Dabrafenib e Trametinib nel trattamento di pazienti con melanoma con mutazione BRAF in stadio III-IV che non può essere rimosso chirurgicamente
10 novembre 2026 aggiornato da: National Cancer Institute (NCI)
Uno studio randomizzato di fase II sulla somministrazione intermittente rispetto alla somministrazione continua di Dabrafenib (NSC-763760) e Trametinib (NSC-763093) nel melanoma con mutazione BRAF V600E/K
This phase II trial compares the effect of dabrafenib and trametinib given continuously to given with a break in treatment (intermittent) in treating patients with stage III-IV melanoma that cannot be removed by surgery and contains a B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving dabrafenib and trametinib with intermittent dosing may be as effect as when given continuously in treating patients with stage III-IV melanoma with a BRAF mutation that cannot be removed by surgery.
Panoramica dello studio
Stato
Attivo, non reclutante
Condizioni
Descrizione dettagliata
PRIMARY OBJECTIVE:
I. To compare progression-free survival with intermittent dosing and continuous dosing of dabrafenib and trametinib among patients with metastatic BRAF V600E/K mutant melanoma.
SECONDARY OBJECTIVES:
I. To estimate the frequency and severity of toxicities of the two dosing schedules.
II. To compare the frequency and severity of fever >= grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) 4.0 of the two dosing schedules.
III. To compare the response rate (complete and partial response, confirmed and unconfirmed), overall survival, and survival after progression between the two dosing schedules on step 2.
TRANSLATIONAL MEDICINE OBJECTIVES:
I. To evaluate whether acquired molecular events leading to reactivation of the MAPK pathway are more common among patients on the continuous dosing arm than on the intermittent dosing arm using circulating tumor deoxyribonucleic acid (DNA) (ctDNA).
II. To assess the prognostic association between baseline biomarkers and early molecular events with progression free survival (PFS).
III. To explore the potential interaction between treatment arm and baseline biomarkers/early molecular events with PFS.
IV. To bank tissue and whole blood in anticipation of future studies to evaluate molecular events associated with clinical benefit and disease progression in patients treated with continuous versus intermittent dabrafenib and trametinib.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I (CONTINUOUS DOSING): Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo positron emission tomography/computed tomography (PET/CT) or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, echocardiography (ECHO) or multigated acquisition scan (MUGA) on study.
ARM II (INTERMITTENT DOSING): Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study.
After completion of study treatment, patients are followed up every 6 months for 3 years and then yearly for 2 years.
Tipo di studio
Interventistico
Iscrizione (Stimato)
280
Fase
- Fase 2
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
-
-
Alabama
-
Birmingham, Alabama, Stati Uniti, 35233
- University of Alabama at Birmingham Cancer Center
-
-
Alaska
-
Anchorage, Alaska, Stati Uniti, 98508
- Anchorage Associates in Radiation Medicine
-
Anchorage, Alaska, Stati Uniti, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, Stati Uniti, 99508
- Alaska Oncology and Hematology LLC
-
Anchorage, Alaska, Stati Uniti, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, Stati Uniti, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, Stati Uniti, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Stati Uniti, 99508
- Providence Alaska Medical Center
-
Anchorage, Alaska, Stati Uniti, 99504
- Anchorage Radiation Therapy Center
-
Anchorage, Alaska, Stati Uniti, 99508
- Alaska Regional Hospital
-
Fairbanks, Alaska, Stati Uniti, 99701
- Fairbanks Memorial Hospital
-
-
Arizona
-
Tucson, Arizona, Stati Uniti, 85719
- Banner University Medical Center - Tucson
-
Tucson, Arizona, Stati Uniti, 85719
- University of Arizona Cancer Center-North Campus
-
Yuma, Arizona, Stati Uniti, 85364
- Onvida Health Yuma Medical Center
-
-
Arkansas
-
Fort Smith, Arkansas, Stati Uniti, 72903
- Mercy Hospital Fort Smith
-
Hot Springs, Arkansas, Stati Uniti, 71913
- CHI Saint Vincent Cancer Center Hot Springs
-
Jonesboro, Arkansas, Stati Uniti, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
Little Rock, Arkansas, Stati Uniti, 72205
- University of Arkansas for Medical Sciences
-
Little Rock, Arkansas, Stati Uniti, 72205
- John L McClellan Memorial Veterans Hospital
-
Rogers, Arkansas, Stati Uniti, 72758
- Highlands Oncology Group - Rogers
-
-
California
-
Anaheim, California, Stati Uniti, 92806
- Kaiser Permanente-Anaheim
-
Antioch, California, Stati Uniti, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande, California, Stati Uniti, 93420
- PCR Oncology
-
Baldwin Park, California, Stati Uniti, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Stati Uniti, 90706
- Kaiser Permanente-Bellflower
-
Burbank, California, Stati Uniti, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Dublin, California, Stati Uniti, 94568
- Epic Care-Dublin
-
Emeryville, California, Stati Uniti, 94608
- Bay Area Breast Surgeons Inc
-
Emeryville, California, Stati Uniti, 94608
- Epic Care Partners in Cancer Care
-
Fontana, California, Stati Uniti, 92335
- Kaiser Permanente-Fontana
-
Fremont, California, Stati Uniti, 94538
- Kaiser Permanente-Fremont
-
Fresno, California, Stati Uniti, 93720
- Kaiser Permanente-Fresno
-
Harbor City, California, Stati Uniti, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Stati Uniti, 92618
- Kaiser Permanente-Irvine
-
Loma Linda, California, Stati Uniti, 92354
- Loma Linda University Medical Center
-
Los Angeles, California, Stati Uniti, 90095
- UCLA / Jonsson Comprehensive Cancer Center
-
Los Angeles, California, Stati Uniti, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Stati Uniti, 90034
- Kaiser Permanente West Los Angeles
-
Martinez, California, Stati Uniti, 94553-3156
- Contra Costa Regional Medical Center
-
Modesto, California, Stati Uniti, 95356
- Kaiser Permanente-Modesto
-
Oakland, California, Stati Uniti, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, Stati Uniti, 94611
- Kaiser Permanente Oakland-Broadway
-
Oakland, California, Stati Uniti, 94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland, California, Stati Uniti, 94609
- Hematology and Oncology Associates-Oakland
-
Oakland, California, Stati Uniti, 94609
- Bay Area Tumor Institute
-
Panorama City, California, Stati Uniti, 91402
- Kaiser Permanente - Panorama City
-
Rancho Cordova, California, Stati Uniti, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
-
Rancho Mirage, California, Stati Uniti, 92270
- Eisenhower Medical Center
-
Redwood City, California, Stati Uniti, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, Stati Uniti, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, Stati Uniti, 92505
- Kaiser Permanente-Riverside
-
Rohnert Park, California, Stati Uniti, 94928
- Rohnert Park Cancer Center
-
Roseville, California, Stati Uniti, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
-
Roseville, California, Stati Uniti, 95661
- Kaiser Permanente-Roseville
-
Sacramento, California, Stati Uniti, 95814
- Kaiser Permanente Downtown Commons
-
Sacramento, California, Stati Uniti, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, Stati Uniti, 95823
- South Sacramento Cancer Center
-
Sacramento, California, Stati Uniti, 95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego, California, Stati Uniti, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Stati Uniti, 92108
- Kaiser Permanente-Rio San Diego
-
San Francisco, California, Stati Uniti, 94115
- Kaiser Permanente-San Francisco
-
San Francisco, California, Stati Uniti, 94115
- UCSF Medical Center-Mount Zion
-
San Jose, California, Stati Uniti, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro, California, Stati Uniti, 94577
- Kaiser Permanente San Leandro
-
San Marcos, California, Stati Uniti, 92078
- Kaiser Permanente-San Marcos
-
San Rafael, California, Stati Uniti, 94903
- Kaiser San Rafael-Gallinas
-
San Rafael, California, Stati Uniti, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, Stati Uniti, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Rosa, California, Stati Uniti, 95403
- Kaiser Permanente-Santa Rosa
-
South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente Cancer Treatment Center
-
South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente-South San Francisco
-
Stockton, California, Stati Uniti, 95210
- Kaiser Permanente-Stockton
-
Vacaville, California, Stati Uniti, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo, California, Stati Uniti, 94589
- Kaiser Permanente-Vallejo
-
Walnut Creek, California, Stati Uniti, 94596
- Kaiser Permanente-Walnut Creek
-
Walnut Creek, California, Stati Uniti, 94597
- Epic Care Cyberknife Center
-
Woodland Hills, California, Stati Uniti, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Stati Uniti, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, Stati Uniti, 80012
- The Medical Center of Aurora
-
Aurora, Colorado, Stati Uniti, 80045
- UCHealth University of Colorado Hospital
-
Boulder, Colorado, Stati Uniti, 80303
- Boulder Community Foothills Hospital
-
Boulder, Colorado, Stati Uniti, 80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs, Colorado, Stati Uniti, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Stati Uniti, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, Stati Uniti, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Stati Uniti, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Stati Uniti, 80220
- Rose Medical Center
-
Denver, Colorado, Stati Uniti, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, Stati Uniti, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, Stati Uniti, 80204
- Denver Health Medical Center
-
Denver, Colorado, Stati Uniti, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, Stati Uniti, 80209
- The Women's Imaging Center
-
Denver, Colorado, Stati Uniti, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver, Colorado, Stati Uniti, 80210
- AdventHealth Porter
-
Durango, Colorado, Stati Uniti, 81301
- Mercy Medical Center
-
Durango, Colorado, Stati Uniti, 81301
- CommonSpirit Cancer Center Mercy
-
Englewood, Colorado, Stati Uniti, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, Stati Uniti, 80113
- Swedish Medical Center
-
Fort Collins, Colorado, Stati Uniti, 80524
- Poudre Valley Hospital
-
Golden, Colorado, Stati Uniti, 80401
- Mountain Blue Cancer Care Center
-
Golden, Colorado, Stati Uniti, 80401
- National Jewish Health-Western Hematology Oncology
-
Grand Junction, Colorado, Stati Uniti, 81501
- Saint Mary's Hospital and Regional Medical Center
-
Grand Junction, Colorado, Stati Uniti, 81505
- Grand Valley Oncology
-
Greeley, Colorado, Stati Uniti, 80631
- Banner North Colorado Medical Center
-
Greenwood Village, Colorado, Stati Uniti, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
-
Lafayette, Colorado, Stati Uniti, 80026
- Kaiser Permanente-Rock Creek
-
Lafayette, Colorado, Stati Uniti, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
-
Lakewood, Colorado, Stati Uniti, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lakewood, Colorado, Stati Uniti, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
-
Littleton, Colorado, Stati Uniti, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton, Colorado, Stati Uniti, 80122
- AdventHealth Littleton
-
Lone Tree, Colorado, Stati Uniti, 80124
- Kaiser Permanente-Lone Tree
-
Lone Tree, Colorado, Stati Uniti, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, Stati Uniti, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont, Colorado, Stati Uniti, 80501
- Longmont United Hospital
-
Longmont, Colorado, Stati Uniti, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland, Colorado, Stati Uniti, 80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker, Colorado, Stati Uniti, 80138
- Rocky Mountain Cancer Centers-Parker
-
Parker, Colorado, Stati Uniti, 80138
- AdventHealth Parker
-
Pueblo, Colorado, Stati Uniti, 81004
- Saint Mary Corwin Medical Center
-
Pueblo, Colorado, Stati Uniti, 81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton, Colorado, Stati Uniti, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Thornton, Colorado, Stati Uniti, 80260
- National Jewish Health-Northern Hematology Oncology
-
Wheat Ridge, Colorado, Stati Uniti, 80401
- Intermountain Health Lutheran Hospital
-
-
Delaware
-
Lewes, Delaware, Stati Uniti, 19958
- Beebe Medical Center
-
Newark, Delaware, Stati Uniti, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Stati Uniti, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Stati Uniti, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Stati Uniti, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Stati Uniti, 19971
- Beebe Health Campus
-
Seaford, Delaware, Stati Uniti, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, Stati Uniti, 19801
- Christiana Care Health System-Wilmington Hospital
-
-
Florida
-
Altamonte Springs, Florida, Stati Uniti, 32701
- AdventHealth Altamonte
-
Aventura, Florida, Stati Uniti, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
-
Fort Lauderdale, Florida, Stati Uniti, 33308
- Holy Cross Hospital
-
Gainesville, Florida, Stati Uniti, 32610
- UF Health Cancer Institute - Gainesville
-
Kissimmee, Florida, Stati Uniti, 34744
- AdventHealth Kissimmee
-
Miami Beach, Florida, Stati Uniti, 33140
- Mount Sinai Medical Center
-
Orlando, Florida, Stati Uniti, 32806
- Orlando Health Cancer Institute
-
Orlando, Florida, Stati Uniti, 32803
- AdventHealth Orlando
-
Orlando, Florida, Stati Uniti, 32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando, Florida, Stati Uniti, 32822
- AdventHealth East Orlando
-
Winter Park, Florida, Stati Uniti, 32792
- AdventHealth Winter Park
-
-
Georgia
-
Atlanta, Georgia, Stati Uniti, 30322
- Emory University Hospital/Winship Cancer Institute
-
Savannah, Georgia, Stati Uniti, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Stati Uniti, 31404
- Memorial Health University Medical Center
-
Savannah, Georgia, Stati Uniti, 31404
- Summit Cancer Care-Memorial
-
Savannah, Georgia, Stati Uniti, 31405
- Summit Cancer Care-Candler
-
Savannah, Georgia, Stati Uniti, 31404
- Low Country Cancer Care
-
-
Hawaii
-
Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Stati Uniti, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Stati Uniti, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Stati Uniti, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Stati Uniti, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Stati Uniti, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, Stati Uniti, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Stati Uniti, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Stati Uniti, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, Stati Uniti, 96813
- Island Urology
-
Honolulu, Hawaii, Stati Uniti, 96819
- Kaiser Permanente Moanalua Medical Center
-
Honolulu, Hawaii, Stati Uniti, 96859
- Tripler Army Medical Center
-
Lihue, Hawaii, Stati Uniti, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea, Hawaii, Stati Uniti, 96701
- Hawaii Cancer Care - Westridge
-
‘Aiea, Hawaii, Stati Uniti, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Stati Uniti, 96701
- Queen's Cancer Center - Pearlridge
-
‘Aiea, Hawaii, Stati Uniti, 96701
- The Cancer Center of Hawaii-Pali Momi
-
-
Idaho
-
Boise, Idaho, Stati Uniti, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Stati Uniti, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, Stati Uniti, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Stati Uniti, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, Stati Uniti, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Stati Uniti, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Stati Uniti, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Stati Uniti, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Stati Uniti, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Stati Uniti, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Stati Uniti, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Stati Uniti, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Stati Uniti, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Aurora, Illinois, Stati Uniti, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Stati Uniti, 61704
- Illinois CancerCare-Bloomington
-
Bloomington, Illinois, Stati Uniti, 61701
- OSF Saint Joseph Medical Center
-
Canton, Illinois, Stati Uniti, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Stati Uniti, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Stati Uniti, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Stati Uniti, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Stati Uniti, 62801
- Centralia Oncology Clinic
-
Danville, Illinois, Stati Uniti, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Stati Uniti, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Stati Uniti, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham, Illinois, Stati Uniti, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Stati Uniti, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, Stati Uniti, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Stati Uniti, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, Stati Uniti, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Stati Uniti, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Stati Uniti, 60134
- Northwestern Medicine Cancer Center Delnor
-
Glenview, Illinois, Stati Uniti, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park, Illinois, Stati Uniti, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Kewanee, Illinois, Stati Uniti, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, Stati Uniti, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Stati Uniti, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Stati Uniti, 60153
- Loyola University Medical Center
-
Mount Vernon, Illinois, Stati Uniti, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Stati Uniti, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Stati Uniti, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Stati Uniti, 61350
- Radiation Oncology of Northern Illinois
-
Pekin, Illinois, Stati Uniti, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Stati Uniti, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Stati Uniti, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Stati Uniti, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Stati Uniti, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Stati Uniti, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Stati Uniti, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Stati Uniti, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Stati Uniti, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Stati Uniti, 61114
- UW Health Carbone Cancer Center Rockford
-
Silvis, Illinois, Stati Uniti, 61282
- MercyOne Genesis Silvis Cancer Center
-
Skokie, Illinois, Stati Uniti, 60076
- North Shore Medical Center
-
Springfield, Illinois, Stati Uniti, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Stati Uniti, 62702
- Springfield Clinic
-
Springfield, Illinois, Stati Uniti, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Stati Uniti, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Stati Uniti, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Stati Uniti, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stati Uniti, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Stati Uniti, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Stati Uniti, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Evansville, Indiana, Stati Uniti, 47713
- Deaconess Clinic Downtown
-
Michigan City, Indiana, Stati Uniti, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Stati Uniti, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Stati Uniti, 46545
- Memorial Regional Cancer Center Day Road
-
Newburgh, Indiana, Stati Uniti, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, Stati Uniti, 47374
- Reid Health
-
South Bend, Indiana, Stati Uniti, 46601
- Memorial Hospital of South Bend
-
-
Iowa
-
Ames, Iowa, Stati Uniti, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Stati Uniti, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Stati Uniti, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Stati Uniti, 50036
- McFarland Clinic - Boone
-
Clive, Iowa, Stati Uniti, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Stati Uniti, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Stati Uniti, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Stati Uniti, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Stati Uniti, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, Stati Uniti, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, Stati Uniti, 52803
- MercyOne Genesis Davenport Medical Center
-
Des Moines, Iowa, Stati Uniti, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Stati Uniti, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Stati Uniti, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Stati Uniti, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Stati Uniti, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Stati Uniti, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Stati Uniti, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Stati Uniti, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, Stati Uniti, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Stati Uniti, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Stati Uniti, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Stati Uniti, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Stati Uniti, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Stati Uniti, 66720
- Cancer Center of Kansas - Chanute
-
Coffeyville, Kansas, Stati Uniti, 67337
- Coffeyville Regional Medical Center
-
Dodge City, Kansas, Stati Uniti, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Stati Uniti, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, Stati Uniti, 66801
- Newman Regional Health
-
Fort Scott, Kansas, Stati Uniti, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Stati Uniti, 67846
- Central Care Cancer Center - Garden City
-
Garden City, Kansas, Stati Uniti, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Stati Uniti, 67530
- Central Care Cancer Center - Great Bend
-
Great Bend, Kansas, Stati Uniti, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Stati Uniti, 67601
- HaysMed
-
Independence, Kansas, Stati Uniti, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Stati Uniti, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Stati Uniti, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Stati Uniti, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Stati Uniti, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Stati Uniti, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Stati Uniti, 66219
- Minimally Invasive Surgery Hospital
-
Liberal, Kansas, Stati Uniti, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Stati Uniti, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Stati Uniti, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Stati Uniti, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Stati Uniti, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Stati Uniti, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Stati Uniti, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Stati Uniti, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Stati Uniti, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Stati Uniti, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, Stati Uniti, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Stati Uniti, 67401
- Salina Regional Health Center
-
Salina, Kansas, Stati Uniti, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Stati Uniti, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, Stati Uniti, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Stati Uniti, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Stati Uniti, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Stati Uniti, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Stati Uniti, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Stati Uniti, 67208
- Associates In Womens Health
-
Winfield, Kansas, Stati Uniti, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Stati Uniti, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Stati Uniti, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Stati Uniti, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Stati Uniti, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Stati Uniti, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Stati Uniti, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Stati Uniti, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Stati Uniti, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Stati Uniti, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Stati Uniti, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Stati Uniti, 40202
- Jewish Hospital
-
Louisville, Kentucky, Stati Uniti, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Stati Uniti, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Stati Uniti, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Stati Uniti, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Stati Uniti, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Stati Uniti, 40165
- Jewish Hospital Medical Center South
-
-
Maine
-
Augusta, Maine, Stati Uniti, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Stati Uniti, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Stati Uniti, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Stati Uniti, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Stati Uniti, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, Stati Uniti, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Stati Uniti, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Stati Uniti, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Stati Uniti, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, Stati Uniti, 21204
- Greater Baltimore Medical Center
-
Bethesda, Maryland, Stati Uniti, 20889-5600
- Walter Reed National Military Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Stati Uniti, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Stati Uniti, 01805
- Lahey Clinic
-
Winchester, Massachusetts, Stati Uniti, 01890
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
-
-
Michigan
-
Adrian, Michigan, Stati Uniti, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Stati Uniti, 48109
- University of Michigan Rogel Cancer Center
-
Battle Creek, Michigan, Stati Uniti, 49017
- Bronson Battle Creek
-
Dearborn, Michigan, Stati Uniti, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Stati Uniti, 48201
- Wayne State University/Karmanos Cancer Institute
-
Farmington Hills, Michigan, Stati Uniti, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Stati Uniti, 48336
- Corewell Health Farmington Hills Hospital
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe, Michigan, Stati Uniti, 48230
- William Beaumont Hospital-Grosse Pointe
-
Kalamazoo, Michigan, Stati Uniti, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Stati Uniti, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Stati Uniti, 49048
- Beacon Kalamazoo
-
Monroe, Michigan, Stati Uniti, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, Stati Uniti, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Stati Uniti, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Port Huron, Michigan, Stati Uniti, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Stati Uniti, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Stati Uniti, 49677
- Corewell Health Reed City Hospital
-
Roseville, Michigan, Stati Uniti, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Stati Uniti, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Stati Uniti, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Stati Uniti, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Stati Uniti, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Stati Uniti, 48073
- Corewell Health William Beaumont University Hospital
-
Saint Joseph, Michigan, Stati Uniti, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Stati Uniti, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Stati Uniti, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Stati Uniti, 48314
- Mitchell Folbe MD PC
-
Traverse City, Michigan, Stati Uniti, 49684
- Munson Medical Center
-
Troy, Michigan, Stati Uniti, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Stati Uniti, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Stati Uniti, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Stati Uniti, 48085
- Corewell Health Beaumont Troy Hospital
-
Wyoming, Michigan, Stati Uniti, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Brainerd, Minnesota, Stati Uniti, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Stati Uniti, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Stati Uniti, 55433
- Mercy Hospital
-
Duluth, Minnesota, Stati Uniti, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Stati Uniti, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Stati Uniti, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Stati Uniti, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Stati Uniti, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Stati Uniti, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Stati Uniti, 55350
- Hutchinson Area Health Care
-
Maple Grove, Minnesota, Stati Uniti, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Stati Uniti, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stati Uniti, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stati Uniti, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stati Uniti, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stati Uniti, 55454
- Health Partners Inc
-
Monticello, Minnesota, Stati Uniti, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Stati Uniti, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Stati Uniti, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Stati Uniti, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Stati Uniti, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stati Uniti, 55102
- United Hospital
-
Shakopee, Minnesota, Stati Uniti, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Stati Uniti, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Stati Uniti, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stati Uniti, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stati Uniti, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, Stati Uniti, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Jackson, Mississippi, Stati Uniti, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, Stati Uniti, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, Stati Uniti, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Stati Uniti, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Stati Uniti, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Stati Uniti, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Independence, Missouri, Stati Uniti, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Stati Uniti, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Stati Uniti, 64804
- Freeman Health System
-
Joplin, Missouri, Stati Uniti, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Stati Uniti, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Stati Uniti, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Stati Uniti, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Stati Uniti, 64132
- Research Medical Center
-
Kansas City, Missouri, Stati Uniti, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Stati Uniti, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Stati Uniti, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, Stati Uniti, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, Stati Uniti, 64068
- Liberty Hospital
-
Rolla, Missouri, Stati Uniti, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Stati Uniti, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Stati Uniti, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Stati Uniti, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Stati Uniti, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stati Uniti, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stati Uniti, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Stati Uniti, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Stati Uniti, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Stati Uniti, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Stati Uniti, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, Stati Uniti, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Stati Uniti, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Stati Uniti, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Stati Uniti, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Stati Uniti, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stati Uniti, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stati Uniti, 59405
- Great Falls Clinic
-
Great Falls, Montana, Stati Uniti, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Stati Uniti, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Stati Uniti, 59901
- Logan Health Medical Center
-
Missoula, Montana, Stati Uniti, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Stati Uniti, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Stati Uniti, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Stati Uniti, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Stati Uniti, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Stati Uniti, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Stati Uniti, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Stati Uniti, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Stati Uniti, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Stati Uniti, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Stati Uniti, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Stati Uniti, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Stati Uniti, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stati Uniti, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Stati Uniti, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Stati Uniti, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Stati Uniti, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stati Uniti, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stati Uniti, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stati Uniti, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stati Uniti, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stati Uniti, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Stati Uniti, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stati Uniti, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stati Uniti, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stati Uniti, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Stati Uniti, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stati Uniti, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Stati Uniti, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Stati Uniti, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89169
- University Cancer Center
-
Las Vegas, Nevada, Stati Uniti, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Stati Uniti, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Stati Uniti, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Brick, New Jersey, Stati Uniti, 08724
- Ocean University Medical Center
-
Hackensack, New Jersey, Stati Uniti, 07601
- Hackensack University Medical Center
-
Holmdel, New Jersey, Stati Uniti, 07733
- Bayshore Community Hospital
-
Manahawkin, New Jersey, Stati Uniti, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, Stati Uniti, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, Stati Uniti, 07753
- Jersey Shore Medical Center
-
Red Bank, New Jersey, Stati Uniti, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, Stati Uniti, 07902
- Overlook Hospital
-
-
New York
-
Lake Success, New York, Stati Uniti, 11042
- Northwell Health/Center for Advanced Medicine
-
Middletown, New York, Stati Uniti, 10940
- Garnet Health Medical Center
-
New York, New York, Stati Uniti, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Rochester, New York, Stati Uniti, 14642
- University of Rochester
-
-
North Carolina
-
Asheville, North Carolina, Stati Uniti, 28801
- Mission Hospital
-
Asheville, North Carolina, Stati Uniti, 28806
- Messino Cancer Centers
-
Asheville, North Carolina, Stati Uniti, 28803
- AdventHealth Infusion Center Asheville
-
Charlotte, North Carolina, Stati Uniti, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Stati Uniti, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, Stati Uniti, 28262
- Southern Oncology Specialists-Charlotte
-
Charlotte, North Carolina, Stati Uniti, 28207
- Novant Health Carolina Surgical - Randolph
-
Clinton, North Carolina, Stati Uniti, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clinton, North Carolina, Stati Uniti, 28328
- Sampson Radiation Oncology
-
Clyde, North Carolina, Stati Uniti, 28721
- AdventHealth Infusion Center Haywood
-
Goldsboro, North Carolina, Stati Uniti, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Stati Uniti, 27534
- Wayne Memorial Hospital
-
Goldsboro, North Carolina, Stati Uniti, 27534
- Wayne Radiation Oncology
-
Hendersonville, North Carolina, Stati Uniti, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Stati Uniti, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Stati Uniti, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Stati Uniti, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, Stati Uniti, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Stati Uniti, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, Stati Uniti, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Stati Uniti, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, Stati Uniti, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, Stati Uniti, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Stati Uniti, 28117
- Novant Health Cancer Institute - Mooresville
-
Richlands, North Carolina, Stati Uniti, 28574
- ECU Health Oncology Richlands
-
-
North Dakota
-
Fargo, North Dakota, Stati Uniti, 58103
- Essentia Health Cancer Center-South University Clinic
-
-
Ohio
-
Beavercreek, Ohio, Stati Uniti, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Stati Uniti, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Stati Uniti, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, Stati Uniti, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Stati Uniti, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Stati Uniti, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Stati Uniti, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Stati Uniti, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Stati Uniti, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Stati Uniti, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Stati Uniti, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Stati Uniti, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Stati Uniti, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Stati Uniti, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Stati Uniti, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Stati Uniti, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Stati Uniti, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Stati Uniti, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Stati Uniti, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Stati Uniti, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Stati Uniti, 43228
- Doctors Hospital
-
Columbus, Ohio, Stati Uniti, 43215
- Grant Medical Center
-
