Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language
調査の概要
詳細な説明
Background:
Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).
Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.
Aim and procedure:
The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.
Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Fribourg、スイス、1700
- Laboratory for Cognitive and Neurological Sciences
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- L1 French, knowledge of English as a foreign language
- 18-45 years of age
- Right-handedness
Exclusion Criteria:
- epilepsy /family history of epilepsy
- brain surgery, traumatic brain injuries
- cardiac pacemaker, metallic objects in the body
- history of neurological diseases or psychiatric disorders
- drug use (alcohol, psychoactive medication)
- developmental language disorder
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
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偽コンパレータ：偽rTMS
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Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.
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実験的：rTMS
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repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area.
This change in excitability has been shown to last beyond the duration of the stimulation.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Language production
時間枠：within 30 mins after rTMS/sham rTMS
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Picture naming task and word translation task
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within 30 mins after rTMS/sham rTMS
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二次結果の測定
結果測定 |
時間枠 |
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non-verbal executive functions task
時間枠：within 30 mins after rTMS/sham rTMS
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within 30 mins after rTMS/sham rTMS
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Jean-Marie Annoni, Prof. Dr.、University of Fribourg
出版物と役立つリンク
一般刊行物
- Cotelli M, Calabria M, Manenti R, Rosini S, Zanetti O, Cappa SF, Miniussi C. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):794-7. doi: 10.1136/jnnp.2009.197848. Epub 2010 Jun 23.
- Holtzheimer P, Fawaz W, Wilson C, Avery D. Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients. Brain Lang. 2005 Sep;94(3):274-7. doi: 10.1016/j.bandl.2005.01.003.
- Nardone R, De Blasi P, Bergmann J, Caleri F, Tezzon F, Ladurner G, Golaszewski S, Trinka E. Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report. Neurosci Lett. 2011 Jan 10;487(3):378-82. doi: 10.1016/j.neulet.2010.10.060. Epub 2010 Oct 29.
- Osaka N, Otsuka Y, Hirose N, Ikeda T, Mima T, Fukuyama H, Osaka M. Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. Neurosci Lett. 2007 May 18;418(3):232-5. doi: 10.1016/j.neulet.2007.01.087. Epub 2007 Apr 8.
- Fabbro F, Skrap M, Aglioti S. Pathological switching between languages after frontal lesions in a bilingual patient. J Neurol Neurosurg Psychiatry. 2000 May;68(5):650-2. doi: 10.1136/jnnp.68.5.650.
- Abutalebi J, Green D. Bilingual language production: The neurocognition of language representation and control. Journal of Neurolinguistics, 20, 242-275, 2007.
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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rTMSの臨床試験
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Changping LaboratoryWuhan Mental Health Centre一時停止
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Changping LaboratoryBeijing HuiLongGuan Hospital募集
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Centre hospitalier de Ville-Evrard, France募集
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National Taiwan University Hospital Hsin-Chu Branchまだ募集していません