유산 연구--유전학, 운동 및 위험 요인 (HERITAGE)
2014년 5월 27일 업데이트: Washington University School of Medicine
건강, 위험 요인, 운동 훈련 및 유전학
유산소 운동 훈련에 대한 심혈관 및 대사 반응에서의 유전자형의 역할과 여러 심혈관 질환 및 당뇨병 위험 요인에 대한 규칙적인 운동으로 인한 변화에 대한 유전적 요인의 기여를 문서화합니다.
미국과 캐나다에 있는 5개 기관의 실험실 컨소시엄이 이 연구를 수행하고 있습니다.
연구 개요
상세 설명
배경:
이 연구는 인간 변이, 운동 훈련에 대한 적응의 유전학, 심혈관 질환 및 당뇨병 위험 요인의 수반되는 변화에 대한 이해를 높여야 합니다.
디자인 내러티브:
총 742명의 좌식 피험자를 모집하여 초기 테스트를 실시하고 실험실에서 동일한 프로그램으로 20주 동안 운동 훈련을 받은 후 재테스트를 실시했습니다. 대상자는 부모와 세 명의 생물학적 성인 자손 및 아프리카계 미국인 조상의 가족이 있는 백인 혈통의 가족에서 나왔습니다. 훈련 전후에 운동 중 산소 섭취량, 호기량 및 호흡 교환 비율, 혈압, 심박수, 혈중 젖산, 포도당, 글리세롤 및 유리 지방산, 일회 박출량 및 심박출량을 측정하여 최대 산소 섭취량을 결정했습니다. 혈장 지질, 지단백질 및 아포단백질, 포도당 내성 및 정맥 포도당 부하에 대한 인슐린 반응, 혈장 성 스테로이드 및 글루코코르티코이드, 휴식기 수축기 및 이완기 혈압, 체지방 및 국소 지방 분포도 평가되었습니다. 식습관, 습관적인 신체 활동 수준 및 기타 라이프 스타일 구성 요소를 설문지로 평가했습니다. 유전자 분석에는 각 표현형에 대한 유전 가능성 수준 결정 및 규칙적인 운동에 대한 반응, 부계 또는 모계 효과, 성별 제한 효과, 주요 유전자 효과 및 분리 패턴의 존재에 대한 테스트가 포함되었습니다. 운동 훈련에 대한 반응의 유전적 기초에 관한 가설을 개발하기 위해 다변량 유전 분석 및 복합 분리 분석이 사용되었습니다.
이 연구는 1997년 9월에 갱신되어 1단계에서 수집된 데이터를 분석했습니다. 데이터 세트에 대해 일련의 비유전적 연구가 수행되었습니다. 앉아 있는 상태와 훈련에 대한 반응에서 심폐 지구력의 최대 및 준최대 지표의 생리학적, 행동적 및 사회적 결정요인을 연령, 성별 및 인종의 기여도를 고려하여 조사했습니다. 연구에서 모니터링된 심혈관 질환 및 비인슐린 의존성 진성 당뇨병(NIDDM) 위험 요인에 대해 유사한 분석이 수행되었습니다. 유전적 분석은 유전 가능성 수준을 결정하고 부계 또는 모계 영향, 주요 유전자 영향 및 지구력 운동에 대한 반응의 유전적 기반에 관한 가설을 개발하는 데 사용된 분리 패턴에 대해 테스트했습니다. 후보 유전자 패널을 타이핑하여 연관 및 연관 연구에 사용했습니다. 지구력 운동에 대한 반응을 위한 새로운 후보 유전자를 식별하기 위해 골격근 전사체의 차등 디스플레이 분석이 사용되었습니다. 마지막으로, 심폐 지구력 및 심혈관 및 NIDDM 위험 인자 표현형의 반응을 위한 후보 게놈 영역 및 위치 후보 유전자를 분리하기 위해 게놈 전체 검색을 수행했습니다.
이 연구는 데이터 분석을 계속하기 위해 4년 동안 2001년에 갱신되었습니다.