Columbus, Ohio, Stati Uniti, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Stati Uniti, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Stati Uniti, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stati Uniti, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Stati Uniti, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Stati Uniti, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Stati Uniti, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Stati Uniti, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Stati Uniti, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Stati Uniti, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Stati Uniti, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Stati Uniti, 45840
- Orion Cancer Care
-
Franklin, Ohio, Stati Uniti, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Stati Uniti, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Stati Uniti, 45331
- Wayne Hospital
-
Greenville, Ohio, Stati Uniti, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Stati Uniti, 45429
- Kettering Medical Center
-
Kettering, Ohio, Stati Uniti, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Stati Uniti, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Stati Uniti, 43130
- Fairfield Medical Center
-
Marietta, Ohio, Stati Uniti, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Stati Uniti, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Stati Uniti, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mount Vernon, Ohio, Stati Uniti, 43050
- Knox Community Hospital
-
Newark, Ohio, Stati Uniti, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Stati Uniti, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Stati Uniti, 43616
- Saint Charles Hospital
-
Perrysburg, Ohio, Stati Uniti, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Stati Uniti, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Stati Uniti, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Stati Uniti, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Stati Uniti, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, Stati Uniti, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Stati Uniti, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, Stati Uniti, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Stati Uniti, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Stati Uniti, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Stati Uniti, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Stati Uniti, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, Stati Uniti, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Stati Uniti, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Stati Uniti, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Stati Uniti, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Stati Uniti, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Stati Uniti, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, Stati Uniti, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, Stati Uniti, 73142
- Integris Cancer Institute of Oklahoma
-
Tulsa, Oklahoma, Stati Uniti, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Stati Uniti, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Stati Uniti, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Stati Uniti, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Stati Uniti, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Stati Uniti, 97420
- Bay Area Hospital
-
Newberg, Oregon, Stati Uniti, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Stati Uniti, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Stati Uniti, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Stati Uniti, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Stati Uniti, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Stati Uniti, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Stati Uniti, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington, Pennsylvania, Stati Uniti, 19001
- Jefferson Abington Hospital
-
Beaver, Pennsylvania, Stati Uniti, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Stati Uniti, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Stati Uniti, 17822
- Geisinger Medical Center
-
Greensburg, Pennsylvania, Stati Uniti, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, Stati Uniti, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Johnstown, Pennsylvania, Stati Uniti, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Stati Uniti, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Stati Uniti, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Stati Uniti, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Moon Township, Pennsylvania, Stati Uniti, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Pittsburgh, Pennsylvania, Stati Uniti, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Stati Uniti, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Stati Uniti, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Stati Uniti, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Stati Uniti, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Stati Uniti, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, Stati Uniti, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Stati Uniti, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Stati Uniti, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Stati Uniti, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading, Pennsylvania, Stati Uniti, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Stati Uniti, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Stati Uniti, 17701
- UPMC Susquehanna
-
-
South Carolina
-
Anderson, South Carolina, Stati Uniti, 29621
- AnMed Health Cancer Center
-
Charleston, South Carolina, Stati Uniti, 29401
- Roper Hospital
-
Charleston, South Carolina, Stati Uniti, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, Stati Uniti, 29414
- Bon Secours Saint Francis Hospital
-
Charleston, South Carolina, Stati Uniti, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, Stati Uniti, 29414
- Charleston Oncology - Saint Francis
-
Charleston, South Carolina, Stati Uniti, 29414
- Lowcountry Oncology Associates - West Ashley
-
Gaffney, South Carolina, Stati Uniti, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Stati Uniti, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Stati Uniti, 29601
- Saint Francis Hospital
-
Greer, South Carolina, Stati Uniti, 29651
- Gibbs Cancer Center-Pelham
-
Mt. Pleasant, South Carolina, Stati Uniti, 29464
- Lowcountry Oncology Associates - Mount Pleasant
-
Spartanburg, South Carolina, Stati Uniti, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Stati Uniti, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Rapid City, South Dakota, Stati Uniti, 57701
- Rapid City Regional Hospital
-
-
Tennessee
-
Bristol, Tennessee, Stati Uniti, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Bristol, Tennessee, Stati Uniti, 37620
- Bristol Regional Medical Center
-
Chattanooga, Tennessee, Stati Uniti, 37404
- Memorial Hospital
-
Hixson, Tennessee, Stati Uniti, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Johnson City, Tennessee, Stati Uniti, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Stati Uniti, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Stati Uniti, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Ooltewah, Tennessee, Stati Uniti, 37363
- Memorial GYN Plus
-
-
Texas
-
Bryan, Texas, Stati Uniti, 77802
- Saint Joseph Regional Cancer Center
-
-
Utah
-
American Fork, Utah, Stati Uniti, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Stati Uniti, 84720
- Sandra L Maxwell Cancer Center
-
Farmington, Utah, Stati Uniti, 84025
- Farmington Health Center
-
Logan, Utah, Stati Uniti, 84321
- Logan Regional Hospital
-
Murray, Utah, Stati Uniti, 84107
- Intermountain Medical Center
-
Ogden, Utah, Stati Uniti, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Stati Uniti, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Stati Uniti, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Stati Uniti, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Stati Uniti, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Stati Uniti, 84143
- LDS Hospital
-
South Jordan, Utah, Stati Uniti, 84009
- South Jordan Health Center
-
St. George, Utah, Stati Uniti, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Bristol, Virginia, Stati Uniti, 24201
- Ballad Health Cancer Care - Bristol
-
Norton, Virginia, Stati Uniti, 24273
- Ballad Health Cancer Care - Norton
-
-
Washington
-
Aberdeen, Washington, Stati Uniti, 98520
- Providence Regional Cancer System-Aberdeen
-
Anacortes, Washington, Stati Uniti, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, Stati Uniti, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Stati Uniti, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Stati Uniti, 98004
- Overlake Medical Center
-
Bellevue, Washington, Stati Uniti, 98005
- Swedish Cancer Institute-Eastside Oncology Hematology
-
Bellingham, Washington, Stati Uniti, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Stati Uniti, 98166
- Saint Anne Hospital
-
Centralia, Washington, Stati Uniti, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Stati Uniti, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Stati Uniti, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Stati Uniti, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Stati Uniti, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Stati Uniti, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Stati Uniti, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Stati Uniti, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Stati Uniti, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Stati Uniti, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Stati Uniti, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Stati Uniti, 98499
- Saint Clare Hospital
-
Longview, Washington, Stati Uniti, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, Stati Uniti, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, Stati Uniti, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Stati Uniti, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Stati Uniti, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Stati Uniti, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Stati Uniti, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, Stati Uniti, 98055
- Valley Medical Center
-
Seattle, Washington, Stati Uniti, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Stati Uniti, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Stati Uniti, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Stati Uniti, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Stati Uniti, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Stati Uniti, 98104
- Pacific Gynecology Specialists
-
Sedro-Woolley, Washington, Stati Uniti, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Stati Uniti, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Stati Uniti, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Stati Uniti, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Stati Uniti, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Stati Uniti, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Stati Uniti, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Stati Uniti, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Stati Uniti, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Stati Uniti, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Stati Uniti, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Stati Uniti, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Stati Uniti, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Stati Uniti, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Stati Uniti, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Burlington, Wisconsin, Stati Uniti, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Fond du Lac, Wisconsin, Stati Uniti, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Stati Uniti, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stati Uniti, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stati Uniti, 54311
- Aurora BayCare Medical Center
-
Johnson Creek, Wisconsin, Stati Uniti, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Stati Uniti, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Stati Uniti, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Stati Uniti, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, Stati Uniti, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Stati Uniti, 54143
- Bay Area Medical Center
-
Milwaukee, Wisconsin, Stati Uniti, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stati Uniti, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stati Uniti, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stati Uniti, 53233
- Aurora Sinai Medical Center
-
Mukwonago, Wisconsin, Stati Uniti, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Stati Uniti, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Stati Uniti, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Stati Uniti, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stati Uniti, 53406
- Aurora Cancer Care-Racine
-
Sheboygan, Wisconsin, Stati Uniti, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, Stati Uniti, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stati Uniti, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stati Uniti, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Stati Uniti, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, Stati Uniti, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Stati Uniti, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, Stati Uniti, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Stati Uniti, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Stati Uniti, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Stati Uniti, 82801
- Welch Cancer Center
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
18 anni e precedenti (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
-
STEP 1: REGISTRATION
-
Patients must have histologically or cytologically confirmed stage IV or unresectable stage III BRAF V600E or BRAF V600K mutant melanoma
-
Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic techniques include but are not restricted to DNA sequencing, pyrosequencing, polymerase chain reaction (PCR), melting point assays, and immunohistochemistry
-
Contrast-enhanced CT scans of the neck, chest, abdomen and pelvis are required; a whole body PET/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
-
Patients must not have received a prior BRAF or MEK inhibitor
-
Patients with a history of brain metastases are eligible if the patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to registration
-
Patients must not have received any anti-cancer drug within 28 days prior to registration, and must not have received any nitrosoureas or mitomycin C within 42 days prior to registration
-
Patients must not have received any major surgery or immunotherapy within 28 days prior to registration
-
Patients must not have any unresolved toxicity greater than National Cancer Institute (NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia within 7 days prior to registration
-
Patients must be age >= 18 years of age
-
Absolute neutrophil count (ANC) >= 1,200/ul (obtained within 28 days prior to registration)
-
Platelets >= 100,000/ul (obtained within 28 days prior to registration)
-
Hemoglobin >= 9 g/dL (obtained within 28 days prior to registration)
-
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert's syndrome) (obtained within 28 days prior to registration)
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
-
Serum albumin >= 2.5 g/dL (obtained within 28 days prior to registration)
-
Serum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration
-
Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to registration in order to obtain baseline stratification information
-
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by ECHO or MUGA within 28 days prior to registration
-
Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG) (corrected using the Bazett's formula) within 28 days prior to registration
-
Patients with known history or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) are not eligible:
-
History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension, diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes)
-
Visible retinal pathology as assessed by ophthalmic exam that is considered a risk factor for RVO or CSR such as:
- Evidence of new optic disc cupping
- Evidence of new visual field defects
- Intraocular pressure > 21 mmHg
-
NOTE: ophthalmic exam is required for all patients; exam must be obtained within 28 days prior to registration
-
-
Patients must be able to take oral medications; patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
-
Patients receiving anticoagulation treatment are allowed to participate with international normalized ratio (INR) established within the therapeutic range
-
Patients must not have a history of pneumonitis or interstitial lung disease
-
Patients must not have any grade II/III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis]) can be entered on study; patients with a history of atrial fibrillation must have atrial fibrillation controlled for at least 30 days prior to registration
-
Patients with known hepatitis B or hepatitis C are not eligible, regardless of concomitant antiretroviral therapy or current viral load
-
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:
-
Cluster of differentiation (CD)4 cells >= 500/uL
-
Serum HIV viral load of < 25,000 IU/ml
-
No current antiretroviral therapy
- Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
-
-
Pre-study history and physical must be obtained with 28 days prior to registration
-
Patients must have dermatology exam obtained within 28 days prior to registration to obtain baseline measurement; exam to be performed by treating physician or designated dermatologist
-
Patients must have Zubrod performance status of 0, 1 or 2
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years; exception: patients with known history of colon cancer, cancer of the pancreas, or any cancer known to harbor an activating RAS mutation are ineligible regardless of stage or time since diagnosis
-
Patients must not be pregnant or nursing because of the risk of fetal harm; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; hormonal contraception is not allowed due to drug interactions which can render hormonal contraceptives ineffective
-
Patients must be offered the opportunity to participate in specimen banking
-
Patients with cutaneous or superficial lesions that do not require imaging guidance for biopsy must be willing to undergo biopsies for tissue submission and blood draws for translational medicine
-
Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
-
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
-
STEP 2: RANDOMIZATION
-
After completing one cycle of therapy, patients will be registered for randomization between intermittent and continuous dosing, provided that they were eligible for the initial step 1 registration and satisfy the following criteria
-
Patients must not have unequivocal disease progression (by RECIST v1.1) during the first cycle; patients must have disease assessed using the same method as baseline within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1, or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up tumor assessment form (RECIST 1.1)
-
Patients must be registered to step 2: randomization within +/- 5 days of starting cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Arm I (continuous dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
Altri nomi:
Undergo ECHO
Altri nomi:
Undergo MUGA
Altri nomi:
Undergo CT or PET/CT
Altri nomi:
Undergo PET/CT
Altri nomi:
Given PO
Altri nomi:
Given PO
Altri nomi:
|
|
Sperimentale: Arm II (intermittent dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study. |
Undergo blood sample collection
Altri nomi:
Undergo ECHO
Altri nomi:
Undergo MUGA
Altri nomi:
Undergo CT or PET/CT
Altri nomi:
Undergo PET/CT
Altri nomi:
Given PO
Altri nomi:
Given PO
Altri nomi:
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Progression-free survival (PFS)
Lasso di tempo: Measured from date of randomization, assessed up to 5 years
|
Testing of the superiority of intermittent dosing of dabrafenib and trametinib compared to continuous dosing with these two same agents will be based on progression-free survival. Stratified Cox regression models stratified by stratification factors will be used for all analyses. |
Measured from date of randomization, assessed up to 5 years
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Overall survival
Lasso di tempo: Up to 5 years
|
Overall survival between patients on each arm and survival after progression will be compared using Cox regression models. |
Up to 5 years
|
|
Response rates
Lasso di tempo: Up to 5 years
|
Response rates between arms will be compared using Fisher's exact test. |
Up to 5 years
|
|
Rates of fever
Lasso di tempo: Up to 5 years
|
Defined as >= grade 3 per Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 with attribution possibly, probably, or definitely related to treatment; or any >= grade 1 per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment with chills, dehydration, hypotension, dizziness, or muscle weakness per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment reported during the same course. Rates of fever between arms will also be compared using Fisher's exact test. |
Up to 5 years
|
Altre misure di risultato
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Molecular events leading to reactivation of the MAPK pathway
Lasso di tempo: Up to 5 years
|
Compared between patients of the two treatment groups. |
Up to 5 years
|
|
Change in biomarkers associated with PFS of archived tissue
Lasso di tempo: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
|
Interaction between baseline biomarkers and treatment arm
Lasso di tempo: Baseline up to 5 years
|
Cox regression analyses will be used to evaluate biomarkers' associations with PFS. |
Baseline up to 5 years
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Investigatore principale: Alain P Algazi, SWOG Cancer Research Network
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS. Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023. Epub 2021 Aug 19.
- Algazi AP, Othus M, Daud AI, Lo RS, Mehnert JM, Truong TG, Conry R, Kendra K, Doolittle GC, Clark JI, Messino MJ, Moore DF Jr, Lao C, Faller BA, Govindarajan R, Harker-Murray A, Dreisbach L, Moon J, Grossmann KF, Ribas A. Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial. Nat Med. 2020 Oct;26(10):1564-1568. doi: 10.1038/s41591-020-1060-8. Epub 2020 Oct 5.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
19 settembre 2014
Completamento primario (Stimato)
15 marzo 2027
Completamento dello studio (Stimato)
15 marzo 2027
Date di iscrizione allo studio
Primo inviato
18 luglio 2014
Primo inviato che soddisfa i criteri di controllo qualità
18 luglio 2014
Primo Inserito (Stimato)
21 luglio 2014
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
12 novembre 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
10 novembre 2026
Ultimo verificato
1 settembre 2026
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
- Neoplasie per sede
- Neoplasie
- Neoplasie per tipo istologico
- Malattie della pelle
- Tumori neuroectodermici
- Neoplasie, cellule germinali ed embrionali
- Neoplasie, tessuto nervoso
- Tumori neuroendocrini
- Nevi e melanomi
- Neoplasie cutanee
- Malattie della pelle e del tessuto connettivo
- Melanoma
- Tecniche investigative
- Tecniche di laboratorio clinico
- Tecniche e procedure diagnostiche
- Diagnosi
- Tecniche di chimica, analitiche
- Analisi dello spettro
- Gestione dei campioni
- Dabrafenib
- trametinib
- Spettroscopia di risonanza magnetica
Altri numeri di identificazione dello studio
- NCI-2014-01470
- U10CA032102 (Sovvenzione/contratto NIH degli Stati Uniti)
- U10CA180888 (Sovvenzione/contratto NIH degli Stati Uniti)
- NCI-2014-01470 (Identificatore di registro: CTRP (Clinical Trial Reporting Program))
- S1320 (Altro identificatore: CTEP)
- S1320 (Altro identificatore: SWOG)
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .