Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
sunnuntai 9. elokuuta 2020 päivittänyt: Wanqi Zhang, Tianjin Medical University
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and lactating women and infants were found during the recent revision of Chinese dietary reference intakes (DRIs) of iodine in 2013 by the applicant Pro.
Zhang, and no systematical research about compensatory mechanism of iodine nutrition in lactating women was found yet.
Previous study funded by United Nations International Children's Emergency Fund (UNICEF) cooperated with the international experts on iodine and key project of national natural science foundation of China under the guidance of Pro.
Zhang, had obtained the safe intake range of iodine from children and pregnant women, more than 10 joint papers were published, which laid the foundation of population study and international cooperation.
Tutkimuksen yleiskatsaus
Yksityiskohtainen kuvaus
Studies indicate lactating women and their infants are the most vulnerable population to the adverse effects of iodine deficiency and excess, and because of the complexity of the study of lactating mothers and infants and the difficulty of sample collection, it is proposed to overcome this problem with the help of the advanced dried blood spot technique and iodine balance study method from the panel of Iodine Global Network (IGN). Investigators intend to recruit 900 late pregnant women in Tianjin, Hebei and Shandong;then establishing a dynamic cohort of breastfeeding mother-infant to 6 months after delivery to investigate the physiological compensatory mechanism of iodine nutrition in lactating women with the combination of animal experiment; On the other hand, 180 exclusively breastfeeding mother and infants within postpartum 0-6 months, will be selected to participate the iodine balance study.
Optimized method of iodine balance experiment of infants by both foreign partner and Pro. Zhang's team will be adopted to obtain the first iodine balance value of Chinese lactating women and infants,providing the direct evidence for the revision of DRIs in lactating women and infants, and guide the lactating women proper iodine supplementation to meet the requirements of both mothers and infants.
Opintotyyppi
Havainnollistava
Ilmoittautuminen (Odotettu)
600
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskeluyhteys
- Nimi: ying ye
- Puhelinnumero: 022-83336717
- Sähköposti: yeying@tmu.edu.cn
Tutki yhteystietojen varmuuskopiointi
- Nimi: WanQi Zhang, doctorate
- Puhelinnumero: 022-83336595
- Sähköposti: wqzhang@tmu.edu.cn
Opiskelupaikat
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Beijing, Kiina
- Rekrytointi
- Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
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Ottaa yhteyttä:
- ying ye
- Puhelinnumero: 022-83336717
- Sähköposti: yeying@tmu.edu.cn
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Ottaa yhteyttä:
- WanQi Zhang
- Puhelinnumero: 022-83336595
- Sähköposti: wqzhang@tmu.edu.cn
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Shandong, Kiina
- Rekrytointi
- Shandong Institute of Endemic Disease Control and Prevention
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Ottaa yhteyttä:
- Zhang WanQi
- Puhelinnumero: 022-83336595
- Sähköposti: wqzhang@tmu.edu.cn
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Ottaa yhteyttä:
- Ye ying
- Puhelinnumero: 022-83336717
- Sähköposti: yeying@tmu.edu.cn
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Zurich, Sveitsi
- Rekrytointi
- Swiss federal institute of Technology (ETH)
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Ottaa yhteyttä:
- Michael B Zimmermann
- Puhelinnumero: +41-44-632-8657
- Sähköposti: michael.zimmermann@hest.ethz.ch
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Alatutkija:
- Maria Andersson
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Massachusetts
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Boston, Massachusetts, Yhdysvallat, 02101-02117
- Rekrytointi
- Boston University School of Medicine; Iodine Global Network (IGN)
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Ottaa yhteyttä:
- Elizabeth N Pearce
- Puhelinnumero: 617-414-1348
- Sähköposti: elizabeth.pearce@bmc.org
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Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
1 päivä - 40 vuotta (Lapsi, Aikuinen)
Hyväksyy terveitä vapaaehtoisia
Joo
Sukupuolet, jotka voivat opiskella
Kaikki
Näytteenottomenetelmä
Ei-todennäköisyysnäyte
Tutkimusväestö
Women in the third trimester (18-40 years old), lactating women (38-42 weeks of gestation) and infants (0-6 months), all from Tianjin, Hebei and Shandong
Kuvaus
Inclusion Criteria:
- Women in their third trimester:⑴Aged 18-40, who have lived in the area for 1 year;⑵Single pregnancy;⑶Those who have no special dietary habits;
- Lactating woman:⑴Breastfeeding a child;⑵Normal thyroid function during pregnancy;⑶Term delivery (38-42 weeks of gestation);
- Infants and young children:⑴0-6 months;⑵Breastfeeding;⑶Full term (38-42 weeks of gestation);⑷Normal birth weight (2500-4000g);⑸The thyroid-stimulating hormone (TSH) value of heel blood was normal;⑹Apgar score 8.
Exclusion Criteria:
- Women in their third trimester:⑴Smoking or drinking;⑵Iodized drugs or contrast agents have been used in the past year;⑶A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc;
- Lactating woman:⑴A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc;
- Infants and young children:⑴Have pathological jaundice, autoimmune disease, congenital heart disease and other diseases.
