Taste Perception and Chronic Disease Risk
21. mai 2014 oppdatert av: Tufts University
Relationship Between Variations in Taste Perception and Chronic Disease Risk Factors as a Function of Age
The purpose of the Taste Perception Study is to assess variations in the ability to taste and perceive sensations from various stimuli in younger (18-49 years) and older (50-85 years) volunteers.
The study's goal is to determine how these sensations influence what one likes to eat, and what one chooses to eat, and whether there is an association with dietary intake, body composition and chronic disease.
Another objective of the study is to determine the association between variations in oral sensations and genes mediating sensory perception and dietary behaviours.
Studieoversikt
Status
Fullført
Detaljert beskrivelse
The objective of the Taste Perception Study is to assess variations in oral sensations in younger (18-49 years; n=35) relative to older (50-85 years; n=35) subjects, and determine the association between variations in oral sensations and measures of chronic disease risk factors, body composition, habitual dietary intake and selected genes mediating sensory perception and dietary behaviors.
Subjects who are participating in the Glycemic Index study (IRB #7196) will be asked for voluntarily participation in the proposed study.
These volunteers will undergo 1-2 hours of standardized testing.
These tests will involve tasting or smelling certain foods/beverages or ingredients in foods/beverages and rating the degree of liking/disliking, intensity and flavor or odor using a validated general Labeled magnitude scale.
Volunteers will also be asked to complete a food preference survey and eating inventory questionnaire, as well as provide a DNA sample from a cheek swab or blood sample.
These data will then be merged with the measures of chronic disease risk factors, body composition and habitual dietary intake data generated from the Glycemic index study in order to better understand if variations in oral sensations influence food preferences and patterns and subsequently chronic disease risk.
Studietype
Observasjonsmessig
Registrering (Faktiske)
90
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Massachusetts
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Boston, Massachusetts, Forente stater, 02111
- Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år til 85 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Prøvetakingsmetode
Ikke-sannsynlighetsprøve
Studiepopulasjon
Community Sample
Beskrivelse
Inclusion Criteria:
- men and women;
- aged 18 to 85 years old;
- free of known chronic disease;
- BMI < 35 kg/ m2.
Exclusion criteria:
- BMI ≥ 35 kg/m2;
- renal or liver disease;
- untreated hypertension;
- irritable bowel syndrome;
- malabsorptive, esophageal and gastrointestinal motility disorders;
- chronic pancreatitis, or history of acute pancreatitis within the last year;
- hypothyroidism or hypothyroidism, as defined as screening TSH outside of normal ranges;
- anemia, as defined by screening hematocrit of 34% for women and 38% for men;
- smoking within the past 6 months;
- diabetes;
- fasting glucose ≥ 125 mg/dL;
- pregnancy or breastfeeding;
- history of polycystic ovary syndrome;
- history of autoimmune or other connective tissue disorders associated with chronic inflammation, such as rheumatoid arthritis; alcohol consumption > 7 drinks/ week;
- use of medications known to affect glucose or lipid metabolism;
- established CVD (myocardial infarction, stroke, heart failure, coronary artery bypass, graft, stenosis > 50%, peripheral arterial disease);
- unwillingness to adhere to study protocol;
- weight gain or loss of more than 15 lbs within 6 months prior to enrollment and other abnormal screening laboratory analysis results.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Observasjonsmodeller: Kohort
- Tidsperspektiver: Tverrsnitt
Kohorter og intervensjoner
Gruppe / Kohort |
|---|
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18-49 years
Younger
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50-85 years
Older
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Sensory/hedonic rating
Tidsramme: 1 - 2 hours
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1 - 2 hours
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Genetic Variation
Tidsramme: 1- 2 hours
|
1- 2 hours
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Nirupa R Matthan, Ph.D., HNRCA at Tufts University
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Vega-Lopez S, Ausman LM, Griffith JL, Lichtenstein AH. Interindividual variability and intra-individual reproducibility of glycemic index values for commercial white bread. Diabetes Care. 2007 Jun;30(6):1412-7. doi: 10.2337/dc06-1598. Epub 2007 Mar 23.
- He W, Sengupta M, Velkoff VA, DeBarros KA. U.S. Census Bureau, Current Population Reports, 65+ in the United States: 2005. U.S. Government Printing Office, Washington DC. 2005: 23-209.
- Duffy VB, Chapo AK. Smell, Taste, and Somatosensation in the Elderly. Jones and Bartlett Publishers, 2006: 115-153.
- Seiberling KA, Conley DB. Aging and olfactory and taste function. Otolaryngol Clin North Am. 2004 Dec;37(6):1209-28, vii. doi: 10.1016/j.otc.2004.06.006.
- Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL, Duffy VB. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav. 2006 Feb 28;87(2):304-13. doi: 10.1016/j.physbeh.2005.10.018. Epub 2005 Dec 20.
- Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ. Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1137-48. doi: 10.1098/rstb.2006.1853.
- Drewnowski A. Taste preferences and food intake. Annu Rev Nutr. 1997;17:237-53. doi: 10.1146/annurev.nutr.17.1.237.
- Lanier SA, Hayes JE, Duffy VB. Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol Behav. 2005 Jan 17;83(5):821-31. doi: 10.1016/j.physbeh.2004.10.004. Epub 2004 Nov 21.
- Goldstein GL, Daun H, Tepper BJ. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes Res. 2005 Jun;13(6):1017-23. doi: 10.1038/oby.2005.119.
- Duffy VB. Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite. 2004 Aug;43(1):5-9. doi: 10.1016/j.appet.2004.02.007.
- Rolls BJ. Do chemosensory changes influence food intake in the elderly? Physiol Behav. 1999 Apr;66(2):193-7. doi: 10.1016/s0031-9384(98)00264-9.
- Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav. 1994 Dec;56(6):1165-71. doi: 10.1016/0031-9384(94)90361-1. Erratum In: Physiol Behav 1995 Jul;58(1):203.
- Bartoshuk LM, Duffy VB, Fast K, Green BG, Prutkin K, Snyder DJ. Labeled scales (e.g. category, Likert, VAS) and across-group comparisons: what we have learned from genetic variation in taste. Food Quality and Preference 2003; 14: 125-138.
- Green BG, Dalton P, Cowart B, Shaffer G, Rankin K, Higgins J. Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell. Chem Senses. 1996 Jun;21(3):323-34. doi: 10.1093/chemse/21.3.323.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. juli 2008
Primær fullføring (Faktiske)
1. mars 2010
Studiet fullført (Faktiske)
1. mars 2010
Datoer for studieregistrering
Først innsendt
30. november 2009
Først innsendt som oppfylte QC-kriteriene
1. desember 2009
Først lagt ut (Anslag)
2. desember 2009
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
23. mai 2014
Siste oppdatering sendt inn som oppfylte QC-kriteriene
21. mai 2014
Sist bekreftet
1. mai 2014
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- Ross Aging Initiative
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