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Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

20 augustus 2021 bijgewerkt door: Apostolos Theos, Umeå University

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Studie Overzicht

Toestand

Nog niet aan het werven

Conditie

Interventie / Behandeling

Gedetailleerde beschrijving

Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

Studietype

Ingrijpend

Inschrijving (Verwacht)

40

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studiecontact

Studie Locaties

  • Zweden
    • Västerbotten
      • Umeå, Västerbotten, Zweden, 901 87
        • Umeå Movement and Exercise Laboratory, Umeå University
        • Contact:
        • Contact:

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

9 jaar tot 17 jaar (Kind)

Accepteert gezonde vrijwilligers

Ja

Geslachten die in aanmerking komen voor studie

Mannelijk

Beschrijving

Inclusion Criteria:

  • Healthy boys (n=40)
  • Physically active, defined as a minimum of 2 years experience in a sports club
  • Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
  • No previous experience of structured resistance training

Exclusion Criteria:

  • Chronic diseases that affect full participation
  • Injuries that limit full participation

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Ander
  • Toewijzing: Niet-gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Enkel

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: Resistance Training Session
Resistance training. Heavy resistance training. 10 reps x 3 set of upper- and lower-body resistance exercises
Ander: Resistance Training
Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
Geen tussenkomst: Control
Control activity. None-exercising. 30 min of rest

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Growth Hormone Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood Concentration of Growth Hormone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Growth Hormone Post exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood Concentration of Growth Hormone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Growth Hormone 15 minutes post exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood Concentration of Growth Hormone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Growth Hormone 30 minutes post exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood Concentration of Growth Hormone
30 minutes after the completion of the exercise intervention (Post-30 values)
Insulin-like Growth Factor-1 Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Insulin-like Growth Factor-1
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Insulin-like Growth Factor-1 Post exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Insulin-like Growth Factor-1
Right after the completion of the exercise intervention (Post values)
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Insulin-like Growth Factor-1
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Insulin-like Growth Factor-1
30 minutes after the completion of the exercise intervention (Post-30 values)

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Cortisol Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Cortisol
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Cortisol Post exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Cortisol
Right after the completion of the exercise intervention (Post values)
Change from Baseline Cortisol 15 minutes Post exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Cortisol
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Cortisol 30 minutes Post exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Cortisol
30 minutes after the completion of the exercise intervention (Post-30 values)
Testosterone Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of testosterone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Testosterone Post Exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of testosterone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Testosterone 15 minutes Post Exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of testosterone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Testosterone 30 minutes Post Exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of testosterone
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-6 Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-6
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-6 Post Exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-6
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-6 15 minutes Post Exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-6
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-6 30 minutes Post Exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-6
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-1 alpha Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-1 alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-1 alpha Post Exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-1 alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-1 alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-1 alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Tumor Necrosis Factor alpha Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Tumor Necrosis Factor alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Tumor Necrosis Factor alpha Post Exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Tumor Necrosis Factor alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Tumor Necrosis Factor alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Tumor Necrosis Factor alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Sex Hormone Binding Globulin Baseline
Tijdsspanne: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Sex Hormone Binding Globulin
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Baseline Sex Hormone Binding Post Exercise
Tijdsspanne: Right after the completion of the exercise intervention (Post values)
Blood concentration of Sex Hormone Binding Globulin
Right after the completion of the exercise intervention (Post values)
Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
Tijdsspanne: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Sex Hormone Binding Globulin
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
Tijdsspanne: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Sex Hormone Binding Globulin
30 minutes after the completion of the exercise intervention (Post-30 values)

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Umeå University

Onderzoekers

  • Hoofdonderzoeker: Apostolos Theos, PhD, Umeå University

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Verwacht)

1 september 2021

Primaire voltooiing (Verwacht)

1 december 2021

Studie voltooiing (Verwacht)

1 maart 2022

Studieregistratiedata

Eerst ingediend

11 juni 2021

Eerst ingediend dat voldeed aan de QC-criteria

20 augustus 2021

Eerst geplaatst (Werkelijk)

26 augustus 2021

Updates van studierecords

Laatste update geplaatst (Werkelijk)

26 augustus 2021

Laatste update ingediend die voldeed aan QC-criteria

20 augustus 2021

Laatst geverifieerd

1 augustus 2021

Meer informatie

Termen gerelateerd aan deze studie

Andere studie-ID-nummers

  • 2020-03179

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

NEE

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .

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