Hippocampal-Avoiding Whole Brain Irradiation With Simultaneous Integrated Boost for Treatment of Brain Metastases

The HVLT-R is a validated test to assess neurocognitive function and it incorporates 6 different forms, each including 12 nouns (targets) with 4 words drawn from 3 semantic categories.

*Delayed*recall was measured by recalling the 12 targets after a 20-minute delay.

1 point is awarded for each successfully recalled target. There is no range- recalling more is more memory.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

The HVLT-R is a validated test to assess neurocognitive function and it incorporates 6 different forms, each including 12 nouns (targets) with 4 words drawn from 3 semantic categories.

*Immediate* recall was measured by memorizing a list of 12 targets for 3 consecutive trials.

1 point is awarded for each successfully recalled target. There is no range- recalling more is more memory.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

The HVLT-R is a validated test to assess neurocognitive function and it incorporates 6 different forms, each including 12 nouns (targets) with 4 words drawn from 3 semantic categories.

*Delayed recognition* was measured by using recognition discrimination index.

1 point is awarded for each successfully recalled target. There is no range- recalling more is more memory.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

Controlled Word Association Test (COWAT) is used to assess language and executive/frontal skills. The patient produces as many words as possible in 1 min. (each) for a specific letter (C, F, L or P, R, W). Requires about 5 min to complete.

1 point is awarded for each word produced. Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

Trail Making Test (TMT) is a measure of visuospatial scanning, attention, sequencing, and speed and executive function. Patients must "connect the dots" either in a numbered sequence or alternating letters and numbers.

The TMT has two parts that are referred to as the Trail Making Test Part A and the Trail Making Test Part B.

In Part A, the circles are numbered 1 - 25, and the patient should draw lines to connect the numbers in ascending order.

Possible score ranges from 0-3 minutes with higher score (more seconds/minutes) indicating significant cognitive impairment.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

Trail Making Test (TMT) is a measure of visuospatial scanning, attention, sequencing, and speed and executive function. Patients must "connect the dots" either in a numbered sequence or alternating letters and numbers.

The TMT has two parts that are referred to as the Trail Making Test Part A and the Trail Making Test Part B.

In Part B, the circles include both numbers (1 - 13) and letters (A - L). Possible score ranges from 0-5 minutes with higher score (more seconds/minutes) indicating significant cognitive impairment.

Medical Outcomes Scale (MOS) assess cognitive function with possible score range from 0-100, with higher scores indicating better outcome.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

Mini-Mental Status Examination (MMSE) is a brief, standardized tool to grade patients' global cognitive function. Possible scores range from 0-30, with lower score indicating severe cognitive impairment.

Mean change was calculated by the following formula: 100*(3 month - baseline) / baseline

Cumulative incidence of local failure, defined as tumor recurrence . Percent local failure at 1 year.

The Cox proportional hazards regression model will be used to evaluate Cumulative incidence of local failure.

This is to evaluate local control of brain metastases treated with integrated boost.

Cumulative incidence of intracranial failure was estimated by the Cox proportional hazards regression model.

Intracranial failure is any failure in the brain.

Quality of life will be assessed using the Functional Assessment of Cancer Therapy with Brain Subscale (FACT-BR). The FACT-BR is a multidimensional, self-report quality of life instrument specifically designed and validated for use with brain malignancy patients. It is written at the 4th grade reading level and can be completed in 5-10 minutes with little or no assistance in patients who are not neurologically incapacitated. It measures quality of life related to symptoms or problems across 5 scales: physical well-being (7 items); social/family well-being (7 items);emotional well-being (6 items); functional well-being (7 items); and concerns relevant to patients with brain tumors (23 items).

Items are rated on a 5-point scale (0-5): 0-"not at all", 1- "a little bit", 2-"somewhat", 3-"quite a bit" and 4-"very much", with HIGHER scores indicating a better quality of life.

The EQ (Euroqol)-5D (5 Dimension) health related quality of life questionnaire is a standardized instrument for use as a measure of health outcome.

Applicable to a wide range of health conditions and treatments, it provides a simple descriptive profile and a single index value for health status. . The US version of the EQ-5D will be used, to enable mapping of general HR-QoL (Health-related quality of life) scores from EQ-5D scores into health state utility scores (ranging from 0 to 1) for the US population.

Possible scores range from 0 to 1, with HIGHER scores indicating a better quality of life.