Genomic Study of Relapse Esophageal Cancer After Radiotherapy
調査の概要
詳細な説明
Tumor tissue of patients received radiotherapy with diagnosis of recurrence between Jan 1, 2010 and Dec 1, 2020 were collected retrospectively. Recurrence tumor tissue is collected between Dec 31, 2020 and Dec 31, 2022 prospectively. Blood and preradiotherapy tumor tissue were also collected to be as contrast. A total of 100 paired blood, preradiotherapy tumor tissue and relapse tumor tissue were collected. What is more, a total of 100 paired blood and preradiotherapy tumor tissue with diagnosis of no recurrence were collected. All samples were conducted with whole exome sequencing.
Here the investigators define recurrence period as within 2 years and no recurrence period as more than 3 years after radiotherapy.
Criteria of relapse: (1) pathologic diagnosis is squamous carcinoma before radiotherapy;(2) received radiotherapy; (3)pathologic diagnosis is also squamous carcinoma after radiotherapy; (4) clinical symptoms including feeding obstruction etc; (5) imaging evidence showed disease progression.
研究の種類
入学 (予想される)
連絡先と場所
研究連絡先
- 名前：Kuaile Zhao, doctor
- 電話番号：18017312534
- メール：kuaile_z@sina.com
研究連絡先のバックアップ
- 名前：Jiaying Deng, doctor
- 電話番号：18317088158
- メール：dengjiaying3@sina.com
研究場所
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-
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Shanghai、中国、200032
- 募集
- Fudan University Shanghai Cancer Center
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コンタクト：
- Kuaile Zhao, doctor
- 電話番号：18017312534
- メール：kuaile_z@sina.com
-
コンタクト：
- Jiaying Deng, doctor
- 電話番号：18317088158
- メール：dengjiaying3@sina.com
-
-
参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Recurrence group: 100 paired relapsed tumor tissue,blood and preradiotherapy tumor tissue within 2 years after radiotherapy were collected.
No recurrence group:100 paired blood and preradiotherapy tumor tissue with more than 3 years after radiotherapy were collected
説明
Inclusion Criteria:
- pathologic diagnosis is squamous cell carcinoma before radiotherapy;
- pathologic diagnosis is squamous cell carcinoma after radiotherapy;
- received radiotherapy
- clinical symptoms including dysphagia, feeding obstruction, etc
- image evidence showed disease progression
- the period of recurrence was within 2 years after radiotherapy
Exclusion Criteria:
- pathologic diagnosis is not squamous cell carcinoma before radiotherapy;
- pathologic diagnosis is not squamous cell carcinoma after radiotherapy
- not received radiotherapy
- the period of recurrence was more than 2 years after radiotherapy
- the period of no recurrence was within 3 years after radiotherapy
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：ケースコントロール
- 時間の展望：見込みのある
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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Recurrence
The period of recurrence was within 2 years after radiotherapy.
Pathologic diagnosis was squamous cell carcinoma same with preradiotherapy.
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To seek genomic characteristics of relapsed esophageal cancer with whole exome sequence.
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|
No recurrence
The period was more than 3 years after radiotherapy and no recurrence signs were observed.
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To seek genomic characteristics of relapsed esophageal cancer with whole exome sequence.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
genomic characteristics of relapsed esophageal cancer
時間枠：through study completion, an average of 1 year
|
gene mutations, copy number variants
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through study completion, an average of 1 year
|
協力者と研究者
スポンサー
協力者
捜査官
- 主任研究者：Kuaile Zhao, doctor、Fudan University
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。