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Effectiveness and Costs of Internet-based Treatment for Harmful Alcohol Use and Face-to-face Treatment in Addiction Care

11 september 2026 uppdaterad av: Kristina Sinadinovic, Karolinska Institutet

Comparing Effectiveness and Costs of Internet-based Treatment for Problematic Alcohol Use and Face-to-face Treatment in Addiction Care: A Randomized Controlled Trial

The purpose of this trial is to compare the effectiveness and costs of a five-module Internet-based treatment program (including therapist support) for harmful alcohol use with the effectiveness and cost of the same treatment content delivered face-to-face in specialized addiction treatment. The hypotheses to be tested through this trial are that:

  1. The Internet-based treatment program (including therapist support) is as effective (reducing alcohol consumption) as the same treatment content delivered face-to-face in specialized addiction treatment.
  2. The Internet-based treatment program (including therapist support) is associated with lower cost per treated individual in relation to the achieved effects (in terms of reduced alcohol consumption) compared with the same treatment content delivered face-to-face in specialized addiction treatment.

The design is a two-armed randomized controlled trial, and outcomes are measured in terms of changes in alcohol consumption, problematic alcohol use as well as alcohol dependence, depression, anxiety, quality of life and costs for the treatments. A minimum of 350 participants will be recruited and randomized into two groups:

Intervention group 1: All participants in this group will have access to the five-module Internet-based treatment program for harmful alcohol use and have access to a therapist with training in psychotherapy (CBT) who assists and counsels the participant throughout the program.

Intervention group 2: All participants in this group will attend five face-to-face treatment sessions in specialized addiction treatment.

Studieöversikt

Status

Avslutad

Betingelser

Intervention / Behandling

Studietyp

Interventionell

Inskrivning (Faktisk)

303

Fas

  • Inte tillämpbar

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Sverige
      • Stockholm, Sverige, 171 77
        • Karolinska Institutet

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år och äldre (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Beskrivning

Inclusion Criteria:

  • 18 years or older
  • 16 points on Alcohol Use Disorders Identification Test or at least 3 criteria on the International Classification of Diseases (ICD-10) for Alcohol Dependence
  • Resident in Stockholm County

Exclusion Criteria:

  • Lack of understanding of the Swedish language.
  • Doctor's assessment that there is a risk for severe withdrawal symptoms, risk for suicide or mental illness requiring separate care.
  • Doctor's assessment that there is a need for medication for alcohol dependence.

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

  • Primärt syfte: Behandling
  • Tilldelning: Randomiserad
  • Interventionsmodell: Parallellt uppdrag
  • Maskning: Enda

Vapen och interventioner

Deltagargrupp / Arm
Intervention / Behandling
Experimentell: Internet-based treatment
A five-module Internet-based treatment program for harmful alcohol use (including therapist support) based on Motivational Interviewing, Cognitive Behavioral Treatment and Relapse prevention, focusing on: Motivation to change harmful alcohol use, defining a goal for the treatment, self-control strategies, risk situations, planning alternative behaviors and relapse prevention.
Beteende: Guide to better alcohol habits
A treatment for harmful alcohol use based on Motivational Interviewing, Cognitive Behavioral Treatment and Relapse prevention, focusing on: Motivation to change harmful alcohol use, defining a goal for the treatment, self-control strategies, risk situations, planning alternative behaviors and relapse prevention.
Aktiv komparator: Face-to-face treatment
Same treatment content as in the Internet-based treatment delivered via face-to-face treatment sessions in specialized addiction treatment.
Beteende: Guide to better alcohol habits
A treatment for harmful alcohol use based on Motivational Interviewing, Cognitive Behavioral Treatment and Relapse prevention, focusing on: Motivation to change harmful alcohol use, defining a goal for the treatment, self-control strategies, risk situations, planning alternative behaviors and relapse prevention.

Vad mäter studien?

