenigde Staten, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Verenigde Staten, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Verenigde Staten, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Verenigde Staten, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Verenigde Staten, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Verenigde Staten, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Verenigde Staten, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Verenigde Staten, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Verenigde Staten, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Verenigde Staten, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Verenigde Staten, 40202
- Jewish Hospital
-
Louisville, Kentucky, Verenigde Staten, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Verenigde Staten, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Verenigde Staten, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Verenigde Staten, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Verenigde Staten, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Verenigde Staten, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Verenigde Staten, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, Verenigde Staten, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Verenigde Staten, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, Verenigde Staten, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Verenigde Staten, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Verenigde Staten, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Verenigde Staten, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Verenigde Staten, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, Verenigde Staten, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River, Massachusetts, Verenigde Staten, 02721
- Saint Anne's Hospital
-
Pittsfield, Massachusetts, Verenigde Staten, 01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian, Michigan, Verenigde Staten, 49221
- Bixby Medical Center
-
Adrian, Michigan, Verenigde Staten, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Verenigde Staten, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, Verenigde Staten, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor, Michigan, Verenigde Staten, 48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn, Michigan, Verenigde Staten, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Verenigde Staten, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Verenigde Staten, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Verenigde Staten, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Verenigde Staten, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Verenigde Staten, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Verenigde Staten, 48503
- Hurley Medical Center
-
Flint, Michigan, Verenigde Staten, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe, Michigan, Verenigde Staten, 48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson, Michigan, Verenigde Staten, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Verenigde Staten, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Verenigde Staten, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Verenigde Staten, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, Verenigde Staten, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, Verenigde Staten, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Verenigde Staten, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac, Michigan, Verenigde Staten, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Verenigde Staten, 48060
- Lake Huron Medical Center
-
Roseville, Michigan, Verenigde Staten, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Verenigde Staten, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Verenigde Staten, 48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights, Michigan, Verenigde Staten, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Verenigde Staten, 48314
- Mitchell Folbe MD PC
-
Troy, Michigan, Verenigde Staten, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Verenigde Staten, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Verenigde Staten, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Verenigde Staten, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Verenigde Staten, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Verenigde Staten, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Verenigde Staten, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Verenigde Staten, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Verenigde Staten, 55433
- Mercy Hospital
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Verenigde Staten, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Verenigde Staten, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Verenigde Staten, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Verenigde Staten, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Verenigde Staten, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Verenigde Staten, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Verenigde Staten, 55454
- Health Partners Inc
-
New Ulm, Minnesota, Verenigde Staten, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Verenigde Staten, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Verenigde Staten, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Verenigde Staten, 55102
- United Hospital
-
Shakopee, Minnesota, Verenigde Staten, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Verenigde Staten, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Verenigde Staten, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Verenigde Staten, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Verenigde Staten, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin, Missouri, Verenigde Staten, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Verenigde Staten, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Verenigde Staten, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Verenigde Staten, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Verenigde Staten, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Verenigde Staten, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Verenigde Staten, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City, Missouri, Verenigde Staten, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Verenigde Staten, 64804
- Freeman Health System
-
Joplin, Missouri, Verenigde Staten, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Verenigde Staten, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Verenigde Staten, 65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve, Missouri, Verenigde Staten, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Verenigde Staten, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Verenigde Staten, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Verenigde Staten, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Verenigde Staten, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Verenigde Staten, 63141
