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Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women

22. juni 2026 oppdatert av: Jakub Krejci, Palacky University

Effect of Repeated Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women: A Randomized, Double-blind, Placebo-controlled Crossover Trial

The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are:

  • Does molecular hydrogen reduce the respiratory exchange ratio?
  • Does molecular hydrogen reduce oxygen uptake?

Researchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response.

Participants will:

  • Inhale molecular hydrogen for 60 minutes each day for 7 days.
  • Undergo an exercise testing twice after a two-week washout period.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

This crossover trial examines the effect of repeated inhalation of molecular hydrogen on the metabolic response during graded exercise in healthy female participants. Each participant undergoes two experimental interventions (molecular hydrogen and placebo) in random order, separated by a two-week washout period. The order of the interventions is randomized using a computer random number generator. Each intervention consists of 7 days, during which participants inhale either molecular hydrogen or placebo gas for 60 minutes daily under resting conditions. Molecular hydrogen is produced by electrolysis of water and mixed with ambient air in the chamber to achieve a hydrogen concentration of 3.75 % which is below the lower explosive limit. This gas is administered via a face mask connected to an Ambu bag system with a one-way valve to ensure standardized delivery. Placebo is produced by pumping ambient air without molecular hydrogen. Molecular hydrogen is colorless, odorless, and tasteless, making it indistinguishable from placebo by human senses. On the 7th day of each intervention, participants undergo a graded exercise test on an bicycle ergometer immediately following the final inhalation session. The protocol consists of 8 incremental steps with the workload increasing from 0.5 to 2.25 W/kg. Outcome measures collected at rest before exercise and during exercise include cardiorespiratory variables, capillary blood biomarkers, and perceived exertion. Statistical analysis is based on a two-way analysis of variance for repeated measures, and p < 0.05 is considered statistically significant.

Studietype

Intervensjonell

Registrering (Antatt)

22

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studer Kontakt Backup

Studiesteder

  • Tsjekkia
      • Olomouc, Tsjekkia, 77111
        • Rekruttering
        • Palacky University, Faculty of Physical Culture
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen

Tar imot friske frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Healthy female participants.
  • Regular menstrual cycle with exercise testing scheduled outside the menstrual phase.
  • Signed informed consent.

Exclusion Criteria:

  • Pregnancy or breastfeeding.
  • History or presence of cardiovascular disease.
  • History or presence of respiratory disease.
  • Regular use of medications affecting metabolism.
  • Use of dietary supplements affecting metabolism within 14 days prior to intervention.
  • Strenuous physical activity within 24 hours prior to exercise testing.
  • Any contraindication to exercise testing or study participation determined by a physician.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Grunnvitenskap
  • Tildeling: Randomisert
  • Intervensjonsmodell: Crossover-oppdrag
  • Masking: Dobbelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Molecular hydrogen
Molecular hydrogen inhalation for 60 minutes daily for 7 days.
Annen: Molecular hydrogen
Gas mixture containing 3.75% molecular hydrogen and ambient air.
Andre navn:
  • H2 Air-Blend Generator (H2 Medical Technologies, Ostrava, Czech Republic)
Placebo komparator: Placebo
Ambient air inhalation for 60 minutes daily for 7 days.
Annen: Placebo
Ambient air without molecular hydrogen.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Respiratory exchange ratio
Tidsramme: Change after 2 weeks of crossover.
Respiratory exchange ratio is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Oxygen uptake
Tidsramme: Change after 2 weeks of crossover.
Oxygen uptake is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.
Carbon dioxide production
Tidsramme: Change after 2 weeks of crossover.
Carbon dioxide production is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.
Minute ventilation
Tidsramme: Change after 2 weeks of crossover.
Minute ventilation is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.
Breathing frequency
Tidsramme: Change after 2 weeks of crossover.
Breathing frequency is measured using an Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the exercise, and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.
Heart rate
Tidsramme: Change after 2 weeks of crossover.
Heart rate is continuously recorded during the exercise using a Polar H10 chest strap (Polar, Kempele, Finland), and the average is calculated for 6-minute segments for subsequent analysis.
Change after 2 weeks of crossover.
Blood lactate concentration
Tidsramme: Change after 2 weeks of crossover.
Capillary blood lactate concentration is assessed at baseline (resting condition) and during the final minute of each exercise step using a Lactate Scout device (EKF Diagnostics, Barleben, Germany).
Change after 2 weeks of crossover.
Rating of perceived exertion
Tidsramme: Change after 2 weeks of crossover.
Participants are asked to subjectively rate their perceived exertion at specified time points - at rest and subsequently in the last minute of each exercise step. The Borg's scale 6-20 is used, where 6 means "no exertion" and 20 means "maximal exertion".
Change after 2 weeks of crossover.

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Blood glucose concentration
Tidsramme: Change after 2 weeks of crossover.
Capillary blood glucose concentration is assessed at baseline (resting condition) and during the final minute of each exercise step using an Accu-Chek Inform II device (Roche Diagnostics, Manheim, Germany).
Change after 2 weeks of crossover.

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Palacky University

Etterforskere

  • Hovedetterforsker: Tereza Rysava, Palacky University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

22. juni 2026

Primær fullføring (Antatt)

1. desember 2026

Studiet fullført (Antatt)

1. desember 2026

Datoer for studieregistrering

Først innsendt

8. juni 2026

Først innsendt som oppfylte QC-kriteriene

8. juni 2026

Først lagt ut (Faktiske)

12. juni 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

25. juni 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

22. juni 2026

Sist bekreftet

1. juni 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • FTK_2026_14

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

JA

IPD-planbeskrivelse

All IPD that underlie results in a publication.

IPD-delingstidsramme

Beginning 1 month after the publication of results with no end date.

Tilgangskriterier for IPD-deling

Anonymized IPD will be uploaded to an open-access data repository.

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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