Dabrafenib och Trametinib vid behandling av patienter med stadium III-IV BRAF mutant melanom som inte kan avlägsnas genom kirurgi
10 november 2026 uppdaterad av: National Cancer Institute (NCI)
En randomiserad fas II-studie av intermittent kontra kontinuerlig dosering av Dabrafenib (NSC-763760) och Trametinib (NSC-763093) i BRAF V600E/K mutant melanom
This phase II trial compares the effect of dabrafenib and trametinib given continuously to given with a break in treatment (intermittent) in treating patients with stage III-IV melanoma that cannot be removed by surgery and contains a B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving dabrafenib and trametinib with intermittent dosing may be as effect as when given continuously in treating patients with stage III-IV melanoma with a BRAF mutation that cannot be removed by surgery.
Studieöversikt
Status
Aktiv, inte rekryterande
Betingelser
Detaljerad beskrivning
PRIMARY OBJECTIVE:
I. To compare progression-free survival with intermittent dosing and continuous dosing of dabrafenib and trametinib among patients with metastatic BRAF V600E/K mutant melanoma.
SECONDARY OBJECTIVES:
I. To estimate the frequency and severity of toxicities of the two dosing schedules.
II. To compare the frequency and severity of fever >= grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) 4.0 of the two dosing schedules.
III. To compare the response rate (complete and partial response, confirmed and unconfirmed), overall survival, and survival after progression between the two dosing schedules on step 2.
TRANSLATIONAL MEDICINE OBJECTIVES:
I. To evaluate whether acquired molecular events leading to reactivation of the MAPK pathway are more common among patients on the continuous dosing arm than on the intermittent dosing arm using circulating tumor deoxyribonucleic acid (DNA) (ctDNA).
II. To assess the prognostic association between baseline biomarkers and early molecular events with progression free survival (PFS).
III. To explore the potential interaction between treatment arm and baseline biomarkers/early molecular events with PFS.
IV. To bank tissue and whole blood in anticipation of future studies to evaluate molecular events associated with clinical benefit and disease progression in patients treated with continuous versus intermittent dabrafenib and trametinib.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I (CONTINUOUS DOSING): Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo positron emission tomography/computed tomography (PET/CT) or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, echocardiography (ECHO) or multigated acquisition scan (MUGA) on study.
ARM II (INTERMITTENT DOSING): Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study.
After completion of study treatment, patients are followed up every 6 months for 3 years and then yearly for 2 years.
Studietyp
Interventionell
Inskrivning (Beräknad)
280
Fas
- Fas 2
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
-
Alabama
-
Birmingham, Alabama, Förenta staterna, 35233
- University of Alabama at Birmingham Cancer Center
-
-
Alaska
-
Anchorage, Alaska, Förenta staterna, 98508
- Anchorage Associates in Radiation Medicine
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Oncology and Hematology LLC
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, Förenta staterna, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, Förenta staterna, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Förenta staterna, 99508
- Providence Alaska Medical Center
-
Anchorage, Alaska, Förenta staterna, 99504
- Anchorage Radiation Therapy Center
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Regional Hospital
-
Fairbanks, Alaska, Förenta staterna, 99701
- Fairbanks Memorial Hospital
-
-
Arizona
-
Tucson, Arizona, Förenta staterna, 85719
- Banner University Medical Center - Tucson
-
Tucson, Arizona, Förenta staterna, 85719
- University of Arizona Cancer Center-North Campus
-
Yuma, Arizona, Förenta staterna, 85364
- Onvida Health Yuma Medical Center
-
-
Arkansas
-
Fort Smith, Arkansas, Förenta staterna, 72903
- Mercy Hospital Fort Smith
-
Hot Springs, Arkansas, Förenta staterna, 71913
- CHI Saint Vincent Cancer Center Hot Springs
-
Jonesboro, Arkansas, Förenta staterna, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
Little Rock, Arkansas, Förenta staterna, 72205
- University of Arkansas for Medical Sciences
-
Little Rock, Arkansas, Förenta staterna, 72205
- John L McClellan Memorial Veterans Hospital
-
Rogers, Arkansas, Förenta staterna, 72758
- Highlands Oncology Group - Rogers
-
-
California
-
Anaheim, California, Förenta staterna, 92806
- Kaiser Permanente-Anaheim
-
Antioch, California, Förenta staterna, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande, California, Förenta staterna, 93420
- PCR Oncology
-
Baldwin Park, California, Förenta staterna, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Förenta staterna, 90706
- Kaiser Permanente-Bellflower
-
Burbank, California, Förenta staterna, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Dublin, California, Förenta staterna, 94568
- Epic Care-Dublin
-
Emeryville, California, Förenta staterna, 94608
- Bay Area Breast Surgeons Inc
-
Emeryville, California, Förenta staterna, 94608
- Epic Care Partners in Cancer Care
-
Fontana, California, Förenta staterna, 92335
- Kaiser Permanente-Fontana
-
Fremont, California, Förenta staterna, 94538
- Kaiser Permanente-Fremont
-
Fresno, California, Förenta staterna, 93720
- Kaiser Permanente-Fresno
-
Harbor City, California, Förenta staterna, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Förenta staterna, 92618
- Kaiser Permanente-Irvine
-
Loma Linda, California, Förenta staterna, 92354
- Loma Linda University Medical Center
-
Los Angeles, California, Förenta staterna, 90095
- UCLA / Jonsson Comprehensive Cancer Center
-
Los Angeles, California, Förenta staterna, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Förenta staterna, 90034
- Kaiser Permanente West Los Angeles
-
Martinez, California, Förenta staterna, 94553-3156
- Contra Costa Regional Medical Center
-
Modesto, California, Förenta staterna, 95356
- Kaiser Permanente-Modesto
-
Oakland, California, Förenta staterna, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, Förenta staterna, 94611
- Kaiser Permanente Oakland-Broadway
-
Oakland, California, Förenta staterna, 94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland, California, Förenta staterna, 94609
- Hematology and Oncology Associates-Oakland
-
Oakland, California, Förenta staterna, 94609
- Bay Area Tumor Institute
-
Panorama City, California, Förenta staterna, 91402
- Kaiser Permanente - Panorama City
-
Rancho Cordova, California, Förenta staterna, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
-
Rancho Mirage, California, Förenta staterna, 92270
- Eisenhower Medical Center
-
Redwood City, California, Förenta staterna, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, Förenta staterna, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, Förenta staterna, 92505
- Kaiser Permanente-Riverside
-
Rohnert Park, California, Förenta staterna, 94928
- Rohnert Park Cancer Center
-
Roseville, California, Förenta staterna, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
-
Roseville, California, Förenta staterna, 95661
- Kaiser Permanente-Roseville
-
Sacramento, California, Förenta staterna, 95814
- Kaiser Permanente Downtown Commons
-
Sacramento, California, Förenta staterna, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, Förenta staterna, 95823
- South Sacramento Cancer Center
-
Sacramento, California, Förenta staterna, 95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego, California, Förenta staterna, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Förenta staterna, 92108
- Kaiser Permanente-Rio San Diego
-
San Francisco, California, Förenta staterna, 94115
- Kaiser Permanente-San Francisco
-
San Francisco, California, Förenta staterna, 94115
- UCSF Medical Center-Mount Zion
-
San Jose, California, Förenta staterna, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro, California, Förenta staterna, 94577
- Kaiser Permanente San Leandro
-
San Marcos, California, Förenta staterna, 92078
- Kaiser Permanente-San Marcos
-
San Rafael, California, Förenta staterna, 94903
- Kaiser San Rafael-Gallinas
-