연구 유형
중재적
단계
- 해당 없음
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
- 어린이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
아니
연구 대상 성별
모두
설명
자격 기준 없음
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- Claude Bouchard, LSU Pennington Biomedical Research Center
- Arthur Leon, University of Minnesota
- Dabeeru Rao, Washington University School of Medicine
- James Skinner, Indiana University
- Jack Wilmore, Texas A & M Research Foundation
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Skinner JS, Jaskolski A, Jaskolska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C; HERITAGE Family Study. Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol (1985). 2001 May;90(5):1770-6. doi: 10.1152/jappl.2001.90.5.1770.
- Couillard C, Despres JP, Lamarche B, Bergeron J, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1226-32. doi: 10.1161/hq0701.092137.
- Wilmore JH, Green JS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Bouchard C. Relationship of changes in maximal and submaximal aerobic fitness to changes in cardiovascular disease and non-insulin-dependent diabetes mellitus risk factors with endurance training: the HERITAGE Family Study. Metabolism. 2001 Nov;50(11):1255-63. doi: 10.1053/meta.2001.27214.
- Todorov AA, Borecki IB, Rao DC. Linkage analysis of complex traits using affected sibpairs: effects of single-locus approximations on estimates of the required sample size. Genet Epidemiol. 1997;14(4):389-401. doi: 10.1002/(SICI)1098-2272(1997)14:43.0.CO;2-Z.
- Todorov AA, Province MA, Borecki IB, Rao DC. Trade-off between sibship size and sampling scheme for detecting quantitative trait loci. Hum Hered. 1997 Jan-Feb;47(1):1-5. doi: 10.1159/000154381.
- Gu C, Todorov A, Rao DC. Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci. Genet Epidemiol. 1996;13(6):513-33. doi: 10.1002/(SICI)1098-2272(1996)13:63.0.CO;2-1.
- Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J. The HERITAGE family study. Aims, design, and measurement protocol. Med Sci Sports Exerc. 1995 May;27(5):721-9.
- Li Z. A multiplicative random effects model for meta-analysis with application to estimation of admixture component. Biometrics. 1995 Sep;51(3):864-73.
- Li Z, Bonney GE, Lathrop GM, Rao DC. Genetic analysis combining path analysis with regressive models: the TAU model of multifactorial transmission. Hum Hered. 1994 Nov-Dec;44(6):305-11. doi: 10.1159/000154236.
- Rivera MA, Dionne FT, Simoneau JA, Perusse L, Chagnon M, Chagnon Y, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Muscle-specific creatine kinase gene polymorphism and VO2max in the HERITAGE Family Study. Med Sci Sports Exerc. 1997 Oct;29(10):1311-7. doi: 10.1097/00005768-199710000-00006.
- Gu C, Borecki I, Gagnon J, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC. Familial resemblance for resting blood pressure with particular reference to racial differences: preliminary analyses from the HERITAGE Family Study. Hum Biol. 1998 Feb;70(1):77-90.
- Daw EW, Province MA, Gagnon J, Despres JP, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC. Reproducibility of the HERITAGE Family Study intervention protocol: drift over time. Ann Epidemiol. 1997 Oct;7(7):452-62. doi: 10.1016/s1047-2797(97)00082-3.
- Gagnon J, Ho-Kim MA, Chagnon YC, Perusse L, Dionne T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Absence of linkage between VO2max and its response to training with markers spanning chromosome 22. Med Sci Sports Exerc. 1997 Nov;29(11):1448-53. doi: 10.1097/00005768-199711000-00010.
- Perusse L, Rice T, Despres JP, Bergeron J, Province MA, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3263-9. doi: 10.1161/01.atv.17.11.3263.
- An P, Rice T, Gagnon J, Hong Y, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. A genetic study of dehydroepiandrosterone sulfate measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study. Metabolism. 2000 Mar;49(3):298-304. doi: 10.1016/s0026-0495(00)90044-1.
- Wilmore JH, Stanforth PR, Gagnon J, Leon AS, Rao DC, Skinner JS, Bouchard C. Endurance exercise training has a minimal effect on resting heart rate: the HERITAGE Study. Med Sci Sports Exerc. 1996 Jul;28(7):829-35. doi: 10.1097/00005768-199607000-00009.
- Gagnon J, Province MA, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC. The HERITAGE Family Study: quality assurance and quality control. Ann Epidemiol. 1996 Nov;6(6):520-9. doi: 10.1016/s1047-2797(96)00068-3.
- Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP, Bouchard C. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. J Clin Endocrinol Metab. 2000 Mar;85(3):1026-31. doi: 10.1210/jcem.85.3.6427.
- Skinner JS, Wilmore KM, Krasnoff JB, Jaskolski A, Jaskolska A, Gagnon J, Province MA, Leon AS, Rao DC, Wilmore JH, Bouchard C. Adaptation to a standardized training program and changes in fitness in a large, heterogeneous population: the HERITAGE Family Study. Med Sci Sports Exerc. 2000 Jan;32(1):157-61. doi: 10.1097/00005768-200001000-00023.
- Chagnon YC, Wilmore JH, Borecki IB, Gagnon J, Perusse L, Chagnon M, Collier GR, Leon AS, Skinner JS, Rao DC, Bouchard C. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab. 2000 Jan;85(1):29-34. doi: 10.1210/jcem.85.1.6263.
- Skinner JS, Wilmore KM, Jaskolska A, Jaskolski A, Daw EW, Rice T, Gagnon J, Leon AS, Wilmore JH, Rao DC, Bouchard C. Reproducibility of maximal exercise test data in the HERITAGE family study. Med Sci Sports Exerc. 1999 Nov;31(11):1623-8. doi: 10.1097/00005768-199911000-00020.
- Rice T, Hong Y, Perusse L, Despres JP, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Total body fat and abdominal visceral fat response to exercise training in the HERITAGE Family Study: evidence for major locus but no multifactorial effects. Metabolism. 1999 Oct;48(10):1278-86. doi: 10.1016/s0026-0495(99)90268-8.
- Rankinen T, Gagnon J, Perusse L, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Body fat, resting and exercise blood pressure and the angiotensinogen M235T polymorphism: the heritage family study. Obes Res. 1999 Sep;7(5):423-30. doi: 10.1002/j.1550-8528.1999.tb00429.x.
- Sun G, Gagnon J, Chagnon YC, Perusse L, Despres JP, Leon AS, Wilmore JH, Skinner JS, Borecki I, Rao DC, Bouchard C. Association and linkage between an insulin-like growth factor-1 gene polymorphism and fat free mass in the HERITAGE Family Study. Int J Obes Relat Metab Disord. 1999 Sep;23(9):929-35. doi: 10.1038/sj.ijo.0801021.
- Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, Perusse L, Leon AS, Rao DC. Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol (1985). 1999 Sep;87(3):1003-8. doi: 10.1152/jappl.1999.87.3.1003.
- Wilmore JH, Despres JP, Stanforth PR, Mandel S, Rice T, Gagnon J, Leon AS, Rao D, Skinner JS, Bouchard C. Alterations in body weight and composition consequent to 20 wk of endurance training: the HERITAGE Family Study. Am J Clin Nutr. 1999 Sep;70(3):346-52. doi: 10.1093/ajcn/70.3.346.
- Rivera MA, Perusse L, Gagnon J, Dionne FT, Leon AS, Rao DC, Skinner JS, Wilmore JH, Sjostrom L, Bouchard C. A mitochondrial DNA D-loop polymorphism and obesity in three cohorts of women. Int J Obes Relat Metab Disord. 1999 Jun;23(6):666-8. doi: 10.1038/sj.ijo.0800900.
- Hong Y, Rice T, Despres JP, Gagnon J, Nadeau A, Bergeron J, Perusse L, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC. Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study. Atherosclerosis. 1999 Jun;144(2):393-401. doi: 10.1016/s0021-9150(98)00324-4.
- Bouchard C, Rankinen T, Chagnon YC, Rice T, Perusse L, Gagnon J, Borecki I, An P, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC. Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. J Appl Physiol (1985). 2000 Feb;88(2):551-9. doi: 10.1152/jappl.2000.88.2.551. Erratum In: J Appl Physiol. 2004 Feb;96(2):829.
- Despres JP, Gagnon J, Bergeron J, Couillard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. HEalth, RIsk factors, exercise Training and GEnetics. Clin Biochem. 1999 Apr;32(3):157-65. doi: 10.1016/s0009-9120(98)00106-4.
- Rivera MA, Perusse L, Simoneau JA, Gagnon J, Dionne FT, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC, Bouchard C. Linkage between a muscle-specific CK gene marker and VO2max in the HERITAGE Family Study. Med Sci Sports Exerc. 1999 May;31(5):698-701. doi: 10.1097/00005768-199905000-00012.
- An P, Rice T, Gagnon J, Borecki IB, Perusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Familial aggregation of resting blood pressure and heart rate in a sedentary population: the HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics. Am J Hypertens. 1999 Mar;12(3):264-70. doi: 10.1016/s0895-7061(98)00261-1.
- Stanforth PR, Ruthven MD, Gagnon J, Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH. Accuracy of prediction equations to estimate submaximal VO2 during cycle ergometry: the HERITAGE Family Study. Med Sci Sports Exerc. 1999 Jan;31(1):183-8. doi: 10.1097/00005768-199901000-00028.
- Hong Y, Rice T, Gagnon J, Despres JP, Nadeau A, Perusse L, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC. Familial clustering of insulin and abdominal visceral fat: the HERITAGE Family Study. J Clin Endocrinol Metab. 1998 Dec;83(12):4239-45. doi: 10.1210/jcem.83.12.5312.
- Wilmore JH, Stanforth PR, Hudspeth LA, Gagnon J, Daw EW, Leon AS, Rao DC, Skinner JS, Bouchard C. Alterations in resting metabolic rate as a consequence of 20 wk of endurance training: the HERITAGE Family Study. Am J Clin Nutr. 1998 Jul;68(1):66-71. doi: 10.1093/ajcn/68.1.66.
- Wilmore JH, Stanforth PR, Turley KR, Gagnon J, Daw EW, Leon AS, Rao DC, Skinner JS, Bouchard C. Reproducibility of cardiovascular, respiratory, and metabolic responses to submaximal exercise: the HERITAGE Family Study. Med Sci Sports Exerc. 1998 Feb;30(2):259-65. doi: 10.1097/00005768-199802000-00014.
- Bouchard C, Daw EW, Rice T, Perusse L, Gagnon J, Province MA, Leon AS, Rao DC, Skinner JS, Wilmore JH. Familial resemblance for VO2max in the sedentary state: the HERITAGE family study. Med Sci Sports Exerc. 1998 Feb;30(2):252-8. doi: 10.1097/00005768-199802000-00013.
- An P, Rice T, Perusse L, Borecki IB, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Complex segregation analysis of blood pressure and heart rate measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study. Am J Hypertens. 2000 May;13(5 Pt 1):488-97. doi: 10.1016/s0895-7061(99)00275-7.
- Leon AS, Rice T, Mandel S, Despres JP, Bergeron J, Gagnon J, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. Metabolism. 2000 Apr;49(4):513-20. doi: 10.1016/s0026-0495(00)80018-9.
- Li Z, Bonney GE, Rao DC. Genetic analysis combining path analysis with regressive models: the BETA path model of polygenic and familial environmental transmission. Genet Epidemiol. 1994;11(5):431-42. doi: 10.1002/gepi.1370110505.
- Garenc C, Perusse L, Gagnon J, Chagnon YC, Bergeron J, Despres JP, Province MA, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations: the HERITAGE Family Study. Metabolism. 2000 Apr;49(4):432-9. doi: 10.1016/s0026-0495(00)80004-9.
- An P, Rice T, Gagnon J, Borecki IB, Bergeron J, Despres JP, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Segregation analysis of apolipoproteins A-1 and B-100 measured before and after an exercise training program: the HERITAGE Family Study. Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):807-14. doi: 10.1161/01.atv.20.3.807.
- Rankinen T, Perusse L, Gagnon J, Chagnon YC, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Angiotensin-converting enzyme ID polymorphism and fitness phenotype in the HERITAGE Family Study. J Appl Physiol (1985). 2000 Mar;88(3):1029-35. doi: 10.1152/jappl.2000.88.3.1029.
- Rankinen T, Rice T, Perusse L, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study. Hypertension. 2000 Nov;36(5):885-9. doi: 10.1161/01.hyp.36.5.885.
- An P, Rice T, Gagnon J, Hong Y, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. A genetic study of sex hormone--binding globulin measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study. Metabolism. 2000 Aug;49(8):1014-20. doi: 10.1053/meta.2000.7737.
