Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys
: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.
Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.
研究概览
详细说明
Preliminary measurements:
Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.
Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名:Apostolos Theos, PhD
- 电话号码:+46702811565
- 邮箱:apostolos.theos@umu.se
学习地点
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Västerbotten
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Umeå、Västerbotten、瑞典、901 87
- Umeå Movement and Exercise Laboratory, Umeå University
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接触:
- Apostolos Theos, PhD
- 电话号码:+46702811565
- 邮箱:apostolos.theos@umu.se
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接触:
- Tobias Stenlund, PhD
- 电话号码:+46907868040
- 邮箱:tobias.stenlund@umu.se
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Healthy boys (n=40)
- Physically active, defined as a minimum of 2 years experience in a sports club
- Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
- No previous experience of structured resistance training
Exclusion Criteria:
- Chronic diseases that affect full participation
- Injuries that limit full participation
学习计划
研究是如何设计的?
设计细节
- 主要用途:其他
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:Resistance Training Session
Resistance training.
Heavy resistance training.
10 reps x 3 set of upper- and lower-body resistance exercises
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Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
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无干预:Control
Control activity.
None-exercising.
30 min of rest
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Growth Hormone Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood Concentration of Growth Hormone
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Growth Hormone Post exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood Concentration of Growth Hormone
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Growth Hormone 15 minutes post exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood Concentration of Growth Hormone
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Growth Hormone 30 minutes post exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood Concentration of Growth Hormone
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Insulin-like Growth Factor-1 Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Insulin-like Growth Factor-1
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Insulin-like Growth Factor-1 Post exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Insulin-like Growth Factor-1
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Insulin-like Growth Factor-1
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Insulin-like Growth Factor-1
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30 minutes after the completion of the exercise intervention (Post-30 values)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Cortisol Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Cortisol
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Cortisol Post exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Cortisol
|
Right after the completion of the exercise intervention (Post values)
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Change from Baseline Cortisol 15 minutes Post exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Cortisol
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Cortisol 30 minutes Post exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Cortisol
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Testosterone Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of testosterone
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Testosterone Post Exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of testosterone
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Testosterone 15 minutes Post Exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of testosterone
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Testosterone 30 minutes Post Exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of testosterone
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Interleukin-6 Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Interleukin-6
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Interleukin-6 Post Exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Interleukin-6
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Interleukin-6 15 minutes Post Exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Interleukin-6
|
15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Interleukin-6 30 minutes Post Exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Interleukin-6
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Interleukin-1 alpha Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Interleukin-1 alpha
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Interleukin-1 alpha Post Exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Interleukin-1 alpha
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Interleukin-1 alpha
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Interleukin-1 alpha
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Tumor Necrosis Factor alpha Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Tumor Necrosis Factor alpha
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Tumor Necrosis Factor alpha Post Exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Tumor Necrosis Factor alpha
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Tumor Necrosis Factor alpha
|
15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Tumor Necrosis Factor alpha
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30 minutes after the completion of the exercise intervention (Post-30 values)
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Sex Hormone Binding Globulin Baseline
大体时间:Baseline testing before the exercise intervention (Pre values)
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Blood concentration of Sex Hormone Binding Globulin
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Baseline testing before the exercise intervention (Pre values)
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Change from Baseline Baseline Sex Hormone Binding Post Exercise
大体时间:Right after the completion of the exercise intervention (Post values)
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Blood concentration of Sex Hormone Binding Globulin
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Right after the completion of the exercise intervention (Post values)
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Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
大体时间:15 minutes after the completion of the exercise intervention (Post-15 values)
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Blood concentration of Sex Hormone Binding Globulin
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15 minutes after the completion of the exercise intervention (Post-15 values)
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Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
大体时间:30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood concentration of Sex Hormone Binding Globulin
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30 minutes after the completion of the exercise intervention (Post-30 values)
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合作者和调查者
调查人员
- 首席研究员:Apostolos Theos, PhD、Umeå University
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2020-03179
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计划共享个人参与者数据 (IPD)?
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Resistance Training的临床试验
-
Karolinska InstitutetMinistry of Health and Social Affairs, Sweden完全的
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Mental Health Services in the Capital Region, DenmarkCopenhagen Trial Unit, Center for Clinical Intervention Research; Center for Clinical Intervention...完全的