Primära resultatmått

Resultatmått
Tidsram
Number of standard alcohol units consumed in the past 7 days measured with Time Line Follow Back method
Tidsram: 3 months post-randomization
3 months post-randomization

Sekundära resultatmått

Resultatmått
Tidsram
Number of standard alcohol units consumed in the past 7 days measured with Time Line Follow Back method
Tidsram: 6 months post-randomization
6 months post-randomization
Number of standard alcohol units consumed in the past 7 days measured with Time Line Follow Back method
Tidsram: 12 months post-randomization
12 months post-randomization
Number of standard alcohol units consumed in the past 7 days measured with Time Line Follow Back method
Tidsram: 24 months post-randomization
24 months post-randomization
Alcohol Use Disorders Identification Test score
Tidsram: 3 months post-randomization
3 months post-randomization
Alcohol Use Disorders Identification Test score
Tidsram: 6 months post-randomization
6 months post-randomization
Alcohol Use Disorders Identification Test score
Tidsram: 12 months post-randomization
12 months post-randomization
Alcohol Use Disorders Identification Test score
Tidsram: 24 months post-randomization
24 months post-randomization
Number of criteria for alcohol dependence according to International Classification of Diseases - 10
Tidsram: 3 months post-randomization
3 months post-randomization
Number of criteria for alcohol dependence according to International Classification of Diseases - 10
Tidsram: 6 months post-randomization
6 months post-randomization
Number of criteria for alcohol dependence according to International Classification of Diseases - 10
Tidsram: 12 months post-randomization
12 months post-randomization
Number of criteria for alcohol dependence according to International Classification of Diseases - 10
Tidsram: 24 months post-randomization
24 months post-randomization
Number of criteria for alcohol dependence according to Diagnostic and Statistical Manual of Mental Disorders - V
Tidsram: 3 months post-randomization
3 months post-randomization
Number of criteria for alcohol dependence according to Diagnostic and Statistical Manual of Mental Disorders - V
Tidsram: 6 months post-randomization
6 months post-randomization
Number of criteria for alcohol dependence according to Diagnostic and Statistical Manual of Mental Disorders - V
Tidsram: 12 months post-randomization
12 months post-randomization
Number of criteria for alcohol dependence according to Diagnostic and Statistical Manual of Mental Disorders - V
Tidsram: 24 months post-randomization
24 months post-randomization
Number of days absent from work due to illness
Tidsram: 3 months post-randomization
3 months post-randomization
Number of days absent from work due to illness
Tidsram: 6 months post-randomization
6 months post-randomization
Number of days absent from work due to illness
Tidsram: 12 months post-randomization
12 months post-randomization
Number of days absent from work due to illness
Tidsram: 24 months post-randomization
24 months post-randomization
Score on Montgomery-Åsberg Depression Rating Scale
Tidsram: 3 months post-randomization
3 months post-randomization
Score on Montgomery-Åsberg Depression Rating Scale
Tidsram: 6 months post-randomization
6 months post-randomization
Score on Montgomery-Åsberg Depression Rating Scale
Tidsram: 12 months post-randomization
12 months post-randomization
Score on Montgomery-Åsberg Depression Rating Scale
Tidsram: 24 months post-randomization
24 months post-randomization
Score on Generalised Anxiety Disorder 7-item scale
Tidsram: 3 months post-randomization
3 months post-randomization
Score on Generalised Anxiety Disorder 7-item scale
Tidsram: 6 months post-randomization
6 months post-randomization
Score on Generalised Anxiety Disorder 7-item scale
Tidsram: 12 months post-randomization
12 months post-randomization
Score on Generalised Anxiety Disorder 7-item scale
Tidsram: 24 months post-randomization
24 months post-randomization
Score on EQ-5D measuring the quality of life
Tidsram: 3 months post-randomization
3 months post-randomization
Score on EQ-5D measuring the quality of life
Tidsram: 6 months post-randomization
6 months post-randomization
Score on EQ-5D measuring the quality of life
Tidsram: 12 months post-randomization
12 months post-randomization
Score on EQ-5D measuring the quality of life
Tidsram: 24 months post-randomization
24 months post-randomization
Cost for treatment
Tidsram: 3 months post-randomization
3 months post-randomization
Cost for treatment
Tidsram: 6 months post-randomization
6 months post-randomization
Cost for treatment
Tidsram: 12 months post-randomization
12 months post-randomization
Cost for treatment
Tidsram: 24 months post-randomization
24 months post-randomization

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Karolinska Institutet

Samarbetspartners

Region Stockholm

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

12 november 2015

Primärt slutförande (Faktisk)

31 mars 2020

Avslutad studie (Faktisk)

31 mars 2025

Studieregistreringsdatum

Först inskickad

11 januari 2016

Först inskickad som uppfyllde QC-kriterierna

1 februari 2016

Första postat (Beräknad)

2 februari 2016

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

15 september 2026

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

11 september 2026

Senast verifierad

1 september 2026

Mer information

Termer relaterade till denna studie

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • 2014/1758-31/2

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