Adherence to Immunosuppressive Therapy Liver Transplant Recipients (AIM)
Adherence to Immunosuppressive Therapy in Adult and Adolescent Liver Transplant Recipients: A Questionnaire Survey
Studie Overzicht
Toestand
Interventie / Behandeling
Gedetailleerde beschrijving
Patient's demographic details such as age, gender, body mass index, education level, language, and occupation will be captured. Clinical details such as significant comorbidities, date of liver transplant, type of transplant (cadaveric or living related), underlying liver disease, type of immunosuppressants, and history of rejection with its details will also be recorded.
Participants will be asked to fill in a Questionnaire aimed to capture socioeconomic and clinical background, as well as the number, type, and dosing schedule of their immunosuppressants. Details and frequency of missed doses, the reason for 'missed doses', and patient's dosing preferences will be the questionnaire to access patient's compliance to medication. A liver transplant coordinator trained to administer the questionnaire will assist patients if required.
The participant will be approached either during their clinic visit or through phone call. For participants who are approached during their clinic session, informed consent process will be conducted in the clinic by the assigned study team member(s). Participants will then complete the questionnaire. Some participants may be on 6-monthly or annual follow-up. For this group of participants, a phone call will be made to ask if they would be keen to participate in this questionnaire study. If they are agreeable, 2 copies of DSRB approved version of informed consent forms together with the questionnaire form will be posted to participants for their completion. Participant will sign the informed consent forms, complete the questionnaire and post the completed documents back to study team members.
The primary and secondary outcome is patient compliance and patient preference, respectively. Besides the type of immunosuppressants, factors associated with outcomes will also be analyzed. Data entry and analysis will be conducted using SAS 9.2. Differences in categorical variables will be analyzed with chi-square test and Fisher's-exact test where appropriate and differences in continuous variables will be analyzed with student T-test. A two-sided analysis will be used and a p value of <0.5 will be considered significant.
Studietype
Inschrijving (Verwacht)
Contacten en locaties
Studie Locaties
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Singapore, Singapore, 119228
- Werving
- National University Hospital, Div of Gastroenterology & Hepatology, National University Center for Organ Transplantation
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Contact:
- Kieron Lim, MD
- Telefoonnummer: (65)67726258
- E-mail: kieron_lim@nuhs.edu.sg
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Hoofdonderzoeker:
- Kieron Lim, MD
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Onderonderzoeker:
- Seng Gee Lim, MD
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Onderonderzoeker:
- Krishnakumar Madhavan, MD
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Onderonderzoeker:
- Yock Young Dan, MD
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Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Bemonsteringsmethode
Studie Bevolking
Beschrijving
Inclusion Criteria:
- Males or females, 18 years old and above
- Written informed consent must be obtained from subjects prior to study participation
Exclusion Criteria:
- Patients who have not received any immunosuppresants post liver transplant surgery
- Patients who are not willing to participate in this study.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Tijdsperspectieven: Retrospectief
Cohorten en interventies
Groep / Cohort |
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Immunosuppressive therapy
Liver Transplant recipients who are receiving various doses and types of immunosuppressive therapy
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Compliance / Adherence to immunosuppression
Tijdsspanne: 1 year
|
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1 year
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Patient preferences on dosing of immunosuppression & associated factors
Tijdsspanne: 1 year
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1 year
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Medewerkers en onderzoekers
Studie record data
Bestudeer belangrijke data
Studie start
Primaire voltooiing (Verwacht)
Studie voltooiing (Verwacht)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Schatting)
Updates van studierecords
Laatste update geplaatst (Schatting)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Andere studie-ID-nummers
- AIM Study
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