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Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

20. august 2021 oppdatert av: Apostolos Theos, Umeå University

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

Studietype

Intervensjonell

Registrering (Forventet)

40

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Sverige
    • Västerbotten
      • Umeå, Västerbotten, Sverige, 901 87
        • Umeå Movement and Exercise Laboratory, Umeå University
        • Ta kontakt med:
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

9 år til 17 år (Barn)

Tar imot friske frivillige

Ja

Kjønn som er kvalifisert for studier

Mann

Beskrivelse

Inclusion Criteria:

  • Healthy boys (n=40)
  • Physically active, defined as a minimum of 2 years experience in a sports club
  • Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
  • No previous experience of structured resistance training

Exclusion Criteria:

  • Chronic diseases that affect full participation
  • Injuries that limit full participation

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Annen
  • Tildeling: Ikke-randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Enkelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Resistance Training Session
Resistance training. Heavy resistance training. 10 reps x 3 set of upper- and lower-body resistance exercises
Annen: Resistance Training
Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.
Ingen inngripen: Control
Control activity. None-exercising. 30 min of rest

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Growth Hormone Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood Concentration of Growth Hormone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Growth Hormone Post exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood Concentration of Growth Hormone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Growth Hormone 15 minutes post exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood Concentration of Growth Hormone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Growth Hormone 30 minutes post exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood Concentration of Growth Hormone
30 minutes after the completion of the exercise intervention (Post-30 values)
Insulin-like Growth Factor-1 Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Insulin-like Growth Factor-1
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Insulin-like Growth Factor-1 Post exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Insulin-like Growth Factor-1
Right after the completion of the exercise intervention (Post values)
Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Insulin-like Growth Factor-1
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Insulin-like Growth Factor-1
30 minutes after the completion of the exercise intervention (Post-30 values)

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Cortisol Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Cortisol
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Cortisol Post exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Cortisol
Right after the completion of the exercise intervention (Post values)
Change from Baseline Cortisol 15 minutes Post exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Cortisol
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Cortisol 30 minutes Post exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Cortisol
30 minutes after the completion of the exercise intervention (Post-30 values)
Testosterone Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of testosterone
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Testosterone Post Exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of testosterone
Right after the completion of the exercise intervention (Post values)
Change from Baseline Testosterone 15 minutes Post Exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of testosterone
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Testosterone 30 minutes Post Exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of testosterone
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-6 Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-6
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-6 Post Exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-6
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-6 15 minutes Post Exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-6
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-6 30 minutes Post Exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-6
30 minutes after the completion of the exercise intervention (Post-30 values)
Interleukin-1 alpha Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Interleukin-1 alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Interleukin-1 alpha Post Exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Interleukin-1 alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Interleukin-1 alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Interleukin-1 alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Tumor Necrosis Factor alpha Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Tumor Necrosis Factor alpha
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Tumor Necrosis Factor alpha Post Exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Tumor Necrosis Factor alpha
Right after the completion of the exercise intervention (Post values)
Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Tumor Necrosis Factor alpha
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Tumor Necrosis Factor alpha
30 minutes after the completion of the exercise intervention (Post-30 values)
Sex Hormone Binding Globulin Baseline
Tidsramme: Baseline testing before the exercise intervention (Pre values)
Blood concentration of Sex Hormone Binding Globulin
Baseline testing before the exercise intervention (Pre values)
Change from Baseline Baseline Sex Hormone Binding Post Exercise
Tidsramme: Right after the completion of the exercise intervention (Post values)
Blood concentration of Sex Hormone Binding Globulin
Right after the completion of the exercise intervention (Post values)
Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
Tidsramme: 15 minutes after the completion of the exercise intervention (Post-15 values)
Blood concentration of Sex Hormone Binding Globulin
15 minutes after the completion of the exercise intervention (Post-15 values)
Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
Tidsramme: 30 minutes after the completion of the exercise intervention (Post-30 values)
Blood concentration of Sex Hormone Binding Globulin
30 minutes after the completion of the exercise intervention (Post-30 values)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Umeå University

Etterforskere

  • Hovedetterforsker: Apostolos Theos, PhD, Umea University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Forventet)

1. september 2021

Primær fullføring (Forventet)

1. desember 2021

Studiet fullført (Forventet)

1. mars 2022

Datoer for studieregistrering

Først innsendt

11. juni 2021

Først innsendt som oppfylte QC-kriteriene

20. august 2021

Først lagt ut (Faktiske)

26. august 2021

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

26. august 2021

Siste oppdatering sendt inn som oppfylte QC-kriteriene

20. august 2021

Sist bekreftet

1. august 2021

Mer informasjon

Begreper knyttet til denne studien

Andre studie-ID-numre

  • 2020-03179

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

NEI

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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