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Using Illusions to Boost Social Cognition (SOLLUSIONS)

19. mai 2026 oppdatert av: Hôpital le Vinatier

Socio-cognitive Benefits of Exposure to Visual Illusions in Patients With Psychotic Disorders

This study aims to explore whether the observation of complex visual objects can help improve social cognition in people living with psychotic disorders. Social cognition refers to the ability to understand what others think, feel, or intend, and plays a key role in social relationships and daily interactions.

Main questions this study aims to answer:

  • Does dyadic exposure to complex visual objects improve mental state attribution, as measured by the Faux Pas Test?
  • Does the intervention enhance related domains of social cognition, including implicit intention inference (Hinting Task), interpretation of complex interactions (Movie for the Assessment of Social Cognition, MASC), and reduction of hostile attribution biases (Ambiguous Intentions Hostility Questionnaire, AIHQ)?
  • Are improvements maintained after one month, and do patients who receive the intervention later (waitlist group) show the same benefits once exposed?

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

This study is a randomized, controlled, monocentric trial evaluating a novel sensory-motor rehabilitation approach for social cognition. The study is based on the hypothesis that perception is interpretative and viewpoint-dependent, and that realizing this through concrete experience could generalize to higher-level cognitive processes required for social understanding.

Participants will attend three visits and complete questionnaires and tasks that assess social understanding before and after the activity, and again one month later.

Two groups will take part: one completing the workshop shortly after inclusion, and one completing it after a delay, allowing comparison over time. Participants will be randomized in one condition.

This research does not involve medication. It consists of simple tasks such as observing and describing visual stimuli, followed by a facilitated discussion.

Neuropsychological tests and questionnaires will be used to measure changes over time.

Expected impact: By inducing concrete perspective-shifts, the intervention aims to improve mentalizing, reduce egocentric biases, and strengthen interpretation of social cues. This bottom-up sensory-motor approach may overcome limitations of classical cognitive remediation programs by promoting deep experiential learning rather than top-down instruction.

If effective, the method may support long-term social reintegration, psychosocial functioning, and inspire wider clinical applications due to its low cost, ease of deployment, and strong ecological engagement.

Studietype

Intervensjonell

Registrering (Antatt)

60

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studer Kontakt Backup

Studiesteder

  • Frankrike
      • Bron, Frankrike, 69678
        • CH le Vinatier
        • Hovedetterforsker:
          • Frédéric HAESEBAERT, MD, PhD

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen

Tar imot friske frivillige

Nei

Beskrivelse

Inclusion Criteria:

  • Aged 18 to 40 years
  • Fluent French speaker
  • Has provided written informed consent
  • For individuals under guardianship (curatorship): inclusion is permitted if the curator is available to assist or advise when needed.
  • Established diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or brief psychotic disorder according to theDiagnostic and statistical manual of mental disorders (DSM-5-TR) criteria
  • Presence of social cognition impairment, defined by:subjective complaint reported by the participant or identified by care teams regarding difficulties in social interaction and clinical confirmation of observable difficulties (e.g., social withdrawal, misinterpretation of others' intentions, inappropriate social behaviour)
  • Membership or entitlement to a social security plan

Exclusion Criteria:

  • Clinical state incompatible with participation in group-based activities (e.g., severe psychomotor agitation, severe behavioural disturbance)
  • Concurrent participation in another social cognition remediation program
  • Diagnosis of intellectual disability
  • Insufficient comprehension of French for verbal interaction and test completion
  • Significant change in psychotropic medication within the past month
  • Uncorrectable visual impairment preventing participation
  • Pregnant women
  • Individuals under full guardianship (tutorship)

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Støttende omsorg
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Immediate intervention
Participants receive the visual-perception session shortly after baseline assessment. They complete neurocognitive and social cognition tests before exposure, immediately after, and again at one-month follow-up.
Atferdsmessig: Visual-illusion social cognition session (immediate)

A guided session of approximately 45 minutes. The core rehabilitation tool consists of multiple-perspective illusion boxes. Each participant stands on one side of the box and perceives a different shape than their partner. The session unfolds in 3 structured phases:

  1. For each illusion : Participants observe objects silently and draw what they see.
  2. Perspective confrontation + Card selection: Drawings and interpretation cards are exchanged and discussed.
  3. Perspective switching : Participants swap positions to reveal the alternative visual interpretation.

The session is followed by a short structured discussion with a psychologist focused on perspective-taking and interpretation of social cues.
Aktiv komparator: Delayed Intervention (Wait-list Control)
Participants complete the same assessments as Arm 1 but receive the intervention only after a waiting period. This arm allows comparison between natural progression and workshop effects prior to exposure.
Atferdsmessig: Visual-illusion social cognition session (delayed)
A guided session of approximately 45 minutes. The core rehabilitation tool consists of multiple-perspective illusion boxes. Each participant stands on one side of the box and perceives a different shape than their partner. The session unfolds in 3 structured phases: 1. For each illusion : Participants observe objects silently and draw what they see. 2. Perspective confrontation + Card selection: Drawings and interpretation cards are exchanged and discussed. 3. Perspective switching : Participants swap positions to reveal the alternative visual interpretation. The session is followed by a short structured discussion with a psychologist focused on perspective-taking and interpretation of social cues. Delivered after a delay following baseline assessment.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
"Faux Pas" test total score
Tidsramme: Change from pre to post intervention (up to 3 hours)
  1. Total of correctly recognised "Faux Pas" Score range : 0 - 30 Minimum (0) : no correct detection of faux pas Maximum (30) : all faux pas correctly detected
  2. Total of identified absence of "Faux Pas" Score range : 0 - 10 Minimum (0) : incorrectly identifies absence of faux pas Maximum (10) : correctly identifies absence of faux pas
  3. Total score of control question comprehension Score range : 0 - 20 Minimum (0) : poor comprehension Maximum (20) : Full comprehension
Change from pre to post intervention (up to 3 hours)

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Hinting Task
Tidsramme: Change from pre to post intervention (up to 3 hours)
  1. Number of correctly inferred items with hint 1 Score range : 0 - 20 Minimum (0) : No correct inference of intentions Maximum (20) : All intentions correctly inferred
  2. Number of correctly inferred items with hint 2 Score range : 0 - 20 Minimum (0) : No correct inference of intentions Maximum (20) : All intentions correctly inferred
Change from pre to post intervention (up to 3 hours)
MASC performance
Tidsramme: Change from pre intervention to follow-up session (up to a month and a half)
Number of correct responses Score range 0 - 45 Minimum (0) : No correct mental state inference Maximum (45) : All mental states correctly inferred
Change from pre intervention to follow-up session (up to a month and a half)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Hôpital le Vinatier

Samarbeidspartnere

INSERM 1028

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

1. juli 2026

Primær fullføring (Antatt)

1. januar 2029

Studiet fullført (Antatt)

1. februar 2029

Datoer for studieregistrering

Først innsendt

12. mai 2026

Først innsendt som oppfylte QC-kriteriene

19. mai 2026

Først lagt ut (Faktiske)

22. mai 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

22. mai 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

19. mai 2026

Sist bekreftet

1. mai 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • 2025-A02057-42

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

JA

IPD-planbeskrivelse

Anonymized IPD that underlie results in a publication may be shared upon reasonable scientific request following publication of study results.

IPD-delingstidsramme

IPD available after publication of primary results

Tilgangskriterier for IPD-deling

Requests must be made by qualified researchers for scientific purposes. Data will be shared under controlled access agreement ensuring privacy and ethical standards.

IPD-deling Støtteinformasjonstype

  • STUDY_PROTOCOL
  • SEVJE

Legemiddel- og utstyrsinformasjon, studiedokumenter

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Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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