- Mercy Hospital Saint Louis
-
Sullivan, Missouri, Verenigde Staten, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Verenigde Staten, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, Verenigde Staten, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Verenigde Staten, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Verenigde Staten, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Verenigde Staten, 59102
- Montana Cancer Consortium NCORP
-
Bozeman, Montana, Verenigde Staten, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Verenigde Staten, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Verenigde Staten, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Verenigde Staten, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Verenigde Staten, 59901
- Logan Health Medical Center
-
Missoula, Montana, Verenigde Staten, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Verenigde Staten, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Verenigde Staten, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Verenigde Staten, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Verenigde Staten, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Verenigde Staten, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Verenigde Staten, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Verenigde Staten, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, Verenigde Staten, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Verenigde Staten, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Verenigde Staten, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Verenigde Staten, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Verenigde Staten, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, Verenigde Staten, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Verenigde Staten, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Verenigde Staten, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Verenigde Staten, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Verenigde Staten, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Verenigde Staten, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Verenigde Staten, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Verenigde Staten, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Verenigde Staten, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Verenigde Staten, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Verenigde Staten, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Verenigde Staten, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Verenigde Staten, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Verenigde Staten, 89120
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, Verenigde Staten, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Verenigde Staten, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, Verenigde Staten, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth, New Jersey, Verenigde Staten, 07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood, New Jersey, Verenigde Staten, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Verenigde Staten, 08822
- Hunterdon Medical Center
-
Mullica Hill, New Jersey, Verenigde Staten, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, Verenigde Staten, 07112
- Newark Beth Israel Medical Center
-
Newton, New Jersey, Verenigde Staten, 07860
- Newton Medical Center
-
Pompton, New Jersey, Verenigde Staten, 07444
- Chilton Medical Center
-
Summit, New Jersey, Verenigde Staten, 07902
- Overlook Hospital
-
Vineland, New Jersey, Verenigde Staten, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, Verenigde Staten, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Verenigde Staten, 87106
- Hematology Oncology Associates
-
Las Cruces, New Mexico, Verenigde Staten, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Verenigde Staten, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, Verenigde Staten, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, Verenigde Staten, 12801
- Glens Falls Hospital
-
Middletown, New York, Verenigde Staten, 10940
- Garnet Health Medical Center
-
New York, New York, Verenigde Staten, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, Verenigde Staten, 27203
- Randolph Hospital
-
Asheville, North Carolina, Verenigde Staten, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Verenigde Staten, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Verenigde Staten, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Verenigde Staten, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Verenigde Staten, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Verenigde Staten, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Verenigde Staten, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Verenigde Staten, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Verenigde Staten, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville, North Carolina, Verenigde Staten, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Verenigde Staten, 28501
- ECU Health Oncology Kinston
-
Mebane, North Carolina, Verenigde Staten, 27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy, North Carolina, Verenigde Staten, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Verenigde Staten, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, Verenigde Staten, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, Verenigde Staten, 27320
- Annie Penn Memorial Hospital
-
Salisbury, North Carolina, Verenigde Staten, 28144
- Novant Health Cancer Institute - Rowan
-
Statesville, North Carolina, Verenigde Staten, 28677
- Iredell Memorial Hospital
-
Stateville, North Carolina, Verenigde Staten, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Verenigde Staten, 27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem, North Carolina, Verenigde Staten, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Verenigde Staten, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, Verenigde Staten, 27103
- Novant Health Oncology Specialists
-
Winston-Salem, North Carolina, Verenigde Staten, 27103
- Winston-Salem Health Care
-
Winston-Salem, North Carolina, Verenigde Staten, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Verenigde Staten, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Verenigde Staten, 58201
- Altru Cancer Center
-
Minot, North Dakota, Verenigde Staten, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Verenigde Staten, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Verenigde Staten, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Verenigde Staten, 44203
- Summa Health System - Barberton Campus
-
