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Mother and Infant Study Cohort (MISC)-

22. juni 2018 opdateret af: Hadia Radwan, University of Sharjah

Impact of Feeding Patterns on Adiposity and Cardiometabolic Markers in Baby and Mother: A Prospective Cohort Study

This study aims to explore breastfeeding and complementary feeding practices of mothers in the United Arab Emirates (UAE) and its relation to the early life determinants of obesity and non-communicable diseases (NCDs). This research study will follow a prospective cohort approach. Two hundred and fifty mother-infant pairs will be followed for 18 months.

The hypothesis of this research study is that exclusive breastfeeding of the infant will provide potential protective effect against cardiometabolic risk factors. This study will also hypothesize that mothers who exclusively breastfeed their newborns would experience greater postpartum weight and body fat loss than mothers who are not breastfeeding.

Studieoversigt

Status

Afsluttet

Betingelser

Detaljeret beskrivelse

United Arab Emirates(UAE) is facing two critical situations: high incidence of obesity and chronic diseases and suboptimal infant feeding practices as reported by the Ministry of Health in the UAE. So early identification of preventive markers of cardiometabolic risk factors in breast milk is important for developing early intervention strategies to optimize health care for individuals and communities especially in countries suffering from high rates of obesity and chronic diseases such as the UAE.

The purpose of this study is to prospectively follow up with the mothers and their infants (from 0-18months of infants age). It will explore breastfeeding and complementary feeding practices of mothers in UAE and its relation to the early life determinants of obesity and non-communicable diseases (NCDs). It will examine the components of human milk which might offer a protective benefit against obesity and its health consequences in infancy. It will also evaluate the feeding practices of the mothers and her nutritional status and relates it to their infants' growth and development.

It is expected that this research study will fill an important knowledge gap in the understanding of the feeding practices of mothers and its relation to early-life determinants of obesity and other chronic diseases in the UAE.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

257

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

19 år til 40 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Kvinde

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The sample population is Emirati and Arab expatriate mothers, aged 19 to 40 years old; visiting Mother and Child Centers (MCH) and Primary Healthcare Centers (PHC) in Dubai and Sharjah.

The selected mothers (who will be recruited during their 3rd trimester) were invited to participate in the study after being consented for their procedures and they will sign on the behalf of their babies

Beskrivelse

Inclusion Criteria:

  • Pregnant women:

    • Emirate nationality or Arab expatriate
    • Age: 19-40 years
    • Singleton pregnancy
    • Within the third trimester of pregnancy (27-42 weeks of gestation)
    • Free of chronic diseases (diabetes, hypertension, kidney disease, cancer, or other chronic diseases), autoimmune disorders, or infections with the human immunodeficiency virus, or hepatitis in preconception

Exclusion Criteria:

  • Multiple pregnancies (pregnant with two or more fetuses)
  • High-risk pregnancy or pre-eclampsia
  • History of chronic diseases
  • Preterm (<37 weeks of gestation) or late-term (>42 weeks of gestation) infants
  • Congenital diseases or any health condition that could deter breastfeeding

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
relationship between exclusive breastfeeding and maternal serum levels of adiponectin
Tidsramme: 18 months
measuring the adiponectin level in the maternal serum at 6 months postpartum
18 months
relationships between maternal milk levels of adiponectin with infants serum levels of adiponectin
Tidsramme: 18 months
measuring the adiponectin level and in the infants serum and in the breast milk
18 months
Comparison of the infant adiponectin serum level in exclusive breastfeeding mothers versus mothers who do not exclusively breastfeed their infants
Tidsramme: 18 months
measuring the adiponectin serum level in the infants of exclusive breastfeeding group and other breastfeeding patterns
18 months
Association between duration of breastfeeding and mothers' anthropometric measurements(weight in kilograms and Height in meters )
Tidsramme: 18 months
Measuring the weight in kilograms and height in meters weight and height will be combined to report BMI in kg/m^2 of the mothers at different timelines in relation to breastfeeding duration
18 months
Assessment of the anthropometric measurements (weight in kilograms and height in meters) of the mothers according to the breastfeeding patterns
Tidsramme: 18 months
Measuring the weight in kilograms and height in meters weight and height will be combined to report BMI in kg/m^2 of mothers at different timelines in relation to different breastfeeding patterns
18 months
relationship between exclusive breastfeeding and breast milk levels of adiponectin
Tidsramme: 18 months
measuring the adiponectin level in the breast milk at 6 months postpartum
18 months
Assessment of the anthropometric measurements of the infant according to the breastfeeding patterns
Tidsramme: 18 months
measuring the weight, height, mid upper arm circumference of the infant at different timelines in relation to the breastfeeding patterns
18 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University of Sharjah

Samarbejdspartnere

Al Jalila Foundation

Efterforskere

  • Ledende efterforsker: Hadia Radwan, PhD, University of Sharjah

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. december 2015

Primær færdiggørelse (Faktiske)

20. december 2017

Studieafslutning (Faktiske)

20. februar 2018

Datoer for studieregistrering

Først indsendt

2. maj 2018

Først indsendt, der opfyldte QC-kriterier

22. juni 2018

Først opslået (Faktiske)

5. juli 2018

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

5. juli 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

22. juni 2018

Sidst verificeret

1. juni 2018

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 1501057003-P

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

All collected individual participant data (IPD)

IPD-delingstidsramme

after November 2018

IPD-delingsadgangskriterier

permission from the PI

IPD-deling Understøttende informationstype

  • STUDY_PROTOCOL
  • SAP
  • ICF
  • ANALYTIC_CODE
  • CSR

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Adiposity, Breast Feeding

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Betingelser

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Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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