- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT02840396
Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language
Studieöversikt
Detaljerad beskrivning
Background:
Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).
Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.
Aim and procedure:
The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.
Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.
Studietyp
Inskrivning (Faktisk)
Fas
- Inte tillämpbar
Kontakter och platser
Studieorter
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Fribourg, Schweiz, 1700
- Laboratory for Cognitive and Neurological Sciences
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Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- L1 French, knowledge of English as a foreign language
- 18-45 years of age
- Right-handedness
Exclusion Criteria:
- epilepsy /family history of epilepsy
- brain surgery, traumatic brain injuries
- cardiac pacemaker, metallic objects in the body
- history of neurological diseases or psychiatric disorders
- drug use (alcohol, psychoactive medication)
- developmental language disorder
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Övrig
- Tilldelning: Randomiserad
- Interventionsmodell: Crossover tilldelning
- Maskning: Enda
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
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Sham Comparator: Sham rTMS
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Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.
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Experimentell: rTMS
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repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area.
This change in excitability has been shown to last beyond the duration of the stimulation.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
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Language production
Tidsram: within 30 mins after rTMS/sham rTMS
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Picture naming task and word translation task
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within 30 mins after rTMS/sham rTMS
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Sekundära resultatmått
Resultatmått |
Tidsram |
---|---|
non-verbal executive functions task
Tidsram: within 30 mins after rTMS/sham rTMS
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within 30 mins after rTMS/sham rTMS
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Samarbetspartners och utredare
Sponsor
Samarbetspartners
Utredare
- Huvudutredare: Jean-Marie Annoni, Prof. Dr., University of Fribourg
Publikationer och användbara länkar
Allmänna publikationer
- Cotelli M, Calabria M, Manenti R, Rosini S, Zanetti O, Cappa SF, Miniussi C. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):794-7. doi: 10.1136/jnnp.2009.197848. Epub 2010 Jun 23.
- Holtzheimer P, Fawaz W, Wilson C, Avery D. Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients. Brain Lang. 2005 Sep;94(3):274-7. doi: 10.1016/j.bandl.2005.01.003.
- Nardone R, De Blasi P, Bergmann J, Caleri F, Tezzon F, Ladurner G, Golaszewski S, Trinka E. Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report. Neurosci Lett. 2011 Jan 10;487(3):378-82. doi: 10.1016/j.neulet.2010.10.060. Epub 2010 Oct 29.
- Osaka N, Otsuka Y, Hirose N, Ikeda T, Mima T, Fukuyama H, Osaka M. Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. Neurosci Lett. 2007 May 18;418(3):232-5. doi: 10.1016/j.neulet.2007.01.087. Epub 2007 Apr 8.
- Fabbro F, Skrap M, Aglioti S. Pathological switching between languages after frontal lesions in a bilingual patient. J Neurol Neurosurg Psychiatry. 2000 May;68(5):650-2. doi: 10.1136/jnnp.68.5.650.
- Abutalebi J, Green D. Bilingual language production: The neurocognition of language representation and control. Journal of Neurolinguistics, 20, 242-275, 2007.
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Andra studie-ID-nummer
- SNF325130_156937_2
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
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