환경 및 생식 건강; 비스페놀 A, 프탈레이트, 생식력 및 임신 결과에 대한 인체 노출 (EARTH)
2020년 9월 9일 업데이트: Russ Hauser, National Institute of Environmental Health Sciences (NIEHS)
비스페놀 A, 프탈레이트 및 생식력에 대한 인체 노출, 임신 결과.
연구의 목적은 환경 인자와 생식 건강 사이의 관계를 조사하는 것입니다.
관심 있는 환경 인자에는 폴리염화 비페닐(PCB), 난연제, 다이옥신, 비스페놀 A, 프탈레이트, 살충제, 납 및 카드뮴과 같은 금속과 같은 화학 물질에 대한 노출이 포함됩니다.
우리는 또한 생식 건강과 환경적 담배 연기에 대한 노출과 같은 생활 방식 위험 요소 사이의 관계에 관심이 있습니다.
등록자는 MGH Fertility Center의 환자로서 자연적으로 또는 자궁내 수정(IUI) 및/또는 체외 수정(IVF)을 통해 임신을 시도하는 환자이기 때문에 이 연구에 참여하도록 요청받았습니다.
연구 개요
상세 설명
특정 목표 #1: 프탈레이트 대사물질, BPA 및 파라벤의 부계 소변 농도의 혼합과 착상 실패 및 정상 출산의 1차 결과, 그리고 화학적 임신(후속 임상 임신 없음) 및 자연 발생의 2차 결과와의 연관성을 결정하기 위해 낙태.
가설 1: DEHP, DBP, DiBP, BBzP 및 DiNP의 항안드로겐성 프탈레이트 대사물질 혼합물의 부계 소변 농도가 높을수록 착상 실패 위험 증가 및 출생률 감소, 화학적 임신 및 자연유산 위험 증가와 관련이 있습니다. .
가설 2: 에스트로겐 화학물질(BPA 및 파라벤) 혼합물의 부계 소변 농도가 높을수록 착상 실패 위험 증가, 정상 출생률 감소, 화학적 임신 및 자연유산 위험 증가와 관련이 있습니다.
특정 목표 #2: 프탈레이트 대사물질, BPA 및 파라벤의 산모의 소변 농도 혼합물과 착상 실패 및 정상 출산율, 그리고 화학적 임신 및 자연 유산의 이차 결과와의 연관성을 결정합니다.
가설 2: DEHP, DBP, DiBP, BBzP 및 DiNP의 항안드로겐성 프탈레이트 대사산물 혼합물의 모체 소변 농도가 높을수록 착상 실패 위험 증가 및 출생률 감소, 화학적 임신 및 자연유산 위험 증가와 관련이 있습니다. .
가설 3: 에스트로겐성 BPA와 파라벤 혼합물의 모계 소변 농도가 높을수록 착상 실패 위험 증가, 정상 출생률 감소, 화학적 임신 및 자연 유산 위험 증가와 관련이 있습니다.
특정 목표 #3: 프탈레이트 대사산물, BPA 및 파라벤의 산모 및 부계 소변 농도의 공동 효과를 결정하기 위해 착상 실패 및 출생률을 포함한 주요 관심 결과와 화학적 임신 및 자연 유산의 이차 결과를 확인합니다.
연구 유형
관찰
등록 (실제)
1474
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
-
-
Massachusetts
-
Boston, Massachusetts, 미국, 02115
- Harvard School of Public Health
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 (성인)
건강한 자원 봉사자를 받아들입니다
예
연구 대상 성별
모두
샘플링 방법
비확률 샘플
연구 인구
연구 대상자는 MGH IVF 클리닉에서 불임 치료를 원하는 부부 중에서 모집됩니다.
연구에 참여하려면 남성과 여성이 18세 이상이어야 합니다.
설명
포함 기준:
- MGH클리닉에서 불임 치료를 받고 있는 부부들
- 18-55세 남성
- 18세 - 45세 여성
제외 기준:
1. MGH클리닉에서 불임 치료를 받고 있지 않거나 연령대가 아닌 개인 또는 부부.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
|---|---|
|
불임 환자
Massachusetts General Hospital Infertility Clinic에서 불임 치료를 받고 있는 환자.
|
참가자는 등록 시 기본 인터뷰를 완료한 다음 라이프스타일 및 병력에 대한 온라인 설문지를 작성합니다.
다이어트 설문지는 집에서 작성하여 다시 우편으로 보냅니다.
개인 관리 제품 사용 및 약물에 관한 온라인 설문지는 각 예정된 연구 방문에서 완료됩니다.
