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Concentric vs Eccentric Exercise in Blood Flow Restriction Training

14 juli 2026 bijgewerkt door: METEHAN YANA, Karabuk University

Comparison of the Effectiveness of Concentric and Eccentric Exercises in Blood Flow Restriction Training

This randomized controlled trial will investigate the effects of blood flow restriction (BFR) training combined with concentric or eccentric exercise on upper extremity reaction speed, muscle strength, and muscle oxygenation in healthy adults aged 18-35 years. A total of 34 participants will be randomly allocated to either a BFR combined with concentric exercise group (n=17) or a BFR combined with eccentric exercise group (n=17).

Before the intervention, maximal muscle strength will be determined using a one-repetition maximum (1RM) test for the dominant elbow flexor muscles. Upper extremity reaction speed will be assessed using the Nelson Hand Reaction Test. Biceps brachii muscle strength will be measured with a digital dynamometer, and muscle oxygenation will be evaluated using a near-infrared spectroscopy (NIRS) device. All outcome measures will be obtained 72 hours before the intervention and repeated 72 hours after completion of the training program by the same investigator.

The findings of this study will contribute to understanding whether concentric or eccentric exercise combined with BFR training provides greater improvements in upper extremity reaction speed, muscle strength, and muscle oxygenation in healthy individuals.

Studie Overzicht

Toestand

Aanmelden op uitnodiging

Conditie

Interventie / Behandeling

Studietype

Ingrijpend

Inschrijving (Geschat)

34

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Turkije (Türkiye)
    • Karabük Province
      • Karabük, Karabük Province, Turkije (Türkiye), 78050
        • Karabuk University

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen

Accepteert gezonde vrijwilligers

Ja

Beschrijving

Inclusion Criteria:

  • Being between 18 and 35 years of age
  • Physically inactive or minimally active individuals (International Physical Activity Questionnaire-Short Form. IPAQ-CF, <3000 MET-min/week)

Exclusion Criteria:

  • Having a history of musculoskeletal surgery within the last 6 months
  • Individuals with a history of orthopedic surgery within the last 6 months
  • Having high systolic blood pressure (≥140 mmHg)
  • Having a current history of cardiovascular disease
  • Participants who did not volunteer to participate in the study and did not provide informed consent were excluded from the study.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Ander
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Geen (open label)

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Actieve vergelijker: CONCENTRIC GROUP
Ander: concentric group
Participants assigned to this group will perform blood flow restriction (BFR) training combined with concentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four sets (30-15-15-15 repetitions) with 30-second rest intervals between sets.
Ander: eccentric group
Participants assigned to this group will perform blood flow restriction (BFR) training combined with eccentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four sets (30-15-15-15 repetitions) with 30-second rest intervals between sets.
Actieve vergelijker: ECCENTRIC GROUP
Ander: concentric group
Participants assigned to this group will perform blood flow restriction (BFR) training combined with concentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four sets (30-15-15-15 repetitions) with 30-second rest intervals between sets.
Ander: eccentric group
Participants assigned to this group will perform blood flow restriction (BFR) training combined with eccentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four sets (30-15-15-15 repetitions) with 30-second rest intervals between sets.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Upper Extremity Reaction Time
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Upper extremity reaction time will be assessed using the Nelson Hand Reaction Test. Participants will complete five trials, the highest and lowest values will be discarded, and the mean of the remaining three trials will be used for analysis. Reaction time will be calculated from the ruler drop distance using the standard equation.
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Biceps Brachii Muscle Strength
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Biceps brachii muscle strength will be measured using an ActivForce 2 digital dynamometer. Three maximal isometric contractions will be performed with 30-second rest intervals, and the highest value will be used for analysis.
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Hand Grip Strength
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Hand grip strength will be measured using a hydraulic hand dynamometer. Participants will perform three maximal contractions with 30-second rest intervals, and the highest value will be recorded for analysis.
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Pinch Strength
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Pinch strength will be assessed using a pinch dynamometer. Three maximal trials will be performed with 30-second rest intervals, and the highest value will be used for analysis.
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
One-Repetition Maximum
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Maximum muscle strength of the elbow flexors will be estimated using the Epley equation based on the maximum number of repetitions completed with a fixed load (2 kg for females and 5 kg for males).
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Muscle Oxygen Saturation
Tijdsspanne: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.
Muscle oxygen saturation (SmO₂) of the biceps brachii will be measured using a MOXY near-infrared spectroscopy (NIRS) device. Baseline SmO₂ will be recorded before the 1RM test, continuous SmO₂ values will be monitored throughout the test, and recovery values will be recorded for 2-3 minutes after the test.
Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Karabuk University

Publicaties en nuttige links

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Algemene publicaties

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Geschat)

1 augustus 2026

Primaire voltooiing (Geschat)

1 oktober 2026

Studie voltooiing (Geschat)

1 november 2026

Studieregistratiedata

Eerst ingediend

14 juli 2026

Eerst ingediend dat voldeed aan de QC-criteria

14 juli 2026

Eerst geplaatst (Werkelijk)

17 juli 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

17 juli 2026

Laatste update ingediend die voldeed aan QC-criteria

14 juli 2026

Laatst geverifieerd

1 juli 2026

Meer informatie

Termen gerelateerd aan deze studie

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • blood flow restriction

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

NEE

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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