Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
2020년 8월 9일 업데이트: Wanqi Zhang, Tianjin Medical University
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and lactating women and infants were found during the recent revision of Chinese dietary reference intakes (DRIs) of iodine in 2013 by the applicant Pro.
Zhang, and no systematical research about compensatory mechanism of iodine nutrition in lactating women was found yet.
Previous study funded by United Nations International Children's Emergency Fund (UNICEF) cooperated with the international experts on iodine and key project of national natural science foundation of China under the guidance of Pro.
Zhang, had obtained the safe intake range of iodine from children and pregnant women, more than 10 joint papers were published, which laid the foundation of population study and international cooperation.
연구 개요
상세 설명
Studies indicate lactating women and their infants are the most vulnerable population to the adverse effects of iodine deficiency and excess, and because of the complexity of the study of lactating mothers and infants and the difficulty of sample collection, it is proposed to overcome this problem with the help of the advanced dried blood spot technique and iodine balance study method from the panel of Iodine Global Network (IGN). Investigators intend to recruit 900 late pregnant women in Tianjin, Hebei and Shandong;then establishing a dynamic cohort of breastfeeding mother-infant to 6 months after delivery to investigate the physiological compensatory mechanism of iodine nutrition in lactating women with the combination of animal experiment; On the other hand, 180 exclusively breastfeeding mother and infants within postpartum 0-6 months, will be selected to participate the iodine balance study.
Optimized method of iodine balance experiment of infants by both foreign partner and Pro. Zhang's team will be adopted to obtain the first iodine balance value of Chinese lactating women and infants,providing the direct evidence for the revision of DRIs in lactating women and infants, and guide the lactating women proper iodine supplementation to meet the requirements of both mothers and infants.
연구 유형
관찰
등록 (예상)
600
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: ying ye
- 전화번호: 022-83336717
- 이메일: yeying@tmu.edu.cn
연구 연락처 백업
- 이름: WanQi Zhang, doctorate
- 전화번호: 022-83336595
- 이메일: wqzhang@tmu.edu.cn
연구 장소
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Massachusetts
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Boston, Massachusetts, 미국, 02101-02117
- 모병
- Boston University School of Medicine; Iodine Global Network (IGN)
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연락하다:
- Elizabeth N Pearce
- 전화번호: 617-414-1348
- 이메일: elizabeth.pearce@bmc.org
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Zurich, 스위스
- 모병
- Swiss federal institute of Technology (ETH)
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연락하다:
- Michael B Zimmermann
- 전화번호: +41-44-632-8657
- 이메일: michael.zimmermann@hest.ethz.ch
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부수사관:
- Maria Andersson
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Beijing, 중국
- 모병
- Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
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연락하다:
- ying ye
- 전화번호: 022-83336717
- 이메일: yeying@tmu.edu.cn
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연락하다:
- WanQi Zhang
- 전화번호: 022-83336595
- 이메일: wqzhang@tmu.edu.cn
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Shandong, 중국
- 모병
- Shandong Institute of Endemic Disease Control and Prevention
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연락하다:
- Zhang WanQi
- 전화번호: 022-83336595
- 이메일: wqzhang@tmu.edu.cn
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연락하다:
- Ye ying
- 전화번호: 022-83336717
- 이메일: yeying@tmu.edu.cn
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
1일 (어린이, 성인)
건강한 자원 봉사자를 받아들입니다
예
연구 대상 성별
모두
샘플링 방법
비확률 샘플
연구 인구
Women in the third trimester (18-40 years old), lactating women (38-42 weeks of gestation) and infants (0-6 months), all from Tianjin, Hebei and Shandong
설명
Inclusion Criteria:
- Women in their third trimester:⑴Aged 18-40, who have lived in the area for 1 year;⑵Single pregnancy;⑶Those who have no special dietary habits;
- Lactating woman:⑴Breastfeeding a child;⑵Normal thyroid function during pregnancy;⑶Term delivery (38-42 weeks of gestation);
- Infants and young children:⑴0-6 months;⑵Breastfeeding;⑶Full term (38-42 weeks of gestation);⑷Normal birth weight (2500-4000g);⑸The thyroid-stimulating hormone (TSH) value of heel blood was normal;⑹Apgar score 8.