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
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Disposable random urine
Aikaikkuna: baseline
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μg/L
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baseline
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Venous blood
Aikaikkuna: baseline
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μg/L
|
baseline
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Water iodine intake
Aikaikkuna: baseline
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μg/day
|
baseline
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Salt iodine concentration
Aikaikkuna: baseline
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μg/day
|
baseline
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Colostrum
Aikaikkuna: 1 week
|
μg/L
|
1 week
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Mother and child urine randomly at one time
Aikaikkuna: 1 week
|
μg/L
|
1 week
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Neonatal heel blood
Aikaikkuna: 1 week
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μg/L
|
1 week
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Thyroglobulin(TG)
Aikaikkuna: 1 week
|
ug/L
|
1 week
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Thyroid-stimulating hormone
Aikaikkuna: 1 week
|
mIU/L
|
1 week
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Infant disposable random urine
Aikaikkuna: 4 weeks
|
μg/L
|
4 weeks
|
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Infant disposable random urine
Aikaikkuna: 24 weeks
|
μg/L
|
24 weeks
|
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Infant disposable random urine
Aikaikkuna: 12 weeks
|
μg/L
|
12 weeks
|
|
24 h urine
Aikaikkuna: 4 weeks
|
μg/L
|
4 weeks
|
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24 h urine
Aikaikkuna: 12 weeks
|
μg/L
|
12 weeks
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24 h urine
Aikaikkuna: 24 weeks
|
μg/L
|
24 weeks
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Urinary iodine excretion
Aikaikkuna: 4 weeks
|
μg/day
|
4 weeks
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Urinary iodine excretion
Aikaikkuna: 12 weeks
|
μg/day
|
12 weeks
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Urinary iodine excretion
Aikaikkuna: 24 weeks
|
μg/day
|
24 weeks
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Milk output
Aikaikkuna: 4 weeks
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μg/day
|
4 weeks
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Milk output
Aikaikkuna: 12 weeks
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μg/day
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12 weeks
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Milk output
Aikaikkuna: 24 weeks
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μg/day
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24 weeks
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Milk iodine excretion
Aikaikkuna: 4 weeks
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μg/day
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4 weeks
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Milk iodine excretion
Aikaikkuna: 12 weeks
|
μg/day
|
12 weeks
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Milk iodine excretion
Aikaikkuna: 24 weeks
|
μg/day
|
24 weeks
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Average iodine intake
Aikaikkuna: 4 weeks
|
μg/day
|
4 weeks
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Average iodine intake
Aikaikkuna: 12 weeks
|
μg/day
|
12 weeks
|
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Average iodine intake
Aikaikkuna: 24 weeks
|
μg/day
|
24 weeks
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Thyroid volume
Aikaikkuna: 1 week
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cm³
|
1 week
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Thyroid volume
Aikaikkuna: 4 weeks
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cm³
|
4 weeks
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Thyroid volume
Aikaikkuna: 12 weeks
|
cm³
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12 weeks
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Thyroid volume
Aikaikkuna: 24 weeks
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cm³
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24 weeks
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Thyroid nodule
Aikaikkuna: 1 week
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cm³
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1 week
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Thyroid nodule
Aikaikkuna: 4 weeks
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cm³
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4 weeks
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Thyroid nodule
Aikaikkuna: 12 weeks
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cm³
|
12 weeks
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Thyroid nodule
Aikaikkuna: 24 weeks
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cm³
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24 weeks
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Dried blood spot(DBS)
Aikaikkuna: 3 days
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μg/L
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3 days
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Dried blood spot(DBS)
Aikaikkuna: 12 weeks
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μg/L
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12 weeks
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Diet iodine intake
Aikaikkuna: 1 week
|
μg/day
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1 week
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Fecal iodine excretion
Aikaikkuna: 1 week
|
μg/day
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1 week
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Yhteistyökumppanit ja tutkijat
Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.
Sponsori
Tutkijat
- Päätutkija: ZiYun Pan, Tianjin Medical University
- Päätutkija: JianQiang Lai, Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
- Päätutkija: XueSong Wang, Shandong Institute of Endemic Disease Control and Prevention
- Päätutkija: YiFan Duan, Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
- Päätutkija: GuiJun Tan, Tianjin Medical University
- Päätutkija: Wen Chen, Tianjin Medical University
- Päätutkija: YanTing Chen, Tianjin Medical University
- Päätutkija: Min Gao, Tianjin Medical University
- Opintojen puheenjohtaja: Michael B Zimmermann, doctorate, Swiss federal institute of Technology (ETH)
- Opintojen puheenjohtaja: Elizabeth N Pearce, doctorate, Boston University School of Medicine; Iodine Global Network (IGN)
- Opintojen puheenjohtaja: Maria Andersson, doctorate, Swiss federal institute of Technology (ETH); Iodine Global Network (IGN)
Julkaisuja ja hyödyllisiä linkkejä
Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.
Yleiset julkaisut
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- Stinca S, Andersson M, Herter-Aeberli I, Chabaa L, Cherkaoui M, El Ansari N, Aboussad A, Weibel S, Zimmermann MB. Moderate-to-Severe Iodine Deficiency in the "First 1000 Days" Causes More Thyroid Hypofunction in Infants Than in Pregnant or Lactating Women. J Nutr. 2017 Apr;147(4):589-595. doi: 10.3945/jn.116.244665. Epub 2017 Feb 15.
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- Chen W, Li X, Wu Y, Bian J, Shen J, Jiang W, Tan L, Wang X, Wang W, Pearce EN, Zimmermann MB, Carriquiry AL, Zhang W. Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. Am J Clin Nutr. 2017 Jan;105(1):228-233. doi: 10.3945/ajcn.116.139725. Epub 2016 Dec 7.
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