Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language
研究概览
详细说明
Background:
Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).
Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.
Aim and procedure:
The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.
Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Fribourg、瑞士、1700
- Laboratory for Cognitive and Neurological Sciences
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- L1 French, knowledge of English as a foreign language
- 18-45 years of age
- Right-handedness
Exclusion Criteria:
- epilepsy /family history of epilepsy
- brain surgery, traumatic brain injuries
- cardiac pacemaker, metallic objects in the body
- history of neurological diseases or psychiatric disorders
- drug use (alcohol, psychoactive medication)
- developmental language disorder
学习计划
研究是如何设计的?
设计细节
- 主要用途:其他
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
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假比较器:假 rTMS
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Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.
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实验性的:经颅磁刺激
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repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area.
This change in excitability has been shown to last beyond the duration of the stimulation.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Language production
大体时间:within 30 mins after rTMS/sham rTMS
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Picture naming task and word translation task
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within 30 mins after rTMS/sham rTMS
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次要结果测量
结果测量 |
大体时间 |
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non-verbal executive functions task
大体时间:within 30 mins after rTMS/sham rTMS
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within 30 mins after rTMS/sham rTMS
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合作者和调查者
调查人员
- 首席研究员:Jean-Marie Annoni, Prof. Dr.、University of Fribourg
出版物和有用的链接
一般刊物
- Cotelli M, Calabria M, Manenti R, Rosini S, Zanetti O, Cappa SF, Miniussi C. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):794-7. doi: 10.1136/jnnp.2009.197848. Epub 2010 Jun 23.
- Holtzheimer P, Fawaz W, Wilson C, Avery D. Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients. Brain Lang. 2005 Sep;94(3):274-7. doi: 10.1016/j.bandl.2005.01.003.
- Nardone R, De Blasi P, Bergmann J, Caleri F, Tezzon F, Ladurner G, Golaszewski S, Trinka E. Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report. Neurosci Lett. 2011 Jan 10;487(3):378-82. doi: 10.1016/j.neulet.2010.10.060. Epub 2010 Oct 29.
- Osaka N, Otsuka Y, Hirose N, Ikeda T, Mima T, Fukuyama H, Osaka M. Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. Neurosci Lett. 2007 May 18;418(3):232-5. doi: 10.1016/j.neulet.2007.01.087. Epub 2007 Apr 8.
- Fabbro F, Skrap M, Aglioti S. Pathological switching between languages after frontal lesions in a bilingual patient. J Neurol Neurosurg Psychiatry. 2000 May;68(5):650-2. doi: 10.1136/jnnp.68.5.650.
- Abutalebi J, Green D. Bilingual language production: The neurocognition of language representation and control. Journal of Neurolinguistics, 20, 242-275, 2007.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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rTMS的临床试验
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Changping LaboratoryWuhan Mental Health Centre招聘中
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