Belpre, Ohio, Verenigde Staten, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Verenigde Staten, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Verenigde Staten, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Verenigde Staten, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Verenigde Staten, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Verenigde Staten, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Verenigde Staten, 45219
- The Christ Hospital
-
Cincinnati, Ohio, Verenigde Staten, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Verenigde Staten, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Verenigde Staten, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Verenigde Staten, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Verenigde Staten, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Verenigde Staten, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Verenigde Staten, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Verenigde Staten, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Verenigde Staten, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Verenigde Staten, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Verenigde Staten, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Verenigde Staten, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Verenigde Staten, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Verenigde Staten, 43228
- Doctors Hospital
-
Columbus, Ohio, Verenigde Staten, 43215
- Grant Medical Center
-
Columbus, Ohio, Verenigde Staten, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Verenigde Staten, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Verenigde Staten, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Verenigde Staten, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Verenigde Staten, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Verenigde Staten, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, Verenigde Staten, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Verenigde Staten, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Verenigde Staten, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Verenigde Staten, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Verenigde Staten, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Verenigde Staten, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Verenigde Staten, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Verenigde Staten, 45840
- Orion Cancer Care
-
Franklin, Ohio, Verenigde Staten, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Verenigde Staten, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Verenigde Staten, 45331
- Wayne Hospital
-
Greenville, Ohio, Verenigde Staten, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Verenigde Staten, 45429
- Kettering Medical Center
-
Kettering, Ohio, Verenigde Staten, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Verenigde Staten, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, Verenigde Staten, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, Verenigde Staten, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Verenigde Staten, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Verenigde Staten, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Verenigde Staten, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina, Ohio, Verenigde Staten, 44256
- Summa Health Medina Medical Center
-
Middletown, Ohio, Verenigde Staten, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Verenigde Staten, 43050
- Knox Community Hospital
-
Newark, Ohio, Verenigde Staten, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Verenigde Staten, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Verenigde Staten, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Verenigde Staten, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, Verenigde Staten, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Verenigde Staten, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Verenigde Staten, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Verenigde Staten, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Verenigde Staten, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, Verenigde Staten, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Verenigde Staten, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Verenigde Staten, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Verenigde Staten, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Verenigde Staten, 43614
- University of Toledo
-
Toledo, Ohio, Verenigde Staten, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Verenigde Staten, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Verenigde Staten, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Verenigde Staten, 45373
- Dayton Physicians LLC - Troy
-
Wauseon, Ohio, Verenigde Staten, 43567
- Fulton County Health Center
-
West Chester, Ohio, Verenigde Staten, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Verenigde Staten, 43081
- Saint Ann's Hospital
-
Wpafb, Ohio, Verenigde Staten, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Verenigde Staten, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Verenigde Staten, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Verenigde Staten, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Verenigde Staten, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, Verenigde Staten, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, Verenigde Staten, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland, Oregon, Verenigde Staten, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver, Pennsylvania, Verenigde Staten, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Verenigde Staten, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Verenigde Staten, 17822
- Geisinger Medical Center
-
Easton, Pennsylvania, Verenigde Staten, 18042
- Easton Hospital
-
Greensburg, Pennsylvania, Verenigde Staten, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, Verenigde Staten, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Verenigde Staten, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Verenigde Staten, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills, Pennsylvania, Verenigde Staten, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, Verenigde Staten, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Verenigde Staten, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Verenigde Staten, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Verenigde Staten, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville, Pennsylvania, Verenigde Staten, 15146
- Forbes Hospital
-
Moon Township, Pennsylvania, Verenigde Staten, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, Verenigde Staten, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Verenigde Staten, 19114
- Jefferson Torresdale Hospital
-
