Laparoscopic Sleeve Gastrectomy - A Prospective Study of Weight Loss, Comorbidities and Patients' Quality of Life
Surgery is considered the best therapy for morbid obesity and its comorbidities, where alterations in lifestyle, diets and drugs have failed to achieve weight loss. The most widely performed in Israel is Laparoscopic Sleeve Gastrectomy (LSG), and several studies have reported high success rates in reducing weight and improving comorbidities common among obese patients such as hypertension; diabetes mellitus type II; dyslipidemia; osteoarthritis; obstructive sleep apnea etc.
The hypothesis of this prospective study is that the LSG is an effective treatment for achieving weight loss, for improving and even curing comorbidities and for improving the patient's QOL. Another supposition is that patient's socio-economic status can influence success rates of bariatric procedures.
調査の概要
状態
条件
詳細な説明
Introduction - Morbid obesity is considered an ever growing pandemic. Most morbidly obese patients suffer from comorbidities such as hypertension; diabetes mellitus type II; dyslipidemia; osteoarthritis; obstructive sleep apnea etc. Surgery is considered the best therapy for morbid obesity and its comorbidities, where alterations in lifestyle, diets and drugs have failed to achieve weight loss. There are some procedures, some more commonly practiced than others, most of them done laparoscopically. The most widely performed in Israel is Laparoscopic Sleeve Gastrectomy (LSG), and several studies have reported high success rates in reducing weight and improving comorbidities. However, few studies exists, mostly retrospective, on the long term results after LSG. These studies have demonstrated significant weight loss, significant decrease in excessive body weight and also significant improvement in patients' quality of lives (QOL). However, a single comprehensive prospective research encompassing all three parameters was not found by us in a preliminary literature review. No studies were found regarding the effect of socio-economic status on the late results of LSG.
Goals -The goal of the present study is to prospectively follow patients undergoing LSG and to assess its effectiveness in weight loss and in the improvement of comorbidities and quality of life. We also plan to evaluate the effect of socio-economic status on the results of bariatric surgery, with emphasis on changes in QOL of these patients.
Material and Methods - In an 18 month long prospective research, a set of two questionnaires will be given to each patient undergoing LSG for morbid obesity at three time points: before surgery, 6 and 12 months post-surgery. The first questionnaire includes demographic, socio-economic and physiological data and health related questions regarding comorbidities and their methods of treatment. The second questionnaire is the Short Form 36v2, an accepted QOL questionnaire which, using 36 questions. At the end of the research, a statistical analysis of the results will be performed.
Hypothesis - The hypothesis states that the LSG is an effective treatment for achieving weight loss, for improving and even curing comorbidities and for improving the patient's QOL. Another supposition is that patient's socio-economic status can influence success rates of bariatric procedures.
Importance of the study - Several studies was done reviewing this procedure's efficacy according to physiological parameters and improvement in comorbidities and quality of life. Most of which are retrospective. A prospective research that encompasses all these three parameters was not currently found in the medical literature Keywords - Morbid Obesity, Bariatric surgery, Sleeve Gastrectomy, Quality of Life, Comorbidities, Weight loss.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Kfar Sava、イスラエル、4429900
- Meir Medical Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- age between 18-70
Exclusion Criteria:
- patients who underwent previous bariatric surgery
- patients unwilling to participate in the study
- female patients who are currently pregnant
- patients who are cognitively impaired or lacking judgement
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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Laparoscopic Sleeve Gastrectomy
Patients undergoing Laparoscopic Sleeve Gastrectomy surgery for morbid obesity
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Weight loss
時間枠:1 year
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Observe and record subjects' weight loos over the course of one year.
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1 year
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Improvement in quality of life
時間枠:1 year
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observe and record the improvement in subjects' quality of life as reported by them in the questionnaire
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1 year
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Improvement in comorbidities
時間枠:1 year
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Observe and record improvement in five obesity related comorbidities -
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1 year
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その他の成果指標
結果測定 |
時間枠 |
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The affect of education, socioeconomic status and ethnic origin on the results of the surgery
時間枠:1 year
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1 year
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。