Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys
20 augusti 2021 uppdaterad av: Apostolos Theos, Umeå University
: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.
Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.
Studieöversikt
Status
Har inte rekryterat ännu
Intervention / Behandling
Detaljerad beskrivning
Preliminary measurements:
Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.
Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.
Studietyp
Interventionell
Inskrivning (Förväntat)
40
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studiekontakt
- Namn: Apostolos Theos, PhD
- Telefonnummer: +46702811565
- E-post: apostolos.theos@umu.se
Studieorter
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Västerbotten
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Umeå, Västerbotten, Sverige, 901 87
- Umeå Movement and Exercise Laboratory, Umeå University
-
Kontakt:
- Apostolos Theos, PhD
- Telefonnummer: +46702811565
- E-post: apostolos.theos@umu.se
-
Kontakt:
- Tobias Stenlund, PhD
- Telefonnummer: +46907868040
- E-post: tobias.stenlund@umu.se
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-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
9 år till 17 år (Barn)
Tar emot friska volontärer
Ja
Kön som är behöriga för studier
Manlig
Beskrivning
Inclusion Criteria:
- Healthy boys (n=40)
- Physically active, defined as a minimum of 2 years experience in a sports club
- Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
- No previous experience of structured resistance training
Exclusion Criteria:
- Chronic diseases that affect full participation
- Injuries that limit full participation
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Övrig
- Tilldelning: Icke-randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Enda
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Resistance Training Session
Resistance training.
Heavy resistance training.
10 reps x 3 set of upper- and lower-body resistance exercises
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Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
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Inget ingripande: Control
Control activity.
None-exercising.
30 min of rest
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Growth Hormone Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood Concentration of Growth Hormone
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Growth Hormone Post exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood Concentration of Growth Hormone
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Growth Hormone 15 minutes post exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood Concentration of Growth Hormone
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Growth Hormone 30 minutes post exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
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Blood Concentration of Growth Hormone
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Insulin-like Growth Factor-1 Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Insulin-like Growth Factor-1
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Insulin-like Growth Factor-1 Post exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Insulin-like Growth Factor-1
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Insulin-like Growth Factor-1
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Insulin-like Growth Factor-1
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Cortisol Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Cortisol
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Cortisol Post exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Cortisol
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Cortisol 15 minutes Post exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Cortisol
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Cortisol 30 minutes Post exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Cortisol
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Testosterone Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of testosterone
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Testosterone Post Exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of testosterone
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Testosterone 15 minutes Post Exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of testosterone
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Testosterone 30 minutes Post Exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of testosterone
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Interleukin-6 Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Interleukin-6
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Interleukin-6 Post Exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Interleukin-6
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Interleukin-6 15 minutes Post Exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Interleukin-6
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Interleukin-6 30 minutes Post Exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Interleukin-6
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Interleukin-1 alpha Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Interleukin-1 alpha
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Interleukin-1 alpha Post Exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Interleukin-1 alpha
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Interleukin-1 alpha
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Interleukin-1 alpha
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Tumor Necrosis Factor alpha Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Tumor Necrosis Factor alpha
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Tumor Necrosis Factor alpha Post Exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Tumor Necrosis Factor alpha
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Tumor Necrosis Factor alpha
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Tumor Necrosis Factor alpha
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
|
Sex Hormone Binding Globulin Baseline
Tidsram: Baseline testing before the exercise intervention (Pre values)
|
Blood concentration of Sex Hormone Binding Globulin
|
Baseline testing before the exercise intervention (Pre values)
|
|
Change from Baseline Baseline Sex Hormone Binding Post Exercise
Tidsram: Right after the completion of the exercise intervention (Post values)
|
Blood concentration of Sex Hormone Binding Globulin
|
Right after the completion of the exercise intervention (Post values)
|
|
Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
Tidsram: 15 minutes after the completion of the exercise intervention (Post-15 values)
|
Blood concentration of Sex Hormone Binding Globulin
|
15 minutes after the completion of the exercise intervention (Post-15 values)
|
|
Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
Tidsram: 30 minutes after the completion of the exercise intervention (Post-30 values)
|
Blood concentration of Sex Hormone Binding Globulin
|
30 minutes after the completion of the exercise intervention (Post-30 values)
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Apostolos Theos, PhD, Umeå University
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Förväntat)
1 september 2021
Primärt slutförande (Förväntat)
1 december 2021
Avslutad studie (Förväntat)
1 mars 2022
Studieregistreringsdatum
Först inskickad
11 juni 2021
Först inskickad som uppfyllde QC-kriterierna
20 augusti 2021
Första postat (Faktisk)
26 augusti 2021
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
26 augusti 2021
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
20 augusti 2021
Senast verifierad
1 augusti 2021
Mer information
Termer relaterade till denna studie
Andra studie-ID-nummer
- 2020-03179
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