Phoenixville, Pennsylvania, Verenigde Staten, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Verenigde Staten, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Verenigde Staten, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, Verenigde Staten, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Verenigde Staten, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Verenigde Staten, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Verenigde Staten, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, Verenigde Staten, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, Verenigde Staten, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Verenigde Staten, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Verenigde Staten, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Verenigde Staten, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence, Rhode Island, Verenigde Staten, 02905
- Women and Infants Hospital
-
Warwick, Rhode Island, Verenigde Staten, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, Verenigde Staten, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, Verenigde Staten, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Verenigde Staten, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, Verenigde Staten, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Verenigde Staten, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Verenigde Staten, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Verenigde Staten, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Verenigde Staten, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Verenigde Staten, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Verenigde Staten, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, Verenigde Staten, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, Verenigde Staten, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, Verenigde Staten, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Verenigde Staten, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Verenigde Staten, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Verenigde Staten, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Verenigde Staten, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Verenigde Staten, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Verenigde Staten, 37404
- Memorial Hospital
-
Hixson, Tennessee, Verenigde Staten, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, Verenigde Staten, 38301
- Jackson-Madison County General Hospital
-
Nashville, Tennessee, Verenigde Staten, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, Verenigde Staten, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Verenigde Staten, 79601
- Hendrick Medical Center
-
Houston, Texas, Verenigde Staten, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Verenigde Staten, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Verenigde Staten, 77030
- Ben Taub General Hospital
-
Laredo, Texas, Verenigde Staten, 78041
- Doctor's Hospital of Laredo
-
San Antonio, Texas, Verenigde Staten, 78229
- University Hospital
-
San Antonio, Texas, Verenigde Staten, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Verenigde Staten, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Verenigde Staten, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners, Vermont, Verenigde Staten, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Verenigde Staten, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Verenigde Staten, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg, Virginia, Verenigde Staten, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Verenigde Staten, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville, Virginia, Verenigde Staten, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Verenigde Staten, 23114
- Bon Secours Saint Francis Medical Center
-
Richmond, Virginia, Verenigde Staten, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Verenigde Staten, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Verenigde Staten, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, Verenigde Staten, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn, Washington, Verenigde Staten, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Verenigde Staten, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Verenigde Staten, 98004
- Overlake Medical Center
-
Burien, Washington, Verenigde Staten, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Verenigde Staten, 98531
- Providence Regional Cancer System-Centralia
-
Enumclaw, Washington, Verenigde Staten, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Verenigde Staten, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Verenigde Staten, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Verenigde Staten, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Verenigde Staten, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Verenigde Staten, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, Verenigde Staten, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Verenigde Staten, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Verenigde Staten, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, Verenigde Staten, 98036
- Virginia Mason Lynnwood Medical Center
-
Olympia, Washington, Verenigde Staten, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, Verenigde Staten, 98507
- Capital Medical Center
-
Port Townsend, Washington, Verenigde Staten, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Verenigde Staten, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Verenigde Staten, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Verenigde Staten, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Verenigde Staten, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, Verenigde Staten, 98101
- Virginia Mason Medical Center
-
Silverdale, Washington, Verenigde Staten, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Verenigde Staten, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Verenigde Staten, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Verenigde Staten, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Verenigde Staten, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Verenigde Staten, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, Verenigde Staten, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Verenigde Staten, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Verenigde Staten, 98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport, West Virginia, Verenigde Staten, 26330
- United Hospital Center
-
Charleston, West Virginia, Verenigde Staten, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Verenigde Staten, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Verenigde Staten, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Verenigde Staten, 26506
- West Virginia University Healthcare
-
Morgantown, West Virginia, Verenigde Staten, 26505
- Monongalia Hospital
-