San Rafael, California, Förenta staterna, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, Förenta staterna, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Rosa, California, Förenta staterna, 95403
- Kaiser Permanente-Santa Rosa
-
South San Francisco, California, Förenta staterna, 94080
- Kaiser Permanente Cancer Treatment Center
-
South San Francisco, California, Förenta staterna, 94080
- Kaiser Permanente-South San Francisco
-
Stockton, California, Förenta staterna, 95210
- Kaiser Permanente-Stockton
-
Vacaville, California, Förenta staterna, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo, California, Förenta staterna, 94589
- Kaiser Permanente-Vallejo
-
Walnut Creek, California, Förenta staterna, 94596
- Kaiser Permanente-Walnut Creek
-
Walnut Creek, California, Förenta staterna, 94597
- Epic Care Cyberknife Center
-
Woodland Hills, California, Förenta staterna, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Förenta staterna, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, Förenta staterna, 80012
- The Medical Center of Aurora
-
Aurora, Colorado, Förenta staterna, 80045
- UCHealth University of Colorado Hospital
-
Boulder, Colorado, Förenta staterna, 80303
- Boulder Community Foothills Hospital
-
Boulder, Colorado, Förenta staterna, 80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs, Colorado, Förenta staterna, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Förenta staterna, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, Förenta staterna, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Förenta staterna, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Förenta staterna, 80220
- Rose Medical Center
-
Denver, Colorado, Förenta staterna, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, Förenta staterna, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, Förenta staterna, 80204
- Denver Health Medical Center
-
Denver, Colorado, Förenta staterna, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, Förenta staterna, 80209
- The Women's Imaging Center
-
Denver, Colorado, Förenta staterna, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver, Colorado, Förenta staterna, 80210
- AdventHealth Porter
-
Durango, Colorado, Förenta staterna, 81301
- Mercy Medical Center
-
Durango, Colorado, Förenta staterna, 81301
- CommonSpirit Cancer Center Mercy
-
Englewood, Colorado, Förenta staterna, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, Förenta staterna, 80113
- Swedish Medical Center
-
Fort Collins, Colorado, Förenta staterna, 80524
- Poudre Valley Hospital
-
Golden, Colorado, Förenta staterna, 80401
- Mountain Blue Cancer Care Center
-
Golden, Colorado, Förenta staterna, 80401
- National Jewish Health-Western Hematology Oncology
-
Grand Junction, Colorado, Förenta staterna, 81501
- Saint Mary's Hospital and Regional Medical Center
-
Grand Junction, Colorado, Förenta staterna, 81505
- Grand Valley Oncology
-
Greeley, Colorado, Förenta staterna, 80631
- Banner North Colorado Medical Center
-
Greenwood Village, Colorado, Förenta staterna, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
-
Lafayette, Colorado, Förenta staterna, 80026
- Kaiser Permanente-Rock Creek
-
Lafayette, Colorado, Förenta staterna, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
-
Lakewood, Colorado, Förenta staterna, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lakewood, Colorado, Förenta staterna, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
-
Littleton, Colorado, Förenta staterna, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton, Colorado, Förenta staterna, 80122
- AdventHealth Littleton
-
Lone Tree, Colorado, Förenta staterna, 80124
- Kaiser Permanente-Lone Tree
-
Lone Tree, Colorado, Förenta staterna, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, Förenta staterna, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont, Colorado, Förenta staterna, 80501
- Longmont United Hospital
-
Longmont, Colorado, Förenta staterna, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland, Colorado, Förenta staterna, 80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker, Colorado, Förenta staterna, 80138
- Rocky Mountain Cancer Centers-Parker
-
Parker, Colorado, Förenta staterna, 80138
- AdventHealth Parker
-
Pueblo, Colorado, Förenta staterna, 81004
- Saint Mary Corwin Medical Center
-
Pueblo, Colorado, Förenta staterna, 81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton, Colorado, Förenta staterna, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Thornton, Colorado, Förenta staterna, 80260
- National Jewish Health-Northern Hematology Oncology
-
Wheat Ridge, Colorado, Förenta staterna, 80401
- Intermountain Health Lutheran Hospital
-
-
Delaware
-
Lewes, Delaware, Förenta staterna, 19958
- Beebe Medical Center
-
Newark, Delaware, Förenta staterna, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Förenta staterna, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Förenta staterna, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Förenta staterna, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Förenta staterna, 19971
- Beebe Health Campus
-
Seaford, Delaware, Förenta staterna, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, Förenta staterna, 19801
- Christiana Care Health System-Wilmington Hospital
-
-
Florida
-
Altamonte Springs, Florida, Förenta staterna, 32701
- AdventHealth Altamonte
-
Aventura, Florida, Förenta staterna, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
-
Fort Lauderdale, Florida, Förenta staterna, 33308
- Holy Cross Hospital
-
Gainesville, Florida, Förenta staterna, 32610
- UF Health Cancer Institute - Gainesville
-
Kissimmee, Florida, Förenta staterna, 34744
- AdventHealth Kissimmee
-
Miami Beach, Florida, Förenta staterna, 33140
- Mount Sinai Medical Center
-
Orlando, Florida, Förenta staterna, 32806
- Orlando Health Cancer Institute
-
Orlando, Florida, Förenta staterna, 32803
- AdventHealth Orlando
-
Orlando, Florida, Förenta staterna, 32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando, Florida, Förenta staterna, 32822
- AdventHealth East Orlando
-
Winter Park, Florida, Förenta staterna, 32792
- AdventHealth Winter Park
-
-
Georgia
-
Atlanta, Georgia, Förenta staterna, 30322
- Emory University Hospital/Winship Cancer Institute
-
Savannah, Georgia, Förenta staterna, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Förenta staterna, 31404
- Memorial Health University Medical Center
-
Savannah, Georgia, Förenta staterna, 31404
- Summit Cancer Care-Memorial
-
Savannah, Georgia, Förenta staterna, 31405
- Summit Cancer Care-Candler
-
Savannah, Georgia, Förenta staterna, 31404
- Low Country Cancer Care
-
-
Hawaii
-
Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Förenta staterna, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Förenta staterna, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Förenta staterna, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Förenta staterna, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Förenta staterna, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, Förenta staterna, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Förenta staterna, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Förenta staterna, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, Förenta staterna, 96813
- Island Urology
-
Honolulu, Hawaii, Förenta staterna, 96819
- Kaiser Permanente Moanalua Medical Center
-
Honolulu, Hawaii, Förenta staterna, 96859
- Tripler Army Medical Center
-
Lihue, Hawaii, Förenta staterna, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Hawaii Cancer Care - Westridge
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Queen's Cancer Center - Pearlridge
-
‘Aiea, Hawaii, Förenta staterna, 96701
- The Cancer Center of Hawaii-Pali Momi
-
-
Idaho
-
Boise, Idaho, Förenta staterna, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Förenta staterna, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, Förenta staterna, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Förenta staterna, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, Förenta staterna, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Förenta staterna, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Förenta staterna, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Förenta staterna, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Förenta staterna, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Förenta staterna, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Förenta staterna, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Förenta staterna, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Förenta staterna, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Aurora, Illinois, Förenta staterna, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Förenta staterna, 61704
