Study Evaluating 68GA-FAPI-46 PET/CT in Patients With Interstitial Lung Disease

Inclusion Criteria:

• Clinical diagnosis of interstitial lung disease
• Radiologic lung abnormalities on diagnostic CT chest
• Anatomic imaging (clinical diagnostic CT chest) obtained within ≤ 180 days prior to the planned FAPI 46 imaging exam or within 14 days after the imaging exam.
• Willingness and ability to provide informed consent

Exclusion Criteria:

• Pregnant as determined by a pregnancy test as per institutional guidelines for individuals of child-bearing potential
• Declining to use effective contraceptive methods during the study (for individuals of child-producing potential)
• Need for emergent surgery that would be delayed by participation
• Bacterial, viral, or fungal infections requiring systemic therapy
• Serious co-morbidities and serious nonmalignant disease (e.g., hydronephrosis, kidney failure, liver failure, or other conditions) that in the opinion of the investigator, physician of record and/or Sofie could compromise patient safety and/or protocol objectives.
• No available chest CT radiological data
• No clear diagnosis of ILD
• Intolerability to perform the exam due to exuberant dyspnea or severely low pulmonary capacity.
• Breastfeeding. Note: nursing parents are allowed if the potential participant commits to pumping breast milk and discarding it from injection to ≥ 24 hours from the time of the [68Ga]FAPI-46 injection.
• Known hypersensitivity to any excipients used in [68Ga]FAPI-46