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
환경 화학 물질에 대한 아버지의 노출
기간: 2019년
|
프탈레이트 대사물질, BPA 및 파라벤의 부계 소변 농도의 혼합과 착상 실패 및 정상 출산의 1차 결과, 화학적 임신(후속 임상 임신 없음) 및 자연 유산의 2차 결과와의 연관성을 결정합니다.
|
2019년
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
환경 화학물질에 대한 산모의 노출
기간: 2019년
|
프탈레이트 대사 산물, BPA 및 파라벤의 산모의 소변 농도 혼합물과 착상 실패 및 출생률, 그리고 화학적 임신 및 자연 유산의 이차 결과와의 연관성을 결정합니다.
|
2019년
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: Russ Hauser, MD, ScD, MPH, Harvard School of Public Health (HSPH)
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Hauser R, Gaskins AJ, Souter I, Smith KW, Dodge LE, Ehrlich S, Meeker JD, Calafat AM, Williams PL; EARTH Study Team. Urinary Phthalate Metabolite Concentrations and Reproductive Outcomes among Women Undergoing in Vitro Fertilization: Results from the EARTH Study. Environ Health Perspect. 2016 Jun;124(6):831-9. doi: 10.1289/ehp.1509760. Epub 2015 Nov 6.
- Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Penzias A, Missmer SA, Chavarro JE. Prepregnancy dietary patterns and risk of pregnancy loss. Am J Clin Nutr. 2014 Oct;100(4):1166-72. doi: 10.3945/ajcn.114.083634. Epub 2014 Aug 13.
- Meeker JD, Singh NP, Hauser R. Serum concentrations of estradiol and free T4 are inversely correlated with sperm DNA damage in men from an infertility clinic. J Androl. 2008 Jul-Aug;29(4):379-88. doi: 10.2164/jandrol.107.004416. Epub 2008 Mar 20.
- Chavarro JE, Toth TL, Sadio SM, Hauser R. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Hum Reprod. 2008 Nov;23(11):2584-90. doi: 10.1093/humrep/den243. Epub 2008 Jul 23.
- Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010 May 1;93(7):2222-31. doi: 10.1016/j.fertnstert.2009.01.100. Epub 2009 Mar 3.
- Meeker JD, Missmer SA, Altshul L, Vitonis AF, Ryan L, Cramer DW, Hauser R. Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies. Environ Health. 2009 Jul 14;8:32. doi: 10.1186/1476-069X-8-32.
- Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, Ye X, Hauser R. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl. 2010 Apr;33(2):385-93. doi: 10.1111/j.1365-2605.2009.01014.x. Epub 2009 Nov 30.
- Meeker JD, Calafat AM, Hauser R. Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic. Environ Sci Technol. 2010 Feb 15;44(4):1458-63. doi: 10.1021/es9028292.
- Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, Ye X, Hauser R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol. 2010 Dec;30(4):532-9. doi: 10.1016/j.reprotox.2010.07.005. Epub 2010 Jul 23.
- Chavarro JE, Furtado J, Toth TL, Ford J, Keller M, Campos H, Hauser R. Trans-fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic. Fertil Steril. 2011 Apr;95(5):1794-7. doi: 10.1016/j.fertnstert.2010.10.039. Epub 2010 Nov 11.
- Braun JM, Smith KW, Williams PL, Calafat AM, Berry K, Ehrlich S, Hauser R. Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy. Environ Health Perspect. 2012 May;120(5):739-45. doi: 10.1289/ehp.1104139. Epub 2012 Jan 19. Erratum In: Environ Health Perspect. 2013 Apr;121(4):A114-5.
- Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod. 2012 May;27(5):1466-74. doi: 10.1093/humrep/des065. Epub 2012 Mar 13.
- Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, Calafat AM, Ye X, Petrozza JC, Wright D, Hauser R. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect. 2012 Jul;120(7):978-83. doi: 10.1289/ehp.1104307. Epub 2012 Apr 6.
- Chavarro JE, Ehrlich S, Colaci DS, Wright DL, Toth TL, Petrozza JC, Hauser R. Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction. Fertil Steril. 2012 Jul;98(1):109-16. doi: 10.1016/j.fertnstert.2012.04.012. Epub 2012 May 16.
- Ferguson KK, Hauser R, Altshul L, Meeker JD. Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age. Reprod Toxicol. 2012 Nov;34(3):429-35. doi: 10.1016/j.reprotox.2012.04.006. Epub 2012 May 5.
