环境与生殖健康;人类暴露于双酚 A、邻苯二甲酸盐和生育力及妊娠结局 (EARTH)
2020年9月9日 更新者:Russ Hauser、National Institute of Environmental Health Sciences (NIEHS)
人体暴露于双酚 A、邻苯二甲酸盐和生育力、妊娠结果。
该研究的目的是调查环境因素与生殖健康之间的关系。
感兴趣的环境因素包括接触多氯联苯 (PCB)、阻燃剂、二恶英、双酚 A、邻苯二甲酸盐、杀虫剂以及铅和镉等金属等化学品。
我们还对生殖健康与生活方式风险因素(例如接触环境烟草烟雾)之间的关系感兴趣。
登记者被要求参加这项研究,因为他们和他们的伴侣是 MGH 生育中心的患者,试图自然怀孕或通过宫腔内授精 (IUI) 和/或体外受精 (IVF) 怀孕。
研究概览
详细说明
具体目标 1:确定父亲尿液中邻苯二甲酸酯代谢物、双酚 A 和对羟基苯甲酸酯的混合浓度与植入失败和活产的主要结果以及生化妊娠(没有随后的临床妊娠)和自发妊娠的次要结果之间的关联流产。
假设 1:DEHP、DBP、DiBP、BBzP 和 DiNP 的抗雄激素邻苯二甲酸酯代谢物混合物的父亲尿浓度较高与着床失败风险增加和活产率降低以及化学妊娠和自然流产风险增加有关.
假设 2:雌激素化学物质(双酚 A 和对羟基苯甲酸酯)混合物的父亲尿液浓度较高与着床失败风险增加和活产率降低以及化学妊娠和自然流产风险增加有关。
具体目标 2:确定母体尿液中邻苯二甲酸酯代谢物、双酚 A 和对羟基苯甲酸酯的混合物与着床失败和活产率之间的关系,以及化学妊娠和自然流产的次要结果。
假设 2:DEHP、DBP、DiBP、BBzP 和 DiNP 的抗雄激素邻苯二甲酸酯代谢物混合物的母体尿液浓度较高与着床失败风险增加和活产率降低以及化学妊娠和自然流产风险增加有关.
假设 3:母体尿液中雌激素 BPA 和对羟基苯甲酸酯混合物的较高浓度与着床失败风险增加和活产率降低以及生化妊娠和自然流产风险增加有关。
具体目标 3:确定母体和父体尿液中邻苯二甲酸酯代谢物、BPA 和对羟基苯甲酸酯浓度的联合影响,主要结果包括着床失败和活产率,以及化学妊娠和自然流产的次要结果。
研究类型
观察性的
注册 (实际的)
1474
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Massachusetts
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Boston、Massachusetts、美国、02115
- Harvard School of Public Health
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 55年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
取样方法
非概率样本
研究人群
研究对象将从在 MGH IVF 诊所寻求治疗不孕症的夫妇中招募。
男性和女性必须年满 18 岁才能参与这项研究。
描述
纳入标准:
- 在 MGH 诊所接受不孕症治疗的夫妇
- 18-55岁男性
- 18 - 45 岁的女性
排除标准:
1. 任何未在 MGH Clinic 接受不孕症治疗和/或超出年龄范围的个人或夫妇。
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
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不孕症患者
在马萨诸塞州综合医院不孕症门诊接受不孕症治疗的患者。
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参与者在注册时完成基线访谈,然后完成关于生活方式和病史的在线问卷调查。
饮食问卷在家完成并寄回。
关于个人护理产品使用和药物的在线问卷在每次预定的研究访问时完成。
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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父亲接触环境化学品
大体时间:2019
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确定父亲尿液中邻苯二甲酸酯代谢物、双酚 A 和对羟基苯甲酸酯的混合物浓度与着床失败和活产的主要结局以及生化妊娠(没有随后的临床妊娠)和自然流产的次要结局之间的关联。
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2019
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
母亲接触环境化学品
大体时间:2019
|
确定母体尿液中邻苯二甲酸酯代谢物、双酚 A 和对羟基苯甲酸酯的混合物与着床失败和活产率之间的关系,以及生化妊娠和自然流产的次要结局。
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2019
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Russ Hauser, MD, ScD, MPH、Harvard School of Public Health (HSPH)
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Hauser R, Gaskins AJ, Souter I, Smith KW, Dodge LE, Ehrlich S, Meeker JD, Calafat AM, Williams PL; EARTH Study Team. Urinary Phthalate Metabolite Concentrations and Reproductive Outcomes among Women Undergoing in Vitro Fertilization: Results from the EARTH Study. Environ Health Perspect. 2016 Jun;124(6):831-9. doi: 10.1289/ehp.1509760. Epub 2015 Nov 6.
- Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Penzias A, Missmer SA, Chavarro JE. Prepregnancy dietary patterns and risk of pregnancy loss. Am J Clin Nutr. 2014 Oct;100(4):1166-72. doi: 10.3945/ajcn.114.083634. Epub 2014 Aug 13.
- Meeker JD, Singh NP, Hauser R. Serum concentrations of estradiol and free T4 are inversely correlated with sperm DNA damage in men from an infertility clinic. J Androl. 2008 Jul-Aug;29(4):379-88. doi: 10.2164/jandrol.107.004416. Epub 2008 Mar 20.
- Chavarro JE, Toth TL, Sadio SM, Hauser R. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Hum Reprod. 2008 Nov;23(11):2584-90. doi: 10.1093/humrep/den243. Epub 2008 Jul 23.
- Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010 May 1;93(7):2222-31. doi: 10.1016/j.fertnstert.2009.01.100. Epub 2009 Mar 3.
- Meeker JD, Missmer SA, Altshul L, Vitonis AF, Ryan L, Cramer DW, Hauser R. Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies. Environ Health. 2009 Jul 14;8:32. doi: 10.1186/1476-069X-8-32.
- Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, Ye X, Hauser R. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl. 2010 Apr;33(2):385-93. doi: 10.1111/j.1365-2605.2009.01014.x. Epub 2009 Nov 30.
- Meeker JD, Calafat AM, Hauser R. Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic. Environ Sci Technol. 2010 Feb 15;44(4):1458-63. doi: 10.1021/es9028292.
- Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, Ye X, Hauser R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol. 2010 Dec;30(4):532-9. doi: 10.1016/j.reprotox.2010.07.005. Epub 2010 Jul 23.
- Chavarro JE, Furtado J, Toth TL, Ford J, Keller M, Campos H, Hauser R. Trans-fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic. Fertil Steril. 2011 Apr;95(5):1794-7. doi: 10.1016/j.fertnstert.2010.10.039. Epub 2010 Nov 11.
- Braun JM, Smith KW, Williams PL, Calafat AM, Berry K, Ehrlich S, Hauser R. Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy. Environ Health Perspect. 2012 May;120(5):739-45. doi: 10.1289/ehp.1104139. Epub 2012 Jan 19. Erratum In: Environ Health Perspect. 2013 Apr;121(4):A114-5.
- Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod. 2012 May;27(5):1466-74. doi: 10.1093/humrep/des065. Epub 2012 Mar 13.
- Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, Calafat AM, Ye X, Petrozza JC, Wright D, Hauser R. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect. 2012 Jul;120(7):978-83. doi: 10.1289/ehp.1104307. Epub 2012 Apr 6.
- Chavarro JE, Ehrlich S, Colaci DS, Wright DL, Toth TL, Petrozza JC, Hauser R. Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction. Fertil Steril. 2012 Jul;98(1):109-16. doi: 10.1016/j.fertnstert.2012.04.012. Epub 2012 May 16.
- Ferguson KK, Hauser R, Altshul L, Meeker JD. Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age. Reprod Toxicol. 2012 Nov;34(3):429-35. doi: 10.1016/j.reprotox.2012.04.006. Epub 2012 May 5.
- Meeker JD, Calafat AM, Hauser R. Urinary phthalate metabolites and their biotransformation products: predictors and temporal variability among men and women. J Expo Sci Environ Epidemiol. 2012 Jul;22(4):376-85. doi: 10.1038/jes.2012.7. Epub 2012 Feb 22.
- Smith KW, Braun JM, Williams PL, Ehrlich S, Correia KF, Calafat AM, Ye X, Ford J, Keller M, Meeker JD, Hauser R. Predictors and variability of urinary paraben concentrations in men and women, including before and during pregnancy. Environ Health Perspect. 2012 Nov;120(11):1538-43. doi: 10.1289/ehp.1104614. Epub 2012 Jun 21.
- Colaci DS, Afeiche M, Gaskins AJ, Wright DL, Toth TL, Tanrikut C, Hauser R, Chavarro JE. Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil Steril. 2012 Nov;98(5):1193-9.e1. doi: 10.1016/j.fertnstert.2012.07.1102. Epub 2012 Aug 9.
- Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM, Petrozza JC, Wright D, Hauser R. Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum Reprod. 2012 Dec;27(12):3583-92. doi: 10.1093/humrep/des328. Epub 2012 Sep 26.
- Hernandez-Diaz S, Su YC, Mitchell AA, Kelley KE, Calafat AM, Hauser R. Medications as a potential source of exposure to phthalates among women of childbearing age. Reprod Toxicol. 2013 Jun;37:1-5. doi: 10.1016/j.reprotox.2013.01.001. Epub 2013 Jan 18.
- Smith KW, Souter I, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. Urinary paraben concentrations and ovarian aging among women from a fertility center. Environ Health Perspect. 2013 Nov-Dec;121(11-12):1299-305. doi: 10.1289/ehp.1205350. Epub 2013 Aug 2.
- Cantonwine DE, Hauser R, Meeker JD. Bisphenol A and Human Reproductive Health. Expert Rev Obstet Gynecol. 2013 Jul 1;8(4):10.1586/17474108.2013.811939. doi: 10.1586/17474108.2013.811939.
- Ehrlich S, Williams PL, Hauser R, Missmer SA, Peretz J, Calafat AM, Flaws JA. Urinary bisphenol A concentrations and cytochrome P450 19 A1 (Cyp19) gene expression in ovarian granulosa cells: an in vivo human study. Reprod Toxicol. 2013 Dec;42:18-23. doi: 10.1016/j.reprotox.2013.06.071. Epub 2013 Jul 10.
- Braun JM, Just AC, Williams PL, Smith KW, Calafat AM, Hauser R. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):459-66. doi: 10.1038/jes.2013.69. Epub 2013 Oct 23.
- Machtinger R, Combelles CM, Missmer SA, Correia KF, Williams P, Hauser R, Racowsky C. Bisphenol-A and human oocyte maturation in vitro. Hum Reprod. 2013 Oct;28(10):2735-45. doi: 10.1093/humrep/det312. Epub 2013 Jul 30.
- Souter I, Smith KW, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. Reprod Toxicol. 2013 Dec;42:224-31. doi: 10.1016/j.reprotox.2013.09.008. Epub 2013 Oct 4.
- Afeiche MC, Bridges ND, Williams PL, Gaskins AJ, Tanrikut C, Petrozza JC, Hauser R, Chavarro JE. Dairy intake and semen quality among men attending a fertility clinic. Fertil Steril. 2014 May;101(5):1280-7. doi: 10.1016/j.fertnstert.2014.02.003. Epub 2014 Mar 14.
- Afeiche MC, Gaskins AJ, Williams PL, Toth TL, Wright DL, Tanrikut C, Hauser R, Chavarro JE. Processed meat intake is unfavorably and fish intake favorably associated with semen quality indicators among men attending a fertility clinic. J Nutr. 2014 Jul;144(7):1091-8. doi: 10.3945/jn.113.190173. Epub 2014 May 21.
- Gaskins AJ, Afeiche MC, Hauser R, Williams PL, Gillman MW, Tanrikut C, Petrozza JC, Chavarro JE. Paternal physical and sedentary activities in relation to semen quality and reproductive outcomes among couples from a fertility center. Hum Reprod. 2014 Nov;29(11):2575-82. doi: 10.1093/humrep/deu212. Epub 2014 Aug 27.
- Gaskins AJ, Afeiche MC, Wright DL, Toth TL, Williams PL, Gillman MW, Hauser R, Chavarro JE. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet Gynecol. 2014 Oct;124(4):801-809. doi: 10.1097/AOG.0000000000000477.
- Minguez-Alarcon L, Afeiche MC, Williams PL, Arvizu M, Tanrikut C, Amarasiriwardena CJ, Ford JB, Hauser R, Chavarro JE; Earth Study Team. Hair mercury (Hg) levels, fish consumption and semen parameters among men attending a fertility center. Int J Hyg Environ Health. 2018 Mar;221(2):174-182. doi: 10.1016/j.ijheh.2017.10.014. Epub 2017 Oct 28.
- Messerlian C, Mustieles V, Minguez-Alarcon L, Ford JB, Calafat AM, Souter I, Williams PL, Hauser R; Environment and Reproductive Health (EARTH) Study Team. Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study. Environ Int. 2018 May;114:60-68. doi: 10.1016/j.envint.2018.02.017. Epub 2018 Feb 22.
- Chiu YH, Williams PL, Gillman MW, Gaskins AJ, Minguez-Alarcon L, Souter I, Toth TL, Ford JB, Hauser R, Chavarro JE; EARTH Study Team. Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology. JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.
- Chiu YH, Karmon AE, Gaskins AJ, Arvizu M, Williams PL, Souter I, Rueda BR, Hauser R, Chavarro JE; EARTH Study Team. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Hum Reprod. 2018 Jan 1;33(1):156-165. doi: 10.1093/humrep/dex335.
- Segal TR, Minguez-Alarcon L, Chiu YH, Williams PL, Nassan FL, Dadd R, Ospina M, Calafat AM, Hauser R; Earth Study Team. Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center. Hum Reprod. 2017 Dec 1;32(12):2532-2539. doi: 10.1093/humrep/dex327.
- Messerlian C, Mustieles V, Wylie BJ, Ford JB, Keller M, Ye X, Calafat AM, Williams PL, Hauser R; Environment Team Reproductive Health Study. Ultrasound gel as an unrecognized source of exposure to phthalates and phenols among pregnant women undergoing routine scan. Int J Hyg Environ Health. 2017 Nov;220(8):1285-1294. doi: 10.1016/j.ijheh.2017.08.003. Epub 2017 Aug 14.
- Messerlian C, Braun JM, Minguez-Alarcon L, Williams PL, Ford JB, Mustieles V, Calafat AM, Souter I, Toth T, Hauser R; Environment and Reproductive Health (EARTH) Study Team. Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples. Environ Int. 2017 Oct;107:55-64. doi: 10.1016/j.envint.2017.06.015. Epub 2017 Jun 27.
- Messerlian C, Bellinger D, Minguez-Alarcon L, Romano ME, Ford JB, Williams PL, Calafat AM, Hauser R, Braun JM. Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior. Environ Res. 2017 Oct;158:720-728. doi: 10.1016/j.envres.2017.07.032. Epub 2017 Jul 21.
- Souter I, Chiu YH, Batsis M, Afeiche MC, Williams PL, Hauser R, Chavarro JE; EARTH Study Team. The association of protein intake (amount and type) with ovarian antral follicle counts among infertile women: results from the EARTH prospective study cohort. BJOG. 2017 Sep;124(10):1547-1555. doi: 10.1111/1471-0528.14630. Epub 2017 Apr 10.
- Abadia L, Chiu YH, Williams PL, Toth TL, Souter I, Hauser R, Chavarro JE, Gaskins AJ; EARTH Study Team. The association between pre-treatment maternal alcohol and caffeine intake and outcomes of assisted reproduction in a prospectively followed cohort. Hum Reprod. 2017 Sep 1;32(9):1846-1854. doi: 10.1093/humrep/dex237.
- Carignan CC, Minguez-Alarcon L, Butt CM, Williams PL, Meeker JD, Stapleton HM, Toth TL, Ford JB, Hauser R; EARTH Study Team. Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization. Environ Health Perspect. 2017 Aug 25;125(8):087018. doi: 10.1289/EHP1021. Erratum In: Environ Health Perspect. 2017 Nov 01;125(11):119001.
- Minguez-Alarcon L, Christou G, Messerlian C, Williams PL, Carignan CC, Souter I, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic. Fertil Steril. 2017 Aug;108(2):312-319. doi: 10.1016/j.fertnstert.2017.05.020. Epub 2017 Jun 2.
- Tiseo BC, Gaskins AJ, Hauser R, Chavarro JE, Tanrikut C; EARTH Study Team. Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population. Urology. 2017 Apr;102:100-105. doi: 10.1016/j.urology.2016.11.022. Epub 2016 Nov 22.
- Chiu YH, Minguez-Alarcon L, Ford JB, Keller M, Seely EW, Messerlian C, Petrozza J, Williams PL, Ye X, Calafat AM, Hauser R, James-Todd T; for EARTH Study Team. Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic. J Clin Endocrinol Metab. 2017 Apr 1;102(4):1350-1357. doi: 10.1210/jc.2017-00022.
- Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE; Earth Study Team. Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology. 2017 Mar;5(2):354-361. doi: 10.1111/andr.12310. Epub 2017 Feb 10.
- Lewis RC, Minguez-Alarcon L, Meeker JD, Williams PL, Mezei G, Ford JB, Hauser R; EARTH Study Team. Self-reported mobile phone use and semen parameters among men from a fertility clinic. Reprod Toxicol. 2017 Jan;67:42-47. doi: 10.1016/j.reprotox.2016.11.008. Epub 2016 Nov 9.
- Vanegas JC, Chavarro JE, Williams PL, Ford JB, Toth TL, Hauser R, Gaskins AJ. Discrete survival model analysis of a couple's smoking pattern and outcomes of assisted reproduction. Fertil Res Pract. 2017;3:5. doi: 10.1186/s40738-017-0032-2. Epub 2017 Feb 20.
- Lewis RC, Hauser R, Maynard AD, Neitzel RL, Wang L, Kavet R, Morey P, Ford JB, Meeker JD; Earth Study Team. PERSONAL MEASURES OF POWER-FREQUENCY MAGNETIC FIELD EXPOSURE AMONG MEN FROM AN INFERTILITY CLINIC: DISTRIBUTION, TEMPORAL VARIABILITY AND CORRELATION WITH THEIR FEMALE PARTNERS' EXPOSURE. Radiat Prot Dosimetry. 2016 Dec;172(4):401-408. doi: 10.1093/rpd/ncv515. Epub 2015 Dec 24.
- Minguez-Alarcon L, Souter I, Chiu YH, Williams PL, Ford JB, Ye X, Calafat AM, Hauser R; Earth Study Team. Urinary concentrations of cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester, a metabolite of the non-phthalate plasticizer di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), and markers of ovarian response among women attending a fertility center. Environ Res. 2016 Nov;151:595-600. doi: 10.1016/j.envres.2016.08.012. Epub 2016 Sep 2.
- Messerlian C, Wylie BJ, Minguez-Alarcon L, Williams PL, Ford JB, Souter IC, Calafat AM, Hauser R; Earth Study Team. Urinary Concentrations of Phthalate Metabolites and Pregnancy Loss Among Women Conceiving with Medically Assisted Reproduction. Epidemiology. 2016 Nov;27(6):879-88. doi: 10.1097/EDE.0000000000000525.
- Gaskins AJ, Williams PL, Keller MG, Souter I, Hauser R, Chavarro JE; EARTH Study Team. Maternal physical and sedentary activities in relation to reproductive outcomes following IVF. Reprod Biomed Online. 2016 Oct;33(4):513-521. doi: 10.1016/j.rbmo.2016.07.002. Epub 2016 Jul 20.
- Minguez-Alarcon L, Gaskins AJ, Chiu YH, Souter I, Williams PL, Calafat AM, Hauser R, Chavarro JE; EARTH Study team. Dietary folate intake and modification of the association of urinary bisphenol A concentrations with in vitro fertilization outcomes among women from a fertility clinic. Reprod Toxicol. 2016 Oct;65:104-112. doi: 10.1016/j.reprotox.2016.07.012. Epub 2016 Jul 14.
- Minguez-Alarcon L, Hauser R, Gaskins AJ. Effects of bisphenol A on male and couple reproductive health: a review. Fertil Steril. 2016 Sep 15;106(4):864-70. doi: 10.1016/j.fertnstert.2016.07.1118. Epub 2016 Aug 4.
- Abadia L, Gaskins AJ, Chiu YH, Williams PL, Keller M, Wright DL, Souter I, Hauser R, Chavarro JE; Environment and Reproductive Health Study Team. Serum 25-hydroxyvitamin D concentrations and treatment outcomes of women undergoing assisted reproduction. Am J Clin Nutr. 2016 Sep;104(3):729-35. doi: 10.3945/ajcn.115.126359. Epub 2016 Jul 27.
- Hu Y, Chiu YH, Hauser R, Chavarro J, Sun Q. Overall and class-specific scores of pesticide residues from fruits and vegetables as a tool to rank intake of pesticide residues in United States: A validation study. Environ Int. 2016 Jul-Aug;92-93:294-300. doi: 10.1016/j.envint.2016.04.028. Epub 2016 Apr 26.
- Gaskins AJ, Chiu YH, Williams PL, Keller MG, Toth TL, Hauser R, Chavarro JE; EARTH Study Team. Maternal whole grain intake and outcomes of in vitro fertilization. Fertil Steril. 2016 Jun;105(6):1503-1510.e4. doi: 10.1016/j.fertnstert.2016.02.015. Epub 2016 Feb 28.
- Xia W, Chiu YH, Afeiche MC, Williams PL, Ford JB, Tanrikut C, Souter I, Hauser R, Chavarro JE; EARTH study team. Impact of men's dairy intake on assisted reproductive technology outcomes among couples attending a fertility clinic. Andrology. 2016 Mar;4(2):277-83. doi: 10.1111/andr.12151. Epub 2016 Jan 29.
- Chavarro JE, Minguez-Alarcon L, Chiu YH, Gaskins AJ, Souter I, Williams PL, Calafat AM, Hauser R; EARTH Study Team. Soy Intake Modifies the Relation Between Urinary Bisphenol A Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction. J Clin Endocrinol Metab. 2016 Mar;101(3):1082-90. doi: 10.1210/jc.2015-3473. Epub 2016 Jan 27.
- Afeiche MC, Chiu YH, Gaskins AJ, Williams PL, Souter I, Wright DL, Hauser R, Chavarro JE; EARTH Study team. Dairy intake in relation to in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod. 2016 Mar;31(3):563-71. doi: 10.1093/humrep/dev344. Epub 2016 Jan 18.
- Minguez-Alarcon L, Chiu YH, Messerlian C, Williams PL, Sabatini ME, Toth TL, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic. Fertil Steril. 2016 Mar;105(3):714-721. doi: 10.1016/j.fertnstert.2015.11.021. Epub 2015 Dec 2.
- Lewis RC, Hauser R, Wang L, Kavet R, Meeker JD. Personal power-frequency magnetic field exposure in women recruited at an infertility clinic: association with physical activity and temporal variability. Radiat Prot Dosimetry. 2016 Mar;168(4):478-88. doi: 10.1093/rpd/ncv365. Epub 2015 Jul 7.
- Messerlian C, Souter I, Gaskins AJ, Williams PL, Ford JB, Chiu YH, Calafat AM, Hauser R; Earth Study Team. Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. Hum Reprod. 2016 Jan;31(1):75-83. doi: 10.1093/humrep/dev292. Epub 2015 Nov 15.
- Braun JM, Gennings C, Hauser R, Webster TF. What Can Epidemiological Studies Tell Us about the Impact of Chemical Mixtures on Human Health? Environ Health Perspect. 2016 Jan;124(1):A6-9. doi: 10.1289/ehp.1510569.
- Lewis RC, Hauser R, Maynard AD, Neitzel RL, Wang L, Kavet R, Meeker JD. Exposure to Power-Frequency Magnetic Fields and the Risk of Infertility and Adverse Pregnancy Outcomes: Update on the Human Evidence and Recommendations for Future Study Designs. J Toxicol Environ Health B Crit Rev. 2016;19(1):29-45. doi: 10.1080/10937404.2015.1134370.
- Dodge LE, Williams PL, Williams MA, Missmer SA, Souter I, Calafat AM, Hauser R; EARTH Study Team. Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment. Reprod Toxicol. 2015 Dec;58:184-93. doi: 10.1016/j.reprotox.2015.09.007. Epub 2015 Oct 9.
- Styer AK, Gaskins AJ, Brady PC, Sluss PM, Chavarro JE, Hauser RB, Toth TL. Dynamic antimullerian hormone levels during controlled ovarian hyperstimulation predict in vitro fertilization response and pregnancy outcomes. Fertil Steril. 2015 Nov;104(5):1153-61.e1-7. doi: 10.1016/j.fertnstert.2015.07.1161. Epub 2015 Aug 24.
- Gaskins AJ, Chiu YH, Williams PL, Ford JB, Toth TL, Hauser R, Chavarro JE; EARTH Study Team. Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015 Oct;102(4):943-50. doi: 10.3945/ajcn.115.112185. Epub 2015 Sep 9.
- Xia W, Chiu YH, Williams PL, Gaskins AJ, Toth TL, Tanrikut C, Hauser R, Chavarro JE. Men's meat intake and treatment outcomes among couples undergoing assisted reproduction. Fertil Steril. 2015 Oct;104(4):972-979. doi: 10.1016/j.fertnstert.2015.06.037. Epub 2015 Jul 20.
- Minguez-Alarcon L, Gaskins AJ, Chiu YH, Williams PL, Ehrlich S, Chavarro JE, Petrozza JC, Ford JB, Calafat AM, Hauser R; EARTH Study Team. Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod. 2015 Sep;30(9):2120-8. doi: 10.1093/humrep/dev183. Epub 2015 Jul 24.
- Minguez-Alarcon L, Afeiche MC, Chiu YH, Vanegas JC, Williams PL, Tanrikut C, Toth TL, Hauser R, Chavarro JE. Male soy food intake was not associated with in vitro fertilization outcomes among couples attending a fertility center. Andrology. 2015 Jul;3(4):702-8. doi: 10.1111/andr.12046. Epub 2015 Jun 20.
- Dodge LE, Williams PL, Williams MA, Missmer SA, Toth TL, Calafat AM, Hauser R. Paternal Urinary Concentrations of Parabens and Other Phenols in Relation to Reproductive Outcomes among Couples from a Fertility Clinic. Environ Health Perspect. 2015 Jul;123(7):665-71. doi: 10.1289/ehp.1408605. Epub 2015 Mar 13.
- Chiu YH, Afeiche MC, Gaskins AJ, Williams PL, Petrozza JC, Tanrikut C, Hauser R, Chavarro JE. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic. Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30.
- Dodge LE, Kelley KE, Williams PL, Williams MA, Hernandez-Diaz S, Missmer SA, Hauser R. Medications as a source of paraben exposure. Reprod Toxicol. 2015 Apr;52:93-100. doi: 10.1016/j.reprotox.2015.02.002. Epub 2015 Feb 26.
- Vanegas JC, Afeiche MC, Gaskins AJ, Minguez-Alarcon L, Williams PL, Wright DL, Toth TL, Hauser R, Chavarro JE. Soy food intake and treatment outcomes of women undergoing assisted reproductive technology. Fertil Steril. 2015 Mar;103(3):749-55.e2. doi: 10.1016/j.fertnstert.2014.12.104. Epub 2015 Jan 7.
- Wright DL, Afeiche MC, Ehrlich S, Smith K, Williams PL, Chavarro JE, Batsis M, Toth TL, Hauser R. Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic. Reprod Toxicol. 2015 Jan;51:125-132. doi: 10.1016/j.reprotox.2015.01.003. Epub 2015 Jan 17.
- Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ Health Perspect. 2014 Aug;122(8):775-86. doi: 10.1289/ehp.1307728. Epub 2014 Jun 4.
- Gaskins AJ, Rich-Edwards JW, Hauser R, Williams PL, Gillman MW, Ginsburg ES, Missmer SA, Chavarro JE. Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Obstet Gynecol. 2014 Jul;124(1):23-31. doi: 10.1097/AOG.0000000000000343.
- Meeker JD, Cooper EM, Stapleton HM, Hauser R. Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health. Endocr Disruptors (Austin). 2013 Oct 1;1(1):e26306. doi: 10.4161/endo.26306.
- Meeker JD, Cooper EM, Stapleton HM, Hauser R. Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environ Health Perspect. 2013 May;121(5):580-5. doi: 10.1289/ehp.1205907. Epub 2013 Mar 5.
- Braun JM, Sathyanarayana S, Hauser R. Phthalate exposure and children's health. Curr Opin Pediatr. 2013 Apr;25(2):247-54. doi: 10.1097/MOP.0b013e32835e1eb6.
- Johnson PI, Stapleton HM, Mukherjee B, Hauser R, Meeker JD. Associations between brominated flame retardants in house dust and hormone levels in men. Sci Total Environ. 2013 Feb 15;445-446:177-84. doi: 10.1016/j.scitotenv.2012.12.017. Epub 2013 Jan 16.
- McAuliffe ME, Williams PL, Korrick SA, Dadd R, Perry MJ. The association between sperm sex chromosome disomy and semen concentration, motility and morphology. Hum Reprod. 2012 Oct;27(10):2918-26. doi: 10.1093/humrep/des302. Epub 2012 Aug 14.
- Mendiola J, Meeker JD, Jorgensen N, Andersson AM, Liu F, Calafat AM, Redmon JB, Drobnis EZ, Sparks AE, Wang C, Hauser R, Swan SH. Urinary concentrations of di(2-ethylhexyl) phthalate metabolites and serum reproductive hormones: pooled analysis of fertile and infertile men. J Androl. 2012 May-Jun;33(3):488-98. doi: 10.2164/jandrol.111.013557. Epub 2011 May 19.
- McAuliffe ME, Williams PL, Korrick SA, Altshul LM, Perry MJ. Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy. Environ Health Perspect. 2012 Apr;120(4):535-40. doi: 10.1289/ehp.1104017. Epub 2011 Dec 21.
- Perry MJ, Chen X, McAuliffe ME, Maity A, Deloid GM. Semi-automated scoring of triple-probe FISH in human sperm: methods and further validation. Cytometry A. 2011 Aug;79(8):661-6. doi: 10.1002/cyto.a.21078. Epub 2011 May 12.
- Meeker JD, Yang T, Ye X, Calafat AM, Hauser R. Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. Environ Health Perspect. 2011 Feb;119(2):252-7. doi: 10.1289/ehp.1002238. Epub 2010 Sep 28.
- Johnson PI, Stapleton HM, Sjodin A, Meeker JD. Relationships between polybrominated diphenyl ether concentrations in house dust and serum. Environ Sci Technol. 2010 Jul 15;44(14):5627-32. doi: 10.1021/es100697q.
- Meeker JD, Stapleton HM. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environ Health Perspect. 2010 Mar;118(3):318-23. doi: 10.1289/ehp.0901332.
- Meeker JD, Johnson PI, Camann D, Hauser R. Polybrominated diphenyl ether (PBDE) concentrations in house dust are related to hormone levels in men. Sci Total Environ. 2009 May 1;407(10):3425-9. doi: 10.1016/j.scitotenv.2009.01.030. Epub 2009 Feb 10.
- Meeker JD, Calafat AM, Hauser R. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl. 2009 May-Jun;30(3):287-97. doi: 10.2164/jandrol.108.006403. Epub 2008 Dec 4.
- Meeker JD, Barr DB, Hauser R. Pyrethroid insecticide metabolites are associated with serum hormone levels in adult men. Reprod Toxicol. 2009 Apr;27(2):155-60. doi: 10.1016/j.reprotox.2008.12.012. Epub 2009 Jan 24.
- Mahalingaiah S, Meeker JD, Pearson KR, Calafat AM, Ye X, Petrozza J, Hauser R. Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environ Health Perspect. 2008 Feb;116(2):173-8. doi: 10.1289/ehp.10605.
- Meeker JD, Ravi SR, Barr DB, Hauser R. Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides. Reprod Toxicol. 2008 Feb;25(2):184-91. doi: 10.1016/j.reprotox.2007.12.005. Epub 2007 Dec 28.
- Meeker JD, Calafat AM, Hauser R. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ Health Perspect. 2007 Jul;115(7):1029-34. doi: 10.1289/ehp.9852.
- Meeker JD, Altshul L, Hauser R. Serum PCBs, p,p'-DDE and HCB predict thyroid hormone levels in men. Environ Res. 2007 Jun;104(2):296-304. doi: 10.1016/j.envres.2006.11.007. Epub 2006 Dec 26.
- Duty SM, Ackerman RM, Calafat AM, Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect. 2005 Nov;113(11):1530-5. doi: 10.1289/ehp.8083.
- Chen Z, Godfrey-Bailey L, Schiff I, Hauser R. Impact of seasonal variation, age and smoking status on human semen parameters: The Massachusetts General Hospital experience. J Exp Clin Assist Reprod. 2004 Sep 30;1(1):2. doi: 10.1186/1743-1050-1-2.
- Kadir M, Hood RB, Minguez-Alarcon L, Maldonado-Carceles AB, Ford JB, Souter I, Chavarro JE, Gaskins AJ; EARTH Study Team. Folate intake and ovarian reserve among women attending a fertility center. Fertil Steril. 2022 Jan;117(1):171-180. doi: 10.1016/j.fertnstert.2021.09.037. Epub 2021 Nov 19.
- Nassan FL, Chiu YH, Vanegas JC, Gaskins AJ, Williams PL, Ford JB, Attaman J, Hauser R, Chavarro JE; EARTH Study Team. Intake of protein-rich foods in relation to outcomes of infertility treatment with assisted reproductive technologies. Am J Clin Nutr. 2018 Nov 1;108(5):1104-1112. doi: 10.1093/ajcn/nqy185.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
1999年10月1日
初级完成 (实际的)
2020年9月1日
研究完成 (实际的)
2020年9月1日
研究注册日期
首次提交
2001年2月27日
首先提交符合 QC 标准的
2001年2月28日
首次发布 (估计)
2001年3月1日
研究记录更新
最后更新发布 (实际的)
2020年9月11日
上次提交的符合 QC 标准的更新
2020年9月9日
最后验证
2020年9月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.