Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- One hour of rest (CON)
- One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
- One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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-
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Copenhagen、デンマーク、2100
- Center for Physical Activity Research (CFAS)
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Type 2 Diabetes Mellitus
- BMI > 25
Exclusion Criteria:
- Pregnancy
- Smoking
- Contraindication to increased levels of physical activity
- Eating disorder
- Insulin dependence
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：CON
Control (CON).
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No exercise intervention.
|
|
実験的：CW
Continuous Walking (CW).
|
One hour of continuous walking on a treadmill.
|
|
実験的：IW
Interval Walking (IW).
|
One hour of interval (repeated cycles of 3 minutes of fast and 3 minutes of slow) walking on treadmill.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Ad-libitum meal energy intake
時間枠：Initiated 3 hours after the intervention
|
Subjects will receive a standardized ad-libitum meal and energy intake will be assessed
|
Initiated 3 hours after the intervention
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Free-living energy intake
時間枠：For 32 hours following the ad-libitum meal.
|
Subjects will complete diet records for 32 hours following the ad-libitum meal and energy intake will be assessed.
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For 32 hours following the ad-libitum meal.
|
|
Appetite-related hormones
時間枠：Regularly during the 3 hours following the intervention
|
Appetite-related hormones (insulin, ghrelin, leptin, cholecyctokinin, PYY) will be analysed in blood samples collected regularly during the liquid mixed-meal tolerance test following the intervention
|
Regularly during the 3 hours following the intervention
|
|
Satiety
時間枠：Regular assessments for 36 hours following the intervention
|
Satiety questionaires will be completed at regular intervals after the intervention
|
Regular assessments for 36 hours following the intervention
|
協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。