- Meeker JD, Calafat AM, Hauser R. Urinary phthalate metabolites and their biotransformation products: predictors and temporal variability among men and women. J Expo Sci Environ Epidemiol. 2012 Jul;22(4):376-85. doi: 10.1038/jes.2012.7. Epub 2012 Feb 22.
- Smith KW, Braun JM, Williams PL, Ehrlich S, Correia KF, Calafat AM, Ye X, Ford J, Keller M, Meeker JD, Hauser R. Predictors and variability of urinary paraben concentrations in men and women, including before and during pregnancy. Environ Health Perspect. 2012 Nov;120(11):1538-43. doi: 10.1289/ehp.1104614. Epub 2012 Jun 21.
- Colaci DS, Afeiche M, Gaskins AJ, Wright DL, Toth TL, Tanrikut C, Hauser R, Chavarro JE. Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil Steril. 2012 Nov;98(5):1193-9.e1. doi: 10.1016/j.fertnstert.2012.07.1102. Epub 2012 Aug 9.
- Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM, Petrozza JC, Wright D, Hauser R. Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum Reprod. 2012 Dec;27(12):3583-92. doi: 10.1093/humrep/des328. Epub 2012 Sep 26.
- Hernandez-Diaz S, Su YC, Mitchell AA, Kelley KE, Calafat AM, Hauser R. Medications as a potential source of exposure to phthalates among women of childbearing age. Reprod Toxicol. 2013 Jun;37:1-5. doi: 10.1016/j.reprotox.2013.01.001. Epub 2013 Jan 18.
- Smith KW, Souter I, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. Urinary paraben concentrations and ovarian aging among women from a fertility center. Environ Health Perspect. 2013 Nov-Dec;121(11-12):1299-305. doi: 10.1289/ehp.1205350. Epub 2013 Aug 2.
- Cantonwine DE, Hauser R, Meeker JD. Bisphenol A and Human Reproductive Health. Expert Rev Obstet Gynecol. 2013 Jul 1;8(4):10.1586/17474108.2013.811939. doi: 10.1586/17474108.2013.811939.
- Ehrlich S, Williams PL, Hauser R, Missmer SA, Peretz J, Calafat AM, Flaws JA. Urinary bisphenol A concentrations and cytochrome P450 19 A1 (Cyp19) gene expression in ovarian granulosa cells: an in vivo human study. Reprod Toxicol. 2013 Dec;42:18-23. doi: 10.1016/j.reprotox.2013.06.071. Epub 2013 Jul 10.
- Braun JM, Just AC, Williams PL, Smith KW, Calafat AM, Hauser R. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):459-66. doi: 10.1038/jes.2013.69. Epub 2013 Oct 23.
- Machtinger R, Combelles CM, Missmer SA, Correia KF, Williams P, Hauser R, Racowsky C. Bisphenol-A and human oocyte maturation in vitro. Hum Reprod. 2013 Oct;28(10):2735-45. doi: 10.1093/humrep/det312. Epub 2013 Jul 30.
- Souter I, Smith KW, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. Reprod Toxicol. 2013 Dec;42:224-31. doi: 10.1016/j.reprotox.2013.09.008. Epub 2013 Oct 4.
- Afeiche MC, Bridges ND, Williams PL, Gaskins AJ, Tanrikut C, Petrozza JC, Hauser R, Chavarro JE. Dairy intake and semen quality among men attending a fertility clinic. Fertil Steril. 2014 May;101(5):1280-7. doi: 10.1016/j.fertnstert.2014.02.003. Epub 2014 Mar 14.
- Afeiche MC, Gaskins AJ, Williams PL, Toth TL, Wright DL, Tanrikut C, Hauser R, Chavarro JE. Processed meat intake is unfavorably and fish intake favorably associated with semen quality indicators among men attending a fertility clinic. J Nutr. 2014 Jul;144(7):1091-8. doi: 10.3945/jn.113.190173. Epub 2014 May 21.
- Gaskins AJ, Afeiche MC, Hauser R, Williams PL, Gillman MW, Tanrikut C, Petrozza JC, Chavarro JE. Paternal physical and sedentary activities in relation to semen quality and reproductive outcomes among couples from a fertility center. Hum Reprod. 2014 Nov;29(11):2575-82. doi: 10.1093/humrep/deu212. Epub 2014 Aug 27.
- Gaskins AJ, Afeiche MC, Wright DL, Toth TL, Williams PL, Gillman MW, Hauser R, Chavarro JE. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet Gynecol. 2014 Oct;124(4):801-809. doi: 10.1097/AOG.0000000000000477.
- Minguez-Alarcon L, Afeiche MC, Williams PL, Arvizu M, Tanrikut C, Amarasiriwardena CJ, Ford JB, Hauser R, Chavarro JE; Earth Study Team. Hair mercury (Hg) levels, fish consumption and semen parameters among men attending a fertility center. Int J Hyg Environ Health. 2018 Mar;221(2):174-182. doi: 10.1016/j.ijheh.2017.10.014. Epub 2017 Oct 28.
- Messerlian C, Mustieles V, Minguez-Alarcon L, Ford JB, Calafat AM, Souter I, Williams PL, Hauser R; Environment and Reproductive Health (EARTH) Study Team. Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study. Environ Int. 2018 May;114:60-68. doi: 10.1016/j.envint.2018.02.017. Epub 2018 Feb 22.
- Chiu YH, Williams PL, Gillman MW, Gaskins AJ, Minguez-Alarcon L, Souter I, Toth TL, Ford JB, Hauser R, Chavarro JE; EARTH Study Team. Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology. JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.
- Chiu YH, Karmon AE, Gaskins AJ, Arvizu M, Williams PL, Souter I, Rueda BR, Hauser R, Chavarro JE; EARTH Study Team. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Hum Reprod. 2018 Jan 1;33(1):156-165. doi: 10.1093/humrep/dex335.
- Segal TR, Minguez-Alarcon L, Chiu YH, Williams PL, Nassan FL, Dadd R, Ospina M, Calafat AM, Hauser R; Earth Study Team. Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center. Hum Reprod. 2017 Dec 1;32(12):2532-2539. doi: 10.1093/humrep/dex327.
- Messerlian C, Mustieles V, Wylie BJ, Ford JB, Keller M, Ye X, Calafat AM, Williams PL, Hauser R; Environment Team Reproductive Health Study. Ultrasound gel as an unrecognized source of exposure to phthalates and phenols among pregnant women undergoing routine scan. Int J Hyg Environ Health. 2017 Nov;220(8):1285-1294. doi: 10.1016/j.ijheh.2017.08.003. Epub 2017 Aug 14.
- Messerlian C, Braun JM, Minguez-Alarcon L, Williams PL, Ford JB, Mustieles V, Calafat AM, Souter I, Toth T, Hauser R; Environment and Reproductive Health (EARTH) Study Team. Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples. Environ Int. 2017 Oct;107:55-64. doi: 10.1016/j.envint.2017.06.015. Epub 2017 Jun 27.
- Messerlian C, Bellinger D, Minguez-Alarcon L, Romano ME, Ford JB, Williams PL, Calafat AM, Hauser R, Braun JM. Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior. Environ Res. 2017 Oct;158:720-728. doi: 10.1016/j.envres.2017.07.032. Epub 2017 Jul 21.
- Souter I, Chiu YH, Batsis M, Afeiche MC, Williams PL, Hauser R, Chavarro JE; EARTH Study Team. The association of protein intake (amount and type) with ovarian antral follicle counts among infertile women: results from the EARTH prospective study cohort. BJOG. 2017 Sep;124(10):1547-1555. doi: 10.1111/1471-0528.14630. Epub 2017 Apr 10.
- Abadia L, Chiu YH, Williams PL, Toth TL, Souter I, Hauser R, Chavarro JE, Gaskins AJ; EARTH Study Team. The association between pre-treatment maternal alcohol and caffeine intake and outcomes of assisted reproduction in a prospectively followed cohort. Hum Reprod. 2017 Sep 1;32(9):1846-1854. doi: 10.1093/humrep/dex237.
- Carignan CC, Minguez-Alarcon L, Butt CM, Williams PL, Meeker JD, Stapleton HM, Toth TL, Ford JB, Hauser R; EARTH Study Team. Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization. Environ Health Perspect. 2017 Aug 25;125(8):087018. doi: 10.1289/EHP1021. Erratum In: Environ Health Perspect. 2017 Nov 01;125(11):119001.
- Minguez-Alarcon L, Christou G, Messerlian C, Williams PL, Carignan CC, Souter I, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic. Fertil Steril. 2017 Aug;108(2):312-319. doi: 10.1016/j.fertnstert.2017.05.020. Epub 2017 Jun 2.
- Tiseo BC, Gaskins AJ, Hauser R, Chavarro JE, Tanrikut C; EARTH Study Team. Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population. Urology. 2017 Apr;102:100-105. doi: 10.1016/j.urology.2016.11.022. Epub 2016 Nov 22.
