Docetaxel, Carboplatin, Trastuzumab og Pertuzumab med eller uden østrogenmangel til behandling af patienter med hormonreceptorpositiv, HER2-positiv operabel eller lokalt fremskreden brystkræft
15. september 2026 opdateret af: National Cancer Institute (NCI)
Et randomiseret fase III-forsøg, der evaluerer patologiske fuldstændige responsrater hos patienter med hormonreceptorpositiv, HER2-positiv, stor operabel og lokalt avanceret brystkræft behandlet med neoadjuverende terapi af Docetaxel, Carboplatin, Trastuzumab og Pertuzumab (TCHP) med deprivation (TCHP)
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
- Medicin: Carboplatin
- Biologisk: Trastuzumab
- Andet: Laboratory Biomarker Analysis
- Andet: Quality-of-Life Assessment
- Medicin: Docetaxel
- Andet: Cytology Specimen Collection Procedure
- Biologisk: Pertuzumab
- Procedure: Therapeutic Conventional Surgery
- Stråling: Whole Breast Irradiation
- Medicin: Aromatase Inhibition Therapy
- Medicin: Goserelin Acetate
Detaljeret beskrivelse
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
315
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alaska
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arkansas
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Forenede Stater, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Forenede Stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Forenede Stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forenede Stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, Forenede Stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Forenede Stater, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Forenede Stater, 90710
- Kaiser Permanente South Bay
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Irvine, California, Forenede Stater, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, Forenede Stater, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forenede Stater, 90048
- Cedars Sinai Medical Center
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Los Angeles, California, Forenede Stater, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Modesto, California, Forenede Stater, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Forenede Stater, 94040
- El Camino Hospital
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Oakland, California, Forenede Stater, 94602
- Wilma Chan Highland Hospital
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Orange, California, Forenede Stater, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forenede Stater, 91402
- Kaiser Permanente - Panorama City
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Pleasanton, California, Forenede Stater, 94588
- Valley Medical Oncology Consultants
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forenede Stater, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Forenede Stater, 92078
- Kaiser Permanente-San Marcos
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San Pablo, California, Forenede Stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forenede Stater, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forenede Stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Forenede Stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Forenede Stater, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Forenede Stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, Forenede Stater, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Forenede Stater, 80210
- AdventHealth Porter
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Southwest Oncology PC
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Golden, Colorado, Forenede Stater, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, Forenede Stater, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, Forenede Stater, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forenede Stater, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80539
- Banner McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Forenede Stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forenede Stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, Forenede Stater, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Delaware
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forenede Stater, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Florida
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Deerfield Beach, Florida, Forenede Stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Gainesville, Florida, Forenede Stater, 32610
- University of Florida Health Science Center - Gainesville
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Orlando, Florida, Forenede Stater, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, Forenede Stater, 32803
- AdventHealth Orlando
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Georgia
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Athens, Georgia, Forenede Stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Augusta, Georgia, Forenede Stater, 30912
- Augusta University Medical Center
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Cumming, Georgia, Forenede Stater, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, Forenede Stater, 30033
- Emory Decatur Hospital
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center-Gainesville
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forenede Stater, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, Forenede Stater, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, Forenede Stater, 31404
- Low Country Cancer Care
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Lewiston, Idaho, Forenede Stater, 83501
- Saint Joseph Regional Medical Center
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, Forenede Stater, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Forenede Stater, 60612
- University of Illinois
-
Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Forenede Stater, 60631
- Presence Resurrection Medical Center
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, Forenede Stater, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forenede Stater, 60202
- Saint Francis Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Kankakee, Illinois, Forenede Stater, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, Forenede Stater, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Forenede Stater, 61350
- Radiation Oncology of Northern Illinois
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Forenede Stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Plainfield, Illinois, Forenede Stater, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, Forenede Stater, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
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Springfield, Illinois, Forenede Stater, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Forenede Stater, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
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Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Crown Point, Indiana, Forenede Stater, 46307
- Michiana Hematology Oncology PC-Crown Point
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Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
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Elkhart, Indiana, Forenede Stater, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, Forenede Stater, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Health Indianapolis
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Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
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La Porte, Indiana, Forenede Stater, 46350
- IU Health La Porte Hospital
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Michigan City, Indiana, Forenede Stater, 46360
- Franciscan Saint Anthony Health-Michigan City
