Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer

DISEASE CHARACTERISTICS:

• Histologically confirmed metastatic, recurrent, or refractory carcinoma
• Measurable disease by CT, MRI, or physical examination
• No brain metastases or other CNS disorders

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Karnofsky 60-100%

Life expectancy:

• At least 12 weeks

Hematopoietic:

• Absolute granulocyte count at least 1,500/mm^3
• Platelet count at least 90,000/mm^3
• Bone marrow cellularity normal on bone marrow biopsy
• No coagulopathy disorder

Hepatic:

• Bilirubin no greater than 2.0 mg/dL
• SGOT no greater than 2 times upper limit of normal
• PT less than 14 seconds
• PTT less than 35 seconds
• No inadequate liver function (no greater than 20% involvement)

Renal:

• Creatinine no greater than 1.8 mg/dL
• Creatinine clearance at least 45 mL/min
• BUN no greater than 25 mg/dL

Cardiovascular:

• Adequate cardiac function documented by history, physical exam, or stress exercise test (MUGA or ECHO) with resting blood pressure and heart rate increasing appropriately with exercise
• LVEF at least 45%
• No prior myocardial infarction
• No symptomatic coronary artery disease
• No angina
• No significant arrhythmia
• No uncontrolled hypertension
• No thromboembolic disease

Pulmonary:

• FEV_1 at least 70% of predicted
• Arterial PO_2 at least 60 mmHg on room air
• No massive (greater than 30% involvement) lung disease
• DLCO greater than 50% of predicted

Other:

• Not pregnant or nursing
• Fertile patients must use effective contraception
• HIV negative
• No seizure disorders
• No significant emotional instability
• No history of malignant hyperthermia following general anesthesia
• No other concurrent medical illness that would prevent compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• Prior chemotherapy allowed

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• At least 6 days since major thoracic or abdominal surgery

Other:

• No concurrent cardiac glycosides, antiangina drugs, arrhythmia drugs, anticoagulants, thrombolytic agents, adrenal corticosteroids, or aspirin