- Illinois CancerCare-Bloomington
-
Bloomington, Illinois, Förenta staterna, 61701
- OSF Saint Joseph Medical Center
-
Canton, Illinois, Förenta staterna, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Förenta staterna, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Förenta staterna, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Förenta staterna, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Förenta staterna, 62801
- Centralia Oncology Clinic
-
Danville, Illinois, Förenta staterna, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Förenta staterna, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Förenta staterna, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham, Illinois, Förenta staterna, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Förenta staterna, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, Förenta staterna, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Förenta staterna, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, Förenta staterna, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Förenta staterna, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Förenta staterna, 60134
- Northwestern Medicine Cancer Center Delnor
-
Glenview, Illinois, Förenta staterna, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park, Illinois, Förenta staterna, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Kewanee, Illinois, Förenta staterna, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, Förenta staterna, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Förenta staterna, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Förenta staterna, 60153
- Loyola University Medical Center
-
Mount Vernon, Illinois, Förenta staterna, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Förenta staterna, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Förenta staterna, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Förenta staterna, 61350
- Radiation Oncology of Northern Illinois
-
Pekin, Illinois, Förenta staterna, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Förenta staterna, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Förenta staterna, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Förenta staterna, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Förenta staterna, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Förenta staterna, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Förenta staterna, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Förenta staterna, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Förenta staterna, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Förenta staterna, 61114
- UW Health Carbone Cancer Center Rockford
-
Silvis, Illinois, Förenta staterna, 61282
- MercyOne Genesis Silvis Cancer Center
-
Skokie, Illinois, Förenta staterna, 60076
- North Shore Medical Center
-
Springfield, Illinois, Förenta staterna, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Förenta staterna, 62702
- Springfield Clinic
-
Springfield, Illinois, Förenta staterna, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Förenta staterna, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Förenta staterna, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Förenta staterna, 61801
- Carle Cancer Center
-
Urbana, Illinois, Förenta staterna, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Förenta staterna, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Förenta staterna, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Evansville, Indiana, Förenta staterna, 47713
- Deaconess Clinic Downtown
-
Michigan City, Indiana, Förenta staterna, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Förenta staterna, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Förenta staterna, 46545
- Memorial Regional Cancer Center Day Road
-
Newburgh, Indiana, Förenta staterna, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, Förenta staterna, 47374
- Reid Health
-
South Bend, Indiana, Förenta staterna, 46601
- Memorial Hospital of South Bend
-
-
Iowa
-
Ames, Iowa, Förenta staterna, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Förenta staterna, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Förenta staterna, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Förenta staterna, 50036
- McFarland Clinic - Boone
-
Clive, Iowa, Förenta staterna, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Förenta staterna, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Förenta staterna, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Förenta staterna, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Förenta staterna, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, Förenta staterna, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, Förenta staterna, 52803
- MercyOne Genesis Davenport Medical Center
-
Des Moines, Iowa, Förenta staterna, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Förenta staterna, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Förenta staterna, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Förenta staterna, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Förenta staterna, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Förenta staterna, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Förenta staterna, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Förenta staterna, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, Förenta staterna, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Förenta staterna, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Förenta staterna, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Förenta staterna, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Förenta staterna, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Förenta staterna, 66720
- Cancer Center of Kansas - Chanute
-
Coffeyville, Kansas, Förenta staterna, 67337
- Coffeyville Regional Medical Center
-
Dodge City, Kansas, Förenta staterna, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Förenta staterna, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, Förenta staterna, 66801
- Newman Regional Health
-
Fort Scott, Kansas, Förenta staterna, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Förenta staterna, 67846
- Central Care Cancer Center - Garden City
-
Garden City, Kansas, Förenta staterna, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Förenta staterna, 67530
- Central Care Cancer Center - Great Bend
-
Great Bend, Kansas, Förenta staterna, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Förenta staterna, 67601
- HaysMed
-
Independence, Kansas, Förenta staterna, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Förenta staterna, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Förenta staterna, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Förenta staterna, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Förenta staterna, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Förenta staterna, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Förenta staterna, 66219
- Minimally Invasive Surgery Hospital
-
Liberal, Kansas, Förenta staterna, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Förenta staterna, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Förenta staterna, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Förenta staterna, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Förenta staterna, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Förenta staterna, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Förenta staterna, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Förenta staterna, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Förenta staterna, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Förenta staterna, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, Förenta staterna, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Förenta staterna, 67401
- Salina Regional Health Center
-
Salina, Kansas, Förenta staterna, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Förenta staterna, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, Förenta staterna, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Förenta staterna, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Förenta staterna, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Förenta staterna, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Förenta staterna, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Förenta staterna, 67208
- Associates In Womens Health
-
Winfield, Kansas, Förenta staterna, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Förenta staterna, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Förenta staterna, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Förenta staterna, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Förenta staterna, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Förenta staterna, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Förenta staterna, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Förenta staterna, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Förenta staterna, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Förenta staterna, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Förenta staterna, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Förenta staterna, 40202
- Jewish Hospital
-
Louisville, Kentucky, Förenta staterna, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Förenta staterna, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Förenta staterna, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Förenta staterna, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Förenta staterna, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Förenta staterna, 40165
- Jewish Hospital Medical Center South
-
-
Maine
-
Augusta, Maine, Förenta staterna, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Förenta staterna, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Förenta staterna, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Förenta staterna, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Förenta staterna, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, Förenta staterna, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Förenta staterna, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Förenta staterna, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Förenta staterna, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, Förenta staterna, 21204
- Greater Baltimore Medical Center
-
Bethesda, Maryland, Förenta staterna, 20889-5600
- Walter Reed National Military Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Förenta staterna, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Förenta staterna, 01805
- Lahey Clinic
-
Winchester, Massachusetts, Förenta staterna, 01890
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
-
-
Michigan
-
Adrian, Michigan, Förenta staterna, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Förenta staterna, 48109
- University of Michigan Rogel Cancer Center
-
Battle Creek, Michigan, Förenta staterna, 49017
- Bronson Battle Creek
-
Dearborn, Michigan, Förenta staterna, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Förenta staterna, 48201
- Wayne State University/Karmanos Cancer Institute
-
Farmington Hills, Michigan, Förenta staterna, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Förenta staterna, 48336
- Corewell Health Farmington Hills Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe, Michigan, Förenta staterna, 48230
- William Beaumont Hospital-Grosse Pointe
-
Kalamazoo, Michigan, Förenta staterna, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Förenta staterna, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Förenta staterna, 49048
- Beacon Kalamazoo
-
Monroe, Michigan, Förenta staterna, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, Förenta staterna, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Förenta staterna, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Port Huron, Michigan, Förenta staterna, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Förenta staterna, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Förenta staterna, 49677
- Corewell Health Reed City Hospital
-
Roseville, Michigan, Förenta staterna, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Förenta staterna, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Förenta staterna, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Förenta staterna, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Förenta staterna, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Förenta staterna, 48073
- Corewell Health William Beaumont University Hospital
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Förenta staterna, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Förenta staterna, 48314
- Mitchell Folbe MD PC
-
Traverse City, Michigan, Förenta staterna, 49684
- Munson Medical Center
-
Troy, Michigan, Förenta staterna, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Förenta staterna, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Förenta staterna, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Förenta staterna, 48085
- Corewell Health Beaumont Troy Hospital
-
Wyoming, Michigan, Förenta staterna, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Brainerd, Minnesota, Förenta staterna, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Förenta staterna, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Förenta staterna, 55433
- Mercy Hospital
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Förenta staterna, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Förenta staterna, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Förenta staterna, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Förenta staterna, 55350
- Hutchinson Area Health Care
-
Maple Grove, Minnesota, Förenta staterna, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Förenta staterna, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Förenta staterna, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Förenta staterna, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Förenta staterna, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Förenta staterna, 55454
- Health Partners Inc
-
Monticello, Minnesota, Förenta staterna, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Förenta staterna, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Förenta staterna, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Förenta staterna, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Förenta staterna, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Förenta staterna, 55102
- United Hospital
-
Shakopee, Minnesota, Förenta staterna, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Förenta staterna, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Förenta staterna, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Förenta staterna, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Förenta staterna, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, Förenta staterna, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Jackson, Mississippi, Förenta staterna, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, Förenta staterna, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, Förenta staterna, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Förenta staterna, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Förenta staterna, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Förenta staterna, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Independence, Missouri, Förenta staterna, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Förenta staterna, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Förenta staterna, 64804
- Freeman Health System
-
Joplin, Missouri, Förenta staterna, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Förenta staterna, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Förenta staterna, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Förenta staterna, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Förenta staterna, 64132
- Research Medical Center
-
Kansas City, Missouri, Förenta staterna, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Förenta staterna, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Förenta staterna, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, Förenta staterna, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, Förenta staterna, 64068
- Liberty Hospital
-
Rolla, Missouri, Förenta staterna, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Förenta staterna, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Förenta staterna, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Förenta staterna, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Förenta staterna, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Förenta staterna, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Förenta staterna, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Förenta staterna, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Förenta staterna, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Förenta staterna, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Förenta staterna, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, Förenta staterna, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Förenta staterna, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Förenta staterna, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Förenta staterna, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Förenta staterna, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Förenta staterna, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Förenta staterna, 59405
- Great Falls Clinic
-
Great Falls, Montana, Förenta staterna, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Förenta staterna, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Förenta staterna, 59901
- Logan Health Medical Center
-
Missoula, Montana, Förenta staterna, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Förenta staterna, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Förenta staterna, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Förenta staterna, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Förenta staterna, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Förenta staterna, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Förenta staterna, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Förenta staterna, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Förenta staterna, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Förenta staterna, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Förenta staterna, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Förenta staterna, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Förenta staterna, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Förenta staterna, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Förenta staterna, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Förenta staterna, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Förenta staterna, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Förenta staterna, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Förenta staterna, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Förenta staterna, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Förenta staterna, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Förenta staterna, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Förenta staterna, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Förenta staterna, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Förenta staterna, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Förenta staterna, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Förenta staterna, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Förenta staterna, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Förenta staterna, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Förenta staterna, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89169
- University Cancer Center
-
Las Vegas, Nevada, Förenta staterna, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Förenta staterna, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Förenta staterna, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Brick, New Jersey, Förenta staterna, 08724
- Ocean University Medical Center
-
Hackensack, New Jersey, Förenta staterna, 07601
- Hackensack University Medical Center
-
Holmdel, New Jersey, Förenta staterna, 07733
- Bayshore Community Hospital
-
Manahawkin, New Jersey, Förenta staterna, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, Förenta staterna, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, Förenta staterna, 07753
- Jersey Shore Medical Center
-
Red Bank, New Jersey, Förenta staterna, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, Förenta staterna, 07902
- Overlook Hospital
-
-
New York
-
Lake Success, New York, Förenta staterna, 11042
- Northwell Health/Center for Advanced Medicine
-
Middletown, New York, Förenta staterna, 10940
- Garnet Health Medical Center
-
New York, New York, Förenta staterna, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Rochester, New York, Förenta staterna, 14642
- University of Rochester
-
-
North Carolina
-
Asheville, North Carolina, Förenta staterna, 28801
- Mission Hospital
-
Asheville, North Carolina, Förenta staterna, 28806
- Messino Cancer Centers
-
Asheville, North Carolina, Förenta staterna, 28803
- AdventHealth Infusion Center Asheville
-
Charlotte, North Carolina, Förenta staterna, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Förenta staterna, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, Förenta staterna, 28262
- Southern Oncology Specialists-Charlotte
-
Charlotte, North Carolina, Förenta staterna, 28207
- Novant Health Carolina Surgical - Randolph
-
Clinton, North Carolina, Förenta staterna, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clinton, North Carolina, Förenta staterna, 28328
- Sampson Radiation Oncology
-
Clyde, North Carolina, Förenta staterna, 28721
- AdventHealth Infusion Center Haywood
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Wayne Memorial Hospital
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Wayne Radiation Oncology
-
Hendersonville, North Carolina, Förenta staterna, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Förenta staterna, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Förenta staterna, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Förenta staterna, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, Förenta staterna, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Förenta staterna, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, Förenta staterna, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Förenta staterna, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, Förenta staterna, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, Förenta staterna, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Förenta staterna, 28117
- Novant Health Cancer Institute - Mooresville
-
Richlands, North Carolina, Förenta staterna, 28574
- ECU Health Oncology Richlands
-
-
North Dakota
-
Fargo, North Dakota, Förenta staterna, 58103
- Essentia Health Cancer Center-South University Clinic
-
-
Ohio
-
Beavercreek, Ohio, Förenta staterna, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Förenta staterna, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Förenta staterna, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, Förenta staterna, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Förenta staterna, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Förenta staterna, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Förenta staterna, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Förenta staterna, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Förenta staterna, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Förenta staterna, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Förenta staterna, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Förenta staterna, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Förenta staterna, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Förenta staterna, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Förenta staterna, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Förenta staterna, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Förenta staterna, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Förenta staterna, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Förenta staterna, 43228
- Doctors Hospital
-
Columbus, Ohio, Förenta staterna, 43215
- Grant Medical Center
-
Columbus, Ohio, Förenta staterna, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Förenta staterna, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Förenta staterna, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Förenta staterna, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Förenta staterna, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Förenta staterna, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Förenta staterna, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Förenta staterna, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Förenta staterna, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Förenta staterna, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Förenta staterna, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Förenta staterna, 45840
- Orion Cancer Care
-
Franklin, Ohio, Förenta staterna, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Förenta staterna, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Förenta staterna, 45331
- Wayne Hospital
-
Greenville, Ohio, Förenta staterna, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Förenta staterna, 45429
- Kettering Medical Center
-
Kettering, Ohio, Förenta staterna, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Förenta staterna, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Förenta staterna, 43130
- Fairfield Medical Center
-
Marietta, Ohio, Förenta staterna, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Förenta staterna, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Förenta staterna, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mount Vernon, Ohio, Förenta staterna, 43050
- Knox Community Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Förenta staterna, 43616
- Saint Charles Hospital
-
Perrysburg, Ohio, Förenta staterna, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Förenta staterna, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Förenta staterna, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, Förenta staterna, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Förenta staterna, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, Förenta staterna, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Förenta staterna, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Förenta staterna, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Förenta staterna, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Förenta staterna, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, Förenta staterna, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Förenta staterna, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Förenta staterna, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Förenta staterna, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Förenta staterna, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Förenta staterna, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, Förenta staterna, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, Förenta staterna, 73142
- Integris Cancer Institute of Oklahoma
-
Tulsa, Oklahoma, Förenta staterna, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Förenta staterna, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Förenta staterna, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Förenta staterna, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Förenta staterna, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Förenta staterna, 97420
- Bay Area Hospital
-
Newberg, Oregon, Förenta staterna, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Förenta staterna, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Förenta staterna, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Förenta staterna, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Förenta staterna, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Förenta staterna, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Förenta staterna, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington, Pennsylvania, Förenta staterna, 19001
- Jefferson Abington Hospital
-
Beaver, Pennsylvania, Förenta staterna, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Förenta staterna, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Förenta staterna, 17822
- Geisinger Medical Center
-
Greensburg, Pennsylvania, Förenta staterna, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, Förenta staterna, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Johnstown, Pennsylvania, Förenta staterna, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Förenta staterna, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Förenta staterna, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Förenta staterna, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Moon Township, Pennsylvania, Förenta staterna, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Pittsburgh, Pennsylvania, Förenta staterna, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Förenta staterna, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Förenta staterna, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Förenta staterna, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Förenta staterna, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Förenta staterna, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Förenta staterna, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Förenta staterna, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Förenta staterna, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Förenta staterna, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, Förenta staterna, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Förenta staterna, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Förenta staterna, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Förenta staterna, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading, Pennsylvania, Förenta staterna, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Förenta staterna, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Förenta staterna, 17701
- UPMC Susquehanna
-
-
South Carolina
-
Anderson, South Carolina, Förenta staterna, 29621
- AnMed Health Cancer Center
-
Charleston, South Carolina, Förenta staterna, 29401
- Roper Hospital
-
Charleston, South Carolina, Förenta staterna, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, Förenta staterna, 29414
- Bon Secours Saint Francis Hospital
-
Charleston, South Carolina, Förenta staterna, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, Förenta staterna, 29414
- Charleston Oncology - Saint Francis
-
Charleston, South Carolina, Förenta staterna, 29414
- Lowcountry Oncology Associates - West Ashley
-
Gaffney, South Carolina, Förenta staterna, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Förenta staterna, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Förenta staterna, 29601
- Saint Francis Hospital
-
Greer, South Carolina, Förenta staterna, 29651
- Gibbs Cancer Center-Pelham
-
Mt. Pleasant, South Carolina, Förenta staterna, 29464
- Lowcountry Oncology Associates - Mount Pleasant
-
Spartanburg, South Carolina, Förenta staterna, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Förenta staterna, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Rapid City, South Dakota, Förenta staterna, 57701
- Rapid City Regional Hospital
-
-
Tennessee
-
Bristol, Tennessee, Förenta staterna, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Bristol, Tennessee, Förenta staterna, 37620
- Bristol Regional Medical Center
-
Chattanooga, Tennessee, Förenta staterna, 37404
- Memorial Hospital
-
Hixson, Tennessee, Förenta staterna, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Johnson City, Tennessee, Förenta staterna, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Förenta staterna, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Förenta staterna, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Ooltewah, Tennessee, Förenta staterna, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, Förenta staterna, 77802
- Saint Joseph Regional Cancer Center
-
-
Utah
-
American Fork, Utah, Förenta staterna, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Förenta staterna, 84720
- Sandra L Maxwell Cancer Center
-
Farmington, Utah, Förenta staterna, 84025
- Farmington Health Center
-
Logan, Utah, Förenta staterna, 84321
- Logan Regional Hospital
-
Murray, Utah, Förenta staterna, 84107
- Intermountain Medical Center
-
Ogden, Utah, Förenta staterna, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Förenta staterna, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Förenta staterna, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Förenta staterna, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Förenta staterna, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Förenta staterna, 84143
- LDS Hospital
-
South Jordan, Utah, Förenta staterna, 84009
- South Jordan Health Center
-
St. George, Utah, Förenta staterna, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Bristol, Virginia, Förenta staterna, 24201
- Ballad Health Cancer Care - Bristol
-
Norton, Virginia, Förenta staterna, 24273
- Ballad Health Cancer Care - Norton
-
-
Washington
-
Aberdeen, Washington, Förenta staterna, 98520
- Providence Regional Cancer System-Aberdeen
-
Anacortes, Washington, Förenta staterna, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, Förenta staterna, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Förenta staterna, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Förenta staterna, 98004
- Overlake Medical Center
-
Bellevue, Washington, Förenta staterna, 98005
- Swedish Cancer Institute-Eastside Oncology Hematology
-
Bellingham, Washington, Förenta staterna, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Förenta staterna, 98166
- Saint Anne Hospital
-
Centralia, Washington, Förenta staterna, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Förenta staterna, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Förenta staterna, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Förenta staterna, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Förenta staterna, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Förenta staterna, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Förenta staterna, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Förenta staterna, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Förenta staterna, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Förenta staterna, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Förenta staterna, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Förenta staterna, 98499
- Saint Clare Hospital
-
Longview, Washington, Förenta staterna, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, Förenta staterna, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, Förenta staterna, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Förenta staterna, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Förenta staterna, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Förenta staterna, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Förenta staterna, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, Förenta staterna, 98055
- Valley Medical Center
-
Seattle, Washington, Förenta staterna, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Förenta staterna, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Förenta staterna, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Förenta staterna, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Förenta staterna, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Förenta staterna, 98104
- Pacific Gynecology Specialists
-
Sedro-Woolley, Washington, Förenta staterna, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Förenta staterna, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Förenta staterna, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Förenta staterna, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Förenta staterna, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Förenta staterna, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Förenta staterna, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Förenta staterna, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Förenta staterna, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Förenta staterna, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Förenta staterna, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Förenta staterna, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Förenta staterna, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Förenta staterna, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Förenta staterna, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Burlington, Wisconsin, Förenta staterna, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Fond du Lac, Wisconsin, Förenta staterna, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Förenta staterna, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Förenta staterna, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Förenta staterna, 54311
- Aurora BayCare Medical Center
-
Johnson Creek, Wisconsin, Förenta staterna, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Förenta staterna, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Förenta staterna, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Förenta staterna, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, Förenta staterna, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Förenta staterna, 54143
- Bay Area Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Förenta staterna, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Förenta staterna, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53233
- Aurora Sinai Medical Center
-
Mukwonago, Wisconsin, Förenta staterna, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Förenta staterna, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Förenta staterna, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Förenta staterna, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Förenta staterna, 53406
- Aurora Cancer Care-Racine
-
Sheboygan, Wisconsin, Förenta staterna, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, Förenta staterna, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Förenta staterna, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Förenta staterna, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Förenta staterna, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, Förenta staterna, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Förenta staterna, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, Förenta staterna, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Förenta staterna, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Förenta staterna, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Förenta staterna, 82801
- Welch Cancer Center
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
-
STEP 1: REGISTRATION
-
Patients must have histologically or cytologically confirmed stage IV or unresectable stage III BRAF V600E or BRAF V600K mutant melanoma
-
Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic techniques include but are not restricted to DNA sequencing, pyrosequencing, polymerase chain reaction (PCR), melting point assays, and immunohistochemistry
-
Contrast-enhanced CT scans of the neck, chest, abdomen and pelvis are required; a whole body PET/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
-
Patients must not have received a prior BRAF or MEK inhibitor
-
Patients with a history of brain metastases are eligible if the patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to registration
-
Patients must not have received any anti-cancer drug within 28 days prior to registration, and must not have received any nitrosoureas or mitomycin C within 42 days prior to registration
-
Patients must not have received any major surgery or immunotherapy within 28 days prior to registration
-
Patients must not have any unresolved toxicity greater than National Cancer Institute (NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia within 7 days prior to registration
-
Patients must be age >= 18 years of age
-
Absolute neutrophil count (ANC) >= 1,200/ul (obtained within 28 days prior to registration)
-
Platelets >= 100,000/ul (obtained within 28 days prior to registration)
-
Hemoglobin >= 9 g/dL (obtained within 28 days prior to registration)
-
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert's syndrome) (obtained within 28 days prior to registration)