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Michigan City, Indiana, Forenede Stater, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Forenede Stater, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Forenede Stater, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
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Plymouth, Indiana, Forenede Stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
South Bend, Indiana, Forenede Stater, 46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute, Indiana, Forenede Stater, 47804
- Union Hospital
-
Westville, Indiana, Forenede Stater, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Forenede Stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Forenede Stater, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forenede Stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forenede Stater, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Forenede Stater, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Forenede Stater, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Forenede Stater, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Forenede Stater, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, Forenede Stater, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Forenede Stater, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, Forenede Stater, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River, Massachusetts, Forenede Stater, 02721
- Saint Anne's Hospital
-
Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian, Michigan, Forenede Stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn, Michigan, Forenede Stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forenede Stater, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Forenede Stater, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Forenede Stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe, Michigan, Forenede Stater, 48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, Forenede Stater, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, Forenede Stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac, Michigan, Forenede Stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Forenede Stater, 48060
- Lake Huron Medical Center
-
Roseville, Michigan, Forenede Stater, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Forenede Stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Forenede Stater, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Forenede Stater, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Forenede Stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forenede Stater, 48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Forenede Stater, 48314
- Mitchell Folbe MD PC
-
Troy, Michigan, Forenede Stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forenede Stater, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Forenede Stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Forenede Stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forenede Stater, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forenede Stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Forenede Stater, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City, Missouri, Forenede Stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forenede Stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forenede Stater, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Montana Cancer Consortium NCORP
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forenede Stater, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forenede Stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forenede Stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forenede Stater, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Forenede Stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forenede Stater, 89120
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth, New Jersey, Forenede Stater, 07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Forenede Stater, 08822
- Hunterdon Medical Center
-
Mullica Hill, New Jersey, Forenede Stater, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, Forenede Stater, 07112
- Newark Beth Israel Medical Center
-
Newton, New Jersey, Forenede Stater, 07860
- Newton Medical Center
-
Pompton, New Jersey, Forenede Stater, 07444
- Chilton Medical Center
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Vineland, New Jersey, Forenede Stater, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87106
- Hematology Oncology Associates
-
Las Cruces, New Mexico, Forenede Stater, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Forenede Stater, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Middletown, New York, Forenede Stater, 10940
- Garnet Health Medical Center
-
New York, New York, Forenede Stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forenede Stater, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Forenede Stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Forenede Stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Forenede Stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Forenede Stater, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Forenede Stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville, North Carolina, Forenede Stater, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Forenede Stater, 28501
- ECU Health Oncology Kinston
-
Mebane, North Carolina, Forenede Stater, 27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy, North Carolina, Forenede Stater, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Forenede Stater, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Memorial Hospital
-
Salisbury, North Carolina, Forenede Stater, 28144
- Novant Health Cancer Institute - Rowan
-
Statesville, North Carolina, Forenede Stater, 28677
- Iredell Memorial Hospital
-
Stateville, North Carolina, Forenede Stater, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Forenede Stater, 27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Novant Health Oncology Specialists
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Winston-Salem Health Care
-
Winston-Salem, North Carolina, Forenede Stater, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
Minot, North Dakota, Forenede Stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Forenede Stater, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Forenede Stater, 44203
- Summa Health System - Barberton Campus
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Forenede Stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45219
- The Christ Hospital
-
Cincinnati, Ohio, Forenede Stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Forenede Stater, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Forenede Stater, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Forenede Stater, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forenede Stater, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Forenede Stater, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, Forenede Stater, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina, Ohio, Forenede Stater, 44256
- Summa Health Medina Medical Center
-
Middletown, Ohio, Forenede Stater, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Forenede Stater, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Forenede Stater, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, Forenede Stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forenede Stater, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43614
- University of Toledo
-
Toledo, Ohio, Forenede Stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forenede Stater, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Wauseon, Ohio, Forenede Stater, 43567
- Fulton County Health Center
-
West Chester, Ohio, Forenede Stater, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wpafb, Ohio, Forenede Stater, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, Forenede Stater, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver, Pennsylvania, Forenede Stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Easton, Pennsylvania, Forenede Stater, 18042
- Easton Hospital
-
Greensburg, Pennsylvania, Forenede Stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills, Pennsylvania, Forenede Stater, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, Forenede Stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Forenede Stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- Forbes Hospital
-
Moon Township, Pennsylvania, Forenede Stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Jefferson Torresdale Hospital
-
Phoenixville, Pennsylvania, Forenede Stater, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forenede Stater, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, Forenede Stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Forenede Stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, Forenede Stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, Forenede Stater, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Forenede Stater, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02905
- Women and Infants Hospital
-
Warwick, Rhode Island, Forenede Stater, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, Forenede Stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Forenede Stater, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, Forenede Stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, Forenede Stater, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, Forenede Stater, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forenede Stater, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Forenede Stater, 37404
- Memorial Hospital
-
Hixson, Tennessee, Forenede Stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, Forenede Stater, 38301
- Jackson-Madison County General Hospital
-
Nashville, Tennessee, Forenede Stater, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, Forenede Stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Forenede Stater, 79601
- Hendrick Medical Center
-
Houston, Texas, Forenede Stater, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
Laredo, Texas, Forenede Stater, 78041
- Doctor's Hospital of Laredo
-
San Antonio, Texas, Forenede Stater, 78229
- University Hospital
-
San Antonio, Texas, Forenede Stater, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Forenede Stater, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Forenede Stater, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Forenede Stater, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, Forenede Stater, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn, Washington, Forenede Stater, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Forenede Stater, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Forenede Stater, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Forenede Stater, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, Forenede Stater, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, Forenede Stater, 98036
- Virginia Mason Lynnwood Medical Center
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, Forenede Stater, 98507
- Capital Medical Center
-
Port Townsend, Washington, Forenede Stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Forenede Stater, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Forenede Stater, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, Forenede Stater, 98101
- Virginia Mason Medical Center
-
Silverdale, Washington, Forenede Stater, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Forenede Stater, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Forenede Stater, 98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport, West Virginia, Forenede Stater, 26330
- United Hospital Center
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Forenede Stater, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
Morgantown, West Virginia, Forenede Stater, 26505
- Monongalia Hospital
-
Parkersburg, West Virginia, Forenede Stater, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Forenede Stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, Forenede Stater, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, Forenede Stater, 54848
- Marshfield Medical Center - Ladysmith
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, Forenede Stater, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Forenede Stater, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, Forenede Stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forenede Stater, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00936
- San Juan City Hospital
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Kvinde
Beskrivelse
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andre navne:
Given IV
Andre navne:
Correlative studies Ancillary studies
Andre navne:
Given IV
Andre navne:
Undergo 2 core biopsies
Andre navne:
Given IV
Andre navne:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
Eksperimentel: Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andre navne:
Given IV
Andre navne:
Correlative studies Ancillary studies
Andre navne:
Given IV
Andre navne:
Undergo 2 core biopsies
Andre navne:
Given IV
Andre navne:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
Andre navne:
Given SC
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
Tidsramme: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
Tidsramme: Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
Tidsramme: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Tidsramme: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
Tidsramme: Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Tidsramme: Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Tidsramme: 2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Tidsramme: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Mothaffar F Rimawi, NRG Oncology
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
18. februar 2014
Primær færdiggørelse (Faktiske)
31. oktober 2016
Studieafslutning (Faktiske)
30. juni 2025
Datoer for studieregistrering
Først indsendt
2. december 2013
Først indsendt, der opfyldte QC-kriterier
2. december 2013
Først opslået (Anslået)
6. december 2013
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
6. oktober 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
15. september 2026
Sidst verificeret
1. september 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter sted
- Neoplasmer
- Hudsygdomme
- Brystsygdomme
- Hud- og bindevævssygdomme
- Brystneoplasmer
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Hormoner
- Hormoner, hormonsubstitutter og hormonantagonister
- Enzymhæmmere
- Steroidsyntesehæmmere
- Hormonantagonister
- Østrogenantagonister
- Hypofysehormon-frigivende hormoner
- Hypothalamiske hormoner
- Peptidhormoner
- Neuropeptider
- Peptider
- Aminosyrer, peptider og proteiner
- Oligopeptider
- Nervevævsproteiner
- Proteiner
- Organiske kemikalier
- Farmakologiske handlinger
- Kemiske handlinger og anvendelser
- Kulbrinter
- Cycloparaffiner
- Kulbrinter, alicyklisk
- Kulbrinter, cyklisk
- Terpenes
- Antistoffer, monoklonal, humaniseret
- Antistoffer, monoklonal
- Antistoffer
- Immunoglobuliner
- Immunoproteiner
- Blodproteiner
- Serum globuliner
- Globuliner
- Koordinationskomplekser
- Taxoider
- Cyclodecanes
- Diterpenes
- Gonadotropin-frigivende hormon
- Docetaxel
- Trastuzumab
- Carboplatin
- Goserelin
- Aromatasehæmmere
- Pertuzumab
- 2C4 antistof
- CT-P6
- PF-05280014
- Trastuzumab Biosimilar HLX02
- Ogivri
- Ontruzant
Andre undersøgelses-id-numre
- NCI-2013-02228
- U10CA180868 (U.S. NIH-bevilling/kontrakt)
- U10CA012027 (U.S. NIH-bevilling/kontrakt)
- NCI-2013-02228 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (Anden identifikator: CTEP)
- NSABP-B-52 (Anden identifikator: NRG Oncology)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .