- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01075893
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Colorectal cancer is a common disease worldwide. Increasing evidence is demonstrating that colorectal cancers arise from 'cancer stem cells.' Stem cells in the colon reside at the bottom of thousands of microscopic crypts throughout the wall of the colon. They create all the cells lining the bowel wall. These cells are created in the base of the crypt and ascend to the top acquiring the characteristics of mature cells of the bowel wall as they ascend.
It is now thought that colorectal cancer cells arise from stem cells where the genetic material regulating growth and division of the stem cell has become defective. This leads to unregulated production of cells which in turn have defective genetic information and cancer formation.
Prior studies have demonstrated that the earliest changes before a cancer develops are changes in cellular proliferation. Now that reliable markers to identify stem cells have been found, the researchers aim to investigate stem cell numbers and changes in distribution in those at normal risk of colorectal cancer and those at higher risk. The researchers hypothesise that changes in cellular proliferation at the top of the crypt in individuals at higher risk of colorectal cancer are due to a change in the number of stem cells in the crypt base.
Studieöversikt
Status
Betingelser
Studietyp
Inskrivning (Faktisk)
Kontakter och platser
Studieorter
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Tyne & Wear
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Ashington, Tyne & Wear, Storbritannien, NE63 9JJ
- Wansbeck General Hospital
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North Shields, Tyne & Wear, Storbritannien, NE29 8NH
- North Tyneside Hospital
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Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Referred for endoscopy at participating centre
Exclusion Criteria:
- Age <16 or >85
- Familial polyposis syndrome
- Lynch syndrome
- Known colorectal tumour
- Previous colorectal resection
- Pregnancy
- Chemotherapy in last 6 months
- Therapy with aspirin/other nonsteroidal anti-inflammatory drug (NSAID)
- Other immunosuppressive medication
- Incomplete left sided examination
- Colorectal carcinoma found at endoscopy
- Iatrogenic perforation at endoscopy
- Colorectal cancer on histology
- Microscopic colitis on histology
For the colitis group
- Simple clinical colitis activity index (SCCAI) score > 5
Studieplan
Hur är studien utformad?
Designdetaljer
- Observationsmodeller: Case-Control
- Tidsperspektiv: Blivande
Kohorter och interventioner
Grupp / Kohort |
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Adenomatous polyp
Patients who have begun the polyp-cancer sequence (ie.
are in polyp surveillance after excision of a prior adenomatous polyp) will be used to test those patients at higher risk of colorectal.
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Patients at normal risk of cancer
Patients found to have endoscopically and histological normal mucosa.
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Ulcerative colitis
Patients who are under surveillance for known ulcerative colitis will be used to test those patients at higher risk of colorectal.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
---|---|
Number of stem cells in the colonic crypt
Tidsram: On day of endoscopy
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On day of endoscopy
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Sekundära resultatmått
Resultatmått |
Tidsram |
---|---|
Stem cell position in colonic crypt
Tidsram: On day of endoscopy
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On day of endoscopy
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Samarbetspartners och utredare
Sponsor
Samarbetspartners
Utredare
- Huvudutredare: Iain JD McCallum, MBChB MRCS, Newcastle University, UK
- Studiestol: John C Mathers, PhD, Newcastle University, UK
- Studierektor: Seamus B Kelly, MD FRCS, Newcastle University, UK
- Studierektor: Mike Bradburn, MD FRCS, Northumbria NHS Foundation Trust
Publikationer och användbara länkar
Allmänna publikationer
- Dronamraju SS, Coxhead JM, Kelly SB, Burn J, Mathers JC. Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial. Gut. 2009 Mar;58(3):413-20. doi: 10.1136/gut.2008.162933. Epub 2008 Oct 31.
- Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007 Oct 25;449(7165):1003-7. doi: 10.1038/nature06196. Epub 2007 Oct 14.
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- McCallum-001
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Kliniska prövningar på Kolorektal cancer
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Incyte CorporationMerck Sharp & Dohme LLCAvslutadMelanom | Lymfom | Huvud- och halscancer | Magcancer | Äggstockscancer | Hepatocellulärt karcinom (HCC) | Lungcancer | Blåscancer | Endometriecancer | Fasta tumörer | Njurcellscancer (RCC) | Trippel negativ bröstcancer (TNBC) | UC (Urotelial cancer) | Microsatellite-instability (MSI) High Colorectal Cancer (CRC)Förenta staterna