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
-
Serum albumin >= 2.5 g/dL (obtained within 28 days prior to registration)
-
Serum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration
-
Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to registration in order to obtain baseline stratification information
-
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by ECHO or MUGA within 28 days prior to registration
-
Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG) (corrected using the Bazett's formula) within 28 days prior to registration
-
Patients with known history or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) are not eligible:
-
History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension, diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes)
-
Visible retinal pathology as assessed by ophthalmic exam that is considered a risk factor for RVO or CSR such as:
- Evidence of new optic disc cupping
- Evidence of new visual field defects
- Intraocular pressure > 21 mmHg
-
NOTE: ophthalmic exam is required for all patients; exam must be obtained within 28 days prior to registration
-
-
Patients must be able to take oral medications; patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
-
Patients receiving anticoagulation treatment are allowed to participate with international normalized ratio (INR) established within the therapeutic range
-
Patients must not have a history of pneumonitis or interstitial lung disease
-
Patients must not have any grade II/III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis]) can be entered on study; patients with a history of atrial fibrillation must have atrial fibrillation controlled for at least 30 days prior to registration
-
Patients with known hepatitis B or hepatitis C are not eligible, regardless of concomitant antiretroviral therapy or current viral load
-
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:
-
Cluster of differentiation (CD)4 cells >= 500/uL
-
Serum HIV viral load of < 25,000 IU/ml
-
No current antiretroviral therapy
- Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
-
-
Pre-study history and physical must be obtained with 28 days prior to registration
-
Patients must have dermatology exam obtained within 28 days prior to registration to obtain baseline measurement; exam to be performed by treating physician or designated dermatologist
-
Patients must have Zubrod performance status of 0, 1 or 2
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years; exception: patients with known history of colon cancer, cancer of the pancreas, or any cancer known to harbor an activating RAS mutation are ineligible regardless of stage or time since diagnosis
-
Patients must not be pregnant or nursing because of the risk of fetal harm; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; hormonal contraception is not allowed due to drug interactions which can render hormonal contraceptives ineffective
-
Patients must be offered the opportunity to participate in specimen banking
-
Patients with cutaneous or superficial lesions that do not require imaging guidance for biopsy must be willing to undergo biopsies for tissue submission and blood draws for translational medicine
-
Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
-
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
-
STEP 2: RANDOMIZATION
-
After completing one cycle of therapy, patients will be registered for randomization between intermittent and continuous dosing, provided that they were eligible for the initial step 1 registration and satisfy the following criteria
-
Patients must not have unequivocal disease progression (by RECIST v1.1) during the first cycle; patients must have disease assessed using the same method as baseline within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1, or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up tumor assessment form (RECIST 1.1)
-
Patients must be registered to step 2: randomization within +/- 5 days of starting cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Arm I (continuous dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
Andra namn:
Undergo ECHO
Andra namn:
Undergo MUGA
Andra namn:
Undergo CT or PET/CT
Andra namn:
Undergo PET/CT
Andra namn:
Given PO
Andra namn:
Given PO
Andra namn:
|
|
Experimentell: Arm II (intermittent dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
Andra namn:
Undergo ECHO
Andra namn:
Undergo MUGA
Andra namn:
Undergo CT or PET/CT
Andra namn:
Undergo PET/CT
Andra namn:
Given PO
Andra namn:
Given PO
Andra namn:
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Progression-free survival (PFS)
Tidsram: Measured from date of randomization, assessed up to 5 years
|
Testing of the superiority of intermittent dosing of dabrafenib and trametinib compared to continuous dosing with these two same agents will be based on progression-free survival. Stratified Cox regression models stratified by stratification factors will be used for all analyses. |
Measured from date of randomization, assessed up to 5 years
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Overall survival
Tidsram: Up to 5 years
|
Overall survival between patients on each arm and survival after progression will be compared using Cox regression models. |
Up to 5 years
|
|
Response rates
Tidsram: Up to 5 years
|
Response rates between arms will be compared using Fisher's exact test. |
Up to 5 years
|
|
Rates of fever
Tidsram: Up to 5 years
|
Defined as >= grade 3 per Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 with attribution possibly, probably, or definitely related to treatment; or any >= grade 1 per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment with chills, dehydration, hypotension, dizziness, or muscle weakness per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment reported during the same course. Rates of fever between arms will also be compared using Fisher's exact test. |
Up to 5 years
|
Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Molecular events leading to reactivation of the MAPK pathway
Tidsram: Up to 5 years
|
Compared between patients of the two treatment groups. |
Up to 5 years
|
|
Change in biomarkers associated with PFS of archived tissue
Tidsram: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
|
Interaction between baseline biomarkers and treatment arm
Tidsram: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Alain P Algazi, SWOG Cancer Research Network
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS. Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023. Epub 2021 Aug 19.
- Algazi AP, Othus M, Daud AI, Lo RS, Mehnert JM, Truong TG, Conry R, Kendra K, Doolittle GC, Clark JI, Messino MJ, Moore DF Jr, Lao C, Faller BA, Govindarajan R, Harker-Murray A, Dreisbach L, Moon J, Grossmann KF, Ribas A. Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial. Nat Med. 2020 Oct;26(10):1564-1568. doi: 10.1038/s41591-020-1060-8. Epub 2020 Oct 5.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
19 september 2014
Primärt slutförande (Beräknad)
15 mars 2027
Avslutad studie (Beräknad)
15 mars 2027
Studieregistreringsdatum
Först inskickad
18 juli 2014
Först inskickad som uppfyllde QC-kriterierna
18 juli 2014
Första postat (Beräknad)
21 juli 2014
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
12 november 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
10 november 2026
Senast verifierad
1 september 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
- Neoplasmer efter plats
- Neoplasmer
- Neoplasmer efter histologisk typ
- Hudsjukdomar
- Neuroektodermala tumörer
- Neoplasmer, könsceller och embryonala
- Neoplasmer, nervvävnad
- Neuroendokrina tumörer
- Nevi och melanom
- Neoplasmer i huden
- Hud- och bindvävssjukdomar
- Melanom
- Undersökningstekniker
- Kliniska laboratorietekniker
- Diagnostiska tekniker och procedurer
- Diagnos
- Kemitekniker, analytiska
- Spektrumanalys
- Provhantering
- dabrafenib
- trametinib
- Magnetresonansspektroskopi
Andra studie-ID-nummer
- NCI-2014-01470
- U10CA032102 (U.S.S. NIH-anslag/kontrakt)
- U10CA180888 (U.S.S. NIH-anslag/kontrakt)
- NCI-2014-01470 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
- S1320 (Annan identifierare: CTEP)
- S1320 (Annan identifierare: SWOG)
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .