Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion
Influence of Hyperoxia and Hypergravity on Pulmonary Ventilation and Perfusion
Studieoversikt
Detaljert beskrivelse
Experiments were conducted in a human centrifuge. The protocol aimed at mimicking a routine peacetime flight in combat aircraft, and included 10-min exposure to +1.4 - +3.5 Gz. Subjects were exposed three times to this sequence, breathing air, 44.5% O2 or 100% O2.
Ten volunteers wearing anti-G trousers participated in the study. The Ethics Committee Ile-de-France III and the French National Agency for Drug Safety (ANSM) approved the protocol (number 2009-A01092-55).
Three different imaging techniques, electrical impedance tomography (EIT), pulmonary ultrasound and chest SPECT/CT were used and compared. EIT enabled ventilation monitoring in the human centrifuge, whereas pulmonary ultrasound and SPECT/CT gave functional and topographical information before and after exposure to +Gz accelerations. EIT analysis focused on regional ventilation, SPECT on global lung ventilation and perfusion, CT on the presence of atelectasis, and pulmonary ultrasound analysis looked for comet tails in 64 chest areas. Arterial blood pressure was recorded continuously by finger photoplethysmography. Cardiac output and stroke volume were computed from these recordings, using three different algorithms. Echocardiography was used as reference non-invasive technique for stroke volume determination and performed before and after exposure to +Gz accelerations.
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
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Brétigny-sur-Orge, Frankrike, 91 223
- Armed Forces Biomedical Research Institute
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Paris, Frankrike, 75005
- Department of Nuclear Medicine, Val-de-Grâce hospital
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- normal lung function checked by pulmonary function tests
Part 1 exclusion Criteria:
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- smoking
- bad tolerance to +Gz accelerations (G-induced loss of consciousness, motion sickness)
Part 2 exclusion criteria:
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- smoking
- The use of medication for hypertension
- asymmetric values of left/right humeral arterial blood pressure
- significant echocardiographic abnormalities or bad echogenicity
- bad tolerance to +Gz accelerations (G-induced loss of consciousness, motion sickness)
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
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Eksperimentell: ventilation
hypergravity gas mixture
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1hr sitting rest followed by 10 min of hypergravity (2 centrifuge runs)
breathing air, 44.5%O2 or 100%O2
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
change in regional ventilation distribution
Tidsramme: baseline, 2hrs 30min
|
"per lobe and per quadrant at 5th intercostal space level"
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baseline, 2hrs 30min
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
change in regional pulmonary perfusion
Tidsramme: baseline, 2hrs 30min
|
"per lobe and per quadrant at 5th intercostal space level"
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baseline, 2hrs 30min
|
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cardiac output (L/min)
Tidsramme: 2hrs
|
"echocardiography (sub-aortic diameter), photoplethysmography (Liljestrand, systolic area and Windkessel algorithms)"
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2hrs
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Andre resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
tidal volume
Tidsramme: 2hrs 30min
|
global (mL, area under the flow versus time curve) and regional (% change per quadrant at 5th intercostal space level)
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2hrs 30min
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Samarbeidspartnere og etterforskere
Etterforskere
- Studiestol: Daniel Garin, MD, PhD, Armed Forces Biomedical Research Institute
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 10co706
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