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Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

20. August 2021 aktualisiert von: Apostolos Theos, Umeå University

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Studienübersicht

Status

Noch keine Rekrutierung

Bedingungen

Intervention / Behandlung

Detaillierte Beschreibung

Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

Studientyp

Interventionell

Einschreibung (Voraussichtlich)

40

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienkontakt

Studienorte

  • Schweden
    • Västerbotten
      • Umeå, Västerbotten, Schweden, 901 87
        • Umeå Movement and Exercise Laboratory, Umeå University
        • Kontakt:
        • Kontakt:

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

9 Jahre bis 17 Jahre (Kind)

Akzeptiert gesunde Freiwillige

Ja

Studienberechtigte Geschlechter

Männlich

Beschreibung

Inclusion Criteria:

  • Healthy boys (n=40)
  • Physically active, defined as a minimum of 2 years experience in a sports club
  • Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
  • No previous experience of structured resistance training

Exclusion Criteria:

  • Chronic diseases that affect full participation
  • Injuries that limit full participation

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Sonstiges
  • Zuteilung: Nicht randomisiert
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Single

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Experimental: Resistance Training Session
Resistance training. Heavy resistance training. 10 reps x 3 set of upper- and lower-body resistance exercises
Sonstiges: Resistance Training
Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
Kein Eingriff: Control
Control activity. None-exercising. 30 min of rest

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Growth Hormone Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood Concentration of Growth Hormone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Growth Hormone Post exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood Concentration of Growth Hormone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Growth Hormone 15 minutes post exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood Concentration of Growth Hormone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Growth Hormone 30 minutes post exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood Concentration of Growth Hormone
30 minutes after the completion of the exercise intervention (Post-30 values)
Insulin-like Growth Factor-1 Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Insulin-like Growth Factor-1
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Insulin-like Growth Factor-1 Post exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Insulin-like Growth Factor-1
Right after the completion of the exercise intervention (Post values)
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Insulin-like Growth Factor-1
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Insulin-like Growth Factor-1
30 minutes after the completion of the exercise intervention (Post-30 values)

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Cortisol Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Cortisol
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Cortisol Post exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Cortisol
Right after the completion of the exercise intervention (Post values)
Change from Baseline Cortisol 15 minutes Post exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Cortisol
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Cortisol 30 minutes Post exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Cortisol
30 minutes after the completion of the exercise intervention (Post-30 values)
Testosterone Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of testosterone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Testosterone Post Exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of testosterone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Testosterone 15 minutes Post Exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of testosterone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Testosterone 30 minutes Post Exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of testosterone
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-6 Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-6
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-6 Post Exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-6
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-6 15 minutes Post Exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-6
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-6 30 minutes Post Exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-6
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-1 alpha Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-1 alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-1 alpha Post Exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-1 alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-1 alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-1 alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Tumor Necrosis Factor alpha Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Tumor Necrosis Factor alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Tumor Necrosis Factor alpha Post Exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Tumor Necrosis Factor alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Tumor Necrosis Factor alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Tumor Necrosis Factor alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Sex Hormone Binding Globulin Baseline
Zeitfenster: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Sex Hormone Binding Globulin
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Baseline Sex Hormone Binding Post Exercise
Zeitfenster: Right after the completion of the exercise intervention (Post values)
Blood concentration of Sex Hormone Binding Globulin
Right after the completion of the exercise intervention (Post values)
Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
Zeitfenster: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Sex Hormone Binding Globulin
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
Zeitfenster: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Sex Hormone Binding Globulin
30 minutes after the completion of the exercise intervention (Post-30 values)

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

Umeå University

Ermittler

  • Hauptermittler: Apostolos Theos, PhD, Umeå University

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Voraussichtlich)

1. September 2021

Primärer Abschluss (Voraussichtlich)

1. Dezember 2021

Studienabschluss (Voraussichtlich)

1. März 2022

Studienanmeldedaten

Zuerst eingereicht

11. Juni 2021

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

20. August 2021

Zuerst gepostet (Tatsächlich)

26. August 2021

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

26. August 2021

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

20. August 2021

Zuletzt verifiziert

1. August 2021

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Andere Studien-ID-Nummern

  • 2020-03179

Plan für individuelle Teilnehmerdaten (IPD)

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NEIN

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

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