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Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

2021년 8월 20일 업데이트: Apostolos Theos, Umeå University

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

연구 개요

상태

아직 모집하지 않음

정황

개입 / 치료

상세 설명

Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

연구 유형

중재적

등록 (예상)

40

단계

  • 해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

연구 장소

  • 스웨덴
    • Västerbotten
      • Umeå, Västerbotten, 스웨덴, 901 87
        • Umeå Movement and Exercise Laboratory, Umeå University
        • 연락하다:
        • 연락하다:

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

9년 (어린이)

건강한 자원 봉사자를 받아들입니다

예

연구 대상 성별

남성

설명

Inclusion Criteria:

  • Healthy boys (n=40)
  • Physically active, defined as a minimum of 2 years experience in a sports club
  • Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
  • No previous experience of structured resistance training

Exclusion Criteria:

  • Chronic diseases that affect full participation
  • Injuries that limit full participation

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 다른
  • 할당: 무작위화되지 않음
  • 중재 모델: 병렬 할당
  • 마스킹: 하나의

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: Resistance Training Session
Resistance training. Heavy resistance training. 10 reps x 3 set of upper- and lower-body resistance exercises
다른: Resistance Training
Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
간섭 없음: Control
Control activity. None-exercising. 30 min of rest

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Growth Hormone Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood Concentration of Growth Hormone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Growth Hormone Post exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood Concentration of Growth Hormone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Growth Hormone 15 minutes post exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood Concentration of Growth Hormone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Growth Hormone 30 minutes post exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood Concentration of Growth Hormone
30 minutes after the completion of the exercise intervention (Post-30 values)
Insulin-like Growth Factor-1 Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Insulin-like Growth Factor-1
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Insulin-like Growth Factor-1 Post exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Insulin-like Growth Factor-1
Right after the completion of the exercise intervention (Post values)
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Insulin-like Growth Factor-1
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Insulin-like Growth Factor-1
30 minutes after the completion of the exercise intervention (Post-30 values)

2차 결과 측정

결과 측정
측정값 설명
기간
Cortisol Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Cortisol
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Cortisol Post exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Cortisol
Right after the completion of the exercise intervention (Post values)
Change from Baseline Cortisol 15 minutes Post exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Cortisol
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Cortisol 30 minutes Post exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Cortisol
30 minutes after the completion of the exercise intervention (Post-30 values)
Testosterone Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of testosterone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Testosterone Post Exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of testosterone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Testosterone 15 minutes Post Exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of testosterone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Testosterone 30 minutes Post Exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of testosterone
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-6 Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-6
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-6 Post Exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-6
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-6 15 minutes Post Exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-6
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-6 30 minutes Post Exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-6
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-1 alpha Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-1 alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-1 alpha Post Exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-1 alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-1 alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-1 alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Tumor Necrosis Factor alpha Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Tumor Necrosis Factor alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Tumor Necrosis Factor alpha Post Exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Tumor Necrosis Factor alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Tumor Necrosis Factor alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Tumor Necrosis Factor alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Sex Hormone Binding Globulin Baseline
기간: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Sex Hormone Binding Globulin
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Baseline Sex Hormone Binding Post Exercise
기간: Right after the completion of the exercise intervention (Post values)
Blood concentration of Sex Hormone Binding Globulin
Right after the completion of the exercise intervention (Post values)
Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
기간: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Sex Hormone Binding Globulin
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
기간: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Sex Hormone Binding Globulin
30 minutes after the completion of the exercise intervention (Post-30 values)

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

Umeå University

수사관

  • 수석 연구원: Apostolos Theos, PhD, Umeå University

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (예상)

2021년 9월 1일

기본 완료 (예상)

2021년 12월 1일

연구 완료 (예상)

2022년 3월 1일

연구 등록 날짜

최초 제출

2021년 6월 11일

QC 기준을 충족하는 최초 제출

2021년 8월 20일

처음 게시됨 (실제)

2021년 8월 26일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2021년 8월 26일

QC 기준을 충족하는 마지막 업데이트 제출

2021년 8월 20일

마지막으로 확인됨

2021년 8월 1일

추가 정보

이 연구와 관련된 용어

기타 연구 ID 번호

  • 2020-03179

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

아니요

약물 및 장치 정보, 연구 문서

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아니

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

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