Exclusion Criteria:
- Women in their third trimester:⑴Smoking or drinking;⑵Iodized drugs or contrast agents have been used in the past year;⑶A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc;
- Lactating woman:⑴A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc;
- Infants and young children:⑴Have pathological jaundice, autoimmune disease, congenital heart disease and other diseases.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Disposable random urine
기간: baseline
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μg/L
|
baseline
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Venous blood
기간: baseline
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μg/L
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baseline
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Water iodine intake
기간: baseline
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μg/day
|
baseline
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Salt iodine concentration
기간: baseline
|
μg/day
|
baseline
|
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Colostrum
기간: 1 week
|
μg/L
|
1 week
|
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Mother and child urine randomly at one time
기간: 1 week
|
μg/L
|
1 week
|
|
Neonatal heel blood
기간: 1 week
|
μg/L
|
1 week
|
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Thyroglobulin(TG)
기간: 1 week
|
ug/L
|
1 week
|
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Thyroid-stimulating hormone
기간: 1 week
|
mIU/L
|
1 week
|
|
Infant disposable random urine
기간: 4 weeks
|
μg/L
|
4 weeks
|
|
Infant disposable random urine
기간: 24 weeks
|
μg/L
|
24 weeks
|
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Infant disposable random urine
기간: 12 weeks
|
μg/L
|
12 weeks
|
|
24 h urine
기간: 4 weeks
|
μg/L
|
4 weeks
|
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24 h urine
기간: 12 weeks
|
μg/L
|
12 weeks
|
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24 h urine
기간: 24 weeks
|
μg/L
|
24 weeks
|
|
Urinary iodine excretion
기간: 4 weeks
|
μg/day
|
4 weeks
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Urinary iodine excretion
기간: 12 weeks
|
μg/day
|
12 weeks
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Urinary iodine excretion
기간: 24 weeks
|
μg/day
|
24 weeks
|
|
Milk output
기간: 4 weeks
|
μg/day
|
4 weeks
|
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Milk output
기간: 12 weeks
|
μg/day
|
12 weeks
|
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Milk output
기간: 24 weeks
|
μg/day
|
24 weeks
|
|
Milk iodine excretion
기간: 4 weeks
|
μg/day
|
4 weeks
|
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Milk iodine excretion
기간: 12 weeks
|
μg/day
|
12 weeks
|
|
Milk iodine excretion
기간: 24 weeks
|
μg/day
|
24 weeks
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Average iodine intake
기간: 4 weeks
|
μg/day
|
4 weeks
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Average iodine intake
기간: 12 weeks
|
μg/day
|
12 weeks
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Average iodine intake
기간: 24 weeks
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μg/day
|
24 weeks
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Thyroid volume
기간: 1 week
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cm³
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1 week
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Thyroid volume
기간: 4 weeks
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cm³
|
4 weeks
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Thyroid volume
기간: 12 weeks
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cm³
|
12 weeks
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Thyroid volume
기간: 24 weeks
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cm³
|
24 weeks
|
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Thyroid nodule
기간: 1 week
|
cm³
|
1 week
|
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Thyroid nodule
기간: 4 weeks
|
cm³
|
4 weeks
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Thyroid nodule
기간: 12 weeks
|
cm³
|
12 weeks
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Thyroid nodule
기간: 24 weeks
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cm³
|
24 weeks
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Dried blood spot(DBS)
기간: 3 days
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μg/L
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3 days
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Dried blood spot(DBS)
기간: 12 weeks
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μg/L
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12 weeks
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Diet iodine intake
기간: 1 week
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μg/day
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1 week
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Fecal iodine excretion
기간: 1 week
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μg/day
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1 week
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: ZiYun Pan, Tianjin Medical University
- 수석 연구원: JianQiang Lai, Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
- 수석 연구원: XueSong Wang, Shandong Institute of Endemic Disease Control and Prevention
- 수석 연구원: YiFan Duan, Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
- 수석 연구원: GuiJun Tan, Tianjin Medical University
- 수석 연구원: Wen Chen, Tianjin Medical University
- 수석 연구원: YanTing Chen, Tianjin Medical University
- 수석 연구원: Min Gao, Tianjin Medical University
- 연구 의자: Michael B Zimmermann, doctorate, Swiss federal institute of Technology (ETH)
- 연구 의자: Elizabeth N Pearce, doctorate, Boston University School of Medicine; Iodine Global Network (IGN)
- 연구 의자: Maria Andersson, doctorate, Swiss federal institute of Technology (ETH); Iodine Global Network (IGN)
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. Available from http://www.ncbi.nlm.nih.gov/books/NBK222310/
- Stinca S, Andersson M, Herter-Aeberli I, Chabaa L, Cherkaoui M, El Ansari N, Aboussad A, Weibel S, Zimmermann MB. Moderate-to-Severe Iodine Deficiency in the "First 1000 Days" Causes More Thyroid Hypofunction in Infants Than in Pregnant or Lactating Women. J Nutr. 2017 Apr;147(4):589-595. doi: 10.3945/jn.116.244665. Epub 2017 Feb 15.
- Sang Z, Wang PP, Yao Z, Shen J, Halfyard B, Tan L, Zhao N, Wu Y, Gao S, Tan J, Liu J, Chen Z, Zhang W. Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. Am J Clin Nutr. 2012 Feb;95(2):367-73. doi: 10.3945/ajcn.111.028001. Epub 2011 Dec 28.
- Chen W, Li X, Wu Y, Bian J, Shen J, Jiang W, Tan L, Wang X, Wang W, Pearce EN, Zimmermann MB, Carriquiry AL, Zhang W. Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. Am J Clin Nutr. 2017 Jan;105(1):228-233. doi: 10.3945/ajcn.116.139725. Epub 2016 Dec 7.
- Chen W, Zhang Y, Hao Y, Wang W, Tan L, Bian J, Pearce EN, Zimmermann MB, Shen J, Zhang W. Adverse effects on thyroid of Chinese children exposed to long-term iodine excess: optimal and safe Tolerable Upper Intake Levels of iodine for 7- to 14-y-old children. Am J Clin Nutr. 2018 May 1;107(5):780-788. doi: 10.1093/ajcn/nqy011.
- Sang Z, Wei W, Zhao N, Zhang G, Chen W, Liu H, Shen J, Liu J, Yan Y, Zhang W. Thyroid dysfunction during late gestation is associated with excessive iodine intake in pregnant women. J Clin Endocrinol Metab. 2012 Aug;97(8):E1363-9. doi: 10.1210/jc.2011-3438. Epub 2012 Jun 5.
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2020년 1월 1일
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2021년 12월 31일
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2024년 12월 31일
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2020년 7월 21일
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2020년 7월 27일
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