- Chiu YH, Minguez-Alarcon L, Ford JB, Keller M, Seely EW, Messerlian C, Petrozza J, Williams PL, Ye X, Calafat AM, Hauser R, James-Todd T; for EARTH Study Team. Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic. J Clin Endocrinol Metab. 2017 Apr 1;102(4):1350-1357. doi: 10.1210/jc.2017-00022.
- Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE; Earth Study Team. Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology. 2017 Mar;5(2):354-361. doi: 10.1111/andr.12310. Epub 2017 Feb 10.
- Lewis RC, Minguez-Alarcon L, Meeker JD, Williams PL, Mezei G, Ford JB, Hauser R; EARTH Study Team. Self-reported mobile phone use and semen parameters among men from a fertility clinic. Reprod Toxicol. 2017 Jan;67:42-47. doi: 10.1016/j.reprotox.2016.11.008. Epub 2016 Nov 9.
- Vanegas JC, Chavarro JE, Williams PL, Ford JB, Toth TL, Hauser R, Gaskins AJ. Discrete survival model analysis of a couple's smoking pattern and outcomes of assisted reproduction. Fertil Res Pract. 2017;3:5. doi: 10.1186/s40738-017-0032-2. Epub 2017 Feb 20.
- Lewis RC, Hauser R, Maynard AD, Neitzel RL, Wang L, Kavet R, Morey P, Ford JB, Meeker JD; Earth Study Team. PERSONAL MEASURES OF POWER-FREQUENCY MAGNETIC FIELD EXPOSURE AMONG MEN FROM AN INFERTILITY CLINIC: DISTRIBUTION, TEMPORAL VARIABILITY AND CORRELATION WITH THEIR FEMALE PARTNERS' EXPOSURE. Radiat Prot Dosimetry. 2016 Dec;172(4):401-408. doi: 10.1093/rpd/ncv515. Epub 2015 Dec 24.
- Minguez-Alarcon L, Souter I, Chiu YH, Williams PL, Ford JB, Ye X, Calafat AM, Hauser R; Earth Study Team. Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center. Environ Res. 2016 Nov;151:595-600. doi: 10.1016/j.envres.2016.08.012. Epub 2016 Sep 2.
- Messerlian C, Wylie BJ, Minguez-Alarcon L, Williams PL, Ford JB, Souter IC, Calafat AM, Hauser R; Earth Study Team. Urinary Concentrations of Phthalate Metabolites and Pregnancy Loss Among Women Conceiving with Medically Assisted Reproduction. Epidemiology. 2016 Nov;27(6):879-88. doi: 10.1097/EDE.0000000000000525.
- Gaskins AJ, Williams PL, Keller MG, Souter I, Hauser R, Chavarro JE; EARTH Study Team. Maternal physical and sedentary activities in relation to reproductive outcomes following IVF. Reprod Biomed Online. 2016 Oct;33(4):513-521. doi: 10.1016/j.rbmo.2016.07.002. Epub 2016 Jul 20.
- Minguez-Alarcon L, Gaskins AJ, Chiu YH, Souter I, Williams PL, Calafat AM, Hauser R, Chavarro JE; EARTH Study team. Dietary folate intake and modification of the association of urinary bisphenol A concentrations with in vitro fertilization outcomes among women from a fertility clinic. Reprod Toxicol. 2016 Oct;65:104-112. doi: 10.1016/j.reprotox.2016.07.012. Epub 2016 Jul 14.
- Minguez-Alarcon L, Hauser R, Gaskins AJ. Effects of bisphenol A on male and couple reproductive health: a review. Fertil Steril. 2016 Sep 15;106(4):864-70. doi: 10.1016/j.fertnstert.2016.07.1118. Epub 2016 Aug 4.
- Abadia L, Gaskins AJ, Chiu YH, Williams PL, Keller M, Wright DL, Souter I, Hauser R, Chavarro JE; Environment and Reproductive Health Study Team. Serum 25-hydroxyvitamin D concentrations and treatment outcomes of women undergoing assisted reproduction. Am J Clin Nutr. 2016 Sep;104(3):729-35. doi: 10.3945/ajcn.115.126359. Epub 2016 Jul 27.
- Hu Y, Chiu YH, Hauser R, Chavarro J, Sun Q. Overall and class-specific scores of pesticide residues from fruits and vegetables as a tool to rank intake of pesticide residues in United States: A validation study. Environ Int. 2016 Jul-Aug;92-93:294-300. doi: 10.1016/j.envint.2016.04.028. Epub 2016 Apr 26.
- Gaskins AJ, Chiu YH, Williams PL, Keller MG, Toth TL, Hauser R, Chavarro JE; EARTH Study Team. Maternal whole grain intake and outcomes of in vitro fertilization. Fertil Steril. 2016 Jun;105(6):1503-1510.e4. doi: 10.1016/j.fertnstert.2016.02.015. Epub 2016 Feb 28.
- Xia W, Chiu YH, Afeiche MC, Williams PL, Ford JB, Tanrikut C, Souter I, Hauser R, Chavarro JE; EARTH study team. Impact of men's dairy intake on assisted reproductive technology outcomes among couples attending a fertility clinic. Andrology. 2016 Mar;4(2):277-83. doi: 10.1111/andr.12151. Epub 2016 Jan 29.
- Chavarro JE, Minguez-Alarcon L, Chiu YH, Gaskins AJ, Souter I, Williams PL, Calafat AM, Hauser R; EARTH Study Team. Soy Intake Modifies the Relation Between Urinary Bisphenol A Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction. J Clin Endocrinol Metab. 2016 Mar;101(3):1082-90. doi: 10.1210/jc.2015-3473. Epub 2016 Jan 27.
- Afeiche MC, Chiu YH, Gaskins AJ, Williams PL, Souter I, Wright DL, Hauser R, Chavarro JE; EARTH Study team. Dairy intake in relation to in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod. 2016 Mar;31(3):563-71. doi: 10.1093/humrep/dev344. Epub 2016 Jan 18.
- Minguez-Alarcon L, Chiu YH, Messerlian C, Williams PL, Sabatini ME, Toth TL, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic. Fertil Steril. 2016 Mar;105(3):714-721. doi: 10.1016/j.fertnstert.2015.11.021. Epub 2015 Dec 2.
- Lewis RC, Hauser R, Wang L, Kavet R, Meeker JD. Personal power-frequency magnetic field exposure in women recruited at an infertility clinic: association with physical activity and temporal variability. Radiat Prot Dosimetry. 2016 Mar;168(4):478-88. doi: 10.1093/rpd/ncv365. Epub 2015 Jul 7.
- Messerlian C, Souter I, Gaskins AJ, Williams PL, Ford JB, Chiu YH, Calafat AM, Hauser R; Earth Study Team. Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. Hum Reprod. 2016 Jan;31(1):75-83. doi: 10.1093/humrep/dev292. Epub 2015 Nov 15.
- Braun JM, Gennings C, Hauser R, Webster TF. What Can Epidemiological Studies Tell Us about the Impact of Chemical Mixtures on Human Health? Environ Health Perspect. 2016 Jan;124(1):A6-9. doi: 10.1289/ehp.1510569.
- Lewis RC, Hauser R, Maynard AD, Neitzel RL, Wang L, Kavet R, Meeker JD. Exposure to Power-Frequency Magnetic Fields and the Risk of Infertility and Adverse Pregnancy Outcomes: Update on the Human Evidence and Recommendations for Future Study Designs. J Toxicol Environ Health B Crit Rev. 2016;19(1):29-45. doi: 10.1080/10937404.2015.1134370.
- Dodge LE, Williams PL, Williams MA, Missmer SA, Souter I, Calafat AM, Hauser R; EARTH Study Team. Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment. Reprod Toxicol. 2015 Dec;58:184-93. doi: 10.1016/j.reprotox.2015.09.007. Epub 2015 Oct 9.
- Styer AK, Gaskins AJ, Brady PC, Sluss PM, Chavarro JE, Hauser RB, Toth TL. Dynamic antimullerian hormone levels during controlled ovarian hyperstimulation predict in vitro fertilization response and pregnancy outcomes. Fertil Steril. 2015 Nov;104(5):1153-61.e1-7. doi: 10.1016/j.fertnstert.2015.07.1161. Epub 2015 Aug 24.
- Gaskins AJ, Chiu YH, Williams PL, Ford JB, Toth TL, Hauser R, Chavarro JE; EARTH Study Team. Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015 Oct;102(4):943-50. doi: 10.3945/ajcn.115.112185. Epub 2015 Sep 9.
- Xia W, Chiu YH, Williams PL, Gaskins AJ, Toth TL, Tanrikut C, Hauser R, Chavarro JE. Men's meat intake and treatment outcomes among couples undergoing assisted reproduction. Fertil Steril. 2015 Oct;104(4):972-979. doi: 10.1016/j.fertnstert.2015.06.037. Epub 2015 Jul 20.
- Minguez-Alarcon L, Gaskins AJ, Chiu YH, Williams PL, Ehrlich S, Chavarro JE, Petrozza JC, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod. 2015 Sep;30(9):2120-8. doi: 10.1093/humrep/dev183. Epub 2015 Jul 24.
- Minguez-Alarcon L, Afeiche MC, Chiu YH, Vanegas JC, Williams PL, Tanrikut C, Toth TL, Hauser R, Chavarro JE. Male soy food intake was not associated with in vitro fertilization outcomes among couples attending a fertility center. Andrology. 2015 Jul;3(4):702-8. doi: 10.1111/andr.12046. Epub 2015 Jun 20.
- Dodge LE, Williams PL, Williams MA, Missmer SA, Toth TL, Calafat AM, Hauser R. Paternal Urinary Concentrations of Parabens and Other Phenols in Relation to Reproductive Outcomes among Couples from a Fertility Clinic. Environ Health Perspect. 2015 Jul;123(7):665-71. doi: 10.1289/ehp.1408605. Epub 2015 Mar 13.
- Chiu YH, Afeiche MC, Gaskins AJ, Williams PL, Petrozza JC, Tanrikut C, Hauser R, Chavarro JE. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic. Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30.
- Dodge LE, Kelley KE, Williams PL, Williams MA, Hernandez-Diaz S, Missmer SA, Hauser R. Medications as a source of paraben exposure. Reprod Toxicol. 2015 Apr;52:93-100. doi: 10.1016/j.reprotox.2015.02.002. Epub 2015 Feb 26.
- Vanegas JC, Afeiche MC, Gaskins AJ, Minguez-Alarcon L, Williams PL, Wright DL, Toth TL, Hauser R, Chavarro JE. Soy food intake and treatment outcomes of women undergoing assisted reproductive technology. Fertil Steril. 2015 Mar;103(3):749-55.e2. doi: 10.1016/j.fertnstert.2014.12.104. Epub 2015 Jan 7.
- Wright DL, Afeiche MC, Ehrlich S, Smith K, Williams PL, Chavarro JE, Batsis M, Toth TL, Hauser R. Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic. Reprod Toxicol. 2015 Jan;51:125-132. doi: 10.1016/j.reprotox.2015.01.003. Epub 2015 Jan 17.
- Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ Health Perspect. 2014 Aug;122(8):775-86. doi: 10.1289/ehp.1307728. Epub 2014 Jun 4.
- Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Ginsburg ES, Missmer SA, Chavarro JE. Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Obstet Gynecol. 2014 Jul;124(1):23-31. doi: 10.1097/AOG.0000000000000343.
- Meeker JD, Cooper EM, Stapleton HM, Hauser R. Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health. Endocr Disruptors (Austin). 2013 Oct 1;1(1):e26306. doi: 10.4161/endo.26306.
- Meeker JD, Cooper EM, Stapleton HM, Hauser R. Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environ Health Perspect. 2013 May;121(5):580-5. doi: 10.1289/ehp.1205907. Epub 2013 Mar 5.
- Braun JM, Sathyanarayana S, Hauser R. Phthalate exposure and children's health. Curr Opin Pediatr. 2013 Apr;25(2):247-54. doi: 10.1097/MOP.0b013e32835e1eb6.
- Johnson PI, Stapleton HM, Mukherjee B, Hauser R, Meeker JD. Associations between brominated flame retardants in house dust and hormone levels in men. Sci Total Environ. 2013 Feb 15;445-446:177-84. doi: 10.1016/j.scitotenv.2012.12.017. Epub 2013 Jan 16.
- McAuliffe ME, Williams PL, Korrick SA, Dadd R, Perry MJ. The association between sperm sex chromosome disomy and semen concentration, motility and morphology. Hum Reprod. 2012 Oct;27(10):2918-26. doi: 10.1093/humrep/des302. Epub 2012 Aug 14.
- Mendiola J, Meeker JD, Jorgensen N, Andersson AM, Liu F, Calafat AM, Redmon JB, Drobnis EZ, Sparks AE, Wang C, Hauser R, Swan SH. Urinary concentrations of di(2-ethylhexyl) phthalate metabolites and serum reproductive hormones: pooled analysis of fertile and infertile men. J Androl. 2012 May-Jun;33(3):488-98. doi: 10.2164/jandrol.111.013557. Epub 2011 May 19.
- McAuliffe ME, Williams PL, Korrick SA, Altshul LM, Perry MJ. Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy. Environ Health Perspect. 2012 Apr;120(4):535-40. doi: 10.1289/ehp.1104017. Epub 2011 Dec 21.
- Perry MJ, Chen X, McAuliffe ME, Maity A, Deloid GM. Semi-automated scoring of triple-probe FISH in human sperm: methods and further validation. Cytometry A. 2011 Aug;79(8):661-6. doi: 10.1002/cyto.a.21078. Epub 2011 May 12.
- Meeker JD, Yang T, Ye X, Calafat AM, Hauser R. Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. Environ Health Perspect. 2011 Feb;119(2):252-7. doi: 10.1289/ehp.1002238. Epub 2010 Sep 28.
- Johnson PI, Stapleton HM, Sjodin A, Meeker JD. Relationships between polybrominated diphenyl ether concentrations in house dust and serum. Environ Sci Technol. 2010 Jul 15;44(14):5627-32. doi: 10.1021/es100697q.
- Meeker JD, Stapleton HM. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environ Health Perspect. 2010 Mar;118(3):318-23. doi: 10.1289/ehp.0901332.
- Meeker JD, Johnson PI, Camann D, Hauser R. Polybrominated diphenyl ether (PBDE) concentrations in house dust are related to hormone levels in men. Sci Total Environ. 2009 May 1;407(10):3425-9. doi: 10.1016/j.scitotenv.2009.01.030. Epub 2009 Feb 10.
- Meeker JD, Calafat AM, Hauser R. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl. 2009 May-Jun;30(3):287-97. doi: 10.2164/jandrol.108.006403. Epub 2008 Dec 4.
- Meeker JD, Barr DB, Hauser R. Pyrethroid insecticide metabolites are associated with serum hormone levels in adult men. Reprod Toxicol. 2009 Apr;27(2):155-60. doi: 10.1016/j.reprotox.2008.12.012. Epub 2009 Jan 24.
- Mahalingaiah S, Meeker JD, Pearson KR, Calafat AM, Ye X, Petrozza J, Hauser R. Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environ Health Perspect. 2008 Feb;116(2):173-8. doi: 10.1289/ehp.10605.
- Meeker JD, Ravi SR, Barr DB, Hauser R. Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides. Reprod Toxicol. 2008 Feb;25(2):184-91. doi: 10.1016/j.reprotox.2007.12.005. Epub 2007 Dec 28.
- Meeker JD, Calafat AM, Hauser R. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ Health Perspect. 2007 Jul;115(7):1029-34. doi: 10.1289/ehp.9852.
- Meeker JD, Altshul L, Hauser R. Serum PCBs, p,p'-DDE and HCB predict thyroid hormone levels in men. Environ Res. 2007 Jun;104(2):296-304. doi: 10.1016/j.envres.2006.11.007. Epub 2006 Dec 26.
- Duty SM, Ackerman RM, Calafat AM, Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect. 2005 Nov;113(11):1530-5. doi: 10.1289/ehp.8083.
- Chen Z, Godfrey-Bailey L, Schiff I, Hauser R. Impact of seasonal variation, age and smoking status on human semen parameters: The Massachusetts General Hospital experience. J Exp Clin Assist Reprod. 2004 Sep 30;1(1):2. doi: 10.1186/1743-1050-1-2.
- Kadir M, Hood RB, Minguez-Alarcon L, Maldonado-Carceles AB, Ford JB, Souter I, Chavarro JE, Gaskins AJ; EARTH Study Team. Folate intake and ovarian reserve among women attending a fertility center. Fertil Steril. 2022 Jan;117(1):171-180. doi: 10.1016/j.fertnstert.2021.09.037. Epub 2021 Nov 19.
- Nassan FL, Chiu YH, Vanegas JC, Gaskins AJ, Williams PL, Ford JB, Attaman J, Hauser R, Chavarro JE; EARTH Study Team. Intake of protein-rich foods in relation to outcomes of infertility treatment with assisted reproductive technologies. Am J Clin Nutr. 2018 Nov 1;108(5):1104-1112. doi: 10.1093/ajcn/nqy185.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
1999년 10월 1일
기본 완료 (실제)
2020년 9월 1일
연구 완료 (실제)
2020년 9월 1일
연구 등록 날짜
최초 제출
2001년 2월 27일
QC 기준을 충족하는 최초 제출
2001년 2월 28일
처음 게시됨 (추정)
2001년 3월 1일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2020년 9월 11일
QC 기준을 충족하는 마지막 업데이트 제출
2020년 9월 9일
마지막으로 확인됨
2020년 9월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .