Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- One hour of rest (CON)
- One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
- One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Type d'étude
Inscription (Réel)
Phase
- N'est pas applicable
Contacts et emplacements
Lieux d'étude
-
-
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Copenhagen, Danemark, 2100
- Center for Physical Activity Research (CFAS)
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-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Type 2 Diabetes Mellitus
- BMI > 25
Exclusion Criteria:
- Pregnancy
- Smoking
- Contraindication to increased levels of physical activity
- Eating disorder
- Insulin dependence
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation croisée
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: CON
Control (CON).
|
No exercise intervention.
|
|
Expérimental: CW
Continuous Walking (CW).
|
One hour of continuous walking on a treadmill.
|
|
Expérimental: IW
Interval Walking (IW).
|
One hour of interval (repeated cycles of 3 minutes of fast and 3 minutes of slow) walking on treadmill.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Ad-libitum meal energy intake
Délai: Initiated 3 hours after the intervention
|
Subjects will receive a standardized ad-libitum meal and energy intake will be assessed
|
Initiated 3 hours after the intervention
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Free-living energy intake
Délai: For 32 hours following the ad-libitum meal.
|
Subjects will complete diet records for 32 hours following the ad-libitum meal and energy intake will be assessed.
|
For 32 hours following the ad-libitum meal.
|
|
Appetite-related hormones
Délai: Regularly during the 3 hours following the intervention
|
Appetite-related hormones (insulin, ghrelin, leptin, cholecyctokinin, PYY) will be analysed in blood samples collected regularly during the liquid mixed-meal tolerance test following the intervention
|
Regularly during the 3 hours following the intervention
|
|
Satiety
Délai: Regular assessments for 36 hours following the intervention
|
Satiety questionaires will be completed at regular intervals after the intervention
|
Regular assessments for 36 hours following the intervention
|
Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Anticipé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- H-15008542
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