Parkersburg, West Virginia, Verenigde Staten, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington, Wisconsin, Verenigde Staten, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Verenigde Staten, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Verenigde Staten, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Verenigde Staten, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Verenigde Staten, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Verenigde Staten, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Verenigde Staten, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, Verenigde Staten, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha, Wisconsin, Verenigde Staten, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, Verenigde Staten, 54848
- Marshfield Medical Center - Ladysmith
-
Marinette, Wisconsin, Verenigde Staten, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Verenigde Staten, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Verenigde Staten, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Verenigde Staten, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Verenigde Staten, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Verenigde Staten, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Verenigde Staten, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Verenigde Staten, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Verenigde Staten, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, Verenigde Staten, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Verenigde Staten, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Verenigde Staten, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Verenigde Staten, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Verenigde Staten, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Verenigde Staten, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Verenigde Staten, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Verenigde Staten, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Verenigde Staten, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Verenigde Staten, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Verenigde Staten, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Verenigde Staten, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Verenigde Staten, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Verenigde Staten, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, Verenigde Staten, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, Verenigde Staten, 54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids, Wisconsin, Verenigde Staten, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Verenigde Staten, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, Verenigde Staten, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Verenigde Staten, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Verenigde Staten, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Verenigde Staten, 82801
- Welch Cancer Center
-
-
Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
18 jaar en ouder (Volwassen, Oudere volwassene)
Accepteert gezonde vrijwilligers
Nee
Geslachten die in aanmerking komen voor studie
Vrouw
Beschrijving
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
|
Actieve vergelijker: Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andere namen:
Given IV
Andere namen:
Correlative studies Ancillary studies
Andere namen:
Given IV
Andere namen:
Undergo 2 core biopsies
Andere namen:
Given IV
Andere namen:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
Experimenteel: Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andere namen:
Given IV
Andere namen:
Correlative studies Ancillary studies
Andere namen:
Given IV
Andere namen:
Undergo 2 core biopsies
Andere namen:
Given IV
Andere namen:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
Andere namen:
Given SC
Andere namen:
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Tijdsspanne: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Tijdsspanne: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
Tijdsspanne: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
Tijdsspanne: Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
Tijdsspanne: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Tijdsspanne: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Tijdsspanne: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
Tijdsspanne: Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Tijdsspanne: Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Tijdsspanne: 2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Tijdsspanne: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Medewerkers
Onderzoekers
- Hoofdonderzoeker: Mothaffar F Rimawi, NRG Oncology
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
18 februari 2014
Primaire voltooiing (Werkelijk)
31 oktober 2016
Studie voltooiing (Werkelijk)
30 juni 2025
Studieregistratiedata
Eerst ingediend
2 december 2013
Eerst ingediend dat voldeed aan de QC-criteria
2 december 2013
Eerst geplaatst (Geschat)
6 december 2013
Updates van studierecords
Laatste update geplaatst (Werkelijk)
6 oktober 2026
Laatste update ingediend die voldeed aan QC-criteria
15 september 2026
Laatst geverifieerd
1 september 2026
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
- Neoplasmata per site
- Neoplasmata
- Huidziektes
- Borst ziekten
- Huid- en bindweefselaandoeningen
- Borstneoplasmata
- Fysiologische effecten van medicijnen
- Moleculaire mechanismen van farmacologische werking
- Hormonen
- Hormonen, hormoonvervangers en hormoonantagonisten
- Enzym-remmers
- Steroïdesyntheseremmers
- Hormoonantagonisten
- Oestrogeen antagonisten
- Hypofyse hormoonafgooiende hormonen
- Hypothalamische hormonen
- Peptide hormonen
- Neuropeptiden
- Peptiden
- Aminozuren, peptiden en eiwitten
- Oligopeptiden
- Zenuwweefsel eiwitten
- Eiwitten
- Organische chemicaliën
- Farmacologische acties
- Chemische acties en gebruik
- Koolwaterstoffen
- Cycloparaffins
- Koolwaterstoffen, alicyclisch
- Koolwaterstoffen, cyclisch
- Terpenen
- Antilichamen, monoklonaal, gehumaniseerd
- Antilichamen, monoklonaal
- Antilichamen
- Immunoglobulinen
- Immunoproteïnen
- Bloedeiwitten
- Serum -globulines
- Globulines
- Coördinatiecomplexen
- Taxoids
- Cyclodecanes
- Diterpenen
- Gonadotropine-afgevende hormoon
- Docetaxel
- Trastuzumab
- Carboplatine
- Gosereline
- Aromatase-remmers
- pertuzumab
- 2c4 antilichaam
- CT-P6
- PF-05280014
- trastuzumab biosimilar HLX02
- Ogivri
- Ontruzant
Andere studie-ID-nummers
- NCI-2013-02228
- U10CA180868 (Subsidie/contract van de Amerikaanse NIH)
- U10CA012027 (Subsidie/contract van de Amerikaanse NIH)
- NCI-2013-02228 (Register-ID: CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (Andere identificatie: CTEP)
- NSABP-B-52 (Andere identificatie: NRG Oncology)
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .