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Mother and Infant Study Cohort (MISC)-

22. juni 2018 oppdatert av: Hadia Radwan, University of Sharjah

Impact of Feeding Patterns on Adiposity and Cardiometabolic Markers in Baby and Mother: A Prospective Cohort Study

This study aims to explore breastfeeding and complementary feeding practices of mothers in the United Arab Emirates (UAE) and its relation to the early life determinants of obesity and non-communicable diseases (NCDs). This research study will follow a prospective cohort approach. Two hundred and fifty mother-infant pairs will be followed for 18 months.

The hypothesis of this research study is that exclusive breastfeeding of the infant will provide potential protective effect against cardiometabolic risk factors. This study will also hypothesize that mothers who exclusively breastfeed their newborns would experience greater postpartum weight and body fat loss than mothers who are not breastfeeding.

Studieoversikt

Status

Fullført

Forhold

Adiposity, Breast Feeding

Detaljert beskrivelse

United Arab Emirates(UAE) is facing two critical situations: high incidence of obesity and chronic diseases and suboptimal infant feeding practices as reported by the Ministry of Health in the UAE. So early identification of preventive markers of cardiometabolic risk factors in breast milk is important for developing early intervention strategies to optimize health care for individuals and communities especially in countries suffering from high rates of obesity and chronic diseases such as the UAE.

The purpose of this study is to prospectively follow up with the mothers and their infants (from 0-18months of infants age). It will explore breastfeeding and complementary feeding practices of mothers in UAE and its relation to the early life determinants of obesity and non-communicable diseases (NCDs). It will examine the components of human milk which might offer a protective benefit against obesity and its health consequences in infancy. It will also evaluate the feeding practices of the mothers and her nutritional status and relates it to their infants' growth and development.

It is expected that this research study will fill an important knowledge gap in the understanding of the feeding practices of mothers and its relation to early-life determinants of obesity and other chronic diseases in the UAE.

Studietype

Observasjonsmessig

Registrering (Faktiske)

257

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

De forente arabiske emirater
- Shajah
  - Sharjah, Shajah, De forente arabiske emirater, 27272
    - Hadia Radwan

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

19 år til 40 år (Voksen)

Tar imot friske frivillige

Kjønn som er kvalifisert for studier

Hunn

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

The sample population is Emirati and Arab expatriate mothers, aged 19 to 40 years old; visiting Mother and Child Centers (MCH) and Primary Healthcare Centers (PHC) in Dubai and Sharjah.

The selected mothers (who will be recruited during their 3rd trimester) were invited to participate in the study after being consented for their procedures and they will sign on the behalf of their babies

Beskrivelse

Inclusion Criteria:

Pregnant women:
- Emirate nationality or Arab expatriate
- Age: 19-40 years
- Singleton pregnancy
- Within the third trimester of pregnancy (27-42 weeks of gestation)
- Free of chronic diseases (diabetes, hypertension, kidney disease, cancer, or other chronic diseases), autoimmune disorders, or infections with the human immunodeficiency virus, or hepatitis in preconception

Exclusion Criteria:

Multiple pregnancies (pregnant with two or more fetuses)
High-risk pregnancy or pre-eclampsia
History of chronic diseases
Preterm (<37 weeks of gestation) or late-term (>42 weeks of gestation) infants
Congenital diseases or any health condition that could deter breastfeeding

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
relationship between exclusive breastfeeding and maternal serum levels of adiponectin Tidsramme: 18 months	measuring the adiponectin level in the maternal serum at 6 months postpartum	18 months
relationships between maternal milk levels of adiponectin with infants serum levels of adiponectin Tidsramme: 18 months	measuring the adiponectin level and in the infants serum and in the breast milk	18 months
Comparison of the infant adiponectin serum level in exclusive breastfeeding mothers versus mothers who do not exclusively breastfeed their infants Tidsramme: 18 months	measuring the adiponectin serum level in the infants of exclusive breastfeeding group and other breastfeeding patterns	18 months
Association between duration of breastfeeding and mothers' anthropometric measurements(weight in kilograms and Height in meters ) Tidsramme: 18 months	Measuring the weight in kilograms and height in meters weight and height will be combined to report BMI in kg/m^2 of the mothers at different timelines in relation to breastfeeding duration	18 months
Assessment of the anthropometric measurements (weight in kilograms and height in meters) of the mothers according to the breastfeeding patterns Tidsramme: 18 months	Measuring the weight in kilograms and height in meters weight and height will be combined to report BMI in kg/m^2 of mothers at different timelines in relation to different breastfeeding patterns	18 months
relationship between exclusive breastfeeding and breast milk levels of adiponectin Tidsramme: 18 months	measuring the adiponectin level in the breast milk at 6 months postpartum	18 months
Assessment of the anthropometric measurements of the infant according to the breastfeeding patterns Tidsramme: 18 months	measuring the weight, height, mid upper arm circumference of the infant at different timelines in relation to the breastfeeding patterns	18 months

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

University of Sharjah

Samarbeidspartnere

Al Jalila Foundation

Etterforskere

Hovedetterforsker: Hadia Radwan, PhD, University of Sharjah

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. desember 2015

Primær fullføring (Faktiske)

20. desember 2017

Studiet fullført (Faktiske)

20. februar 2018

Datoer for studieregistrering

Først innsendt

2. mai 2018

Først innsendt som oppfylte QC-kriteriene

22. juni 2018

Først lagt ut (Faktiske)

5. juli 2018

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)