IncobotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or Radiation

Inclusion Criteria:

• Subjects 18- 80 years, both sexes, all races and ethnic groups.
• Diagnosis of post- surgical/post - radiation cancer pain.
• Focal pain duration longer than 3 months
• Pain of moderate to severe intensity ( mean VAS over the previous week >4 )
• Subjects who are able to read, speak, and understand English.

Exclusion Criteria:

• Existing significant acute medical condition (i.e. cardiovascular, endocrine, hematologic, neoplastic, infectious, or autoimmune disorders).
• Pregnancy or planned pregnancy (determined by urine pregnancy test). Women of childbearing age should use a reliable mode of contraception during the study period (abstinence, etc).
• Active breast feeding.
• Enrollment in any clinical trial (currently or within the past 3 months) in which treatments are imposed by a protocol.
• Any subject for whom botulinum toxin treatment would be contraindicated; known allergy or sensitivity to medication.
• Subjects who are younger than 18 years of age.
• Neuromuscular-junction disorders.
• Axis I diagnosis determined by a neurologist or psychiatrist.
• Use of anesthetic medications within two weeks or corticosteroid injections within 4 weeks of enrollment.
• Received botulinum toxin injections in the past 4 months.
• Patients taking high doses of aminoglycosides or other drugs affecting the function of neuromuscular junction ( anticholinergic, muscle relaxants)
• Patients who have unstable pain in/at sites other than areas of planned injection