Subthalamic Nucleus-Targeted Transcranial Temporal Interference Stimulation for Motor and Non-Motor Symptoms in Parkinson's Disease (STN-tTIS-PD)

Inclusion Criteria:

• Aged 50-85 years, male or female.
• Diagnosed with "clinically established" or "clinically probable" Parkinson's disease according to the 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease.
• Hoehn-Yahr stage ≥ 2, and judged by the investigator to be able to cooperate in completing scale-based assessments and MRI examinations.
• Stable regimen of anti-Parkinsonian medication for at least 4 weeks before enrollment, and agreement to maintain a stable regimen during the main study phase unless medically necessary to change.
• Written informed consent signed by the study participant.

Exclusion Criteria:

• Non-primary Parkinson's disease or other parkinsonism / atypical parkinsonism.
• Previous receipt of invasive neuromodulation therapies such as deep brain stimulation (DBS) or other intracranial implantation/stereotactic brain surgery.
• Presence of contraindications or high-risk conditions for transcranial electrical stimulation (e.g., incompatible metal implants/implantable electrical stimulation devices, etc.), or judged by the investigator as unsuitable to receive transcranial electrical stimulation.
• Receipt of non-invasive neuromodulation interventions such as transcranial magnetic stimulation or transcranial electrical stimulation within the past six months.
• Presence of contraindications to MRI or inability to tolerate MRI examination.
• Significant cognitive impairment or severe psychiatric symptoms that prevent completion of assessments or result in poor compliance.
• New initiation or dose adjustment of medications or treatments that significantly affect sleep architecture/consciousness status within the past 4 weeks.
• History of epilepsy.
• Pregnancy or breastfeeding.
• Any other condition judged by the investigator as unsuitable for participation in the study.