- Hong Y, Rice T, Gagnon J, Perusse L, Province M, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC, Despres JP. Familiality of triglyceride and LPL response to exercise training: the HERITAGE study. Med Sci Sports Exerc. 2000 Aug;32(8):1438-44. doi: 10.1097/00005768-200008000-00012.
- Stanforth PR, Gagnon J, Rice T, Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH. Reproducibility of resting blood pressure and heart rate measurements. The HERITAGE Family Study. Ann Epidemiol. 2000 Jul;10(5):271-7. doi: 10.1016/s1047-2797(00)00047-8.
- Despres JP, Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1932-8. doi: 10.1161/01.atv.20.8.1932.
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- Feitosa MF, Rice T, Rosmond R, Borecki IB, An P, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. A genetic study of cortisol measured before and after endurance training: the HERITAGE Family Study. Metabolism. 2002 Mar;51(3):360-5. doi: 10.1053/meta.2002.30519.
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- Leon AS, Gaskill SE, Rice T, Bergeron J, Gagnon J, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study. Int J Sports Med. 2002 Jan;23(1):1-9. doi: 10.1055/s-2002-19270.
- An P, Rice T, Gagnon J, Borecki IB, Rankinen T, Gu C, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: the HERITAGE Family Study. Am J Hum Biol. 2001 Nov-Dec;13(6):832-7. doi: 10.1002/ajhb.1128.
- Bergeron J, Couillard C, Despres JP, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study. Atherosclerosis. 2001 Dec;159(2):399-406. doi: 10.1016/s0021-9150(01)00515-9.
- Gaskill SE, Walker AJ, Serfass RA, Bouchard C, Gagnon J, Rao DC, Skinner JS, Wilmore JH, Leon AS. Changes in ventilatory threshold with exercise training in a sedentary population: the HERITAGE Family Study. Int J Sports Med. 2001 Nov;22(8):586-92. doi: 10.1055/s-2001-18522.
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- Rice T, Chagnon YC, Borecki IB, Perusse L, Collier G, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Familial resemblance for plasma leptin: sample homogeneity across adiposity and ethnic groups. Obes Res. 2002 May;10(5):351-60. doi: 10.1038/oby.2002.49.
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- Rankinen T, An P, Perusse L, Rice T, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study. Physiol Genomics. 2002 Aug 14;10(2):57-62. doi: 10.1152/physiolgenomics.00043.2002.
- Ukkola O, Rankinen T, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study. J Clin Endocrinol Metab. 2002 Aug;87(8):3708-20. doi: 10.1210/jcem.87.8.8725.
- Garenc C, Perusse L, Chagnon YC, Rankinen T, Gagnon J, Borecki IB, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Mol Med. 2002 Feb;8(2):88-94.
- Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Bouchard C, Wilmore JH. The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study. Int J Obes Relat Metab Disord. 2002 Jun;26(6):789-96. doi: 10.1038/sj.ijo.0802006.
- Jacobson P, Ukkola O, Rankinen T, Snyder EE, Leon AS, Rao DC, Skinner JS, Wilmore JH, Lonn L, Cowan GS Jr, Sjostrom L, Bouchard C. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab. 2002 Oct;87(10):4442-6. doi: 10.1210/jc.2002-020568.
- Feitosa MF, Borecki IB, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Lack of pleiotropic genetic effects between adiposity and sex hormone-binding globulin concentrations before and after 20 weeks of exercise training: the HERITAGE family study. Metabolism. 2003 Jan;52(1):35-41. doi: 10.1053/meta.2003.50004.
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- Ukkola O, Rankinen T, Rice T, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C; HERITAGE Family Study. Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat and abdominal fat level in the HERITAGE Family Study. Int J Obes Relat Metab Disord. 2003 Mar;27(3):389-93. doi: 10.1038/sj.ijo.0802248.
- An P, Hong Y, Weisnagel SJ, Rice T, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Chagnon YC, Bergman RN, Bouchard C, Rao DC. Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study. Metabolism. 2003 Feb;52(2):246-53. doi: 10.1053/meta.2003.50030.
- Argyropoulos G, Rankinen T, Bai F, Rice T, Province MA, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. The agouti-related protein and body fatness in humans. Int J Obes Relat Metab Disord. 2003 Feb;27(2):276-80. doi: 10.1038/sj.ijo.802201.
- An P, Perusse L, Rankinen T, Borecki IB, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Familial aggregation of exercise heart rate and blood pressure in response to 20 weeks of endurance training: the HERITAGE family study. Int J Sports Med. 2003 Jan;24(1):57-62. doi: 10.1055/s-2003-37200.
- Rico-Sanz J, Rankinen T, Joanisse DR, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C; HERITAGE Family study. Associations between cardiorespiratory responses to exercise and the C34T AMPD1 gene polymorphism in the HERITAGE Family Study. Physiol Genomics. 2003 Jul 7;14(2):161-6. doi: 10.1152/physiolgenomics.00165.2002.
- Rankinen T, Rice T, Boudreau A, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study. Physiol Genomics. 2003 Sep 29;15(1):27-33. doi: 10.1152/physiolgenomics.00147.2002.
- Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C; Heritage Family Study. A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study. Diabetes. 2003 Jun;52(6):1583-7. doi: 10.2337/diabetes.52.6.1583.
- An P, Borecki IB, Rankinen T, Perusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Evidence of major genes for exercise heart rate and blood pressure at baseline and in response to 20 weeks of endurance training: the HERITAGE family study. Int J Sports Med. 2003 Oct;24(7):492-8. doi: 10.1055/s-2003-42011.
- Leon AS, Togashi K, Rankinen T, Despres JP, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study. Metabolism. 2004 Jan;53(1):108-16. doi: 10.1016/j.metabol.2003.08.013.
- Loos RJ, Katzmarzyk PT, Rao DC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rankinen T, Bouchard C; HERITAGE Family Study. Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study. J Clin Endocrinol Metab. 2003 Dec;88(12):5935-43. doi: 10.1210/jc.2003-030553.
- Couillard C, Bergeron J, Despres JP, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Apolipoprotein AI- and AI:AII-containing lipoproteins in white men and women of the HERITAGE Family study: Associations with metabolic risk profile variables. Metabolism. 2003 Dec;52(12):1530-6. doi: 10.1016/j.metabol.2003.07.003.
- Desmeules A, Couillard C, Tchernof A, Bergeron J, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP, Bouchard C. Post-heparin lipolytic enzyme activities, sex hormones and sex hormone-binding globulin (SHBG) in men and women: The HERITAGE Family Study. Atherosclerosis. 2003 Dec;171(2):343-50. doi: 10.1016/j.atherosclerosis.2003.08.018.
- Rico-Sanz J, Rankinen T, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study. Physiol Genomics. 2004 Jan 15;16(2):256-60. doi: 10.1152/physiolgenomics.00035.2003.
- Skinner JS, Gaskill SE, Rankinen T, Leon AS, Rao DC, Wilmore JH, Bouchard C. Heart rate versus %VO2max: age, sex, race, initial fitness, and training response--HERITAGE. Med Sci Sports Exerc. 2003 Nov;35(11):1908-13. doi: 10.1249/01.MSS.0000093607.57995.E3. Erratum In: Med Sci Sports Exerc. 2004 Feb;36(2):348.
- Katzmarzyk PT, Leon AS, Wilmore JH, Skinner JS, Rao DC, Rankinen T, Bouchard C. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc. 2003 Oct;35(10):1703-9. doi: 10.1249/01.MSS.0000089337.73244.9B.
- Rico-Sanz J, Rankinen T, Joanisse DR, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C; HERITAGE Family Study. Familial resemblance for muscle phenotypes in the HERITAGE Family Study. Med Sci Sports Exerc. 2003 Aug;35(8):1360-6. doi: 10.1249/01.MSS.0000079031.22755.63. Erratum In: Med Sci Sports Exerc. 2005 Nov;37(11):2017.
- Simonen RL, Rankinen T, Perusse L, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. A dopamine D2 receptor gene polymorphism and physical activity in two family studies. Physiol Behav. 2003 Apr;78(4-5):751-7. doi: 10.1016/s0031-9384(03)00084-2.
- Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Lakka HM, Ukkola O, Boule N, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Bouchard C. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes. 2004 Jun;53(6):1603-8. doi: 10.2337/diabetes.53.6.1603.
- Stanforth PR, Jackson AS, Green JS, Gagnon J, Rankinen T, Despres JP, Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH. Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: the HERITAGE Family Study. Int J Obes Relat Metab Disord. 2004 Jul;28(7):925-32. doi: 10.1038/sj.ijo.0802563.
- Bai F, Rankinen T, Charbonneau C, Belsham DD, Rao DC, Bouchard C, Argyropoulos G. Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium. J Med Genet. 2004 May;41(5):350-3. doi: 10.1136/jmg.2003.014092.
- Collaku A, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. Am J Clin Nutr. 2004 May;79(5):881-6. doi: 10.1093/ajcn/79.5.881.
- Sklan EH, Lowenthal A, Korner M, Ritov Y, Landers DM, Rankinen T, Bouchard C, Leon AS, Rice T, Rao DC, Wilmore JH, Skinner JS, Soreq H. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5512-7. doi: 10.1073/pnas.0307659101. Epub 2004 Apr 1.
- Janssen I, Katzmarzyk PT, Ross R, Leon AS, Skinner JS, Rao DC, Wilmore JH, Rankinen T, Bouchard C. Fitness alters the associations of BMI and waist circumference with total and abdominal fat. Obes Res. 2004 Mar;12(3):525-37. doi: 10.1038/oby.2004.60.
- Feitosa MF, Borecki IB, Rankinen T, Rice T, Despres JP, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Bouchard C, Province MA, Rao DC. Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study. J Lipid Res. 2005 Feb;46(2):281-6. doi: 10.1194/jlr.M400252-JLR200. Epub 2004 Dec 1.
- Green JS, Stanforth PR, Rankinen T, Leon AS, Rao Dc Dc, Skinner JS, Bouchard C, Wilmore JH. The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family study. Metabolism. 2004 Sep;53(9):1192-6. doi: 10.1016/j.metabol.2004.04.008.
- Loos RJ, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study. J Nutr. 2004 Jul;134(7):1772-8. doi: 10.1093/jn/134.7.1772.
- Boule NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C; HERITAGE Family Study. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care. 2005 Jan;28(1):108-14. doi: 10.2337/diacare.28.1.108.
- Ardern CI, Katzmarzyk PT, Janssen I, Leon AS, Wilmore JH, Skinner JS, Rao DC, Despres JP, Rankinen T, Bouchard C. Race and sex similarities in exercise-induced changes in blood lipids and fatness. Med Sci Sports Exerc. 2004 Sep;36(9):1610-5. doi: 10.1249/01.mss.0000139798.54405.af.
- Teran-Garcia M, Rankinen T, Koza RA, Rao DC, Bouchard C. Endurance training-induced changes in insulin sensitivity and gene expression. Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1168-78. doi: 10.1152/ajpendo.00467.2004. Epub 2005 Feb 1.
- Ukkola O, Rankinen T, Lakka T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Kesaniemi YA, Bouchard C. Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. Obes Res. 2005 May;13(5):829-34. doi: 10.1038/oby.2005.95.
- An P, Teran-Garcia M, Rice T, Rankinen T, Weisnagel SJ, Bergman RN, Boston RC, Mandel S, Stefanovski D, Leon AS, Skinner JS, Rao DC, Bouchard C; HERITAGE Family Study. Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study. Diabetologia. 2005 Jun;48(6):1142-9. doi: 10.1007/s00125-005-1769-4. Epub 2005 May 3.
- Feitosa MF, Rice T, Rankinen T, Almasy L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Common genetic and environmental effects on lipid phenotypes: the HERITAGE family study. Hum Hered. 2005;59(1):34-40. doi: 10.1159/000084735.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작
1992년 7월 1일
기본 완료 (실제)
2005년 8월 1일
연구 완료 (실제)
2005년 8월 1일
연구 등록 날짜
최초 제출
2000년 5월 25일
QC 기준을 충족하는 최초 제출
2000년 5월 25일
처음 게시됨 (추정)
2000년 5월 26일
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
2014년 5월 29일
QC 기준을 충족하는 마지막 업데이트 제출
2014년 5월 27일
마지막으로 확인됨
2014년 5월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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